Abstract:
:Background: Bevacizumab combined with chemotherapy is still one of the standard options for treatment of advanced non-small cell lung cancer (NSCLC) patients without driver mutations. Serum inflammatory factors, representing the systemic immune status, are shown to have complicated relationships with tumor angiogenesis, and proved to be associated with survival of advanced NSCLC patients. However, the information from the baseline factors is relatively limited, which cannot reflect the dynamic changes of systemic immune status during bevacizumab treatment. We, thus, attempted to evaluate longitudinal kinetics of systemic inflammatory factors during treatment of bevacizumab and to explore their predictive role in treatment response and patient outcomes in advanced NSCLC. Method: Systemic inflammatory factors (neutrophil/lymphocyte (NLR), platelet/lymphocyte (PLR), neutrophil×platelet/lymphocyte (SII) and lymphocyte/monocyte (LMR)) and clinical variables were collected and analyzed from 161 advanced NSCLC patients treated with bevacizumab. Mixed effect regression models were first performed for longitudinal analysis of the changes of serum inflammatory factors during bevacizumab treatment. Then, univariate and multivariate Cox models were used for overall survival (OS) and progression free survival (PFS) analyses to determine the independent prognostic factors. Results: In the first 6 cycles of bevacizumab treatment, patients with complete response/partial response (CR/PR) had a -0.11, -0.066, -0.15, and 0.073 change every 2 cycles in transformed NLR (95%CI: -0.19--0.03, p=0.008), PLR (95%CI: -0.12--0.013, p=0.015), SII (95%CI: -0.23--0.05, p<0.001) and LMR (95%CI: 0.049-0.14, p=0.036), respectively, compared to patients with progressive disease (PD). With respect to analysis of the longitudinal changes before progression, patients experienced a significant increase in transformed NLR (Coef=0.09, 95%CI: 0.019-0.17, p=0.014), PLR (Coef=0.05, 95%CI: 0.002-0.10, p=0.04), and SII (Coef=0.091, 95%CI: 0.015-0.17, p=0.019), but a decrease in transformed LMR (Coef=-0.08, 95%CI: -0.14-0.018, p=0.012). On multivariate Cox model analyses, decrease of LMR (HR=0.62, 95% CI: 0.4-0.96, p=0.033) was shown to be the independent risk factor for PFS; and low level of baseline LMR (HR=0.4, 95% CI: 0.17-0.94, p=0.036), increase of NLR (HR=2.36, 95%CI: 1.25-4.44, p=0.008), and decrease of LMR (HR=0.42, 95%CI: 0.18-0.97, p=0.041) were the independent risk factors for death. Conclusion: The activation of systemic immune status evaluated by the kinetic changes of serum inflammatory factors was associated with good response to bevacizumab; however, the suppressive status may indicate the resistance to bevacizumab. Dynamic changes of systemic inflammatory factors also had prognostic value in predicting outcomes of advanced NSCLC patients treated with bevacizumab.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Li B,Wang S,Li C,Guo M,Xu Y,Sun X,Yu J,Wang Ldoi
10.7150/jca.30478subject
Has Abstractpub_date
2019-08-28 00:00:00pages
5082-5089issue
21issn
1837-9664pii
jcav10p5082journal_volume
10pub_type
杂志文章abstract::Cachexia is a common term for the wasting symptoms which may appear in almost every chronic illness, such as AIDS, tuberculosis, and cancer. Cancer cachexia (CCA) is a result of the interaction between the host and the tumor, mainly manifested in short-term wasting, malnutrition, and so on. Due to the chronic food sho...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.28246
更新日期:2019-01-01 00:00:00
abstract::Red blood cell distribution width (RDW) has been recently demonstrated to be a predictor of inflammation. High pretreatment RDW level is associated with poor survival outcomes in various malignancies, although the results are controversial. We aimed to investigate the prognostic role of RDW. A systematic literature se...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.31598
更新日期:2019-07-10 00:00:00
abstract::Background: IgA antibodies against Epstein-Barr virus (EBV) capsid antigen (VCA) and nuclear antigen 1 (EBNA1) have been proposed to facilitate the diagnosis and early detection of nasopharyngeal carcinoma (NPC) in high-incidence regions. However, while new methodologies and new platforms for the detection of VCA-IgA ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.47260
更新日期:2020-10-18 00:00:00
abstract::Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human malignancies. The metabolomic approaches are developed to discover the novel biomarkers of PDAC. Methods: 550 preoperative, postoperative PDAC and normal controls (NCs) serums were employed to characterize metabolic alterations in ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.41250
更新日期:2020-05-19 00:00:00
abstract::Until few years ago non-specific cytotoxic agents were considered the tip of the arrow as first line treatment for lung cancer. However; age > 75 was considered a major drawback for this kind of therapy. Few exceptions were made by doctors based on the performance status of the patient. The side effects of these agent...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.14819
更新日期:2016-03-21 00:00:00
abstract::Thyroid transcription factor-1 (TTF-1) is overexpressed in up to 95% of primary lung adenocarcinoma while negative for almost all squamous cell carcinomas. TTF-1 expression has been investigated as a prognostic factor in non-small-cell lung cancer (NSCLC) with conflicting results. We conducted this meta-analysis to ga...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26830
更新日期:2018-10-20 00:00:00
abstract::Endometrium is the mucosal lining of the uterus which expressed a cyclic process of proliferation, secretion and scaling under the control of hormones secreted by the ovary, and it also plays an indispensable role in the embryo implantation, the constitution of fetal-maternal interface, and the maintaining of pregnanc...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.31742
更新日期:2019-06-09 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. However, science has not yet been able to substantially improve the prognosis of lung cancer patients. Accumulating evidence suggests that microRNAs (miRNAs) are key players in the regulation of tumor development and metastasis....
