Abstract：
:Background: Epithelioid trophoblastic tumors (ETTs) are the rarest type of gestational trophoblastic neoplasias. We investigated the clinical features, treatments, outcomes, and prognostic factors in patients with ETT, and explored potential therapeutic targets. Methods: We retrospectively analyzed the clinical features, treatments, survival, and prognostic factors of 21 ETT patients treated at our institution between January 2002 and December 2017. Expression levels of programmed cell death 1 (PD-1), PD-1 ligands (PD-L1and PD-L2), B7 family ligands (B7-H3, B7-H4, V-domain Ig suppressor of T cell activation [VISTA], and B7-H6), and CD105 expression were assessed by immunohistochemistry. Results: Fourteen patients with ETT (66.7%) presented with irregular vaginal bleeding. Three stage I patients (14.3%) with normal β-human chorionic gonadotropin (β- hCG) levels underwent hysterectomy alone. Of the remaining 18 patients who had elevated β-hCG levels (85.7%), 1 received chemotherapy and 17 underwent surgery and multi-agent chemotherapy. After treatment, 17 patients (81.0%) achieved complete remission (2 of whom [11.8%] later relapsed) and 4 (19.0%) with stage IV died of their disease. On univariate and multivariate analyses, stage IV disease was an independent prognostic factor for overall and disease-free survival (P < 0.001). PD-L1, B7-H3, and CD105 were detected in 100% of samples, PD-L2 and VISTA in 82%, B7-H6 in 18%, and B7-H4 was undetectable in ETT cells. Conclusions: Hysterectomy and metastatic lesion resection are essential for controlling ETT. Surgery plus chemotherapy are recommended for patients with abnormal β-hCG levels and metastatic disease. PD-L1, PD-L2, B7-H3, VISTA and CD105 are potential therapeutic targets for metastatic ETT.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Yang J,Zong L,Wang J,Wan X,Feng F,Xiang Ydoi
10.7150/jca.28134subject
Has Abstractpub_date
2019-01-01 00:00:00pages
11-19issue
1issn
1837-9664pii
jcav10p0011journal_volume
10pub_type
杂志文章abstract：:Background: Malignant biliary and/or pancreatic obstruction has often encountered in the advanced stages of periampullary and cholangicarcinomas. HabibTM Radiofrequency (RF) ablation has been successfully used in the management of various cancers of liver and pancreas. Percutaneous HPB probe (EMcision Ltd, London, UK)...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.23280
更新日期：2018-01-05 00:00:00
abstract：:Transarterial chemoembolization (TACE) has been considered the standard treatment for intermediate-stage hepatocellular carcinoma according to BCLC algorithm. However, it has been unclear about the TACE-related predictive bio-markers and underlying molecular mechanisms. This investigation revealed that HCCs with highe...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.35631
更新日期：2020-01-01 00:00:00
abstract：:Liver kinase B1 (LKB1) is a critical tumor suppressor that is frequently mutated in human cancers. LKB1 has serine/threonine protein kinase activity, which regulates gene expression by phosphorylation of Yes-Associated protein (YAP). The phosphorylation-dependent YAP shuttling is critically important intracellular mec...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.33237
更新日期：2019-06-09 00:00:00
abstract：BACKGROUND:Neoadjuvant chemotherapy with concurrent docetaxel, doxorubicin and cyclophosphamide is commonly used for patients with locally advanced breast cancer. Epirubicin is another anthracycline used in breast cancer but the concurrent use of epirubicin and taxane is not well-established. We conducted a single inst...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.3980
更新日期：2012-01-01 00:00:00
abstract：:In 2006, a remarkable collaboration between University of Texas MD Anderson Cancer Center clinicians and Texas and New Mexico State legislators led to the formation of a dedicated IBC Research Program and Clinic at MD Anderson. This initiative provided funding and infrastructure to foster coordination of an IBC World ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.21200
更新日期：2017-10-09 00:00:00
abstract：:Tissue-derived RNA, DNA and protein samples become more and more crucial for molecular detection in clinical research, personalized and targeted cancer therapy. This study evaluated how to biobanking colorectal tissues through examining the influences of cold ischemic time and freeze-thaw cycles on RNA, DNA and protei...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.29372
更新日期：2019-08-27 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is the sixth most common tumor worldwide. The relationship between the gene methylation accumulation and HCC has been widely studied. In our study, we used the Sequenom EpiTYPER assay to investigate the methylation levels of the RASA3 in 164 HCC samples and paired adjacent non-cancerous ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.24567
