Combinational inhibition of EGFR and YAP reverses 5-Fu resistance in colorectal cancer.

abstract：BACKGROUND:To identify predictors for development of mastoiditis after intensity-modulated radiation therapy (IMRT) in nasopharyngeal carcinoma (NPC). METHODS:Data for 146 NPC patients treated with IMRT was retrospectively reviewed under institutional ethics committee approval. Clinical factors associated with mastoid...

journal_title：Journal of Cancer

authors： Yao JJ,Zhou GQ,Jin YN,Zhang WJ,Lin L,Yu XL,Shao JY,Ma J,Sun Y

更新日期：2016-01-08 00:00:00

abstract：:Background: Surgery for pancreatic cancer with liver metastases (PCL) is not recommended in the international guidelines, and investigation of its clinical significance in patients with PCL is very limited. This study explored whether surgery, especially synchronous resection of the primary tumor and liver metastases ...

journal_title：Journal of Cancer

authors： Su BB,Bai DS,Yu JQ,Zhang C,Jin SJ,Zhou BH,Jiang GQ

更新日期：2021-01-01 00:00:00

abstract：:Junctional adhesion molecule B (JAM-B) is a multifunctional transmembrane protein that plays an important role in tumor progression. JAM-B is significantly upregulated in gastric cancer, melanoma cell metastasis and oral squamous cell carcinoma. JAM-2 may also function as a putative tumor suppressor in the progression...

journal_title：Journal of Cancer

authors： Zhang W,He R,Chen S,Zhang L,Cao G,Yang W,Li J

更新日期：2020-03-05 00:00:00

abstract：:Objective: First, to evaluate the sensitivity and positive predictive value (PPV) of intra-operative frozen section (FS) diagnosis in borderline ovarian tumors (BOTs), and to explore the factors affecting the diagnostic accuracy. Second, to assess the clinical outcomes of misdiagnosed BOT patients. Methods: We perform...

journal_title：Journal of Cancer

authors： Huang Z,Li L,Li C,Ngaujah S,Yao S,Chu R,Xie L,Yang X,Zhang X,Liu P,Jiang J,Zhang Y,Cui B,Song K,Kong B

更新日期：2018-07-16 00:00:00

abstract：:Oncogenic activation of the ETS Related Gene (ERG) in humans was originally identified in subsets of Ewing sarcomas, myeloid leukemias and, recently, in the majority of prostate cancers. Expression of human ERG protein and consequently its functions in normal and disease states needs to be better understood in light o...

journal_title：Journal of Cancer

authors： Mohamed AA,Tan SH,Mikhalkevich N,Ponniah S,Vasioukhin V,Bieberich CJ,Sesterhenn IA,Dobi A,Srivastava S,Sreenath TL

更新日期：2010-10-25 00:00:00

abstract：:Objectives: LncRNA associated with microvascular invasion in hepatocellular carcinoma (lncRNA MVIH) is a newly discovered long non-coding RNA that aberrantly up-regulates and holds prognostic value in various tumors. The aim of the review and meta-analysis is to assess its prognostic potential and functions in maligna...

journal_title：Journal of Cancer

authors： Zhang Y,Lin S,Yang X,Zhang X

更新日期：2019-02-26 00:00:00

abstract：:Background: The Gustave Roussy Immune Score (GRIm-Score) was initially reported to select patients for immunotherapy. Therefore, the purpose of the current retrospective study was to determine whether GRIm-Score, a novel nutritional and inflammatory-based prognostic score, is a useful prognostic marker in patients wit...

journal_title：Journal of Cancer

authors： Feng JF,Wang L,Yang X,Chen S

更新日期：2020-01-01 00:00:00

abstract：:Traditional chemotherapy and radiotherapy for cancer treatment face serious challenges such as drug resistance and toxic side effects. Complementary / Alternative medicine is increasingly being practiced worldwide due to its safety beneficial therapeutic effects. We hypothesized that a super combination (SC) of known ...

journal_title：Journal of Cancer

authors： Ouhtit A,Gaur RL,Abdraboh M,Ireland SK,Rao PN,Raj SG,Al-Riyami H,Shanmuganathan S,Gupta I,Murthy SN,Hollenbach A,Raj MH

更新日期：2013-11-14 00:00:00

abstract：:Dysbindin has been reported to be correlated with several malignancies. However, the clinical significance and biological role of dysbindin in epithelial ovarian cancer remains largely unknown. Here we demonstrated that the mRNA and protein levels of dysbindin were significantly upregulated in EOC tissues compared wit...

journal_title：Journal of Cancer

authors： Lv X,Guo X,Ru Y,Zhou F,Yang X,Ge J,Li J,Liu S,Jiang K,Chen B

更新日期：2020-02-21 00:00:00

abstract：:Background: Programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer (NSCLC) is considered as a predictive biomarker of anti-PD-1/PD-L1 cancer therapies. However, the correlation of PD-L1 expression status between the primary and paired metastatic NSCLC is still not clear. The current study aims to a...

