Tuning the Protein Phosphorylation by Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) in Normal and Cancer Cells.

abstract：:Hepatocellular carcinoma (HCC) is a major malignancy of cancer-related mortality worldwide. Metastasis-associated in colon cancer-1 (MACC1) was suggested as a marker for vascular invasive HCC. This study investigated the MACC1 single-nucleotide polymorphisms (SNPs) to evaluate HCC susceptibility and clinicopathologica...

journal_title：Journal of Cancer

authors： Lin CH,Hsieh MJ,Lee HL,Yang SF,Su SC,Lee WJ,Chou YE

更新日期：2020-01-14 00:00:00

abstract：:Myeloid-derived suppressor cells (MDSCs) have strong immunosuppressive functions and contribute to the formation of the tumor microenvironment. Long non-coding (Lnc) RNAs are highly important factors associated with tumors and may be used as markers for tumor diagnosis, which is valuable for targeted therapy. LncRNA M...

journal_title：Journal of Cancer

authors： Zhou Q,Tang X,Tian X,Tian J,Zhang Y,Ma J,Xu H,Wang S

更新日期：2018-06-14 00:00:00

abstract：:Background & Aims: Primary tumors of colorectal carcinoma (CRC) with liver metastasis might gain some liver-specific characteristics to adapt the liver micro-environment. This study aims to reveal potential liver-like transcriptional characteristics associated with the liver metastasis in primary colorectal carcinoma....

journal_title：Journal of Cancer

authors： Cheng J,Song X,Ao L,Chen R,Chi M,Guo Y,Zhang J,Li H,Zhao W,Guo Z,Wang X

更新日期：2018-04-06 00:00:00

abstract：:Tissue-derived RNA, DNA and protein samples become more and more crucial for molecular detection in clinical research, personalized and targeted cancer therapy. This study evaluated how to biobanking colorectal tissues through examining the influences of cold ischemic time and freeze-thaw cycles on RNA, DNA and protei...

journal_title：Journal of Cancer

authors： Fan XJ,Huang Y,Wu PH,Yin XK,Yu XH,Fu XH,Feng LL,Wang YL,Yi HJ,Chen ZT,Yin JX,Zhang DL,Feng WX,Bai SM,Kim T,Mills GB,Lu YL,Wan XB,Wang L

更新日期：2019-08-27 00:00:00

abstract：:Transforming growth factor β1 (TGF-β1) plays an important role in tumor initiation and development by inducing epithelial-mesenchymal Transition (EMT). Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is a long noncoding RNA (lncRNA) that contributes to the invasion and metastasis of tumors, including e...

journal_title：Journal of Cancer

authors： Liu Q,Zheng S,Chen Y,Liu T,Han X,Zhang X,Shen T,Lu X

更新日期：2020-10-04 00:00:00

abstract：:Background: Surgery for pancreatic cancer with liver metastases (PCL) is not recommended in the international guidelines, and investigation of its clinical significance in patients with PCL is very limited. This study explored whether surgery, especially synchronous resection of the primary tumor and liver metastases ...

journal_title：Journal of Cancer

authors： Su BB,Bai DS,Yu JQ,Zhang C,Jin SJ,Zhou BH,Jiang GQ

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:There is often a finite progression-free interval of time between one systemic therapy and the next when treating patients with advanced cancer. While it appears that progression-free survival (PFS) between systemic therapies tends to get shorter for a number of factors, there has not been a formal evaluatio...

journal_title：Journal of Cancer

authors： Bailey CH,Jameson G,Sima C,Fleck S,White E,Von Hoff DD,Weiss GJ

更新日期：2012-01-01 00:00:00

abstract：:Objective: Liposarcoma is a mesenchymal malignant tumor characterized by adipocyte differentiation which is divided into four subtypes with different prognosis. Accurate histopathological diagnosis is essential for precise treatment. Perilipins, including PLIN1, PLIN2, PLIN3, PLIN4, PLIN5, is a family of lipid droplet...

