Methylation patterns of RASA3 associated with clinicopathological factors in hepatocellular carcinoma.

Abstract:

:Hepatocellular carcinoma (HCC) is the sixth most common tumor worldwide. The relationship between the gene methylation accumulation and HCC has been widely studied. In our study, we used the Sequenom EpiTYPER assay to investigate the methylation levels of the RASA3 in 164 HCC samples and paired adjacent non-cancerous tissues, and the association between methylation level and clinicopathological features. The methylation level of the RASA3 in HCC samples was found significantly lower than that in the adjacent non-cancerous tissues (P<0.0001). Moreover, the hypomethylation of RASA3 in HCC samples was connected with the presence of tumornecrosis (P=0.029) and alcohol intake (P=0.002). Furthermore, it was found that the expression of RASA3 was significantly decreased in tumor tissues (P=0.0053), which was also correlated with the methylation levels of RASA3 gene. Thus, RASA3 hypomethylation is a common feature in HCC, and may be a potential mechanism for HCC development, and serves as a useful biomarker for the early detection, especially in alcohol-associated HCCs.

journal_name

J Cancer

journal_title

Journal of Cancer

authors

Lin H,Fan X,He L,Zhou D

doi

10.7150/jca.24567

subject

Has Abstract

pub_date

2018-05-25 00:00:00

pages

2116-2122

issue

12

issn

1837-9664

pii

jcav09p2116

journal_volume

9

pub_type

杂志文章
  • RAS/RAF mutations in tumor samples and cell-free DNA from plasma and bone marrow aspirates in multiple myeloma patients.

    abstract::Purpose: To evaluate the detection of gene mutations in bone marrow biopsy and circulating free DNA (cfDNA) from plasma in multiple myeloma (MM). Experimental design: We used cell-free DNA from plasma and bone marrow to test BRAF V600, KRAS G12/G13, NRAS G12/G13 and NRAS Q61 mutations using multiplex assays for drople...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.43729

    authors: Li Q,Huang HJ,Ma J,Wang Y,Cao Z,Karlin-Neumann G,Janku F,Liu Z

    更新日期:2020-03-15 00:00:00

  • Gene Signal Distribution and HER2 Amplification in Gastroesophageal Cancer.

    abstract::Background: HER2 serves as an important therapeutic target in gastroesophageal cancer. Differences in HER2 gene signal distribution patterns can be observed at the tissue level, but how it influences the HER2 amplification status has not been studied so far. Here, we investigated the link between HER2 amplification an...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.17878

    authors: Jørgensen JT,Nielsen KB,Kjærsgaard G,Jepsen A,Mollerup J

    更新日期:2017-06-01 00:00:00

  • Risk of immune-related colitis with PD-1/PD-L1 inhibitors vs chemotherapy in solid tumors: systems assessment.

    abstract::Background: We performed a meta-analysis to evaluate the risk of immune-related colitis associated with PD1/PD-L1 inhibitors as compared to chemotherapy in solid tumor patients. Methods: Eligible studies were identified through a comprehensive search of multiple databases and included solid tumor patients in randomize...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.24200

    authors: Su Q,Zhang X,Shen X,Hou Y,Sun Z,Gao ZH

    更新日期:2018-04-12 00:00:00

  • R.E.N.A.L. Nephrometry Score: A Preoperative Risk Factor Predicting the Fuhrman Grade of Clear-Cell Renal Carcinoma.

    abstract::Objective: The purpose of this study was to evaluate the efficacy and feasibility of the R.E.N.A.L. Nephrometry Score to postoperatively predict high-grade clear-cell renal carcinoma (ccRCC). Methods: The study included 288 patients diagnosed with ccRCC who had complete CT/CTA data and R.E.N.A.L. Nephrometry Scores an...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.21189

    authors: Chen SH,Wu YP,Li XD,Lin T,Guo QY,Chen YH,Huang JB,Wei Y,Xue XY,Zheng QS,Xu N

    更新日期:2017-10-17 00:00:00

  • Disruption of learning processes by chemotherapeutic agents in childhood survivors of acute lymphoblastic leukemia and preclinical models.

    abstract:OBJECTIVE:With the survival rate of acute lymphoblastic leukemia (ALL) surpassing 90 percent within this decade, new research is emerging in the field of late effects. A review of the research investigating the relationship of treatment regimens for ALL to specific late effect deficits, underlying mechanisms, and possi...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.2.292

    authors: Bisen-Hersh EB,Hineline PN,Walker EA

    更新日期:2011-01-01 00:00:00

  • A New Method for the Detection of Colorectal Cancer and the Precancerous Lesions: Occult Blood Testing Combination with Promoter Methylation in the Fecal Sample.