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16961
更新日期:2017-06-30 00:00:00
abstract::Background: The Gustave Roussy Immune Score (GRIm-Score) was initially reported to select patients for immunotherapy. Therefore, the purpose of the current retrospective study was to determine whether GRIm-Score, a novel nutritional and inflammatory-based prognostic score, is a useful prognostic marker in patients wit...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.37898
更新日期:2020-01-01 00:00:00
abstract::Background: This study aimed to clarify the impact of node involvement (affected to resected nodes) in optimally cytoreduced (residual tumour ≤1cm) stage IIIC/IV ovarian cancer. Methods: 108 consecutive patients with primary stage IIIC/IV ovarian cancer underwent stage-related surgery and got adjuvant platinum-based c...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.15644
更新日期:2016-11-09 00:00:00
abstract::Purpose: We explored the influence of age on clinicopathologic features and survival of patients with M0 gastric cancer (GC). Methods: 16856 GC patients from Surveillance, Epidemiology and End Results (SEER) database and 1037 GC patients from Chinese multiple centers were enrolled in the U.S. and Chinese cohort, respe...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.22085
更新日期:2018-03-08 00:00:00
abstract::Long non-coding RNAs (LncRNAs) have been reported to be involved in tumorigenesis and tumor progression. Single nucleotide polymorphisms (SNPs) in the lncRNAs also play a vital role in carcinogenesis. The aim of this study was to assess the relationships between the four selected tagSNPs (rs944289, rs3787016, rs145631...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18055
更新日期:2017-04-09 00:00:00
abstract:PURPOSE:Urothelial carcinoma (UC) is a type of tumor, especially of the urinary bladder, that affects people worldwide. Clarification of its detailed tumor biology and discovery of potential targets for developing treatment strategies are imperative because of frequent recurrences and poor prognosis of advanced UCs. By...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.15696
更新日期:2016-07-08 00:00:00
abstract::Background: Malignant biliary and/or pancreatic obstruction has often encountered in the advanced stages of periampullary and cholangicarcinomas. HabibTM Radiofrequency (RF) ablation has been successfully used in the management of various cancers of liver and pancreas. Percutaneous HPB probe (EMcision Ltd, London, UK)...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.23280
更新日期:2018-01-05 00:00:00
abstract::Yes-associated protein (YAP) is a transcriptional coactivator that promotes cell proliferation, migration, and tissue homeostasis in colorectal cancer (CRC). Here, we established 5-Fu resistant CRC cell line (SW620R) and examined the role of YAP in chemotherapy resistance. We showed that YAP promoted cell proliferatio...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.44775
更新日期:2020-07-11 00:00:00
abstract::As a crucial event involved in the metastasis and relapse of esophageal cancer, c-Met overexpression has been considered as one of the culprits responsible for the failure in patients who received radiochemotherapy. Since c-Met has been confirmed to be pivotal for cell survival, proliferation and migration, little is ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18135
更新日期:2017-03-12 00:00:00
abstract::In 2006, a remarkable collaboration between University of Texas MD Anderson Cancer Center clinicians and Texas and New Mexico State legislators led to the formation of a dedicated IBC Research Program and Clinic at MD Anderson. This initiative provided funding and infrastructure to foster coordination of an IBC World ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.21200
更新日期:2017-10-09 00:00:00
abstract::Many preclinical and clinical studies are currently evaluating metformin in combination with classical therapeutic agents as anti-cancer therapy. In this study we used three distinct pancreatic cancer cell lines and evaluated cell death by trypan blue assay and Western Blots using antibodies directed against cleaved c...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.17972
更新日期:2017-07-01 00:00:00
abstract::Chemotherapy resistance represents a major obstacle for the treatment of patients with breast cancer (BC) and greatly restricts the therapeutic effect of the first-line chemotherapeutic agent doxorubicin (DOX). The present study aimed to investigate the feasibility of the recombinant dual-target murine double minute 2...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.32765
