New Prospect for Cancer Cachexia: Medical Cannabinoid.


:Cachexia is a common term for the wasting symptoms which may appear in almost every chronic illness, such as AIDS, tuberculosis, and cancer. Cancer cachexia (CCA) is a result of the interaction between the host and the tumor, mainly manifested in short-term wasting, malnutrition, and so on. Due to the chronic food shortages, absorption dysfunction and metabolic disorders, all of these eventually lead to hypoimmunity, organ failure, and higher susceptibility to pathogenic microorganisms. And then increased morbidity and mortality rates as well as reduced tolerance to anti-cancer treatments will be resulted in patients with CCA. Up to now, no standard guidelines have been established for cachexia treatment. Moreover, progestagens, the only drugs approved by FDA for cancer-related cachexia, can only increase adipose tissue and have not been confirmed to augment lean body mass. Cannabinoid, such as Δ-9-tetrahydrocannabinol (THC) and cannabidiol, is one of a class of diverse chemical compounds. Previous studies have showed that cannabinoid had considerable potential to improve the appetite, body weight, body fat level, caloric intake, mood, quality of life in kinds of diseases. This review will elaborate the anti-CCA role of cannabinoid and explore that whether cannabinoid is effective for CCA and provide a basis for guiding clinical drug use.


J Cancer


Journal of Cancer


Wang J,Wang Y,Tong M,Pan H,Li D




Has Abstract


2019-01-01 00:00:00












  • Clinical study on the prevalence and comparative analysis of metabolic syndrome and its components among Chinese breast cancer women and control population.

    abstract::Metabolic syndrome has been previously identified as a risk factor for breast cancer and is increasingly a public health concern. This study aims to investigate the prevalence of metabolic syndrome and its components among primary breast cancer and control population. The clinical data of metabolic syndrome and its co...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Wu YT,Luo QQ,Li X,Arshad B,Xu Z,Ran L,Zhao CX,Wu H,Shi YL,Chen HR,Li H,Li HY,Wu KN,Kong LQ

    更新日期:2018-01-01 00:00:00

  • The Kinetic Changes of Systemic Inflammatory Factors during Bevacizumab Treatment and Its Prognostic Role in Advanced Non-small Cell Lung Cancer Patients.

    abstract::Background: Bevacizumab combined with chemotherapy is still one of the standard options for treatment of advanced non-small cell lung cancer (NSCLC) patients without driver mutations. Serum inflammatory factors, representing the systemic immune status, are shown to have complicated relationships with tumor angiogenesi...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Li B,Wang S,Li C,Guo M,Xu Y,Sun X,Yu J,Wang L

    更新日期:2019-08-28 00:00:00

  • AIB1 Genomic Amplification Predicts Poor Clinical Outcomes in Female Glioma Patients.

    abstract::Amplified in breast cancer 1 (AIB1) gene, a coactivator for steroid receptor, is frequently amplified in diverse cancers and is considered as an oncogene in tumorigenesis. However, the prognostic significance of AIB1 amplification in gliomas remains totally unclear. In this study, 115 gliomas and 16 benign meningiomas...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Chen L,Wang C,Zhang X,Gao K,Liu R,Shi B,Hou P

    更新日期:2016-10-22 00:00:00

  • GSTP1 Ile105Val polymorphism might be associated with the risk of radiation pneumonitis among lung cancer patients in Chinese population: A prospective study.

    abstract::Background: Growing data suggest that DNA damage repair and detoxification pathways play crucial roles in radiation-induced toxicities. To determine whether common functional single-nucleotide polymorphisms (SNPs) in candidate genes from these pathways can be used as predictors of radiation pneumonitis (RP), we conduc...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Du L,Yu W,Huang X,Zhao N,Liu F,Tong F,Zhang S,Niu B,Liu X,Xu S,Huang Y,Dai X,Xie C,Chen G,Cong X,Qu B

    更新日期:2018-02-01 00:00:00

  • The role and function of PPARγ in bladder cancer.

    abstract::Peroxisome proliferator-activated receptor gamma (PPARγ), a member of the nuclear receptor superfamily, participates in multiple physiological and pathological processes. Extensive studies have revealed the relationship between PPARγ and various tumors. However, the expression and function of PPARγ in bladder cancer s...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审


    authors: Peng T,Wang G,Cheng S,Xiong Y,Cao R,Qian K,Ju L,Wang X,Xiao Y

    更新日期:2020-04-06 00:00:00

  • Alteration of Adaptive Immunity in a Colorectal Peritoneal Carcinomatosis Model.

    abstract::Colorectal cancer (CRC) usually gives rise to transcoelomic spread and ultimately causes peritoneal carcinomatosis (PC). However, mechanism studies, especially the immunological basis of colorectal PC, are rarely revealed due to lack of a suitable PC model. Here we selected a mouse colorectal cancer cell line MC-38 fo...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Shi R,Xiang W,Kang X,Zhang L,Wang J,Miao H,He F

