Prognostic value of MET copy number gain in non-small-cell lung cancer: an updated meta-analysis.

abstract：BACKGROUND:To identify predictors for development of mastoiditis after intensity-modulated radiation therapy (IMRT) in nasopharyngeal carcinoma (NPC). METHODS:Data for 146 NPC patients treated with IMRT was retrospectively reviewed under institutional ethics committee approval. Clinical factors associated with mastoid...

journal_title：Journal of Cancer

authors： Yao JJ,Zhou GQ,Jin YN,Zhang WJ,Lin L,Yu XL,Shao JY,Ma J,Sun Y

更新日期：2016-01-08 00:00:00

abstract：:Background: HER2 serves as an important therapeutic target in gastroesophageal cancer. Differences in HER2 gene signal distribution patterns can be observed at the tissue level, but how it influences the HER2 amplification status has not been studied so far. Here, we investigated the link between HER2 amplification an...

journal_title：Journal of Cancer

authors： Jørgensen JT,Nielsen KB,Kjærsgaard G,Jepsen A,Mollerup J

更新日期：2017-06-01 00:00:00

abstract：:As a crucial event involved in the metastasis and relapse of esophageal cancer, c-Met overexpression has been considered as one of the culprits responsible for the failure in patients who received radiochemotherapy. Since c-Met has been confirmed to be pivotal for cell survival, proliferation and migration, little is ...

journal_title：Journal of Cancer

authors： Chen GZ,Dai WS,Zhu HC,Song HM,Yang X,Wang YD,Min H,Lu Q,Liu S,Sun XC,Zeng XN

更新日期：2017-03-12 00:00:00

abstract：:Liver kinase B1 (LKB1) is a critical tumor suppressor that is frequently mutated in human cancers. LKB1 has serine/threonine protein kinase activity, which regulates gene expression by phosphorylation of Yes-Associated protein (YAP). The phosphorylation-dependent YAP shuttling is critically important intracellular mec...

journal_title：Journal of Cancer

authors： He L,Wu MZ,Wang XB,Qiu XS,Wang EH,Wu GP

更新日期：2019-06-09 00:00:00

abstract：:Accumulating evidence suggests that the malignant phenotypes of cancers are determined not only by the intrinsic properties of cancer cells but also by components in the tumor microenvironment (TME). In this study, we comprehensively characterized the TME of cutaneous melanoma (CM). As a result, tumor stage, tissue si...

journal_title：Journal of Cancer

authors： Wang P,Zhang X,Sun N,Zhao Z,He J

更新日期：2020-04-06 00:00:00

abstract：:Liquid biopsy is becoming a promising method for non-invasive cancer detection. In several proof-of-concept studies, long non-coding RNAs (lncRNAs) were found to be potential biomarkers for bladder cancer detection. The objective of this study was to discover a panel of cell-free, urinary lncRNAs as liquid biopsy biom...

journal_title：Journal of Cancer

authors： Yu X,Wang R,Han C,Wang Z,Jin X

更新日期：2020-01-01 00:00:00

abstract：:Dihydroorotate dehydrogenase (DHODH) is a rate-limiting enzyme in the de novo biosynthesis pathway of pyrimidines. Inhibition of this enzyme impedes cancer cell proliferation but the exact mechanisms of action of these inhibitors in cancer cells are poorly understood. In this study, we showed that cancer cells, namely...

journal_title：Journal of Cancer

authors： Dorasamy MS,Choudhary B,Nellore K,Subramanya H,Wong PF

更新日期：2017-09-05 00:00:00

abstract：:Colorectal cancer(CRC) is a prevalent malignancy in the world. There is growing evidence that microRNAs (miRNAs) as crucial modulator are in connection with many tumor-related diseases including CRC. Though miR-485-5p has been reported as an anti-oncogene in certain cancers, it remains unclear in CRC. In this research...

journal_title：Journal of Cancer

authors： Hu XX,Xu XN,He BS,Sun HL,Xu T,Liu XX,Chen XX,Zeng KX,Wang SK,Pan YQ

更新日期：2018-06-23 00:00:00

abstract：:Purpose Neuroblastoma is an embryonic solid tumor derived from the progenitors of the sympathetic nervous system. More than half of the patients developed metastatic disease at the time of initial diagnosis and had poor outcome with current therapeutic approaches. In recent years, some obligate and facultative anaerob...

journal_title：Journal of Cancer

authors： Ning BT,Yu B,Chan S,Chan JL,Huang JD,Chan GC

更新日期：2017-06-03 00:00:00

abstract：:In the present study, we constructed the recombinant plasmid IL10-PEGFP-C1 and successfully transfected into human mesenchymal stem cells. After culturing for 72 h, the levels of IL6 and TNF-α in the supernatant of the MSCs-IL10 group were significantly lower than the vector group and the control group (17.6 ± 0.68vs7...

