Abstract:
:Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been widely used to treat non-small cell lung cancer (NSCLC) because they inhibit tumour growth and metastasis. However, the underlying mechanisms are not fully understood. Here, we investigate whether anti-lymphangiogenesis mechanisms contribute to the anti-tumour effects of EGFR-TKIs. Three different EGFR-TKIs (Gefitinib, Afatinib, and AZD9291) were used to determine the possible biological effects of EGFR-TKIs on lymphangiogenesis in vitro and in vivo. EGFR-TKIs inhibited human lymphatic endothelial cells (HLEC) proliferation, migration and tube formation at the indicated concentrations. Conditioned medium from human lung adenocarcinoma HCC827 cells treated with EGFR-TKIs also inhibited HLEC migration and tube formation. EGFR-TKIs inhibited VEGFC secretion, which further influenced HLEC behaviour in vitro. Afatinib inhibited tumour growth and lymphangiogenesis in the HCC827 xenograft mouse model. The densities and tube diameters of the lymphatic vessels were decreased in a dose-dependent manner, as shown by lymphatic vessel endothelial hyaluronan receptor 1 (LYVE-1) staining. EGFR-TKIs also inhibited the expression of important lymphangiogenesis regulatory factors vascular endothelial growth factor 2/3 (VEGF2/3), VEGFC, and chemokine receptor 7 (CCR7) as shown by immunocytochemistry (IHC) staining. Additional assays confirmed that the JAK/STAT3 signalling pathways play important roles in the anti-lymphangiogenesis process induced by EGFR-TKIs. Inhibition of lymphangiogenesis is another important role that the three EGFR-TKIs play in the treatment of lung cancer and the Janus kinase/signal transducers and activators of transcription 3 (JAK/STAT3) maybe an important signalling pathway regulating lymphangiogenesis, which provides a new idea for clinical therapy of lung cancer.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Zhang Y,Yang X,Liu H,Cai M,Shentu Ydoi
10.7150/jca.35448subject
Has Abstractpub_date
2020-01-01 00:00:00pages
241-250issue
1issn
1837-9664pii
jcav11p0241journal_volume
11pub_type
杂志文章abstract::Aims: To compare the long-term prognosis of younger and elderly patients with combined hepatocellular-cholangiocarcinoma (CHC) who underwent curative resection between 1993 and 2014 at our center. Methods: Two hundred and thirteen patients who underwent liver resection for CHC were enrolled in our study. The overall s...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.23921
更新日期:2018-02-28 00:00:00
abstract::We studied combinatorial interactions of two phytochemicals, curcumin and silymarin, in their action against cancer cell proliferation. Curcumin is the major component of the spice turmeric. Silymarin is a bioactive component of milk thistle used as a protective supplement against liver disease. We studied antiprolife...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.15690
更新日期:2016-06-23 00:00:00
abstract::Long non-coding RNAs (LncRNAs) have been reported to be involved in tumorigenesis and tumor progression. Single nucleotide polymorphisms (SNPs) in the lncRNAs also play a vital role in carcinogenesis. The aim of this study was to assess the relationships between the four selected tagSNPs (rs944289, rs3787016, rs145631...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18055
更新日期:2017-04-09 00:00:00
abstract::Background: This study aimed to clarify the impact of node involvement (affected to resected nodes) in optimally cytoreduced (residual tumour ≤1cm) stage IIIC/IV ovarian cancer. Methods: 108 consecutive patients with primary stage IIIC/IV ovarian cancer underwent stage-related surgery and got adjuvant platinum-based c...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.15644
更新日期:2016-11-09 00:00:00
abstract::Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase and works as an oncogene in various cancers. Recently, PTK6 has been used as a therapeutic target for breast cancer patients in a clinical study. However, the prognostic value of PTK6 in bladder cancer (BC) remains vague. Therefore, we retrieved 3 inde...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.21318
更新日期:2017-09-27 00:00:00
abstract::MicroRNAs (miRNAs) have been recognized as key regulators of tumorigenesis and progression. Serum miR-302c-3p expression is prominently deregulated in HCV-related hepatocellular carcinoma (HCC). However, the expression of miR-302c-3p and its functional role in HBV-related HCC are rarely investigated. In this study, we...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25569
更新日期:2018-06-23 00:00:00
abstract:PURPOSE:The current study examined quality of life, progression of disease, and survival rate during chemotherapy in newly diagnosed non-small cell lung cancer (NSCLC) patients with depression (n=48) and without depression (n=78). Further, the study explored the hypothesis that the survival benefit resulted from the ch...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.11239