更新日期:2020-01-01 00:00:00
abstract::Aim: BAP1 is frequently mutated in clear cell renal cell carcinoma (ccRCC) with a definitive role still unclear. Methods: In silico analysis of BAP1-mutant and wild-type gene enrichment and functional annotation in TCGA-KIRC dataset was performed. Target gene was studied based on functional clustering and was knowledg...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26275
更新日期:2018-10-01 00:00:00
abstract::Background: The most common metastatic site in cervical cancers is lung. The aim of this study is to identify cervical cancer patients with high risk for developing lung metastasis and further explore their prognosis. Materials and Methods: At first, patients diagnosed with cervical cancer from 2010 to 2015 were ident...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.46258
更新日期:2020-08-08 00:00:00
abstract::The incidence of colorectal cancer (CRC) ranks third among all cancers in China and improvements in screening for CRC have an important impact on prevention and control of the disease. Paraoxonase 1 (PON1) is a calcium ion-dependent hydrolase that is widely distributed in tissue. Its diagnostic value in colorectal can...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.45204
更新日期:2020-09-17 00:00:00
abstract::We discuss the hypothesis that ZEB1-Wnt-p300 signaling integrates epithelial to mesenchymal transition (EMT) and resistance to histone deacetylase inhibitors (HDACis) in colorectal cancer (CRC) cells. The HDACi butyrate, derived from dietary fiber, has been linked to CRC prevention, and other HDACis have been proposed...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18762
更新日期:2017-05-12 00:00:00
abstract::Hedgehog (Hh) signalling plays an important role in cancer; however, its mechanism in ovarian cancer migration and invasion remains unclear. In the present study, we aimed to clarify the effect of the Hh signalling pathway on ovarian cancer migration and invasion through the regulation of CD24 expression, both in vitr...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.17712
更新日期:2017-02-25 00:00:00
abstract::Background: We previously demonstrated that Proline rich 11 (PRR11) gene is associated with the development and progression of tongue squamous cell carcinoma (TSCC), but the underlying mechanism is unknown. This study aimed to investigate the molecular mechanism underlying oncogenic potential of PRR11 in TSCC cells. M...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29265
更新日期:2019-06-02 00:00:00
abstract::The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) with its immunotherapeutic activities and sialic acid binding abilities is a promising cancer adjuvant. The HN was surfaced displayed on Lactococcus lactis and its cancer targeting ability was investigated via attachment to the MDA-MB231 bre...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.13566
更新日期:2016-01-29 00:00:00
abstract::The growth of research in the field of exercise oncology has resulted in a large evidence base for the role of physical activity in preventing and managing cancer outcomes. Nonetheless, there remain many unanswered questions across the multidisciplinary field. This study aimed to determine the priority research questi...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.42992
更新日期:2020-02-19 00:00:00
abstract::Background: The transfusion of blood that has been stored for some time was found to be associated with transfusion-related immune modulation (TRIM) responses in cancer patients, which could result in poor clinical outcomes, such as tumor recurrence, metastasis and reduced survival rate. Given the prior observation of...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.31360
更新日期:2019-06-02 00:00:00
abstract::Macrophages play a critical role in the initiation and progression in various human solid tumors; however, their role and transformation in pancreatic ductal adenocarcinoma (PDAC) were still illusive. Here, immunohistochemistry was used to determine CD206 (specific marker of M2 macrophage) and PKM2 expression in PDAC ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.38981
更新日期:2020-02-03 00:00:00
abstract::Dihydroorotate dehydrogenase (DHODH) is a rate-limiting enzyme in the de novo biosynthesis pathway of pyrimidines. Inhibition of this enzyme impedes cancer cell proliferation but the exact mechanisms of action of these inhibitors in cancer cells are poorly understood. In this study, we showed that cancer cells, namely...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.14835
更新日期:2017-09-05 00:00:00