journal_title：Journal of Cancer

authors： Zhang Q,Zhang P,Li B,Dang H,Jiang J,Meng L,Zhang H,Zhang Y,Wang X,Li Q,Wang Y,Liu C,Li F

更新日期：2020-04-07 00:00:00

abstract：:Objectives: LncRNA associated with microvascular invasion in hepatocellular carcinoma (lncRNA MVIH) is a newly discovered long non-coding RNA that aberrantly up-regulates and holds prognostic value in various tumors. The aim of the review and meta-analysis is to assess its prognostic potential and functions in maligna...

journal_title：Journal of Cancer

authors： Zhang Y,Lin S,Yang X,Zhang X

更新日期：2019-02-26 00:00:00

abstract：:Philadelphia chromosome-positive (Ph+) leukemia is characterized by reciprocal translocation between chromosomes 9 and 22. The resultant BCR/ABL fusion protein displays constitutive tyrosine kinase activity, leading to the induction of aberrant proliferation and neoplastic transformation. The bone marrow (BM) microenv...

journal_title：Journal of Cancer

authors： Kidan N,Khamaisie H,Ruimi N,Roitman S,Eshel E,Dally N,Ruthardt M,Mahajna J

更新日期：2017-10-23 00:00:00

abstract：BACKGROUND:MALAT-1 is significantly overexpressed in various cancers, suggesting that it might be a potential biomarker of cancer. METHODS:A meta-analysis was performed using microarray data obtained via the Affymetrix Human Genome U133 Plus 2.0 platform found in the Gene Expression Omnibus (GEO) database and data obt...

journal_title：Journal of Cancer

authors： Wang Y,Xue D,Li Y,Pan X,Zhang X,Kuang B,Zhou M,Li X,Xiong W,Li G,Zeng Z,Yang T

更新日期：2016-05-20 00:00:00

abstract：:Metabolic syndrome has been previously identified as a risk factor for breast cancer and is increasingly a public health concern. This study aims to investigate the prevalence of metabolic syndrome and its components among primary breast cancer and control population. The clinical data of metabolic syndrome and its co...

journal_title：Journal of Cancer

authors： Wu YT,Luo QQ,Li X,Arshad B,Xu Z,Ran L,Zhao CX,Wu H,Shi YL,Chen HR,Li H,Li HY,Wu KN,Kong LQ

更新日期：2018-01-01 00:00:00

abstract：BACKGROUND:Medullary thyroid cancer (MTC) commonly presents with lymph node (LN) metastases, and has a worse prognosis than papillary thyroid cancer (PTC). Tumor size and LN involvement have been shown to affect stage of disease; however, to our knowledge, ours is the first study that attempts to correlate anterior nec...

journal_title：Journal of Cancer

authors： Guerrero MA,Lindsay S,Suh I,Vriens MR,Khanafshar E,Shen WT,Gosnell J,Kebebew E,Duh QY,Clark OH

更新日期：2011-04-08 00:00:00

abstract：:Studies have indicated the significance of tumor associated macrophages (TAMs) in breast cancer; however, inconsistent results still exist. We retrospectively reviewed the macrophage distribution in 1579 breast cancer specimens with anti-CD68 or anti-CD163 immunohistochemical staining, and further analyzed the overall...

journal_title：Journal of Cancer

authors： Ni C,Yang L,Xu Q,Yuan H,Wang W,Xia W,Gong D,Zhang W,Yu K

更新日期：2019-07-23 00:00:00

abstract：:Objectives: To investigate the effect of the concurrent use of trastuzumab and anthracycline-based neoadjuvant chemotherapy (NAC) for HER2-positive breast cancer in terms of pCR and cardiotoxicity. Methods: We systematically searched Pubmed, Embase, Cochrane and SinoMed databases from inception until 1 July 2017 for r...