journal_title：Journal of Cancer

authors： Zhao C,Pu Y,Zhang H,Hu X,Zhang R,He S,Zhao Q,Mu B

更新日期：2020-07-09 00:00:00

abstract：:Colon cancer is one of the most common types of gastrointestinal cancers and the fourth cause of cancer death worldwide. To discover novel diagnostic biomarkers for colon cancer and investigate potential mechanisms of oncogenesis, quantitative proteomic approach using iTRAQ-tagging and 2D-LC-MS/MS was performed to cha...

journal_title：Journal of Cancer

authors： Li G,Li M,Liang X,Xiao Z,Zhang P,Shao M,Peng F,Chen Y,Li Y,Chen Z

更新日期：2017-02-11 00:00:00

abstract：:Purpose: The aberrant of fibroblast growth factors and their receptors (FGF/FGFR) is an emerging target in the treatment of solid tumors. This study aimed to explore the landscape of FGF/FGFR alterations in a large cohort of cancer patients. Material and Methods: The formalin-fixed paraffin-embedded specimens of cance...

journal_title：Journal of Cancer

authors： Zuo W,He Y,Li W,Wu H,Zhao Z,Zhang Y,Chen S,Yin Y

更新日期：2020-09-23 00:00:00

abstract：:Cancer cells express epithelial markers, and when progressing in malignancy they may express markers of the mesenchymal cell type. Therefore an epithelial-mesenchymal transition of the cancer cells is assumed. However the mesenchymal markers can equally well be interpreted as myeloid markers since they are common in b...

journal_title：Journal of Cancer

authors： Schramm HM

更新日期：2014-01-15 00:00:00

abstract：:Purpose: Diffuse large B cell lymphoma (DLBCL) is one of the most common B cell lymphomas, which displays heterogeneous pathologies. Programmed cell death 1/ programmed cell death ligand 1 (PD-1/PD-L1) plays an essential role in immunosuppression in multiple malignancies. Signal transducer and activator of transcripti...

journal_title：Journal of Cancer

authors： Fei Y,Yu J,Li Y,Li L,Zhou S,Zhang T,Li L,Qiu L,Meng B,Pan Y,Ren X,Qian Z,Wang X,Zhang H

更新日期：2020-10-17 00:00:00

abstract：:Background: IgA antibodies against Epstein-Barr virus (EBV) capsid antigen (VCA) and nuclear antigen 1 (EBNA1) have been proposed to facilitate the diagnosis and early detection of nasopharyngeal carcinoma (NPC) in high-incidence regions. However, while new methodologies and new platforms for the detection of VCA-IgA ...

journal_title：Journal of Cancer

authors： Yu X,Li F,Cheng W,Wu B,Fang H,Xia F,Gong Y,Yu W,Liao P,Cao Y,Yang F,Zhu H,Li J,Huang Y,Gan L,Zhang L,Lou Y,Ji M

更新日期：2020-10-18 00:00:00

abstract：:Purpose: The objective of this study was to develop and validate a nomogram for predicting the cancer-specific survival (CSS) in patients with Wilms' tumor (WT). Methods: Patients with WT diagnosed between 2002 and 2015 in the Surveillance, Epidemiology, and End Results (SEER) database were divided randomly into train...

journal_title：Journal of Cancer

authors： Pan Z,You H,Bu Q,Feng X,Zhao F,Li Y,Lyu J

更新日期：2019-08-28 00:00:00

abstract：:Background: Epithelial-mesenchymal transition (EMT) plays an important role in the invasion and migration during cancer metastasis. Wnt3a is one of the ligands in canonical Wnt/β-catenin signaling pathway, which contributes to the carcinogenesis and progression of lung cancer cell lines. The aim of this study was to e...

journal_title：Journal of Cancer

authors： Xu J,Lv W,Hu Y,Wang L,Wang Y,Cao J,Hu J

更新日期：2017-08-02 00:00:00

abstract：:Dysbindin has been reported to be correlated with several malignancies. However, the clinical significance and biological role of dysbindin in epithelial ovarian cancer remains largely unknown. Here we demonstrated that the mRNA and protein levels of dysbindin were significantly upregulated in EOC tissues compared wit...

journal_title：Journal of Cancer

authors： Lv X,Guo X,Ru Y,Zhou F,Yang X,Ge J,Li J,Liu S,Jiang K,Chen B

更新日期：2020-02-21 00:00:00

abstract：PURPOSE:The current study examined quality of life, progression of disease, and survival rate during chemotherapy in newly diagnosed non-small cell lung cancer (NSCLC) patients with depression (n=48) and without depression (n=78). Further, the study explored the hypothesis that the survival benefit resulted from the ch...

journal_title：Journal of Cancer

authors： Chen J,Li W,Cui L,Qian Y,Zhu Y,Gu H,Chen G,Shen Y,Liu Y

更新日期：2015-09-15 00:00:00

abstract：BACKGROUND:Due to the lack of studies, it remains unclear whether the additional neoadjuvant chemotherapy (NACT) to concurrent chemoradiotherapy (CCRT) is superior to CCRT alone for locoregionally advanced nasopharyngeal carcinoma (NPC). The main objective of this Bayesian network meta-analysis was to determine the eff...