journal_title：Journal of Cancer

authors： Luo L,Luo X,Chen W,Liang C,Yao S,Huang W,Liu C,Ge Y,Lin X,Li Z

更新日期：2020-01-01 00:00:00

abstract：:Purpose: This study aimed to comprehensively investigate the differential expression and prognostic indicators of the tripartite motif-containing (TRIM) gene family in non-small cell lung cancer (NSCLC). Methods: The Cancer Genome Atlas (TCGA) Research Network and three datasets from Gene Expression Omnibus (GEO) data...

journal_title：Journal of Cancer

authors： Han X,Huang C,Qu X,Liu S,Yang X,Wang Y,Bie F,Liu Q,Du J

更新日期：2019-01-29 00:00:00

abstract：:Endocrine resistance in hormone receptor positive breast cancer patients urges us to develop novel approaches such as inhibitors of the cyclin-dependent kinases (CDK) 4/6 to reverse its resistance. Nowadays, three selective CDK4/6 inhibitors (Palbociclib, Ribociclib and Abemaciclib) are approved by Federal Drug Admini...

journal_title：Journal of Cancer

authors： Chen X,Xu D,Li X,Zhang J,Xu W,Hou J,Zhang W,Tang J

更新日期：2019-10-21 00:00:00

abstract：:Colorectal cancer (CRC) usually gives rise to transcoelomic spread and ultimately causes peritoneal carcinomatosis (PC). However, mechanism studies, especially the immunological basis of colorectal PC, are rarely revealed due to lack of a suitable PC model. Here we selected a mouse colorectal cancer cell line MC-38 fo...

journal_title：Journal of Cancer

authors： Shi R,Xiang W,Kang X,Zhang L,Wang J,Miao H,He F

更新日期：2019-01-01 00:00:00

abstract：:PURPOSE: Chronic obstructive pulmonary disease (COPD) is associated with an increased cancer risk. We evaluated the chemopreventive effect of statins against all cancers in COPD patients and identified the statin with the strongest chemopreventive effect. PATIENTS AND METHODS: All patients diagnosed with COPD at healt...

journal_title：Journal of Cancer

authors： Chen CC,Hsu YP,Liu JC,Kao PF,Sung LC,Lin CF,Hao WR,Liu SH,Wu SY

更新日期：2016-09-13 00:00:00

abstract：:Alternative splicing plays critical roles in many disease processes and splicing dysregulation is a hallmark of cancer. The different splicing isoforms may have significantly different effects on the malignant progression of cancer. Checkpoint kinase 1 (CHK1) is a serine/threonine kinase and regulates DNA damage respo...

journal_title：Journal of Cancer

authors： Hu G,Wang S,Wang Y,Gao Y,Zhu H,Liu M,Xu N,Wang L

更新日期：2020-01-17 00:00:00

abstract：:Esophageal cancer is an aggressive disease featured by early lymphatic and hematogenous dissemination, and is the sixth leading cause of cancer-related deaths worldwide. The proper formation of apicobasal polarity is essential for normal epithelium physiology and tissue homeostasis, while loss of polarity is a hallmar...

journal_title：Journal of Cancer

authors： Li XM,Wang H,Zhu LL,Zhao RZ,Ji HL

更新日期：2015-06-11 00:00:00

abstract：:Long non-coding RNAs (lncRNAs) have been considered as biomarkers for the carcinogenesis and development of various cancers. However, the prognostic significance of lncRNAs in renal cell carcinoma (RCC) remains unclear. This study aimed to determine the predictive ability of lncRNAs in clear cell RCC (ccRCC). Among th...

journal_title：Journal of Cancer

authors： Liu H,Ye T,Yang X,Lv P,Wu X,Zhou H,Zeng J,Tang K,Ye Z

更新日期：2020-04-27 00:00:00

abstract：:Early detection and accurate evaluation were both critical to improving the prognosis of clear cell Renal Cell Carcinoma (ccRCC) patients. More importantly, RNA Binding Proteins (RBPs) play a vital role in the tumorigenesis and progression of numerous cancers. However, the relationship between RBPs and ccRCC is still ...

journal_title：Journal of Cancer

authors： Zhu Z,He A,Lin L,Xu C,Cai T,Lin J

更新日期：2020-09-23 00:00:00

abstract：:Background: To elucidate the expression of Aurora kinases (AURK) and the anticancer effects of pan-aurora kinase inhibitor Danusertib in hepatocarcinogenesis model in C56Bl6 mice. Methods: Thirty mice C56Bl6 were randomly divided into Group A or control, Group B animals who underwent experimental hepatocarcinogenesis ...

journal_title：Journal of Cancer

authors： Gavriilidis P,Poutahidis T,Giakoustidis A,Makedou K,Angelopoulou K,Hardas A,Andreani P,Zacharioudaki A,Saridis G,Gargavanis A,Louri E,Antoniadis N,Karampela E,Psychalakis N,Michalopoulos A,Papalois A,Iliadis S,Mudan S,

更新日期：2018-02-27 00:00:00

abstract：:Purpose: To evaluate the detection of gene mutations in bone marrow biopsy and circulating free DNA (cfDNA) from plasma in multiple myeloma (MM). Experimental design: We used cell-free DNA from plasma and bone marrow to test BRAF V600, KRAS G12/G13, NRAS G12/G13 and NRAS Q61 mutations using multiplex assays for drople...