journal_title：Journal of Cancer

authors： Wu YT,Xu Z,Arshad B,Wu JS,Zhang K,Wu H,Li X,Li H,Li YC,Wang ZL,Wu KN,Kong LQ

更新日期：2018-08-06 00:00:00

abstract：:Melanoma is the most aggressive and treatment-resistant form of skin cancer. Curcumol is a Chinese medicinal herb traditionally used as a cancer remedy. However, the molecular mechanisms underlying the anticancer activity of curcumol in melanoma remains largely unknown. In the present study, we observed that Curcumol ...

journal_title：Journal of Cancer

authors： Ning N,Liu S,Liu X,Tian Z,Jiang Y,Yu N,Tan B,Feng H,Feng X,Zou L

更新日期：2020-01-14 00:00:00

abstract：:Background: Regulatory T cells (Tregs) and plasmacytoid dendritic cells (pDCs) are the main immunosuppressive cells in tumor microenvironment of gastric cancer (GC). In this prospective study, the association of prognosis with Tregs subsets and pDCs were further analyzed. Methods: pDCs, Tregs population and its expres...

journal_title：Journal of Cancer

authors： Liu X,Yu H,Yan C,Mei Y,Lin C,Hong Y,Lin X,Zhang Q,Yu J

更新日期：2019-10-22 00:00:00

abstract：:MicroRNA-519d (miR-519d) has been reported to play important roles in tumor development and progression in multiple cancers, either as tumor suppressor or tumor promotor. However, the expression level, biological function and molecular mechanisms of miR-519d in oral squamous cell carcinoma (OSCC) remain unclear. There...

journal_title：Journal of Cancer

authors： Jin Y,Li Y,Wang X,Yang Y

更新日期：2019-06-02 00:00:00

abstract：:Background: Whether metastasectomy improves prognosis of gastric cancer patients with ovarian metastases (Krukenberg tumors) is not clear. In this study, we examined the survival benefit of metastasectomy combined with chemotherapy for treatment of synchronous Krukenberg tumors from gastric cancer and identified the p...

journal_title：Journal of Cancer

authors： Yan D,Du Y,Dai G,Huang L,Xu Q,Yu P

更新日期：2018-10-20 00:00:00

abstract：:Tumor progression is often associated with chronic inflammation in the tumor microenvironment, which is mediated by numerous cytokines, chemokines and growth factors produced by cancer and stroma cells. All these mediators support tumor development and immunosuppression in autocrine and/or paracrine ways. Neutralizati...

journal_title：Journal of Cancer

authors： Sevko A,Umansky V

更新日期：2013-01-01 00:00:00

abstract：:Butyrate, a product of dietary fiber and a histone deacetylase inhibitor, induces apoptosis of colorectal cancer cells; this effect of butyrate is in part mediated by its ability to hyperactivate Wnt signaling, and may in part explain the preventive action of dietary fiber against colorectal cancer. However, the mecha...

journal_title：Journal of Cancer

authors： Bordonaro M

更新日期：2020-01-01 00:00:00

abstract：:The alterations of MET have been detected in non-small-cell lung cancer (NSCLC). However, the prognostic impact of MET gene copy number gain (CNG) has not been consistent among studies. We performed this meta-analysis to evaluate the prognostic value of high MET CNG in patients with NSCLC. A systematic computerized se...

journal_title：Journal of Cancer

authors： Kim JH,Kim HS,Kim BJ

更新日期：2018-04-23 00:00:00

abstract：:Cancer cells express epithelial markers, and when progressing in malignancy they may express markers of the mesenchymal cell type. Therefore an epithelial-mesenchymal transition of the cancer cells is assumed. However the mesenchymal markers can equally well be interpreted as myeloid markers since they are common in b...

journal_title：Journal of Cancer

authors： Schramm HM

更新日期：2014-01-15 00:00:00

abstract：:Background: Uterine cervical cancer (UCC) is a common malignant tumor in women. We conducted this work to provide a though description on the patterns of distant metastases and to investigate the relevant factors for prognosis of UCC patients based on a large population. Patients and methods: UCC patients with FIGO st...

