microRNA-485-5p Functions as a Tumor Suppressor in Colorectal Cancer Cells by Targeting CD147.

Abstract:

:Colorectal cancer(CRC) is a prevalent malignancy in the world. There is growing evidence that microRNAs (miRNAs) as crucial modulator are in connection with many tumor-related diseases including CRC. Though miR-485-5p has been reported as an anti-oncogene in certain cancers, it remains unclear in CRC. In this research, we found that miR-485-5p was at lower level expression in CRC tissues and cell lines compared to the paired paracancerous tissues and the normal colon epithelial cell line FHC, correspondingly. Furthermore, Experimental up-regulation miR-485-5p in DLD-1 and SW480 cells with mimic could inhibit the ability of proliferation, migration, invasion of CRC cell lines and facilitate cells apoptosis. Also, we confirmed that CD147 existed typically negative regulation by miR-485-5p through binding a conserved sequence specifically within the CD147 3'-untranslated region (3'UTR) and reintroduction of CD147 could rescue the phenotypic changes caused by miR-485-5p. The findings provide evidence to demonstrate the role of miR-485-5p/CD147 interaction in CRC and indicate that miR-485-5p might be exploited therapeutically in CRC.

journal_name

J Cancer

journal_title

Journal of Cancer

authors

Hu XX,Xu XN,He BS,Sun HL,Xu T,Liu XX,Chen XX,Zeng KX,Wang SK,Pan YQ

doi

10.7150/jca.24918

subject

Has Abstract

pub_date

2018-06-23 00:00:00

pages

2603-2611

issue

15

issn

1837-9664

pii

jcav09p2603

journal_volume

9

pub_type

杂志文章
  • Multifaceted Mechanisms of Areca Nuts in Oral Carcinogenesis: the Molecular Pathology from Precancerous Condition to Malignant Transformation.

    abstract::Oral cancer is one of the most frequent malignant diseases worldwide, and areca nut is a primary carcinogen causing this cancer in Southeast Asia. It has been widely reported that areca nut induced several cytotoxic effects in oral cells, including ROS generation, inflammation, tissue hypoxia, DNA damage, and cell inv...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.29765

    authors: Li YC,Cheng AJ,Lee LY,Huang YC,Chang JT

    更新日期:2019-07-08 00:00:00

  • Significant prognostic impact of chemoradiotherapy-induced hemoglobin decrease on treatment outcomes of nasopharyngeal carcinoma.

    abstract:PURPOSE:To investigate prognostic impact of chemoradiotherapy-induced hemoglobin (Hb) decrease on treatment outcomes of endemic nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS:Eight hundred and fifteen non-metastatic NPC, receiving neoadjuvant chemotherapy followed by radiotherapy (NACT+RT group) or concomitant ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.11403

    authors: Liang XX,Li Q,Su Z,Lan XW,Ouyang PY,Mao YP,Shi DB,Deng WG,Cheng ZB,Wang SY,Xie FY

    更新日期:2015-04-02 00:00:00

  • The Proportion and Prognostic Significance of T-Regulatory Cells in Patients with Gynecological Cancers: A Systematic Review and Meta-Analysis.

    abstract::Objective: Multiple reports have described the proportion of T-regulatory cells (Tregs) in peripheral blood (PB) and tissues in patients with gynecological cancers (GCs) with controversial results. Thus, the aim of this study was to investigate the proportion of Tregs and its prognostic survival role in GCs patients. ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.42472

    authors: Hu J,Wu X,Huang P,Teng F,Wang Y,Xue F

    更新日期:2020-03-05 00:00:00

  • Whole-exome Sequencing of Prostate Cancer in Sardinian Identify Recurrent UDP-glucuronosyltransferase Amplifications.

    abstract::Globally, prostate cancer is the third most common cancer in the world, and the second most common cancer in men. However, rates for incidence and mortality vary considerably with race, ethnicity, and geography. Over 97 significantly mutated genes that have been identified in prostate cancer; however, a lack of genomi...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.48433

    authors: Zeng T,Fedeli MA,Tanda F,Wang Y,Yang D,Xue B,Jia L,Palmieri G,Sechi LA,Kelvin DJ

