Tuning the Protein Phosphorylation by Receptor Type Protein Tyrosine Phosphatase Epsilon (PTPRE) in Normal and Cancer Cells.


:Tyrosine phosphorylation is an important post-translation modification of proteins that is controlled by tyrosine kinases and phosphatases. Disruption of the balance between the activity of tyrosine kinases and phosphatases may result in diseases. Receptor type protein tyrosine phosphatase epsilon (PTPRE) is closely related with receptor type protein tyrosine phosphatase alpha (PTPRA). PTPRE has been studied in osteoclast cells, nerve cells, hematopoietic cells, cancer cells and others, and it has different functions among various tissues. In this review, we summarized the current knowledge about the regulation of PTPRE on cellular signal transduction and its function under normal and pathological conditions.


J Cancer


Journal of Cancer


Liang J,Shi J,Wang N,Zhao H,Sun J




Has Abstract


2019-01-01 00:00:00












  • Shared liver-like transcriptional characteristics in liver metastases and corresponding primary colorectal tumors.

    abstract::Background & Aims: Primary tumors of colorectal carcinoma (CRC) with liver metastasis might gain some liver-specific characteristics to adapt the liver micro-environment. This study aims to reveal potential liver-like transcriptional characteristics associated with the liver metastasis in primary colorectal carcinoma....

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Cheng J,Song X,Ao L,Chen R,Chi M,Guo Y,Zhang J,Li H,Zhao W,Guo Z,Wang X

    更新日期:2018-04-06 00:00:00

  • Switch of the ovarian cancer cell to a calcifying phenotype in the calcification of ovarian cancer.

    abstract:OBJECTIVE:The main aim of this study was to study swith of the ovarian cancer cell to a calcifying phenotype in the formation of calcification in ovarian cancer, and to offer some help for ovarian cancer's diagnosis and differentiation therapy. METHODS:The mineralization of ovarian cancer cell lines SKOV3 was induced ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Wen J,Zhao Z,Huang L,Li L,Li J,Zeng Y,Wu J,Miao Y

    更新日期:2018-02-28 00:00:00

  • The Relation of HPV Infection and Expression of p53 and p16 Proteins in Esophageal Squamous Cells Carcinoma.

    abstract::GOAL: To investigate the HPV prevalence and characterize the expression of potential molecular surrogate markers of HPV infection in esophageal squamous cell carcinoma. MATERIALS AND METHODS: The prevalence of HPV in individuals with and without esophageal cancer (EC) was determined by using multiplex PCR; p16 and p53...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Pastrez PRA,Mariano VS,da Costa AM,Silva EM,Scapulatempo-Neto C,Guimarães DP,Fava G,Neto SAZ,Nunes EM,Sichero L,Villa LL,Syrjanen KJ,Longatto-Filho A

    更新日期:2017-04-09 00:00:00

  • Cytochalasin H Inhibits Angiogenesis via the Suppression of HIF-1α Protein Accumulation and VEGF Expression through PI3K/AKT/P70S6K and ERK1/2 Signaling Pathways in Non-Small Cell Lung Cancer Cells.

    abstract::Our previous study has demonstrated that cytochalasin H (CyH) isolated from mangrove-derived endophytic fungus induces apoptosis and inhibits migration in A549 non-small cell lung cancer (NSCLC) cells. In this study, we further explored the effect of CyH on angiogenesis in NSCLC cells and the underlying molecular mech...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Ma Y,Xiu Z,Zhou Z,Huang B,Liu J,Wu X,Li S,Tang X

    更新日期:2019-05-12 00:00:00

  • ASPN and GJB2 Are Implicated in the Mechanisms of Invasion of Ductal Breast Carcinomas.

    abstract:UNLABELLED:The mechanism of progression from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) remains largely unknown. We compared gene expression in tumors with simultaneous DCIS and IDC to decipher how diverse proteins participate in the local invasive process.Twenty frozen tumor specimens with conc...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Castellana B,Escuin D,Peiró G,Garcia-Valdecasas B,Vázquez T,Pons C,Pérez-Olabarria M,Barnadas A,Lerma E

    更新日期:2012-01-01 00:00:00

  • Comparison of Three Radiobiological Models in Stereotactic Body Radiotherapy for Non-Small Cell Lung Cancer.

    abstract::Objective: The applicability of the linear quadratic (LQ) model to local control (LC) modeling after hypofractionated radiotherapy to treat lung cancer is highly debated. To date, the differences in predicted outcomes between the LQ model and other radiobiological models, which are characterized by additional dose mod...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Lu JY,Lin Z,Lin PX,Huang BT

    更新日期:2019-08-08 00:00:00

  • Fibroblast growth factor receptor signaling as therapeutic targets in female reproductive system cancers.