更新日期:2015-09-15 00:00:00
abstract::Glioblastoma multiforme (GBM) is commonly known as the most aggressive primary CNS tumor in adults. The mean survival of it is 14 to 15 months, following the standard therapy from surgery, chemotherapy, to radiotherapy. Efforts in recent decades have brought many novel therapies to light, however, with limitations. In...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.32475
更新日期:2019-08-27 00:00:00
abstract::Alternative splicing plays critical roles in many disease processes and splicing dysregulation is a hallmark of cancer. The different splicing isoforms may have significantly different effects on the malignant progression of cancer. Checkpoint kinase 1 (CHK1) is a serine/threonine kinase and regulates DNA damage respo...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.39443
更新日期:2020-01-17 00:00:00
abstract::Cancer-testis (CT) genes played important roles in the progression of malignant tumors and were recognized as promising therapeutic targets. However, the roles of genetic variants in CT genes in lung cancer susceptibility have not been well depicted. This study aimed to evaluate the associations between genetic varian...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.40002
更新日期:2020-02-03 00:00:00
abstract::Distant metastasis is the primary cause of cancer-related death among patients with colorectal cancer (CRC), and the discovery of novel therapeutic targets by further exploring the molecular mechanisms of CRC metastasis is therefore urgently needed. We previously illustrated that CDC27 overexpression promoted prolifer...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19381
更新日期:2017-08-21 00:00:00
abstract::For unresectable Hepatocellular carcinoma (HCC), chemotherapy is still an important treatment strategy. Oxaliplatin (Oxa) is an effective treatment of HCC after sorafenib treatment failure. However, the intrinsic or acquired resistance of Oxa affected the chemotherapeutic sensitivity. By analyzing the data of GEO Data...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25909
更新日期:2018-10-10 00:00:00
abstract:BACKGROUND:Due to the lack of studies, it remains unclear whether the additional neoadjuvant chemotherapy (NACT) to concurrent chemoradiotherapy (CCRT) is superior to CCRT alone for locoregionally advanced nasopharyngeal carcinoma (NPC). The main objective of this Bayesian network meta-analysis was to determine the eff...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.11814
更新日期:2015-07-17 00:00:00
abstract::Taking into account the previously reported relationship between inflammation and carcinogenesis, and the scant amount of data concerning the role of neutrophil extracellular traps (NETs) in carcinogenesis, we decided to study the process of extracellular trap formation in patients with inflammation as well as in pati...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24238
更新日期:2018-04-30 00:00:00
abstract::Galectins are the member of soluble proteins that bind with β-galactoside containing glycans. These proteins have been considered to be associated in various important events such as different types of cancers. It has been found that galectins could contribute to neoplastic transformation or regulate cell growth, cell...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.23628
更新日期:2018-11-25 00:00:00
abstract::Triple negative breast cancer (TNBC) is characterized by distinctive biological features that confer an aggressive clinical behavior. In TNBC patients, the absence of well-defined driver pathways such as hormonal receptor expression or hyperactivation of the human epidermal growth factor receptor 2 (HER2) significantl...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.35109
更新日期:2019-10-12 00:00:00
abstract::Our previous study has demonstrated that cytochalasin H (CyH) isolated from mangrove-derived endophytic fungus induces apoptosis and inhibits migration in A549 non-small cell lung cancer (NSCLC) cells. In this study, we further explored the effect of CyH on angiogenesis in NSCLC cells and the underlying molecular mech...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29933
更新日期:2019-05-12 00:00:00
abstract:BACKGROUND:Neoadjuvant chemotherapy with concurrent docetaxel, doxorubicin and cyclophosphamide is commonly used for patients with locally advanced breast cancer. Epirubicin is another anthracycline used in breast cancer but the concurrent use of epirubicin and taxane is not well-established. We conducted a single inst...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.3980
更新日期:2012-01-01 00:00:00