    更新日期:2021-01-01 00:00:00

  • The somatic mutation landscape of Chinese Colorectal Cancer.

    abstract::Colorectal cancer (CRC) is the fifth leading cause of cancer-related death in China. The incidence of Chinese CRC has increased dramatically with the changes of dietary and lifestyle. However, the genetic landscape of Chinese colorectal cancer mutation is still poorly understood. In this study, we have performed whole...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.37017

    authors: Ma R,Jing C,Zhang Y,Cao H,Liu S,Wang Z,Chen D,Zhang J,Wu Y,Wu J,Feng J

    更新日期:2020-01-01 00:00:00

  • Down-regulation of ACACA suppresses the malignant progression of Prostate Cancer through inhibiting mitochondrial potential.

    abstract::Background and aim: Silencing the expression of ACACA inhibits cell proliferation and induces apoptosis in prostate cancer LNCaP cells. However, the role of ACACA in other prostate cancer cells is not fully understood. Also, the effect of knocking down ACACA gene on mitochondria remains unclear. This study aimed to di...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.49560

    authors: Zhang H,Liu S,Cai Z,Dong W,Ye J,Cai Z,Han Z,Liang Y,Zhuo Y,Luo Y,Zhu X,Deng Y,Zhang Y,Liu R,Feng Y,Lai J,Zhou R,Tan H,Zhong W

    更新日期:2021-01-01 00:00:00

  • Dysbindin facilitates invasion and metastasis by promoting phosphorylation of ERK in epithelial ovarian cancer.

    abstract::Dysbindin has been reported to be correlated with several malignancies. However, the clinical significance and biological role of dysbindin in epithelial ovarian cancer remains largely unknown. Here we demonstrated that the mRNA and protein levels of dysbindin were significantly upregulated in EOC tissues compared wit...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.39269

    authors: Lv X,Guo X,Ru Y,Zhou F,Yang X,Ge J,Li J,Liu S,Jiang K,Chen B

    更新日期:2020-02-21 00:00:00

  • Targeting hepatocarcinogenesis model in C56BL6 mice with pan-aurora kinase inhibitor Danusertib.

    abstract::Background: To elucidate the expression of Aurora kinases (AURK) and the anticancer effects of pan-aurora kinase inhibitor Danusertib in hepatocarcinogenesis model in C56Bl6 mice. Methods: Thirty mice C56Bl6 were randomly divided into Group A or control, Group B animals who underwent experimental hepatocarcinogenesis ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.22329

    authors: Gavriilidis P,Poutahidis T,Giakoustidis A,Makedou K,Angelopoulou K,Hardas A,Andreani P,Zacharioudaki A,Saridis G,Gargavanis A,Louri E,Antoniadis N,Karampela E,Psychalakis N,Michalopoulos A,Papalois A,Iliadis S,Mudan S,

    更新日期:2018-02-27 00:00:00

  • Long non-coding RNA LOC554202 promotes acquired gefitinib resistance in non-small cell lung cancer through upregulating miR-31 expression.

    abstract::Non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation inevitably have a relapse due to the occurrence of acquired resistance, resulting in treatment failure. However, little is known about the mechanisms of acquired resistance of NSCLC patients. Here, we elucidated the expre...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.35097

    authors: He J,Jin S,Zhang W,Wu D,Li J,Xu J,Gao W

    更新日期:2019-10-15 00:00:00

  • Triple-high expression of phosphatase and tensin homolog (PTEN), estrogen receptor (ER) and progesterone receptor (PR) may predict favorable prognosis for patients with Type I endometrial carcinoma.

    abstract::Endometrial carcinoma (EC) is the most common malignant tumors in female derived from the endometrial epithelium. Several previous studies have described estrogen receptors (ER), progesterone Receptor (PR) and phosphatase and tensin homolog (PTEN) are associated with clinicopathological factors and prognosis in EC pat...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.33720

    authors: Liang Y,Lin B,Ye Z,Chen S,Yu H,Chen C,Zhang X,Zhou K,Zeng J

    更新日期:2020-01-13 00:00:00

  • Novel Metabolomics Serum Biomarkers for Pancreatic Ductal Adenocarcinoma by the Comparison of Pre-, Postoperative and Normal Samples.

