Inhibition of malignant human bladder cancer phenotypes through the down-regulation of the long non-coding RNA SNHG7.

abstract：:Until few years ago non-specific cytotoxic agents were considered the tip of the arrow as first line treatment for lung cancer. However; age > 75 was considered a major drawback for this kind of therapy. Few exceptions were made by doctors based on the performance status of the patient. The side effects of these agent...

journal_title：Journal of Cancer

authors： Hohenforst-Schmidt W,Zarogoulidis P,Steinheimer M,Benhassen N,Tsiouda T,Baka S,Yarmus L,Stratakos G,Organtzis J,Pataka A,Tsakiridis K,Karapantzos I,Karapantzou C,Darwiche K,Zissimopoulos A,Pitsiou G,Zarogoulidis K,Man Y

更新日期：2016-03-21 00:00:00

abstract：:Hepatocellular carcinoma (HCC) cells exhibit multidrug resistance (MDR), but the underlying mechanisms remain unclear. Cancer cells that overexpress telomerase are resistant to chemotherapeutic drugs. This study aimed to determine the effects of mitochondrial translocation of telomerase on MDR in HCC cells. HepG2 cell...

journal_title：Journal of Cancer

authors： Yan J,Zhou Y,Chen D,Li L,Yang X,You Y,Ling X

更新日期：2015-01-05 00:00:00

abstract：:Background: Epithelioid trophoblastic tumors (ETTs) are the rarest type of gestational trophoblastic neoplasias. We investigated the clinical features, treatments, outcomes, and prognostic factors in patients with ETT, and explored potential therapeutic targets. Methods: We retrospectively analyzed the clinical featur...

journal_title：Journal of Cancer

authors： Yang J,Zong L,Wang J,Wan X,Feng F,Xiang Y

更新日期：2019-01-01 00:00:00

abstract：:Objective: Multiple reports have described the proportion of T-regulatory cells (Tregs) in peripheral blood (PB) and tissues in patients with gynecological cancers (GCs) with controversial results. Thus, the aim of this study was to investigate the proportion of Tregs and its prognostic survival role in GCs patients. ...

journal_title：Journal of Cancer

authors： Hu J,Wu X,Huang P,Teng F,Wang Y,Xue F

更新日期：2020-03-05 00:00:00

abstract：:Colorectal cancer(CRC) is a prevalent malignancy in the world. There is growing evidence that microRNAs (miRNAs) as crucial modulator are in connection with many tumor-related diseases including CRC. Though miR-485-5p has been reported as an anti-oncogene in certain cancers, it remains unclear in CRC. In this research...

journal_title：Journal of Cancer

authors： Hu XX,Xu XN,He BS,Sun HL,Xu T,Liu XX,Chen XX,Zeng KX,Wang SK,Pan YQ

更新日期：2018-06-23 00:00:00

abstract：:Purpose: Extremity soft tissue leiomyosarcoma (LMS) with metastasis is a rare disease with a poor prognosis. The purpose of our study was to define clinical features of extremity soft tissue LMS with metastasis as well as to identify multivariable predictors of survival. Methods: During 1973-2015, 239 patients with me...

journal_title：Journal of Cancer

authors： Qian SJ,Wu JQ,Wang Z,Zhang B

更新日期：2019-05-21 00:00:00

abstract：:The authors retrospectively examined the contralateral prophylactic mastectomy (CPM) rate among 100 women with ductal carcinoma in situ who are BRCA negative. Of 100 women with ductal carcinoma in situ, 31 elected contralateral prophylactic mastectomy (CPM). Factors associated with increased likelihood of undergoing c...

journal_title：Journal of Cancer

authors： Elsayegh N,Profato J,Barrera AM,Lin H,Kuerer HM,Ardic C,Litton JK,Tripathy D,Arun BK

更新日期：2015-05-23 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is currently one of the most intractable malignancies with a typical scirrhous pattern in histology. Due to its abundant tumor stroma and scant vascularization, chemotherapeutic agents are considered inefficiently permeable to cancer nests, making it highly difficult to cure the...

journal_title：Journal of Cancer

authors： Saito K,Sakaguchi M,Maruyama S,Iioka H,Putranto EW,Sumardika IW,Tomonobu N,Kawasaki T,Homma K,Kondo E

更新日期：2018-07-30 00:00:00

abstract：:Background: Radiotherapy is a standard treatment for a significant fraction of cancer patients. Nonetheless, to this day radiation resistance is a key impediment in gastric cancer (GC) treatment. Moreover, GC is characterized by its substantial neo-angiogenesis, driven by high levels of vascular endothelial growth fac...

journal_title：Journal of Cancer

authors： Li G,Lin H,Tian R,Zhao P,Huang Y,Pang X,Zhao L,Cao B

更新日期：2018-10-18 00:00:00

abstract：:Centromere protein N (CENP-N), an important member of the centromere protein family, is essential for kinetochore assembly and chromosome segregation; however, the relevance of CENP-N in cancers remains unknown. The aim of this study was to investigate CENP-N expression and its functional mechanisms in oral squamous c...