    abstract::Ovarian cancer, cervical cancer and endometrial cancer are three relatively common malignant cancers of the female reproductive system. Despite improvements in female genital tract cancer detection and development of new therapeutic approaches, there are still poor prognoses and some do not respond to therapeutic patt...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审


    authors: Zhu DL,Tuo XM,Rong Y,Zhang K,Guo Y

    更新日期:2020-10-21 00:00:00

  • A meta-analysis of the short- and long-term results of randomized controlled trials that compared laparoscopy-assisted and open colectomy for colon cancer.

    abstract:PURPOSE:We conducted a meta-analysis to evaluate and compare the short- and long-term results of laparoscopy-assisted colectomy (LAC) and open colectomy (OC) for colon cancer. METHODS:We searched MEDLINE, EMBASE, Science Citation Index, and Cochrane Controlled Trial Register for relevant papers published between Janua...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Ohtani H,Tamamori Y,Arimoto Y,Nishiguchi Y,Maeda K,Hirakawa K

    更新日期:2012-01-01 00:00:00

  • MCMs expression in lung cancer: implication of prognostic significance.

    abstract::Minichromosome Maintenance (MCM) proteins play essential roles in various cancers. We previously reported that MCM7 could be a prognostic biomarker in non-small cell lung cancer (NSCLC). The purpose of current study is to explore roles of other MCM proteins in NSCLC and their correlation with clinico-pathologic parame...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Liu YZ,Wang BS,Jiang YY,Cao J,Hao JJ,Zhang Y,Xu X,Cai Y,Wang MR

    更新日期:2017-10-09 00:00:00

  • The Combination of Omega-3 Stearidonic Acid and Docetaxel Enhances Cell Death over Docetaxel Alone in Human Prostate Cancer Cells.

    abstract::Background: Docetaxel (DOC), or Taxotere, is an anthracycline antibiotic used to treat multiple types of cancer. It is a first-line chemotherapy treatment for patients with metastasized, hormone-resistant prostate cancer (PCa) or for patients with high-risk, localized PCa that could benefit from early chemotherapy tre...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Mansour M,van Ginkel S,Dennis JC,Mason B,Elhussin I,Abbott K,Pondugula SR,Samuel T,Morrison E

    更新日期:2018-11-11 00:00:00

  • Methylation patterns of RASA3 associated with clinicopathological factors in hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is the sixth most common tumor worldwide. The relationship between the gene methylation accumulation and HCC has been widely studied. In our study, we used the Sequenom EpiTYPER assay to investigate the methylation levels of the RASA3 in 164 HCC samples and paired adjacent non-cancerous ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Lin H,Fan X,He L,Zhou D

    更新日期:2018-05-25 00:00:00

  • MiR-93 Promotes Tumorigenesis and Metastasis of Non-Small Cell Lung Cancer Cells by Activating the PI3K/Akt Pathway via Inhibition of LKB1/PTEN/CDKN1A.

    abstract:BACKGROUND:Non-small cell lung cancer (NSCLC) accounts for approximately 85% of clinical lung cancer cases. MicroRNA-93 (miR-93) is an oncomiR in many types of human cancer, exerting pivotal effects in the development and progression of malignancies, including NSCLC. However, the mechanism underlying miR-93 involvement...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Li C,Lyu J,Meng QH

    更新日期:2017-03-07 00:00:00

  • Transcatheter arterial chemoembolization (TACE) versus hepatectomy in hepatocellular carcinoma with macrovascular invasion: a meta-analysis of 1683 patients.

    abstract::For hepatocellular carcinoma (HCC) patients with macrovascular invasion (MaVI), hepatectomy and transcatheter arterial chemoembolization (TACE) remain the main treatment options in Asia. However, which could achieve better survivals remains controversial. In present study, we conducted a meta-analysis to clarify the s...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Chen J,Huang J,Chen M,Yang K,Chen J,Wang J,Xu L,Zhou Z,Zhang Y

    更新日期:2017-08-25 00:00:00

  • Effects of MACC1 polymorphisms on hepatocellular carcinoma development and clinical characteristics.

    abstract::Hepatocellular carcinoma (HCC) is a major malignancy of cancer-related mortality worldwide. Metastasis-associated in colon cancer-1 (MACC1) was suggested as a marker for vascular invasive HCC. This study investigated the MACC1 single-nucleotide polymorphisms (SNPs) to evaluate HCC susceptibility and clinicopathologica...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Lin CH,Hsieh MJ,Lee HL,Yang SF,Su SC,Lee WJ,Chou YE

    更新日期:2020-01-14 00:00:00

  • Comprehensive Analysis of BAP1 Somatic Mutation in Clear Cell Renal Cell Carcinoma to Explore Potential Mechanisms in Silico.