    abstract::Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human malignancies. The metabolomic approaches are developed to discover the novel biomarkers of PDAC. Methods: 550 preoperative, postoperative PDAC and normal controls (NCs) serums were employed to characterize metabolic alterations in ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.41250

    authors: Zhang X,Shi X,Lu X,Li Y,Zhan C,Akhtar ML,Yang L,Bai Y,Zhao J,Wang Y,Yao Y,Li Y,Nie H

    更新日期:2020-05-19 00:00:00

  • Glioblastoma Treatment Modalities besides Surgery.

    abstract::Glioblastoma multiforme (GBM) is commonly known as the most aggressive primary CNS tumor in adults. The mean survival of it is 14 to 15 months, following the standard therapy from surgery, chemotherapy, to radiotherapy. Efforts in recent decades have brought many novel therapies to light, however, with limitations. In...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.32475

    authors: Zhang H,Wang R,Yu Y,Liu J,Luo T,Fan F

    更新日期:2019-08-27 00:00:00

  • Clinical and functional significance of CHK1-S, an alternatively spliced isoform of the CHK1 gene, in hepatocellular carcinoma.

    abstract::Alternative splicing plays critical roles in many disease processes and splicing dysregulation is a hallmark of cancer. The different splicing isoforms may have significantly different effects on the malignant progression of cancer. Checkpoint kinase 1 (CHK1) is a serine/threonine kinase and regulates DNA damage respo...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.39443

    authors: Hu G,Wang S,Wang Y,Gao Y,Zhu H,Liu M,Xu N,Wang L

    更新日期:2020-01-17 00:00:00

  • Fibroblast growth factor receptor signaling as therapeutic targets in female reproductive system cancers.

    abstract::Ovarian cancer, cervical cancer and endometrial cancer are three relatively common malignant cancers of the female reproductive system. Despite improvements in female genital tract cancer detection and development of new therapeutic approaches, there are still poor prognoses and some do not respond to therapeutic patt...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.44727

    authors: Zhu DL,Tuo XM,Rong Y,Zhang K,Guo Y

    更新日期:2020-10-21 00:00:00

  • Phase II Trial of Adjuvant Immunotherapy with Autologous Tumor-derived Gp96 Vaccination in Patients with Gastric Cancer.

    abstract::Background/Aims: Autologous, tumor-derived, heat shock protein gp96 peptide complexes have antitumor potential. We conducted the first Phase II trial to evaluate the safety and efficacy of gp96 vaccination in adjuvant settings for patients with gastric cancer. Methods: We enrolled 73 consecutive patients from October ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.18946

    authors: Zhang K,Peng Z,Huang X,Qiao Z,Wang X,Wang N,Xi H,Cui J,Gao Y,Huang X,Gao H,Wei B,Chen L

    更新日期:2017-07-02 00:00:00

  • Perspectives of breast cancer thermotherapies.

    abstract::In this article, the use of different types of thermotherapies to treat breast cancer is reviewed. While hyperthermia is most commonly used as an adjuvant in combination with radiotherapy, chemotherapy, targeted therapy or cryotherapy to enhance the therapeutic effect of these therapies, thermoablation is usually carr...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.8693

    authors: Alphandéry E

    更新日期:2014-05-29 00:00:00

  • CDC27 Induces Metastasis and Invasion in Colorectal Cancer via the Promotion of Epithelial-To-Mesenchymal Transition.

    abstract::Distant metastasis is the primary cause of cancer-related death among patients with colorectal cancer (CRC), and the discovery of novel therapeutic targets by further exploring the molecular mechanisms of CRC metastasis is therefore urgently needed. We previously illustrated that CDC27 overexpression promoted prolifer...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.19381

    authors: Qiu L,Tan X,Lin J,Liu RY,Chen S,Geng R,Wu J,Huang W

    更新日期:2017-08-21 00:00:00

  • The JAM-B/c-src/MMP9 pathway is associated with progression and regulates the invasion of pancreatic cancer.