journal_title：Journal of Cancer

authors： Zhang Y,Guo Y,Zhou X,Wang X,Wang X

更新日期：2020-01-14 00:00:00

abstract：:Various factors modulate the risk of hepatoblastoma. In this study, we aimed to investigate whether single nucleotide polymorphisms (SNPs) in the YTHDF1 gene could predispose to hepatoblastoma. We used TaqMan assay to genotype two YTHDF1 SNPs (rs6011668 C>T and rs6090311 A>G) in a Chinese population composed of 313 su...

journal_title：Journal of Cancer

authors： Luo Z,Li G,Wang M,Zhu J,Yang Z,Li Y,Zhang J,Xin Y,Li S,Li L,Zhuo Z,He J

更新日期：2020-06-28 00:00:00

abstract：:Human papillomavirus (HPV) is a DNA virus that infects epithelial cells and has been implicated in the development of cervical cancer. Few therapeutic strategies have been designed for the treatment of cervical intraepithelial neoplasia, a precursor of cervical cancer. In these early stages, the HPV E2 protein is the ...

journal_title：Journal of Cancer

authors： Bermúdez-Morales VH,Fierros-Zarate G,García-Meléndrez C,Alcocer-Gonzalez JM,Morales-Ortega A,Peralta-Zaragoza O,Torres-Poveda K,Burguete-García AI,Hernández-Márquez E,Madrid-Marina V

更新日期：2016-09-27 00:00:00

abstract：:Background: Infiltration of immune cells and immune microenvironment determine the proliferative activity of the tumor and metastasis. The aim of this study was to analyze the influence of activation or suppression of the immune response mediators on the prognosis of biliary tract cancer (BTC). Methods: We searched Pu...

journal_title：Journal of Cancer

authors： Wang Y,Ding M,Zhang Q,Wang J,Yang X,Zhou F,Li L,Yuan Z,Jin H,Qian Q

更新日期：2017-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is an important health issue worldwide, accounting for the third place of cancer incidence. Chronic inflammation, as seen in Crohn's disease and ulcerative colitis, is the most important risk factor for developing CRC, as it favours neoplastic transformation by enhancing epithelial cell turnove...

journal_title：Journal of Cancer

authors： Figueroa-González G,García-Castillo V,Coronel-Hernández J,López-Urrutia E,León-Cabrera S,Arias-Romero LE,Terrazas LI,Rodríguez-Sosa M,Campos-Parra AD,Zúñiga-Calzada E,Lopez-Camarillo C,Morales-González F,Jacobo-Herrera NJ,Pérez

更新日期：2016-07-25 00:00:00

abstract：:Objective: As a member of the N-myc downregulated gene family, N-Myc downstream-regulated gene 2 (NDRG2) contributes to tumorigenesis of various types of cancer. The expression status of NDRG2 in colorectal cancer (CRC) and its prognostic value remain to be elucidated. The goal of this study was to determine the expre...

journal_title：Journal of Cancer

authors： Chen W,Peng J,Ou Q,Wen Y,Jiang W,Deng Y,Zhao Y,Wan D,Pan Z,Fang Y

更新日期：2019-06-09 00:00:00

abstract：:Purpose: Diffuse large B cell lymphoma (DLBCL) is one of the most common B cell lymphomas, which displays heterogeneous pathologies. Programmed cell death 1/ programmed cell death ligand 1 (PD-1/PD-L1) plays an essential role in immunosuppression in multiple malignancies. Signal transducer and activator of transcripti...

journal_title：Journal of Cancer

authors： Fei Y,Yu J,Li Y,Li L,Zhou S,Zhang T,Li L,Qiu L,Meng B,Pan Y,Ren X,Qian Z,Wang X,Zhang H

更新日期：2020-10-17 00:00:00