Abstract：
:The hemagglutinin-neuraminidase (HN) protein of Newcastle disease virus (NDV) with its immunotherapeutic activities and sialic acid binding abilities is a promising cancer adjuvant. The HN was surfaced displayed on Lactococcus lactis and its cancer targeting ability was investigated via attachment to the MDA-MB231 breast cancers. To surface display the HN protein on the bacterial cell wall, HN was fused to N-acetylmuraminidase (AcmA) anchoring motif of L. lactis and expressed in Chinese hamster ovary cells. The expressed recombinant fusion proteins were purified and mixed with a culture of L. lactis and Lactobacillus plantarum. Immunofluorescence assay showed the binding of the recombinant HN-AcmA protein on the surface of the bacterial cells. The bacterial cells carrying the HN-AcmA protein interacted with the MDA-MB231 breast cancer cells. Direct and fluorescent microscopy confirmed that L. lactis and Lb. plantarum surface displaying the recombinant HN were attached to the breast cancer MDA-MB231 cells, providing evidence for the potential ability of HN in targeting to cancer cells.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Baradaran A,Yusoff K,Shafee N,Rahim RAdoi
10.7150/jca.13566subject
Has Abstractpub_date
2016-01-29 00:00:00pages
462-6issue
4issn
1837-9664pii
jcav07p0462journal_volume
7pub_type
杂志文章abstract：:Background: While curative resection is the established strategy for Hepatocellular carcinoma (HCC) patients, the prognosis still remains poor, and the efficiency of existing prediction models is unsatisfactory. Therefore, we aimed to develop a credible and easy-to-use prognostic index for patients with HCC undergoing...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.22246
更新日期：2018-01-01 00:00:00
abstract：PURPOSE:Urothelial carcinoma (UC) is a type of tumor, especially of the urinary bladder, that affects people worldwide. Clarification of its detailed tumor biology and discovery of potential targets for developing treatment strategies are imperative because of frequent recurrences and poor prognosis of advanced UCs. By...
journal_title：Journal of Cancer
pub_type： 杂志文章
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更新日期：2016-07-08 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.4120
更新日期：2012-01-01 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.33001
更新日期：2019-08-08 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
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更新日期：2020-07-31 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.18188
更新日期：2018-01-01 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.16037
更新日期：2017-01-12 00:00:00
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更新日期：2013-07-18 00:00:00
abstract：:[This retracts the article DOI: 10.7150/jca.29953.]. ...
journal_title：Journal of Cancer
pub_type： 撤回出版物
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更新日期：2019-09-02 00:00:00
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pub_type： 杂志文章,评审
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更新日期：2020-04-06 00:00:00
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更新日期：2020-01-01 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.18776
更新日期：2017-06-03 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.14274
更新日期：2016-04-26 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.18762
更新日期：2017-05-12 00:00:00
abstract：:Introduction: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are a standard first-line treatment for advanced EGFR-mutated NSCLC patients. Factors associated with symptoms and quality of life (QOL) improvements have not been investigated. Methods: We conducted a multicenter, prospective study ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.30507
更新日期：2019-07-10 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.18040
更新日期：2017-07-04 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.34826
更新日期：2019-10-22 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.22968
更新日期：2018-01-01 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.42477
更新日期：2020-03-04 00:00:00
abstract：:Background: Identification of new predictive markers in melanoma is of great clinical importance. This study was aimed to analyze association between selected common variants in the cancer susceptibility genes and melanoma progression at the time of diagnosis. Material and Method: The study included 243 consecutive pa...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.26404
更新日期：2018-08-06 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.14031
更新日期：2016-05-25 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
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更新日期：2021-01-01 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.10944
更新日期：2016-01-01 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章,评审
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更新日期：2020-03-04 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.27856
更新日期：2019-01-29 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.24567
更新日期：2018-05-25 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.33914
更新日期：2019-07-23 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.35448
更新日期：2020-01-01 00:00:00
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journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.13123
更新日期：2016-07-25 00:00:00
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pub_type： 杂志文章
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更新日期：2020-02-03 00:00:00