    abstract::Background: Noninvasive stool-based DNA methylation testing emerges as a new approach for detecting colorectal cancer (CRC). However, its feasibility for early detection of CRC and precancerous lesions in the Chinese population remains inconclusive. Methods: In this study, we establish a possibilities screening method...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.50525

    authors: Wang DY,He KX,Huang Y,Lou QQ,He T,Xu X

    更新日期:2021-01-01 00:00:00

  • A Panel of Four-lncRNA Signature as a Potential Biomarker for Predicting Survival in Clear Cell Renal Cell Carcinoma.

    abstract::Long non-coding RNAs (lncRNAs) have been considered as biomarkers for the carcinogenesis and development of various cancers. However, the prognostic significance of lncRNAs in renal cell carcinoma (RCC) remains unclear. This study aimed to determine the predictive ability of lncRNAs in clear cell RCC (ccRCC). Among th...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.40421

    authors: Liu H,Ye T,Yang X,Lv P,Wu X,Zhou H,Zeng J,Tang K,Ye Z

    更新日期:2020-04-27 00:00:00

  • A Study on Effect of Oxaliplatin in MicroRNA Expression in Human Colon Cancer.

    abstract::Colorectal cancer is a commonly diagnosed malignancy and also the major cause of death worldwide. Chemotherapy is the primary therapy for advanced colorectal cancer. Although oxaliplatin has potential effect in colorectal cancer therapy, the molecular mechanisms involved in its cytotoxic effects are not well elucidate...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.24474

    authors: Evert J,Pathak S,Sun XF,Zhang H

    更新日期:2018-05-22 00:00:00

  • Association between APE1 Single Nucleotide Polymorphism (rs1760944) and Cancer Risk: a Meta-Analysis Based on 6,419 Cancer Cases and 6,781 Case-free Controls.

    abstract::Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential enzyme in the base excision repair pathway. Epidemiological studies have suggested associations between APE1 rs1760944 polymorphism and cancer risk. This study was aimed to evaluate the relationship between APE1 rs1760944 polymorphism and cancer risk. We sear...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.8085

    authors: Dai ZJ,Wang XJ,Kang AJ,Ma XB,Min WL,Lin S,Zhao Y,Yang PT,Wang M,Kang HF

    更新日期:2014-03-13 00:00:00

  • Inhibition of Tumor Lymphangiogenesis is an Important Part that EGFR-TKIs Play in the Treatment of NSCLC.

    abstract::Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been widely used to treat non-small cell lung cancer (NSCLC) because they inhibit tumour growth and metastasis. However, the underlying mechanisms are not fully understood. Here, we investigate whether anti-lymphangiogenesis mechanisms cont...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.35448

    authors: Zhang Y,Yang X,Liu H,Cai M,Shentu Y

    更新日期:2020-01-01 00:00:00

  • The PARP-1 inhibitor Olaparib suppresses BRCA1 protein levels, increases apoptosis and causes radiation hypersensitivity in BRCA1+/- lymphoblastoid cells.

    abstract::The use of polyADPribose polymerase inhibitors in cancer treatment provides a unique opportunity to target DNA repair processes in cancer cells while leaving normal tissue intact. The PARP-1 enzyme repairs DNA single strand breaks (SSB). Therefore PARP-1 inhibition in BRCA1 negative cancers results in the formation of...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.21338

    authors: Bourton EC,Ahorner PA,Plowman PN,Zahir SA,Al-Ali H,Parris CN

    更新日期:2017-10-23 00:00:00

  • Correlations between angiopoietin-2 gene polymorphisms and lung cancer progression in a Chinese Han population.

    abstract::Lung cancer is the most common malignancy in China and is associated with a poor survival rate amongst Han Chinese. The high mortality is largely attributed to late-stage diagnosis, when treatment is largely ineffective. Identification of genetic variants could potentially assist with earlier diagnosis and thus more e...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.31134

    authors: Hu W,Tang CH,Chen HT,Zhao J,Jin L,Kang L,Wu Y,Ying P,Wang CQ,Su CM

    更新日期:2019-06-02 00:00:00

  • Differences and similarities in the phenomenon of NETs formation in oral inflammation and in oral squamous cell carcinoma.

    abstract::Taking into account the previously reported relationship between inflammation and carcinogenesis, and the scant amount of data concerning the role of neutrophil extracellular traps (NETs) in carcinogenesis, we decided to study the process of extracellular trap formation in patients with inflammation as well as in pati...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.24238

    authors: Garley M,Dziemiańczyk-Pakieła D,Grubczak K,Surażyński A,Dąbrowska D,Ratajczak-Wrona W,Sawicka-Powierza J,Borys J,Moniuszko M,Pałka JA,Jabłońska E

    更新日期:2018-04-30 00:00:00

  • Surgery plus chemotherapy improves survival of patients with extremity soft tissue leiomyosarcoma and metastasis at presentation.