更新日期：2018-05-25 00:00:00
abstract：BACKGROUND:Due to the lack of studies, it remains unclear whether the additional neoadjuvant chemotherapy (NACT) to concurrent chemoradiotherapy (CCRT) is superior to CCRT alone for locoregionally advanced nasopharyngeal carcinoma (NPC). The main objective of this Bayesian network meta-analysis was to determine the eff...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.11814
更新日期：2015-07-17 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is the sixth most common cancer, and the third most common cause of cancer related death worldwide. The multi-kinase inhibitor Sorafenib represents the only systemic treatment option until today, and results from clinical trials with allosteric mTOR inhibitors were sobering. Since the PI...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.12452
更新日期：2015-09-16 00:00:00
abstract：:Aim: Skin cutaneous melanoma (SKCM) is one of the most life-threatening malignancies damaging human health. APOBEC3G (A3G) has been found in several cancers; however, the role of A3G in SKCM is rarely studied. This study aimed to investigate the expression of A3G in tumor tissue and its prognostic value in SKCM patien...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.46383
更新日期：2020-07-06 00:00:00
abstract：:Our previous study has demonstrated that cytochalasin H (CyH) isolated from mangrove-derived endophytic fungus induces apoptosis and inhibits migration in A549 non-small cell lung cancer (NSCLC) cells. In this study, we further explored the effect of CyH on angiogenesis in NSCLC cells and the underlying molecular mech...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.29933
更新日期：2019-05-12 00:00:00
abstract：:The purpose of this study was to determine the association between body mass index (BMI) measurements (baseline BMI and changes in BMI during neoadjuvant systemic treatment [NST]) and clinical efficacy (pathologic complete response [pCR] rate and survival outcomes) in locally advanced breast cancer (LABC). We hypothes...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.10580
更新日期：2015-01-22 00:00:00
abstract：:Objectives: This study aims to evaluate influence factors for adjuvant chemotherapy regimen choice on the basis of trastuzumab in older human epidermal growth factor receptor 2 (HER2)-positive breast cancer under multi-disciplinary team (MDT) modality. Materials and Methods: HER2-positive breast cancer patients aged ≥...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.39509
更新日期：2020-02-14 00:00:00
abstract：:Background: Noninvasive stool-based DNA methylation testing emerges as a new approach for detecting colorectal cancer (CRC). However, its feasibility for early detection of CRC and precancerous lesions in the Chinese population remains inconclusive. Methods: In this study, we establish a possibilities screening method...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.50525
更新日期：2021-01-01 00:00:00
abstract：:Angiogenesis, a highly regulated process, is exploited by tumors like breast cancer to ensure a constant supply of oxygen and nutrients and is key for tumor survival and progression. Estrogen and alcohol independently have been observed to contribute to angiogenesis in breast cancer but their combinatorial effects hav...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.25581
更新日期：2018-10-06 00:00:00
abstract：:We hypothesised that the blood levels of immune cells would be related to the progression of colorectal cancer and regional lymph node metastasis. We investigated the association between the blood levels of immune cells and regional lymph node metastasis in colorectal cancer patients. Patients with American Joint Comm...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.18230
更新日期：2017-05-10 00:00:00
abstract：:Circular RNAs (circRNAs), as a type of tissue specific RNA with more stable structure than linear RNAs, was poorly understood on its correlation with gastric cancer (GC). In this review, we outline the synthesis and characteristics of circRNAs and generalize their categories and functions. Through comprehensive analys...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.32927
更新日期：2019-10-15 00:00:00
abstract：:Even with the technological advances of dose-escalated IMRT with the addition of the latest image guidance technologies, local failures still occur. The combination of MRI-based imaging techniques can yield quantitative information that reflects on the biological properties of prostatic tissues. These techniques provi...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.5419
更新日期：2013-01-01 00:00:00