    更新日期:2019-01-01 00:00:00

  • Chemotherapeutic Response and Prognosis among Lung Cancer Patients with and without Depression.

    abstract:PURPOSE:The current study examined quality of life, progression of disease, and survival rate during chemotherapy in newly diagnosed non-small cell lung cancer (NSCLC) patients with depression (n=48) and without depression (n=78). Further, the study explored the hypothesis that the survival benefit resulted from the ch...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Chen J,Li W,Cui L,Qian Y,Zhu Y,Gu H,Chen G,Shen Y,Liu Y

    更新日期:2015-09-15 00:00:00

  • Prognostic Impact of Thrombospodin-2 (THBS2) Overexpression on Patients with Urothelial Carcinomas of Upper Urinary Tracts and Bladders.

    abstract:PURPOSE:Urothelial carcinoma (UC) is a type of tumor, especially of the urinary bladder, that affects people worldwide. Clarification of its detailed tumor biology and discovery of potential targets for developing treatment strategies are imperative because of frequent recurrences and poor prognosis of advanced UCs. By...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Chang IW,Li CF,Lin VC,He HL,Liang PI,Wu WJ,Li CC,Huang CN

    更新日期:2016-07-08 00:00:00

  • A Mathematical Model of Human Papillomavirus (HPV) in the United States and its Impact on Cervical Cancer.

    abstract:BACKGROUND:Mathematical models can be useful tools in exploring disease trends and health consequences of interventions in a population over time. Most cancers, in particular cervical cancer, have long incubation periods. The time from acquisition of HPV infection to development of invasive cancer can be up to two deca...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Lee SL,Tameru AM

    更新日期:2012-01-01 00:00:00

  • A nomogram to predict prognosis of patients with unresected hepatocellular carcinoma undergoing radiotherapy: a population-based study.

    abstract::Background: Radiotherapy is a primary treatment strategy for patients with unresectable hepatocellular carcinoma (HCC); however, the prognostic factors among HCC patients who have received radiotherapy but not undergone surgery have not been systematically studied. Thus, the prognostic factors were investigated in thi...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Zhang L,Yan L,Niu H,Ma J,Yuan BY,Chen YH,Zhuang Y,Hu Y,Zeng ZC,Xiang ZL

    更新日期:2019-07-25 00:00:00

  • TRIM67 Promotes the Proliferation, Migration, and Invasion of Non-Small-Cell Lung Cancer by Positively Regulating the Notch Pathway.

    abstract::Tripartite motif-containing 67 (TRIM67), an E3 ubiquitin ligase, belongs to the TRIM protein family. The relationship between TRIM67 and tumorigenesis is not fully clear. Here, we elucidated TRIM67 function in non-small cell lung cancer (NSCLC). TRIM67 immunostaining results were correlated with clinicopathological fe...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Jiang J,Ren H,Xu Y,Wudu M,Wang Q,Liu Z,Su H,Jiang X,Zhang Y,Zhang B,Qiu X

    更新日期:2020-01-01 00:00:00

  • Switch of the ovarian cancer cell to a calcifying phenotype in the calcification of ovarian cancer.

    abstract:OBJECTIVE:The main aim of this study was to study swith of the ovarian cancer cell to a calcifying phenotype in the formation of calcification in ovarian cancer, and to offer some help for ovarian cancer's diagnosis and differentiation therapy. METHODS:The mineralization of ovarian cancer cell lines SKOV3 was induced ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Wen J,Zhao Z,Huang L,Li L,Li J,Zeng Y,Wu J,Miao Y

    更新日期:2018-02-28 00:00:00

  • Identification of LCA-binding Glycans as a Novel Biomarker for Esophageal Cancer Metastasis using a Lectin Array-based Strategy.

    abstract::Esophageal cancer (EC) is a unique and heterogeneous disease diagnosed mostly at advanced stages. Altered glycans presented on cell surfaces are involved in the occurrence and development of malignancy. However, the effects of glycans on EC progression are largely unexplored. Here, a lectin array was utilized to detec...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Xia M,Shao J,Qiao M,Luo Z,Deng X,Ke Q,Dong X,Shen L

    更新日期:2020-06-01 00:00:00

  • A Bottleneck in Understanding Metastatic Cancer Stem Cell of Peritoneal Seeding from Gastric Cancer: A Null Result in Brief.

    abstract::The capture of peritoneal metastatic cancer stem cell of human gastric cancer (pMCSC-hGC) is important to further understand the mechanism of peritoneal metastasis in gastric cancer patients. Previously, cancer stem cells (CSCs) of gastric and rectal cancers were captured and identified. However, the bottleneck of cap...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Chen XZ,Song XH,Chen XL,Li CC,Mo XM,Hu JK

