VEGFR-2 Inhibitor Apatinib Hinders Endothelial Cells Progression Triggered by Irradiated Gastric Cancer Cells-derived Exosomes.

abstract：:Liquid biopsy is becoming a promising method for non-invasive cancer detection. In several proof-of-concept studies, long non-coding RNAs (lncRNAs) were found to be potential biomarkers for bladder cancer detection. The objective of this study was to discover a panel of cell-free, urinary lncRNAs as liquid biopsy biom...

journal_title：Journal of Cancer

authors： Yu X,Wang R,Han C,Wang Z,Jin X

更新日期：2020-01-01 00:00:00

abstract：:Background: Colorectal cancer (CRC) has been reconsidered as a heterogeneous disease. Among advances of genomic analysis in CRC, the sidedness of tumors (left-sided colon vs. right-sided colon) and microsatellite instability (MSI)-high (H) tumors have been highlighted. Methods: We analyzed 153 CRC patients who were av...

journal_title：Journal of Cancer

authors： Kim ST,Lee SJ,Lee J,Park SH,Park JO,Lim HY,Kang WK,Park YS

更新日期：2017-08-23 00:00:00

abstract：:We discuss the hypothesis that ZEB1-Wnt-p300 signaling integrates epithelial to mesenchymal transition (EMT) and resistance to histone deacetylase inhibitors (HDACis) in colorectal cancer (CRC) cells. The HDACi butyrate, derived from dietary fiber, has been linked to CRC prevention, and other HDACis have been proposed...

journal_title：Journal of Cancer

authors： Lazarova D,Bordonaro M

更新日期：2017-05-12 00:00:00

abstract：: Purpose: Differentiated thyroid cancer (DTC) accounts for approximately 95% of thyroid carcinomas. In the metastatic RAI-refractory disease, chemotherapy has very limited efficacy and is associated with substantial toxicity. With increasing knowledge of the molecular patho...

journal_title：Journal of Cancer

authors： Balmelli C,Railic N,Siano M,Feuerlein K,Cathomas R,Cristina V,Güthner C,Zimmermann S,Weidner S,Pless M,Stenner F,Rothschild SI

更新日期：2018-01-01 00:00:00

abstract：:Dysbindin has been reported to be correlated with several malignancies. However, the clinical significance and biological role of dysbindin in epithelial ovarian cancer remains largely unknown. Here we demonstrated that the mRNA and protein levels of dysbindin were significantly upregulated in EOC tissues compared wit...

journal_title：Journal of Cancer

authors： Lv X,Guo X,Ru Y,Zhou F,Yang X,Ge J,Li J,Liu S,Jiang K,Chen B

更新日期：2020-02-21 00:00:00

abstract：:Early detection and accurate evaluation were both critical to improving the prognosis of clear cell Renal Cell Carcinoma (ccRCC) patients. More importantly, RNA Binding Proteins (RBPs) play a vital role in the tumorigenesis and progression of numerous cancers. However, the relationship between RBPs and ccRCC is still ...

journal_title：Journal of Cancer

authors： Zhu Z,He A,Lin L,Xu C,Cai T,Lin J

更新日期：2020-09-23 00:00:00

abstract：:Amplified in breast cancer 1 (AIB1) gene, a coactivator for steroid receptor, is frequently amplified in diverse cancers and is considered as an oncogene in tumorigenesis. However, the prognostic significance of AIB1 amplification in gliomas remains totally unclear. In this study, 115 gliomas and 16 benign meningiomas...

journal_title：Journal of Cancer

authors： Chen L,Wang C,Zhang X,Gao K,Liu R,Shi B,Hou P

更新日期：2016-10-22 00:00:00

abstract：:MPHOSPH1, which is one of the kinesin superfamily proteins, has been reported to play an essential role in the carcinogenesis and progression of several kinds of cancers. MPHOSPH1 has also been suggested to be involved in STAT3 phosphorylation in hepatocellular carcinoma. However, the biological behavior of MPHOSPH1 i...

journal_title：Journal of Cancer

authors： Abe T,Kohashi K,Takemoto J,Kinoshita F,Eto M,Oda Y

更新日期：2018-10-31 00:00:00

abstract：:Macrophages play a critical role in the initiation and progression in various human solid tumors; however, their role and transformation in pancreatic ductal adenocarcinoma (PDAC) were still illusive. Here, immunohistochemistry was used to determine CD206 (specific marker of M2 macrophage) and PKM2 expression in PDAC ...

journal_title：Journal of Cancer

authors： Hu H,Tu W,Chen Y,Zhu M,Jin H,Huang T,Zou Z,Xia Q

更新日期：2020-02-03 00:00:00

abstract：:Background & Aims: Primary tumors of colorectal carcinoma (CRC) with liver metastasis might gain some liver-specific characteristics to adapt the liver micro-environment. This study aims to reveal potential liver-like transcriptional characteristics associated with the liver metastasis in primary colorectal carcinoma....

