The Role of Galectins in Tumor Progression, Treatment and Prognosis of Gynecological Cancers.


:Galectins are the member of soluble proteins that bind with β-galactoside containing glycans. These proteins have been considered to be associated in various important events such as different types of cancers. It has been found that galectins could contribute to neoplastic transformation or regulate cell growth, cell apoptosis, and immune cells, causing tumor invasion, progression, metastasis and angiogenesis. Somehow, galectins are also found to exert a protective effect on cancer in a tissue-dependent way. These glycans binding proteins have been shown to be involved in the regulation of different tumor suppressor genes and oncogenes with their possible roles in human cancers. Objective of the current review is to summarize the role of galectin-1, -3 -7, and -9 in tumorigenesis of gynecological cancers. Galectin protein may be a potential therapeutic target in gynecological malignancies due to reported radio- and chemo- sensitivities, immunotherapeutic, anti-angiogenic and anti-proliferative activities. This review considers the evidence for the future research that how galectins may be important in the progression and treatment of gynecological cancers along with its potent use as a novel prognostic marker.


J Cancer


Journal of Cancer


Chetry M,Thapa S,Hu X,Song Y,Zhang J,Zhu H,Zhu X




Has Abstract


2018-11-25 00:00:00












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    authors: Zhang L,Zhou H,Gu D,Tian J,Zhang B,Dong D,Mo X,Liu J,Luo X,Pei S,Dong Y,Huang W,Chen Q,Liang C,Lian Z,Zhang S

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  • High serum Androgen and Insulin concentrations increase the tendency of Endometrial Carcinoma.

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    authors: Teng F,Ma X,Yu X,Yan Y,Zhao J,Gao J,Gao C,Wang Y,Tian W,Xue F

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    journal_title:Journal of Cancer

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    authors: Lin H,Fan X,He L,Zhou D

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    journal_title:Journal of Cancer

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    journal_title:Journal of Cancer

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    journal_title:Journal of Cancer



    authors: Tsikitis VL,Corning C,Henderson J,Rose J

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    abstract::The impact of albumin to globulin ratio (AGR) on the prognosis of various human cancers has not been well established. Here, a systemic review and meta-analysis has been performed to comprehensively assess the relationships between AGR and lymph node metastasis (LNM) or overall survival (OS). Systematical search throu...

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    authors: Chi J,Xie Q,Jia J,Liu X,Sun J,Chen J,Yi L

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    authors: He X,Guo S,Chen D,Yang G,Chen X,Zhang Y,He Q,Qin Z,Liu Z,Xue Y,Zhang M,Liu R,Zhou F,Han H,Yao K

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    journal_title:Journal of Cancer

    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Journal of Cancer

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    pub_type: 杂志文章


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    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Oka N,Kasamatsu A,Endo-Sakamoto Y,Eizuka K,Wagai S,Koide-Ishida N,Miyamoto I,Iyoda M,Tanzawa H,Uzawa K

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    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Yan D,Du Y,Dai G,Huang L,Xu Q,Yu P

    更新日期:2018-10-20 00:00:00

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    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Chen L,Wang C,Zhang X,Gao K,Liu R,Shi B,Hou P

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    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Tinoco G,Warsch S,Glück S,Avancha K,Montero AJ

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    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Qian SJ,Wu JQ,Wang Z,Zhang B

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