    更新日期:2017-09-16 00:00:00

  • Hypothesis: Retinoblastoma protein inactivation mediates effects of histone deacetylase inhibitor-induced Wnt hyperactivation in colorectal cancer cells.

    abstract::Butyrate, a product of dietary fiber and a histone deacetylase inhibitor, induces apoptosis of colorectal cancer cells; this effect of butyrate is in part mediated by its ability to hyperactivate Wnt signaling, and may in part explain the preventive action of dietary fiber against colorectal cancer. However, the mecha...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Bordonaro M

    更新日期:2020-01-01 00:00:00

  • Compound Fuling Granule Suppresses Ovarian Cancer Development and Progression by disrupting mitochondrial function, galactose and fatty acid metabolism.

    abstract::Our previous studies have demonstrated that the compound fuling granule (CFG), a traditional Chinese medicine, suppresses ovarian cancer cell growth, migration and metastasis. However, the underlying mechanisms remain to be fully elucidated. In this study, we found that CFG could induce mitochondrial fragmentation, mi...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Ruan S,Zhang Z,Tian X,Huang D,Liu W,Yang B,Shen M,Tao F

    更新日期:2018-09-08 00:00:00

  • GDF15/GFRAL Pathway as a Metabolic Signature for Cachexia in Patients with Cancer.

    abstract::Cachexia is a metabolic mutiny that directly reduces life expectancy in chronic conditions such as cancer. The underlying mechanisms associated with cachexia involve inflammation, metabolism, and anorexia. Therefore, the need to identify cachexia biomarkers is warranted to better understand catabolism change and asses...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审


    authors: Ahmed DS,Isnard S,Lin J,Routy B,Routy JP

    更新日期:2021-01-01 00:00:00

  • Transcatheter arterial chemoembolization (TACE) versus hepatectomy in hepatocellular carcinoma with macrovascular invasion: a meta-analysis of 1683 patients.

    abstract::For hepatocellular carcinoma (HCC) patients with macrovascular invasion (MaVI), hepatectomy and transcatheter arterial chemoembolization (TACE) remain the main treatment options in Asia. However, which could achieve better survivals remains controversial. In present study, we conducted a meta-analysis to clarify the s...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Chen J,Huang J,Chen M,Yang K,Chen J,Wang J,Xu L,Zhou Z,Zhang Y

    更新日期:2017-08-25 00:00:00

  • Spatial and temporal fracture pattern in breast and gynecologic cancer survivors.

    abstract:OBJECTIVE(S):To assess skeletal wide fracture location and time of fracture after cancer treatment Study Design: One hundred thirty-nine women diagnosed with breast or gynecologic cancer between 2003 and 2012 that subsequently had a radiologic diagnosis of fracture were identified retrospectively using electronic medic...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Hui SK,Arentsen L,Wilcox A,Shanley R,Yee D,Ghebre R

    更新日期:2015-01-01 00:00:00

  • Curcumin Sensitizes Silymarin to Exert Synergistic Anticancer Activity in Colon Cancer Cells.

    abstract::We studied combinatorial interactions of two phytochemicals, curcumin and silymarin, in their action against cancer cell proliferation. Curcumin is the major component of the spice turmeric. Silymarin is a bioactive component of milk thistle used as a protective supplement against liver disease. We studied antiprolife...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Montgomery A,Adeyeni T,San K,Heuertz RM,Ezekiel UR

    更新日期:2016-06-23 00:00:00

  • Methylation patterns of RASA3 associated with clinicopathological factors in hepatocellular carcinoma.

    abstract::Hepatocellular carcinoma (HCC) is the sixth most common tumor worldwide. The relationship between the gene methylation accumulation and HCC has been widely studied. In our study, we used the Sequenom EpiTYPER assay to investigate the methylation levels of the RASA3 in 164 HCC samples and paired adjacent non-cancerous ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Lin H,Fan X,He L,Zhou D

    更新日期:2018-05-25 00:00:00

  • Transcriptional cofactor Mask2 is required for YAP-induced cell growth and migration in bladder cancer cell.

    abstract::The highly conserved Hippo signaling pathway is an important pathway involved in tumorigenesis and development. In previous studies, YAP, the transcription coactivator of Hippo pathway, is found to be highly expressed in many clinical bladder cancer samples. To investigate the function of YAP and its cofactor Mask2 in...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Dong L,Lin F,Wu W,Huang W,Cai Z

    更新日期:2016-10-23 00:00:00

  • A retrospective review of the frequency and nature of acute hypersensitivity reactions at a medium-sized infusion center: comparison to reported values and inconsistencies found in literature.