    abstract::Junctional adhesion molecule B (JAM-B) is a multifunctional transmembrane protein that plays an important role in tumor progression. JAM-B is significantly upregulated in gastric cancer, melanoma cell metastasis and oral squamous cell carcinoma. JAM-2 may also function as a putative tumor suppressor in the progression...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.40953

    authors: Zhang W,He R,Chen S,Zhang L,Cao G,Yang W,Li J

    更新日期:2020-03-05 00:00:00

  • Ethanol Enhances Estrogen Mediated Angiogenesis in Breast Cancer.

    abstract::Angiogenesis, a highly regulated process, is exploited by tumors like breast cancer to ensure a constant supply of oxygen and nutrients and is key for tumor survival and progression. Estrogen and alcohol independently have been observed to contribute to angiogenesis in breast cancer but their combinatorial effects hav...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.25581

    authors: Maniyar R,Chakraborty S,Suriano R

    更新日期:2018-10-06 00:00:00

  • High Expression of PQBP1 and Low Expression of PCK2 are Associated with Metastasis and Recurrence of Osteosarcoma and Unfavorable Survival Outcomes of the Patients.

    abstract::Osteosarcoma (OS) is the most common primary bone malignancy, predominately affecting children and adolescents. Due to the introduction of chemotherapy, the 5-year survival rate of OS patients has dramatically improved to 60-70%. Unfortunately, OS patients with recurrence or metastatic disease have less than a 20% cha...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.28480

    authors: Zhang Y,Zhao H,Xu W,Jiang D,Huang L,Li L

    更新日期:2019-05-12 00:00:00

  • A Phase II Study of Concurrent Docetaxel, Epirubicin and Cyclophosphamide as a Neoadjuvant Chemotherapy Regimen in Patients with Locally Advanced Breast Cancer.

    abstract:BACKGROUND:Neoadjuvant chemotherapy with concurrent docetaxel, doxorubicin and cyclophosphamide is commonly used for patients with locally advanced breast cancer. Epirubicin is another anthracycline used in breast cancer but the concurrent use of epirubicin and taxane is not well-established. We conducted a single inst...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.3980

    authors: Yao X,Hosenpud J,Chitambar CR,Charlson J,Cheng YC

    更新日期:2012-01-01 00:00:00

  • The prognostic value of age in non-metastatic gastric cancer after gastrectomy: a retrospective study in the U.S. and China.

    abstract::Purpose: We explored the influence of age on clinicopathologic features and survival of patients with M0 gastric cancer (GC). Methods: 16856 GC patients from Surveillance, Epidemiology and End Results (SEER) database and 1037 GC patients from Chinese multiple centers were enrolled in the U.S. and Chinese cohort, respe...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.22085

    authors: Zhang J,Gan L,Xu MD,Huang M,Zhang X,Gong Y,Wang X,Yu G,Guo W

    更新日期:2018-03-08 00:00:00

  • Association between SNPs in Long Non-coding RNAs and the Risk of Female Breast Cancer in a Chinese Population.

    abstract::Long non-coding RNAs (LncRNAs) have been reported to be involved in tumorigenesis and tumor progression. Single nucleotide polymorphisms (SNPs) in the lncRNAs also play a vital role in carcinogenesis. The aim of this study was to assess the relationships between the four selected tagSNPs (rs944289, rs3787016, rs145631...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.18055

    authors: Xu T,Hu XX,Liu XX,Wang HJ,Lin K,Pan YQ,Sun HL,Peng HX,Chen XX,Wang SK,He BS

    更新日期:2017-04-09 00:00:00

  • Comparison of clinical characteristics and survival after surgery in patients with non-B and non-C hepatocellular carcinoma and hepatitis virus-related hepatocellular carcinoma.