journal_title：Journal of Cancer

authors： Oka N,Kasamatsu A,Endo-Sakamoto Y,Eizuka K,Wagai S,Koide-Ishida N,Miyamoto I,Iyoda M,Tanzawa H,Uzawa K

更新日期：2019-06-09 00:00:00

abstract：:Background/Purpose: In colon cancer (CC) patients preoperative (pre-op) levels of VEGF-A165 (VEGF) is a strong predictor for disease recurrence. Elevated postoperative (post-op) VEGF levels could have undesirable effects by enhancing tumor growth and metastasis formation. It has been suggested that thromboprophylaxis ...

journal_title：Journal of Cancer

authors： Mitsis M,Koliou P,Bali C,Ntounousi E,Tatsis V,Nousias V,Lianos GD,Vartholomatos G,Nastos D

更新日期：2017-08-25 00:00:00

abstract：:Objective: Although previous studies suggest that previous pulmonary tuberculosis was associated with increased risk of lung cancer. It remains controversial whether pulmonary tuberculosis is a risk factor for lung cancer. Our study was aimed to examine the association between pulmonary tuberculosis and lung cancer ri...

journal_title：Journal of Cancer

authors： Oh CM,Roh YH,Lim D,Kong HJ,Cho H,Hwangbo B,Won YJ,Jung KW,Oh K

更新日期：2020-01-20 00:00:00

abstract：:Background: To investigate the relationship between clinical and histopathological characteristics and overall survival of patients with oral mucosal melanoma (OMM) without distal metastasis in order to provide predictive prognostic information of OMM. Methods: Ki67 expression was assessed by immunohistochemistry in 1...

journal_title：Journal of Cancer

authors： Ma X,Wu Y,Zhang T,Song H,Jv H,Guo W,Ren G

更新日期：2017-10-17 00:00:00

abstract：:Background: Hepatitis B virus infection had been identified its relationship with liver diseases, including liver tumors. We aimed to explore diagnostic and prognostic values between the Human Leukocyte Antigen (HLA) complex and hepatocellular carcinoma (HCC). Methods: We used the GSE14520 dataset to explore diagnosti...

journal_title：Journal of Cancer

authors： Wang XK,Liao XW,Yang CK,Yu TD,Liu ZQ,Gong YZ,Huang KT,Zeng XM,Han CY,Zhu GZ,Qin W,Peng T

更新日期：2019-08-28 00:00:00

abstract：:Transforming growth factor β1 (TGF-β1) plays an important role in tumor initiation and development by inducing epithelial-mesenchymal Transition (EMT). Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is a long noncoding RNA (lncRNA) that contributes to the invasion and metastasis of tumors, including e...

journal_title：Journal of Cancer

authors： Liu Q,Zheng S,Chen Y,Liu T,Han X,Zhang X,Shen T,Lu X

更新日期：2020-10-04 00:00:00

abstract：:Early detection and accurate evaluation were both critical to improving the prognosis of clear cell Renal Cell Carcinoma (ccRCC) patients. More importantly, RNA Binding Proteins (RBPs) play a vital role in the tumorigenesis and progression of numerous cancers. However, the relationship between RBPs and ccRCC is still ...

journal_title：Journal of Cancer

authors： Zhu Z,He A,Lin L,Xu C,Cai T,Lin J

更新日期：2020-09-23 00:00:00

abstract：:Objectives: We aimed to investigate the interaction between fasting blood glucose and tumor embolus, and the potential mediation effect of fasting blood glucose on tumor embolus in predicting gastrointestinal tract cancer-specific mortality risk postoperatively. Methods and Results: 4330 patients were consecutively re...

journal_title：Journal of Cancer

authors： Hu D,Zhang X,Lin X,Zhang H,Xia Y,Lin J,Zheng X,Peng F,Niu W

更新日期：2020-01-01 00:00:00

abstract：:Preoperative chemoradiation followed by surgery has been recommended as a standard treatment for patients with stage II/III rectal cancer. However, the optimal sequencing of radiotherapy for metastatic rectal cancer remains unclear. Between 2004 and 2014, patients diagnosed with metastatic rectal cancer who underwent ...

journal_title：Journal of Cancer

authors： Luo D,Liu Q,Zhu J,Ma Y,Cai S,Li Q,Li X

更新日期：2019-01-30 00:00:00

abstract：:Ovarian carcinoma is the most lethal gynecological malignancy worldwide. Recent advance in genomic/epigenomic researches will impact on our prevention, detection and intervention on ovarian carcinoma. Detection of germline mutations in BRCA1/BRCA2, mismatch repair genes, and other genes in the homologous recombination...

journal_title：Journal of Cancer

authors： Dong A,Lu Y,Lu B

更新日期：2016-07-05 00:00:00

abstract：:Background: Infiltration of immune cells and immune microenvironment determine the proliferative activity of the tumor and metastasis. The aim of this study was to analyze the influence of activation or suppression of the immune response mediators on the prognosis of biliary tract cancer (BTC). Methods: We searched Pu...