journal_title：Journal of Cancer

authors： Cheng J,Song X,Ao L,Chen R,Chi M,Guo Y,Zhang J,Li H,Zhao W,Guo Z,Wang X

更新日期：2018-04-06 00:00:00

abstract：:Background: Noninvasive stool-based DNA methylation testing emerges as a new approach for detecting colorectal cancer (CRC). However, its feasibility for early detection of CRC and precancerous lesions in the Chinese population remains inconclusive. Methods: In this study, we establish a possibilities screening method...

journal_title：Journal of Cancer

authors： Wang DY,He KX,Huang Y,Lou QQ,He T,Xu X

更新日期：2021-01-01 00:00:00

abstract：:Cachexia is a common term for the wasting symptoms which may appear in almost every chronic illness, such as AIDS, tuberculosis, and cancer. Cancer cachexia (CCA) is a result of the interaction between the host and the tumor, mainly manifested in short-term wasting, malnutrition, and so on. Due to the chronic food sho...

journal_title：Journal of Cancer

authors： Wang J,Wang Y,Tong M,Pan H,Li D

更新日期：2019-01-01 00:00:00

abstract：:Objectives: Chordomas are slow-growing malignancies that commonly affect vital neurological structures. These neoplasms are highly resistant to current chemotherapeutic regimens and often recur after surgical intervention. Therefore, there is an urgent need to identify molecular targets and more robust drugs to improv...

journal_title：Journal of Cancer

authors： Shen S,Dean DC,Yu Z,Hornicek F,Kan Q,Duan Z

更新日期：2020-01-01 00:00:00

abstract：:Background: Bevacizumab combined with chemotherapy is still one of the standard options for treatment of advanced non-small cell lung cancer (NSCLC) patients without driver mutations. Serum inflammatory factors, representing the systemic immune status, are shown to have complicated relationships with tumor angiogenesi...

journal_title：Journal of Cancer

authors： Li B,Wang S,Li C,Guo M,Xu Y,Sun X,Yu J,Wang L

更新日期：2019-08-28 00:00:00

abstract：:The alterations of MET have been detected in non-small-cell lung cancer (NSCLC). However, the prognostic impact of MET gene copy number gain (CNG) has not been consistent among studies. We performed this meta-analysis to evaluate the prognostic value of high MET CNG in patients with NSCLC. A systematic computerized se...

journal_title：Journal of Cancer

authors： Kim JH,Kim HS,Kim BJ

更新日期：2018-04-23 00:00:00

abstract：:Preoperative chemoradiation followed by surgery has been recommended as a standard treatment for patients with stage II/III rectal cancer. However, the optimal sequencing of radiotherapy for metastatic rectal cancer remains unclear. Between 2004 and 2014, patients diagnosed with metastatic rectal cancer who underwent ...

journal_title：Journal of Cancer

authors： Luo D,Liu Q,Zhu J,Ma Y,Cai S,Li Q,Li X

更新日期：2019-01-30 00:00:00

abstract：:Neural invasion (NI) is one of the important routes for local spread of gastric cancer (GC) correlated with poor prognosis. However, the exact cellular characteristics and molecular mechanisms of NI in GC are still unclear. Netrin-1(NTN1) as an axon guidance molecule was firstly found during neural system development....

journal_title：Journal of Cancer

authors： Yin K,Wang L,Xia Y,Dang S,Zhang X,He Z,Xu J,Shang M,Xu Z

更新日期：2019-06-02 00:00:00

abstract：:The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) with its immunotherapeutic activities and sialic acid binding abilities is a promising cancer adjuvant. The HN was surfaced displayed on Lactococcus lactis and its cancer targeting ability was investigated via attachment to the MDA-MB231 bre...

journal_title：Journal of Cancer

authors： Baradaran A,Yusoff K,Shafee N,Rahim RA

更新日期：2016-01-29 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC), is one of the most common malignant tumor in southern China and southeast Asia. MYH10 is a coding gene of the NMMHC-IIB protein. Previous studies have shown that MYH10 expression was up-regulated in breast cancer, glioma and meningioma. Moreover, it was targeted by miR200 family. Howeve...

journal_title：Journal of Cancer

authors： Liu W,Cai T,Li L,Chen H,Chen R,Zhang M,Zhang W,Zhao L,Xiong H,Qin P,Gao X,Jiang Q

更新日期：2020-03-04 00:00:00

abstract：:Objective: Emerging evidence suggests that calreticulin (CALR) has great impacts on the tumor formation and progression of various cancers, but the role of CALR remains controversial. We investigated the expression and clinical significance of CALR in nasopharyngeal carcinoma (NPC). Methods: Immunohistochemistry was u...

journal_title：Journal of Cancer

authors： Han Y,Liao Q,Wang H,Rao S,Yi P,Tang L,Tian Y,Oyang L,Wang H,Shi Y,Zhou Y