    abstract:BACKGROUND AND AIMS:We compared clinicopathologic data and long-term clinical outcomes among patients with non-B and non-C hepatocellular carcinoma (NBNC-HCC) who underwent curative resection (group A, n=129), those with hepatitis B virus-related HCC (group B, n=62) and those with hepatitis C virus-related HCC (group C...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.6503

    authors: Nishikawa H,Arimoto A,Wakasa T,Kita R,Kimura T,Osaki Y

    更新日期:2013-07-18 00:00:00

  • Chloroma/Granulocytic sarcoma: abdominal & pelvic presentation of acute myelogenous leukemia.

    abstract::There is limited literature documenting granulocytic sarcoma of the colon. We report a case of a 28 year-old female with a colonic granulocystic sarcoma of the colon as a complication of AML, as it is an important consideration with surgical management of typhilitis. ...

    journal_title:Journal of Cancer

    pub_type:

    doi:10.7150/jca.1.98

    authors: Tsikitis VL,Corning C,Henderson J,Rose J

    更新日期:2010-07-14 00:00:00

  • Mast cells induce epithelial-to-mesenchymal transition and migration in non-small cell lung cancer through IL-8/Wnt/β-catenin pathway.

    abstract::Background: In the various cancer, mast cells (MCs) infiltration is correlated with a worse prognosis. There is an increasing evidence that MCs and their mediators are participated in remodeling of the tumor microenvironment and facilitate tumor growth, epithelial-to-mesenchymal transition (EMT) and metastasis. Method...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,收录出版

    doi:10.7150/jca.29953

    authors: Qu J,Cheng T,Liu L,Heng J,Liu X,Sun Z,Wang W,Li K,Yang N

    更新日期:2019-06-09 00:00:00

  • Estradiol and Progesterone Induced Differentiation and Increased Stemness Gene Expression of Human Fallopian Tube Epithelial Cells.

    abstract::Fallopian tube epithelial cells (FTECs) are thought to be the origin of epithelial ovarian cancer. However, the effect of the hormones on FTECs is unknown, and therefore, this study explored this effect. We successfully derived FTECs from the fallopian tube epithelial layer and treated them with estradiol and progeste...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.30588

    authors: Chang YH,Ding DC,Chu TY

    更新日期:2019-06-02 00:00:00

  • Preoperative Albumin to Globulin Ratio (AGR) as Prognostic Factor in Renal Cell Carcinoma.

    abstract::Background: Malnutrition and systemic inflammatory response are frequently associated with prognosis in patients with several types of cancer, including renal cell carcinoma (RCC). The study is aimed to investigate the ability of preoperative serum albumin to globulin ratio (AGR) to predict the long-term mortality of ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.16525

    authors: He X,Guo S,Chen D,Yang G,Chen X,Zhang Y,He Q,Qin Z,Liu Z,Xue Y,Zhang M,Liu R,Zhou F,Han H,Yao K

    更新日期:2017-01-15 00:00:00

  • Combined Preoperative LMR and CA125 for Prognostic Assessment of Ovarian Cancer.

    abstract::Objectives: To investigate the role of inflammation-related factors, lymphocyte-to-monocyte ratio (LMR) alone and combined detection with cancer antigen 125 (CA125), in the prognostic assessment of ovarian cancer (OC). Methods: A retrospective clinicopathologic review was performed. The receiver-operating characterist...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.42477

    authors: Tang Y,Hu HQ,Tang FX,Lin D,Shen R,Deng L,Tang YL,Deng LH,Zhou M,Li J,Su B,Xu F

    更新日期:2020-03-04 00:00:00

  • Clinical Significance of microRNA-196b-5p in Hepatocellular Carcinoma and its Potential Molecular Mechanism.

    abstract::Objective: To enquire into the clinical significance and potential molecular mechanism of microRNA (miRNA)-196b-5p in hepatocellular carcinoma (HCC). Methods: Quantitative reverse transcription and polymerase chain reaction (qRT-PCR) were utilized to examine miR-196b-5p expression level in 67 HCC paraffin embedded tis...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.29293

    authors: Zhang L,Luo B,Dang YW,He RQ,Peng ZG,Chen G,Feng ZB

    更新日期:2019-08-29 00:00:00