    abstract::Purpose: Aim of this study was to comprehensively analyze BRCA1-associated protein-1 (BAP1) somatic mutation in clear cell renal cell carcinoma (ccRCC) and explore potential therapeutic pathways and molecules. Patients and methods: In this study, we analyzed 445 ccRCC cases from The Cancer Genome Atlas (TCGA). Compreh...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Jin S,Wu J,Zhu Y,Gu W,Wan F,Xiao W,Dai B,Zhang H,Shi G,Shen Y,Zhu Y,Ye D

    更新日期:2018-10-18 00:00:00

  • Glasgow PrognosticScore as a Predictor of BevacizumabEfficacy in the First-line Treatment with Metastatic Colorectal Cancer.

    abstract::Background: Inflammation might play an important role in promoting cancer growth partly by affecting tumor angiogenesis. We explored the role of Glasgow prognostic score (GPS) in metastatic colorectal cancer patients receiving first-linebevacizumab. Methods: All consecutive metastatic colorectal cancer patients treate...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Huang Y,Li W,Quan Q,Zhang B,Yang Q

    更新日期:2019-11-15 00:00:00

  • Anti-inflammatory and Antitumor Activity of a Triple Therapy for a Colitis-Related Colorectal Cancer.

    abstract::Colorectal cancer (CRC) is an important health issue worldwide, accounting for the third place of cancer incidence. Chronic inflammation, as seen in Crohn's disease and ulcerative colitis, is the most important risk factor for developing CRC, as it favours neoplastic transformation by enhancing epithelial cell turnove...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Figueroa-González G,García-Castillo V,Coronel-Hernández J,López-Urrutia E,León-Cabrera S,Arias-Romero LE,Terrazas LI,Rodríguez-Sosa M,Campos-Parra AD,Zúñiga-Calzada E,Lopez-Camarillo C,Morales-González F,Jacobo-Herrera NJ,Pérez

    更新日期:2016-07-25 00:00:00

  • Effect of targeted agents on the endocrine response of breast cancer in the neoadjuvant setting: a systematic review.

    abstract::Inhibition of aberrantly activated pathways cross-talking with hormone receptor (HR) improves response to endocrine therapy in patients with HR-positive advanced breast cancer. We performed a Pubmed database systematic review to ascertain the existence of a better clinical response when combining endocrine therapy wit...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审


    authors: Grassadonia A,Caporale M,Tinari N,Zilli M,DeTursi M,Gamucci T,Vici P,Natoli C

    更新日期:2015-05-12 00:00:00

  • AIB1 Genomic Amplification Predicts Poor Clinical Outcomes in Female Glioma Patients.

    abstract::Amplified in breast cancer 1 (AIB1) gene, a coactivator for steroid receptor, is frequently amplified in diverse cancers and is considered as an oncogene in tumorigenesis. However, the prognostic significance of AIB1 amplification in gliomas remains totally unclear. In this study, 115 gliomas and 16 benign meningiomas...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Chen L,Wang C,Zhang X,Gao K,Liu R,Shi B,Hou P

    更新日期:2016-10-22 00:00:00

  • MiR-192-5p reverses cisplatin resistance by targeting ERCC3 and ERCC4 in SGC7901/DDP cells.

    abstract::Cisplatin chemoresistance is a clinical obstacle in the treatment of gastric cancer (GC). Enhanced DNA repair capacity may lead to cisplatin resistance. However, the detailed molecular mechanism of GC cisplatin resistance specifically involving nucleotide excision repair (NER) is not clear. However, the mechanism thro...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Xie X,Huang N,Zhang Y,Wei X,Gao M,Li M,Ning J,Liu W,Zhao Q,Wang H,Gu K

    更新日期:2019-01-29 00:00:00

  • GDF15/GFRAL Pathway as a Metabolic Signature for Cachexia in Patients with Cancer.

    abstract::Cachexia is a metabolic mutiny that directly reduces life expectancy in chronic conditions such as cancer. The underlying mechanisms associated with cachexia involve inflammation, metabolism, and anorexia. Therefore, the need to identify cachexia biomarkers is warranted to better understand catabolism change and asses...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审


    authors: Ahmed DS,Isnard S,Lin J,Routy B,Routy JP

    更新日期:2021-01-01 00:00:00

  • Combined Preoperative LMR and CA125 for Prognostic Assessment of Ovarian Cancer.

    abstract::Objectives: To investigate the role of inflammation-related factors, lymphocyte-to-monocyte ratio (LMR) alone and combined detection with cancer antigen 125 (CA125), in the prognostic assessment of ovarian cancer (OC). Methods: A retrospective clinicopathologic review was performed. The receiver-operating characterist...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Tang Y,Hu HQ,Tang FX,Lin D,Shen R,Deng L,Tang YL,Deng LH,Zhou M,Li J,Su B,Xu F