journal_title：Journal of Cancer

authors： Chen YP,Guo R,Liu N,Liu X,Mao YP,Tang LL,Zhou GQ,Lin AH,Sun Y,Ma J

更新日期：2015-07-17 00:00:00

abstract：:Background: Population-based data on the prognosis of brain metastases at initial diagnosis of ovary cancer (OCBM) are currently lacking. Besides, the effective treatment for OCBM patients is still controversial now. The study aimed to explore the prognostic factors among OCBM. Methods: We retrospectively reviewed the...

journal_title：Journal of Cancer

authors： Xi S,Li Z,Guo Q,Lin W,Liang X,Ma L

更新日期：2020-05-18 00:00:00

abstract：:Melanoma is the most aggressive and treatment-resistant form of skin cancer. Curcumol is a Chinese medicinal herb traditionally used as a cancer remedy. However, the molecular mechanisms underlying the anticancer activity of curcumol in melanoma remains largely unknown. In the present study, we observed that Curcumol ...

journal_title：Journal of Cancer

authors： Ning N,Liu S,Liu X,Tian Z,Jiang Y,Yu N,Tan B,Feng H,Feng X,Zou L

更新日期：2020-01-14 00:00:00

abstract：:Objectives: PD-1 and PD-L1 overexpression in malignant tumors in response to radiotherapy is correlated with a poor prognosis. Human papilloma virus (HPV) infection impacts intrinsic radiosensitivity of head and neck cancers (HNCs). Herein, this study aims to determine PD-1/PD-L1 expression differences in tumors with ...

journal_title：Journal of Cancer

authors： Lyu X,Zhang M,Li G,Jiang Y,Qiao Q

更新日期：2019-01-29 00:00:00

abstract：:Galectins are the member of soluble proteins that bind with β-galactoside containing glycans. These proteins have been considered to be associated in various important events such as different types of cancers. It has been found that galectins could contribute to neoplastic transformation or regulate cell growth, cell...

journal_title：Journal of Cancer

authors： Chetry M,Thapa S,Hu X,Song Y,Zhang J,Zhu H,Zhu X

更新日期：2018-11-25 00:00:00

abstract：:Purpose: The present study aims to explore the potential mechanisms contributing to prostate cancer (PCa), screen the hub genes, and identify potential biomarkers and correlated pathways of PCa progression. Methods: The PCa gene expression profile GSE3325 was operated to analyze the differentially expressed genes (DEG...

journal_title：Journal of Cancer

authors： Song Z,Huang Y,Zhao Y,Ruan H,Yang H,Cao Q,Liu D,Zhang X,Chen K

更新日期：2019-02-23 00:00:00

abstract：PURPOSE:Methotrexate, vinblastine, doxorubicin plus cisplatin (MVAC) and gemcitabine plus cisplatin (GC) are both effective first-line chemotherapy. We explore the responsive variables of MVAC and GC for patients with metastatic urothelial carcinoma of bladder (mUCB). MATERIALS AND METHODS:Patients who were initially ...

journal_title：Journal of Cancer

authors： Hsieh MC,Huang CH,Chiang PH,Chen YY,Tang Y,Su YL

更新日期：2016-06-27 00:00:00

abstract：:Background: To identify associated risk factors and develop a predictive nomogram for the early death of metastatic gastric cancer patients. Methods: A total of 4575 patients in the SEER cohort and 220 patients in the Chinese cohort diagnosed with metastatic gastric cancer in our Cancer Center were obtained. Univariat...

journal_title：Journal of Cancer

authors： Zhu Y,Fang X,Wang L,Zhang T,Yu D

更新日期：2020-07-14 00:00:00

abstract：:Philadelphia chromosome-positive (Ph+) leukemia is characterized by reciprocal translocation between chromosomes 9 and 22. The resultant BCR/ABL fusion protein displays constitutive tyrosine kinase activity, leading to the induction of aberrant proliferation and neoplastic transformation. The bone marrow (BM) microenv...

journal_title：Journal of Cancer

authors： Kidan N,Khamaisie H,Ruimi N,Roitman S,Eshel E,Dally N,Ruthardt M,Mahajna J

更新日期：2017-10-23 00:00:00

abstract：:Objectives: Lung cancer in young adults is a distinct disease with particular socioeconomic implications. This study aimed to clarify the clinicopathological characteristics, best interventions, and outcomes of this distinctive entity. Methods: A retrospective review of patients with lung cancer was performed in our i...

journal_title：Journal of Cancer

authors： Liu B,Quan X,Xu C,Lv J,Li C,Dong L,Liu M

更新日期：2019-06-09 00:00:00

abstract：:Background: Lung carcinoma is the leading cause of malignant tumor related mortality in China in recent decades, and the development of new and effective therapies for patients with advanced lung carcinoma is needed. We recently found that fluorofenidone (FD), a newly developed pyridine compound, reduced the activatio...

journal_title：Journal of Cancer

authors： Deng ZH,Meng J,Tang J,Hu GY,Tao LJ

更新日期：2017-07-04 00:00:00