更新日期：2019-08-29 00:00:00

abstract：:In this short communication we report a quick, cost-free method of purification of DNA fragments from agarose gel. Unlike those procedures that involve commercial kits, this method uses glass wool or absorbent cotton to filter agarose gel during a quick spinning-down of DNA, thus significantly simplifying the routine ...

journal_title：Journal of Cancer

authors： Sun Y,Sriramajayam K,Luo D,Liao DJ

更新日期：2012-01-01 00:00:00

abstract：:Aims: We previously demonstrated that a loss of lean body mass loss at one month after gastrectomy was an independent risk factor for the continuation of adjuvant chemotherapy with S-1. However, it is unclear whether or not lean body mass loss after gastrectomy leads to a poor survival through poor compliance to adjuv...

journal_title：Journal of Cancer

authors： Aoyama T,Yoshikawa T,Maezawa Y,Kano K,Numata M,Hara K,Komori K,Yamada T,Hayashi T,Sato T,Tamagawa H,Yukawa N,Rino Y,Masuda M,Ogata T,Cho H,Oshima T

更新日期：2019-05-28 00:00:00

abstract：:Angiogenesis, a highly regulated process, is exploited by tumors like breast cancer to ensure a constant supply of oxygen and nutrients and is key for tumor survival and progression. Estrogen and alcohol independently have been observed to contribute to angiogenesis in breast cancer but their combinatorial effects hav...

journal_title：Journal of Cancer

authors： Maniyar R,Chakraborty S,Suriano R

更新日期：2018-10-06 00:00:00

abstract：:Stromal fibroblasts are suggested to be a key determinant in the malignant progression of breast cancer. To find an in vitro culture model that best mimics the in vivo tumor microenvironment so we can study the effects of stromal fibroblasts on breast cancer progression, we evaluated several three-dimensional (3D) co-...

journal_title：Journal of Cancer

authors： Li L,Lu Y

更新日期：2011-01-01 00:00:00

abstract：:Purpose: Aim of this study was to comprehensively analyze BRCA1-associated protein-1 (BAP1) somatic mutation in clear cell renal cell carcinoma (ccRCC) and explore potential therapeutic pathways and molecules. Patients and methods: In this study, we analyzed 445 ccRCC cases from The Cancer Genome Atlas (TCGA). Compreh...

journal_title：Journal of Cancer

authors： Jin S,Wu J,Zhu Y,Gu W,Wan F,Xiao W,Dai B,Zhang H,Shi G,Shen Y,Zhu Y,Ye D

更新日期：2018-10-18 00:00:00

abstract：OBJECTIVE:The expression of DACH1 was frequently lost in human breast cancer, which significantly correlated with poor prognosis. Herein, we aim to investigate its underlying mechanisms. METHODS:The expression of miR-217 was detected by Taqman PCR. The mRNA and protein level of DACH1 were investigated by real time PCR...

journal_title：Journal of Cancer

authors： Zhang Q,Yuan Y,Cui J,Xiao T,Jiang D

更新日期：2015-01-01 00:00:00

abstract：:Background: In the various cancer, mast cells (MCs) infiltration is correlated with a worse prognosis. There is an increasing evidence that MCs and their mediators are participated in remodeling of the tumor microenvironment and facilitate tumor growth, epithelial-to-mesenchymal transition (EMT) and metastasis. Method...

journal_title：Journal of Cancer

authors： Qu J,Cheng T,Liu L,Heng J,Liu X,Sun Z,Wang W,Li K,Yang N

更新日期：2019-06-09 00:00:00

abstract：:Background: We previously demonstrated that Proline rich 11 (PRR11) gene is associated with the development and progression of tongue squamous cell carcinoma (TSCC), but the underlying mechanism is unknown. This study aimed to investigate the molecular mechanism underlying oncogenic potential of PRR11 in TSCC cells. M...

journal_title：Journal of Cancer

authors： Wang C,Yu L,Ren X,Wu T,Chen X,Huang Y,Cheng B

更新日期：2019-06-02 00:00:00

abstract：:Background: Although biliary tract cancer (BTC) has a very aggressive nature, some patients maintain a relatively good performance status after failure with first-line treatment of gemcitabine plus cisplatin (GC). Thus, tolerable, feasible, and useful second-line treatments are needed for these patients. We investigat...

journal_title：Journal of Cancer

authors： Kim ST,Oh SY,Lee J,Kang JH,Lee HW,Lee MA,Sohn BS,Hong JH,Park YS,Park JO,Lim HY

更新日期：2019-10-15 00:00:00

abstract：PURPOSE:We conducted a meta-analysis to evaluate and compare the short- and long-term results of laparoscopic colorectal surgery (LCRS) and conventional open surgery (OCRS) for colorectal cancer (CRC). METHODS:We searched relevant papers published between January 1990 and May 2011. We analyzed the outcomes of each typ...

journal_title：Journal of Cancer

authors： Ohtani H,Tamamori Y,Arimoto Y,Nishiguchi Y,Maeda K,Hirakawa K

更新日期：2011-01-01 00:00:00