journal_title：Journal of Cancer

authors： Wang Y,Ding M,Zhang Q,Wang J,Yang X,Zhou F,Li L,Yuan Z,Jin H,Qian Q

更新日期：2017-01-01 00:00:00

abstract：PURPOSE:Our study is designed to develop and certify a promising prognostic signature for hepatocellular carcinoma (HCC). Materials and methods: We retrospectively analyzed mRNA expression profiles and clinicopathological data fetched from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. We fo...

journal_title：Journal of Cancer

authors： Xie H,Liu S,Zhang Z,Chen P,Tao Y

更新日期：2020-07-31 00:00:00

abstract：:We use pulmonary interventional procedures for the diagnosis of pulmonary diseases either for benign or malignant lesions. Flexible bronchoscopy with or without radial endobronchial ultrasound, convex-probe endobronchial ultrasound and electromagnetic navigation are procedures performed in centers with experience in d...

journal_title：Journal of Cancer

authors： Hohenforst-Schmidt W,Zarogoulidis P,Huang H,Man YG,Laskou S,Koulouris C,Giannakidis D,Mantalobas S,Florou MC,Amaniti A,Steinheimer M,Sinha A,Freitag L,Turner JF,Browning R,Vogl T,Roman A,Benhassen N,Kesisoglou I,Sap

更新日期：2018-02-12 00:00:00

abstract：:Our previous studies have demonstrated that the compound fuling granule (CFG), a traditional Chinese medicine, suppresses ovarian cancer cell growth, migration and metastasis. However, the underlying mechanisms remain to be fully elucidated. In this study, we found that CFG could induce mitochondrial fragmentation, mi...

journal_title：Journal of Cancer

authors： Ruan S,Zhang Z,Tian X,Huang D,Liu W,Yang B,Shen M,Tao F

更新日期：2018-09-08 00:00:00

abstract：:Cancer-testis (CT) genes played important roles in the progression of malignant tumors and were recognized as promising therapeutic targets. However, the roles of genetic variants in CT genes in lung cancer susceptibility have not been well depicted. This study aimed to evaluate the associations between genetic varian...

journal_title：Journal of Cancer

authors： Li Z,Tang J,Wen W,Wu W,Wang J,Xu J,Yu Y,He Z,Pan X,Wei H,Zhu Y,Hu S,Cao J,Shen H,Que J,Wang W,Zhu Q,Chen L

更新日期：2020-02-03 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a major malignancy of cancer-related mortality worldwide. Metastasis-associated in colon cancer-1 (MACC1) was suggested as a marker for vascular invasive HCC. This study investigated the MACC1 single-nucleotide polymorphisms (SNPs) to evaluate HCC susceptibility and clinicopathologica...

journal_title：Journal of Cancer

authors： Lin CH,Hsieh MJ,Lee HL,Yang SF,Su SC,Lee WJ,Chou YE

更新日期：2020-01-14 00:00:00

abstract：:Taking into account the previously reported relationship between inflammation and carcinogenesis, and the scant amount of data concerning the role of neutrophil extracellular traps (NETs) in carcinogenesis, we decided to study the process of extracellular trap formation in patients with inflammation as well as in pati...

journal_title：Journal of Cancer

authors： Garley M,Dziemiańczyk-Pakieła D,Grubczak K,Surażyński A,Dąbrowska D,Ratajczak-Wrona W,Sawicka-Powierza J,Borys J,Moniuszko M,Pałka JA,Jabłońska E

更新日期：2018-04-30 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the sixth most common tumor worldwide. The relationship between the gene methylation accumulation and HCC has been widely studied. In our study, we used the Sequenom EpiTYPER assay to investigate the methylation levels of the RASA3 in 164 HCC samples and paired adjacent non-cancerous ...

journal_title：Journal of Cancer

authors： Lin H,Fan X,He L,Zhou D

更新日期：2018-05-25 00:00:00

abstract：:Aim: Skin cutaneous melanoma (SKCM) is one of the most life-threatening malignancies damaging human health. APOBEC3G (A3G) has been found in several cancers; however, the role of A3G in SKCM is rarely studied. This study aimed to investigate the expression of A3G in tumor tissue and its prognostic value in SKCM patien...

journal_title：Journal of Cancer

authors： Han W,Xu J,Shen GL

更新日期：2020-07-06 00:00:00

abstract：:We hypothesised that the blood levels of immune cells would be related to the progression of colorectal cancer and regional lymph node metastasis. We investigated the association between the blood levels of immune cells and regional lymph node metastasis in colorectal cancer patients. Patients with American Joint Comm...

journal_title：Journal of Cancer

authors： Lee JY,Seo EH,Oh CS,Paik JH,Hwang DY,Lee SH,Kim SH

更新日期：2017-05-10 00:00:00

abstract：:Purpose: To evaluate long-term survival trends after primary total laryngectomy (TL) for locally advanced laryngeal carcinoma (LC). Methods: A total of 2094 patients diagnosed with locally advanced LC and underwent primary TL (1992-2011, at least 5-year follow-up) in the Surveillance, Epidemiology, and End Results (SE...

journal_title：Journal of Cancer

authors： Lin Z,Lin H,Chen Y,Xu Y,Chen X,Fan H,Wu X,Ke X,Lin C

更新日期：2021-01-01 00:00:00