    更新日期:2020-03-04 00:00:00

  • Development and validation of a nomogram for predicting cancer-specific survival in patients with Wilms' tumor.

    abstract::Purpose: The objective of this study was to develop and validate a nomogram for predicting the cancer-specific survival (CSS) in patients with Wilms' tumor (WT). Methods: Patients with WT diagnosed between 2002 and 2015 in the Surveillance, Epidemiology, and End Results (SEER) database were divided randomly into train...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Pan Z,You H,Bu Q,Feng X,Zhao F,Li Y,Lyu J

    更新日期:2019-08-28 00:00:00

  • Importance of maintaining body weight for prevention of distant metastasis of nasopharyngeal carcinoma: An alternative workflow for cancer-risk assessment.

    abstract::Purpose: To design an alternative workflow for cancer-risk assessment to predict distant metastasis (DM) of nasopharyngeal carcinoma (NPC). Methods: We enrolled 234 patients with non-disseminated NPC and a family history of cancer who underwent intensity-modulated radiotherapy and concurrent chemo-radiotherapy with/wi...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Zhang W,Chen Y,Chen L,Liu X,Sun Y,Li Y,Ma J

    更新日期:2017-07-20 00:00:00

  • Effect of TTLL6 expression on CDDP sensitivity of EC109/CDDP cells in hypoxia/acidosis microenvironment.

    abstract::Multidrug resistance is a major obstacle to the effective treatment of esophageal carcinoma. It occurs more readily in hypoxia and acidosis microenvironment. TTLL6 is one of Tubulin tyrosine ligase-like family members. In this study, the effect of TTLL6 on the regulation of cisplatin (CDDP) sensitivity was evaluated i...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Qiu Y,Wu C,Li J,Tang M,Zhang S,Jing T,Liao Y,Wang H

    更新日期:2020-09-30 00:00:00

  • Disruption of learning processes by chemotherapeutic agents in childhood survivors of acute lymphoblastic leukemia and preclinical models.

    abstract:OBJECTIVE:With the survival rate of acute lymphoblastic leukemia (ALL) surpassing 90 percent within this decade, new research is emerging in the field of late effects. A review of the research investigating the relationship of treatment regimens for ALL to specific late effect deficits, underlying mechanisms, and possi...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Bisen-Hersh EB,Hineline PN,Walker EA

    更新日期:2011-01-01 00:00:00

  • Capecitabine plus Oxaliplatin as a Second-Line Therapy for Advanced Biliary Tract Cancers: A Multicenter, Open-Label, Phase II Trial.

    abstract::Background: Although biliary tract cancer (BTC) has a very aggressive nature, some patients maintain a relatively good performance status after failure with first-line treatment of gemcitabine plus cisplatin (GC). Thus, tolerable, feasible, and useful second-line treatments are needed for these patients. We investigat...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Kim ST,Oh SY,Lee J,Kang JH,Lee HW,Lee MA,Sohn BS,Hong JH,Park YS,Park JO,Lim HY

    更新日期:2019-10-15 00:00:00

  • Gene expression and single nucleotide polymorphism of ATP7B are associated with platinum-based chemotherapy response in non-small cell lung cancer patients.

    abstract::Objectives: Platinum-based chemotherapy is first-line treatment for non-small cell lung cancer (NSCLC) patients. The efficacy is limited by drug resistance. Recent studies suggest that ATP7B, a copper efflux transporter, may be involved in platinum resistance. However, the clinical significance of ATP7B expression in ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Li YQ,Chen J,Yin JY,Liu ZQ,Li XP

    更新日期:2018-09-08 00:00:00

  • Adjuvant Radiochemotherapy versus Chemotherapy Alone for Gastric Cancer: Implications for Target Definition.

    abstract::The INT0116 trial was a milestone study and laid the foundation for the adjuvant radiotherapy (RT) associated to concurrent chemotherapy (CT) for the treatment of gastric cancer (GC) after gastrectomy. However, it is still controversial whether adding RT to CT could further benefit D2-dissected GC patients. The ARTIST...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审


    authors: Xu J,Zhu J,Wei Q

    更新日期:2019-01-01 00:00:00

  • RBP7 is a clinically prognostic biomarker and linked to tumor invasion and EMT in colon cancer.

    abstract::RBP7 is a member of the cellular retinol-binding protein (CRBP) family and previous data suggested a link between CRBPs and the malignant transformation of colon cancer cells. Here, we investigated the potential of RBP7 as a predictive biomarker for patients with colon cancer and determined its functional relevance fo...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Elmasry M,Brandl L,Engel J,Jung A,Kirchner T,Horst D

    更新日期:2019-08-27 00:00:00