abstract::Purpose: Diffuse large B cell lymphoma (DLBCL) is one of the most common B cell lymphomas, which displays heterogeneous pathologies. Programmed cell death 1/ programmed cell death ligand 1 (PD-1/PD-L1) plays an essential role in immunosuppression in multiple malignancies. Signal transducer and activator of transcripti...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.47816
更新日期:2020-10-17 00:00:00
abstract::Colorectal cancer (CRC) usually gives rise to transcoelomic spread and ultimately causes peritoneal carcinomatosis (PC). However, mechanism studies, especially the immunological basis of colorectal PC, are rarely revealed due to lack of a suitable PC model. Here we selected a mouse colorectal cancer cell line MC-38 fo...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.27947
更新日期:2019-01-01 00:00:00
abstract:PURPOSE:We conducted a meta-analysis to evaluate and compare the short- and long-term results of laparoscopy-assisted colectomy (LAC) and open colectomy (OC) for colon cancer. METHODS:We searched MEDLINE, EMBASE, Science Citation Index, and Cochrane Controlled Trial Register for relevant papers published between Janua...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.3621
更新日期:2012-01-01 00:00:00
abstract:OBJECTIVE:The main aim of this study was to study swith of the ovarian cancer cell to a calcifying phenotype in the formation of calcification in ovarian cancer, and to offer some help for ovarian cancer's diagnosis and differentiation therapy. METHODS:The mineralization of ovarian cancer cell lines SKOV3 was induced ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.22932
更新日期:2018-02-28 00:00:00
abstract::Background: Docetaxel (DOC), or Taxotere, is an anthracycline antibiotic used to treat multiple types of cancer. It is a first-line chemotherapy treatment for patients with metastasized, hormone-resistant prostate cancer (PCa) or for patients with high-risk, localized PCa that could benefit from early chemotherapy tre...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26681
更新日期:2018-11-11 00:00:00
abstract::Background: Uterine cervical cancer (UCC) is a common malignant tumor in women. We conducted this work to provide a though description on the patterns of distant metastases and to investigate the relevant factors for prognosis of UCC patients based on a large population. Patients and methods: UCC patients with FIGO st...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.37390
更新日期:2020-01-14 00:00:00
abstract::Background: The programmed death 1 (PD1)/programmed death ligand 1 (PDL1) targeted therapies have gained positive outcomes in several tumors, but the evidence of the expression and prognosis value of PD1/PDL1 in high risk prostate cancer was rare. Methods: Immunohistochemical analysis of PDL1/PD1 expression by a valid...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.30384
更新日期:2019-06-02 00:00:00
abstract:INTRODUCTION:Bioimpedance is a measure of the electrical properties of biological tissues. In the last two decades bioimpedance has been successfully introduced in clinical diagnosis of cancer. It has been demonstrated that tumoral tissues often show lower bioimpedance values than healthy tissues. The aim of this work ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.11936
更新日期:2015-08-20 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a major malignancy of cancer-related mortality worldwide. Metastasis-associated in colon cancer-1 (MACC1) was suggested as a marker for vascular invasive HCC. This study investigated the MACC1 single-nucleotide polymorphisms (SNPs) to evaluate HCC susceptibility and clinicopathologica...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.38856
更新日期:2020-01-14 00:00:00
abstract::Colorectal cancer(CRC) is a prevalent malignancy in the world. There is growing evidence that microRNAs (miRNAs) as crucial modulator are in connection with many tumor-related diseases including CRC. Though miR-485-5p has been reported as an anti-oncogene in certain cancers, it remains unclear in CRC. In this research...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24918
更新日期:2018-06-23 00:00:00
abstract::Background: The Matrix metalloproteinase-14 (MMP-14) expression has been shown to be overexpressed in different cancers. However, there is no comprehensive quantitative evaluation of the MMP-14 prognostic value in digestive system carcinoma (DSC). The aim of this study is to explore the correlation between the MMP-14 ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.36469
更新日期:2020-01-01 00:00:00
abstract::As a crucial event involved in the metastasis and relapse of esophageal cancer, c-Met overexpression has been considered as one of the culprits responsible for the failure in patients who received radiochemotherapy. Since c-Met has been confirmed to be pivotal for cell survival, proliferation and migration, little is ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18135
更新日期:2017-03-12 00:00:00