Epithelioid Trophoblastic Tumors: Treatments, Outcomes, and Potential Therapeutic Targets.


:Background: Epithelioid trophoblastic tumors (ETTs) are the rarest type of gestational trophoblastic neoplasias. We investigated the clinical features, treatments, outcomes, and prognostic factors in patients with ETT, and explored potential therapeutic targets. Methods: We retrospectively analyzed the clinical features, treatments, survival, and prognostic factors of 21 ETT patients treated at our institution between January 2002 and December 2017. Expression levels of programmed cell death 1 (PD-1), PD-1 ligands (PD-L1and PD-L2), B7 family ligands (B7-H3, B7-H4, V-domain Ig suppressor of T cell activation [VISTA], and B7-H6), and CD105 expression were assessed by immunohistochemistry. Results: Fourteen patients with ETT (66.7%) presented with irregular vaginal bleeding. Three stage I patients (14.3%) with normal β-human chorionic gonadotropin (β- hCG) levels underwent hysterectomy alone. Of the remaining 18 patients who had elevated β-hCG levels (85.7%), 1 received chemotherapy and 17 underwent surgery and multi-agent chemotherapy. After treatment, 17 patients (81.0%) achieved complete remission (2 of whom [11.8%] later relapsed) and 4 (19.0%) with stage IV died of their disease. On univariate and multivariate analyses, stage IV disease was an independent prognostic factor for overall and disease-free survival (P < 0.001). PD-L1, B7-H3, and CD105 were detected in 100% of samples, PD-L2 and VISTA in 82%, B7-H6 in 18%, and B7-H4 was undetectable in ETT cells. Conclusions: Hysterectomy and metastatic lesion resection are essential for controlling ETT. Surgery plus chemotherapy are recommended for patients with abnormal β-hCG levels and metastatic disease. PD-L1, PD-L2, B7-H3, VISTA and CD105 are potential therapeutic targets for metastatic ETT.


J Cancer


Journal of Cancer


Yang J,Zong L,Wang J,Wan X,Feng F,Xiang Y




Has Abstract


2019-01-01 00:00:00












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    authors: Wu YT,Luo QQ,Li X,Arshad B,Xu Z,Ran L,Zhao CX,Wu H,Shi YL,Chen HR,Li H,Li HY,Wu KN,Kong LQ

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  • Risk Factors Associated with Precancerous Lesions of Esophageal Squamous Cell Carcinoma: a Screening Study in a High Risk Chinese Population.

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    authors: Sun Y,Zhang T,Wu W,Zhao D,Zhang N,Cui Y,Liu Y,Gu J,Lu P,Xue F,Yu J,Wang J

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    journal_title:Journal of Cancer

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    journal_title:Journal of Cancer

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    pub_type: 杂志文章


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  • Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor.

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    pub_type: 杂志文章


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    pub_type: 杂志文章


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    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Han Y,Wang J,Xu B

    更新日期:2021-01-01 00:00:00