abstract：:Little is known about the possible oncogenic roles of genes encoding for the phosphatidylinositol 4-kinases, a family of enzymes that regulate an early step in phosphoinositide signalling. To address this issue, the mutational status of all four human phosphatidylinositol 4-kinases genes was analyzed across 852 breast...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.9794
更新日期：2014-10-28 00:00:00
abstract：INTRODUCTION:Bioimpedance is a measure of the electrical properties of biological tissues. In the last two decades bioimpedance has been successfully introduced in clinical diagnosis of cancer. It has been demonstrated that tumoral tissues often show lower bioimpedance values than healthy tissues. The aim of this work ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.11936
更新日期：2015-08-20 00:00:00
abstract：:Background: The purpose of this study was to examine and compare the prognostic value of different immunization-based scoring systems in patients with soft tissue sarcoma (STS). Methods: We conducted a retrospective study evaluating a cohort of 165 patients diagnosed with STS between July 2007 and July 2014. The relat...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.17356
更新日期：2017-02-25 00:00:00
abstract：:Background: Bevacizumab combined with chemotherapy is still one of the standard options for treatment of advanced non-small cell lung cancer (NSCLC) patients without driver mutations. Serum inflammatory factors, representing the systemic immune status, are shown to have complicated relationships with tumor angiogenesi...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.30478
更新日期：2019-08-28 00:00:00
abstract：:Background: Identification of new predictive markers in melanoma is of great clinical importance. This study was aimed to analyze association between selected common variants in the cancer susceptibility genes and melanoma progression at the time of diagnosis. Material and Method: The study included 243 consecutive pa...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.26404
更新日期：2018-08-06 00:00:00
abstract：:Chemotherapy resistance represents a major obstacle for the treatment of patients with breast cancer (BC) and greatly restricts the therapeutic effect of the first-line chemotherapeutic agent doxorubicin (DOX). The present study aimed to investigate the feasibility of the recombinant dual-target murine double minute 2...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.32765
更新日期：2020-01-01 00:00:00
abstract：:Background/Aims: Autologous, tumor-derived, heat shock protein gp96 peptide complexes have antitumor potential. We conducted the first Phase II trial to evaluate the safety and efficacy of gp96 vaccination in adjuvant settings for patients with gastric cancer. Methods: We enrolled 73 consecutive patients from October ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.18946
更新日期：2017-07-02 00:00:00
abstract：:Several studies have reported the association between MAPK signaling pathway gene polymorphisms and papillary thyroid carcinoma (PTC). KRAS gene, an oncogene from the mammalian RAS gene family plays an important role in the MAPK pathway. This study aimed to identify the potential association of KRAS gene polymorphisms...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.16507
更新日期：2016-12-09 00:00:00
abstract：:Purpose: This study aimed to identify the survival benefit and safety of alternative dosage schedules for sunitinib in metastatic renal cell carcinoma. Materials and Methods: Clinicopathologic and survival data of patients treated with sunitinib as first-line therapy were retrospectively reviewed. Patients were classi...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.25693
更新日期：2018-09-07 00:00:00
abstract：:Esophageal cancer (EC) is a unique and heterogeneous disease diagnosed mostly at advanced stages. Altered glycans presented on cell surfaces are involved in the occurrence and development of malignancy. However, the effects of glycans on EC progression are largely unexplored. Here, a lectin array was utilized to detec...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.43806
更新日期：2020-06-01 00:00:00
abstract：:The capture of peritoneal metastatic cancer stem cell of human gastric cancer (pMCSC-hGC) is important to further understand the mechanism of peritoneal metastasis in gastric cancer patients. Previously, cancer stem cells (CSCs) of gastric and rectal cancers were captured and identified. However, the bottleneck of cap...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.21669
更新日期：2017-09-16 00:00:00
abstract：:Cisplatin chemoresistance is a clinical obstacle in the treatment of gastric cancer (GC). Enhanced DNA repair capacity may lead to cisplatin resistance. However, the detailed molecular mechanism of GC cisplatin resistance specifically involving nucleotide excision repair (NER) is not clear. However, the mechanism thro...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.25814
更新日期：2019-01-29 00:00:00