    abstract:PURPOSE:To evaluate acute hypersensitivity reactions at the UCSD Moores Cancer Center in San Diego, compare our findings to those reported previously in the literature, and examine the effectiveness of the objective grading scale as represented by the Common Terminology Criteria for Adverse Events (CTCAE). PATIENTS AN...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Demoor PA,Matusov Y,Kelly C,Kolan S,Barnachea L,Bazhenova LA

    更新日期:2011-03-10 00:00:00

  • Novel Metabolomics Serum Biomarkers for Pancreatic Ductal Adenocarcinoma by the Comparison of Pre-, Postoperative and Normal Samples.

    abstract::Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human malignancies. The metabolomic approaches are developed to discover the novel biomarkers of PDAC. Methods: 550 preoperative, postoperative PDAC and normal controls (NCs) serums were employed to characterize metabolic alterations in ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Zhang X,Shi X,Lu X,Li Y,Zhan C,Akhtar ML,Yang L,Bai Y,Zhao J,Wang Y,Yao Y,Li Y,Nie H

    更新日期:2020-05-19 00:00:00

  • Preoperative Albumin to Globulin Ratio (AGR) as Prognostic Factor in Renal Cell Carcinoma.

    abstract::Background: Malnutrition and systemic inflammatory response are frequently associated with prognosis in patients with several types of cancer, including renal cell carcinoma (RCC). The study is aimed to investigate the ability of preoperative serum albumin to globulin ratio (AGR) to predict the long-term mortality of ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: He X,Guo S,Chen D,Yang G,Chen X,Zhang Y,He Q,Qin Z,Liu Z,Xue Y,Zhang M,Liu R,Zhou F,Han H,Yao K

    更新日期:2017-01-15 00:00:00

  • Human Stromal Cells in the Peripheral Zone of the Prostate Promote Tumorigenesis of Prostatic Cancer Stem Cells through Up-regulation of C-Kit Expression.

    abstract:OBJECTIVE:Most prostate cancers originate from the prostatic peripheral zone (PZ). We tested the hypothesis that the stromal cells from PZ and transitional zone (TZ) have differential effects on the ability of tumorigenesis. METHODS:Stromal cells isolated from the PZ and TZ of normal human prostates mixed with DU145 c...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Peng Y,Chen Q,Gu M,Chen Y,Zhang M,Zhou J,Wang H,Gao Y,Li W,Wang Z,Cai Z

    更新日期:2015-07-03 00:00:00

  • Simultaneous inhibition of cell-cycle, proliferation, survival, metastatic pathways and induction of apoptosis in breast cancer cells by a phytochemical super-cocktail: genes that underpin its mode of action.

    abstract::Traditional chemotherapy and radiotherapy for cancer treatment face serious challenges such as drug resistance and toxic side effects. Complementary / Alternative medicine is increasingly being practiced worldwide due to its safety beneficial therapeutic effects. We hypothesized that a super combination (SC) of known ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Ouhtit A,Gaur RL,Abdraboh M,Ireland SK,Rao PN,Raj SG,Al-Riyami H,Shanmuganathan S,Gupta I,Murthy SN,Hollenbach A,Raj MH

    更新日期:2013-11-14 00:00:00

  • Neoadjuvant Chemoradiation Treatment for Resectable Esophago-Gastric Cancer: A Systematic Review and Meta-Analysis.

    abstract::Background: Neoadjuvant chemoradiation (CRT) remains controversial in the treatment of the oesophagus or gastro-oesophageal junction (GOJ) carcinomas. Methods: We conducted a meta-analysis to assess the efficacy and safety of Neoadjuvant CRT plus surgery comparing with neoadjuvant CT plus surgery or surgery alone. Fea...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Meng X,Wang L,Zhao Y,Zhu B,Sun T,Zhang T,Gu X,Zheng Z

    更新日期:2019-01-01 00:00:00

  • Effects of MACC1 polymorphisms on hepatocellular carcinoma development and clinical characteristics.

    abstract::Hepatocellular carcinoma (HCC) is a major malignancy of cancer-related mortality worldwide. Metastasis-associated in colon cancer-1 (MACC1) was suggested as a marker for vascular invasive HCC. This study investigated the MACC1 single-nucleotide polymorphisms (SNPs) to evaluate HCC susceptibility and clinicopathologica...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Lin CH,Hsieh MJ,Lee HL,Yang SF,Su SC,Lee WJ,Chou YE

    更新日期:2020-01-14 00:00:00

  • Survival analysis for lung adenosquamous carcinoma patients with brain metastasis.

    abstract::Purpose: We retrospectively collected consecutive survival data of lung adenosquamous cell carcinoma (ASC) patients with brain metastasis (BM) in our institute and discussed the factors related to prognosis of these patients. Patients and Methods: A total of 42 patients diagnosed as lung ASC with BM between July 1, 20...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Pan F,Cui S,Wang W,Gu A,Jiang L

    更新日期:2018-09-08 00:00:00