journal_title：Journal of Cancer

authors： Li Q,Huang HJ,Ma J,Wang Y,Cao Z,Karlin-Neumann G,Janku F,Liu Z

更新日期：2020-03-15 00:00:00

abstract：:Objectives: To investigate the effect of the concurrent use of trastuzumab and anthracycline-based neoadjuvant chemotherapy (NAC) for HER2-positive breast cancer in terms of pCR and cardiotoxicity. Methods: We systematically searched Pubmed, Embase, Cochrane and SinoMed databases from inception until 1 July 2017 for r...

journal_title：Journal of Cancer

authors： Wu YT,Xu Z,Arshad B,Wu JS,Zhang K,Wu H,Li X,Li H,Li YC,Wang ZL,Wu KN,Kong LQ

更新日期：2018-08-06 00:00:00

abstract：BACKGROUND:Mathematical models can be useful tools in exploring disease trends and health consequences of interventions in a population over time. Most cancers, in particular cervical cancer, have long incubation periods. The time from acquisition of HPV infection to development of invasive cancer can be up to two deca...

journal_title：Journal of Cancer

authors： Lee SL,Tameru AM

更新日期：2012-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the sixth most common cancer, and the third most common cause of cancer related death worldwide. The multi-kinase inhibitor Sorafenib represents the only systemic treatment option until today, and results from clinical trials with allosteric mTOR inhibitors were sobering. Since the PI...

journal_title：Journal of Cancer

authors： Ewald F,Nörz D,Grottke A,Bach J,Herzberger C,Hofmann BT,Nashan B,Jücker M

更新日期：2015-09-16 00:00:00

abstract：:Introduction: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are a standard first-line treatment for advanced EGFR-mutated NSCLC patients. Factors associated with symptoms and quality of life (QOL) improvements have not been investigated. Methods: We conducted a multicenter, prospective study ...

journal_title：Journal of Cancer

authors： Wei YF,Huang WT,Liu TC,Shieh JM,Chian CF,Wu MF,Chang CC,Lin CH,Ko JC,Lin CM,Hsia TC

更新日期：2019-07-10 00:00:00

abstract：:Purpose: The present study aims to explore the potential mechanisms contributing to prostate cancer (PCa), screen the hub genes, and identify potential biomarkers and correlated pathways of PCa progression. Methods: The PCa gene expression profile GSE3325 was operated to analyze the differentially expressed genes (DEG...

journal_title：Journal of Cancer

authors： Song Z,Huang Y,Zhao Y,Ruan H,Yang H,Cao Q,Liu D,Zhang X,Chen K

更新日期：2019-02-23 00:00:00

abstract：:Background: The effect of adjuvant chemotherapy on stage II colon cancer remains constantly controversial. Recently, however, several studies have reported the definite survival benefit of adjuvant chemotherapy (ACT) in T4 disease (stage IIB and IIC) among stage II colon cancer patients. The following study investigat...

journal_title：Journal of Cancer

authors： Liu Q,Luo D,An H,Zhang S,Cai S,Li Q,Li X

更新日期：2019-01-29 00:00:00

abstract：:Esophageal cancer (EC) is a unique and heterogeneous disease diagnosed mostly at advanced stages. Altered glycans presented on cell surfaces are involved in the occurrence and development of malignancy. However, the effects of glycans on EC progression are largely unexplored. Here, a lectin array was utilized to detec...

journal_title：Journal of Cancer

authors： Xia M,Shao J,Qiao M,Luo Z,Deng X,Ke Q,Dong X,Shen L

更新日期：2020-06-01 00:00:00

abstract：INTRODUCTION:Hürthle cell carcinoma (HCC) is a rare tumor that tends to metastasize to the lymph nodes. Some studies have correlated size of Hürthle cell tumors with the risk of malignancy. Whether the size of HCC correlates with the risk of lymph node (LN) metastases, to our knowledge has not been addressed. METHODS:...

journal_title：Journal of Cancer

authors： Guerrero MA,Suh I,Vriens MR,Shen WT,Gosnell J,Kebebew E,Duh QY,Clark OH

更新日期：2010-06-02 00:00:00

abstract：:Cervical cancer is a commonly diagnosed cancer among females. Polymorphisms in pre-microRNAs have been demonstrated to play critical roles in cancer. However, the roles of pre-microRNA polymorphisms in the aetiology of cervical cancer have not been well documented. We genotyped eight pre-microRNA polymorphisms in 290 ...

journal_title：Journal of Cancer

authors： Chen G,Zhang M,Zhu J,Chen F,Yu D,Zhang A,He J,Hua W,Duan P

更新日期：2020-02-03 00:00:00

abstract：:The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) with its immunotherapeutic activities and sialic acid binding abilities is a promising cancer adjuvant. The HN was surfaced displayed on Lactococcus lactis and its cancer targeting ability was investigated via attachment to the MDA-MB231 bre...

journal_title：Journal of Cancer

authors： Baradaran A,Yusoff K,Shafee N,Rahim RA

更新日期：2016-01-29 00:00:00