    abstract::Purpose: Extremity soft tissue leiomyosarcoma (LMS) with metastasis is a rare disease with a poor prognosis. The purpose of our study was to define clinical features of extremity soft tissue LMS with metastasis as well as to identify multivariable predictors of survival. Methods: During 1973-2015, 239 patients with me...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.29874

    authors: Qian SJ,Wu JQ,Wang Z,Zhang B

    更新日期:2019-05-21 00:00:00

  • Risk factors and prognostic predictors for Cervical Cancer patients with lung metastasis.

    abstract::Background: The most common metastatic site in cervical cancers is lung. The aim of this study is to identify cervical cancer patients with high risk for developing lung metastasis and further explore their prognosis. Materials and Methods: At first, patients diagnosed with cervical cancer from 2010 to 2015 were ident...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.46258

    authors: Chen X,Chen L,Zhu H,Tao J

    更新日期:2020-08-08 00:00:00

  • Neoadjuvant Chemoradiation Treatment for Resectable Esophago-Gastric Cancer: A Systematic Review and Meta-Analysis.

    abstract::Background: Neoadjuvant chemoradiation (CRT) remains controversial in the treatment of the oesophagus or gastro-oesophageal junction (GOJ) carcinomas. Methods: We conducted a meta-analysis to assess the efficacy and safety of Neoadjuvant CRT plus surgery comparing with neoadjuvant CT plus surgery or surgery alone. Fea...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.25915

    authors: Meng X,Wang L,Zhao Y,Zhu B,Sun T,Zhang T,Gu X,Zheng Z

    更新日期:2019-01-01 00:00:00

  • Association between the KRAS Gene Polymorphisms and Papillary Thyroid Carcinoma in a Chinese Han Population.

    abstract::Several studies have reported the association between MAPK signaling pathway gene polymorphisms and papillary thyroid carcinoma (PTC). KRAS gene, an oncogene from the mammalian RAS gene family plays an important role in the MAPK pathway. This study aimed to identify the potential association of KRAS gene polymorphisms...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.16507

    authors: Ning L,Rao W,Yu Y,Liu X,Pan Y,Ma Y,Liu R,Zhang S,Sun H,Yu Q

    更新日期:2016-12-09 00:00:00

  • Comparison of RECIST 1.0 and RECIST 1.1 in Patients with Metastatic Cancer: A Pooled Analysis.

    abstract:BACKGROUND:We conducted this pooled analysis to investigate the impact of RECIST 1.1 on the selection of target lesions and classification of tumor response, in comparison with RECIST 1.0. Methods : We searched MEDLINE and EMBASE for articles with terms of RECIST 1.0 or RECIST 1.1. We looked into all abstracts and virt...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.11316

    authors: Kim JH,Min SJ,Jang HJ,Cho JW,Kim SH,Kim HS

    更新日期:2015-02-25 00:00:00

  • Spatial and temporal fracture pattern in breast and gynecologic cancer survivors.

    abstract:OBJECTIVE(S):To assess skeletal wide fracture location and time of fracture after cancer treatment Study Design: One hundred thirty-nine women diagnosed with breast or gynecologic cancer between 2003 and 2012 that subsequently had a radiologic diagnosis of fracture were identified retrospectively using electronic medic...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.10288

    authors: Hui SK,Arentsen L,Wilcox A,Shanley R,Yee D,Ghebre R

    更新日期:2015-01-01 00:00:00

  • Decreased KPNB1 Expression is Induced by PLK1 Inhibition and Leads to Apoptosis in Lung Adenocarcinoma.

    abstract::Lung cancer is a major cause of death worldwide, with lung adenocarcinoma being the most frequently diagnosed subtype in Japan. Finding the target of an anticancer drug can improve lung adenocarcinoma treatments. Polo-like kinase 1 (PLK1) is an essential mitotic kinase in mitotic progression, and PLK1 inhibition induc...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.21802

    authors: Sekimoto N,Suzuki Y,Sugano S

    更新日期:2017-11-06 00:00:00

  • BCR-ABL1 transcript decline ratio combined BCR-ABL1IS as a precise predictor for imatinib response and outcome in the patients with chronic myeloid leukemia.

    abstract::Purpose: The early BCR-ABL1 reduction had the prognostic impact of the chronic-phase chronic myeloid leukemia (CML-CP) patients. This study was to find a more precise early prognosis index at 3 months in the patients with newly diagnosed CML-CP, especially for the patients with BCR-ABL1IS >10%. Methods: We retrospecti...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.38752

    authors: Cai Z,Jia X,Zi J,Song H,Wang S,McGrath M,Zhao L,Song C,Ge Z

    更新日期:2020-02-03 00:00:00

  • The oncogenic potential of PRR11 gene in Tongue Squamous Cell Carcinoma cells.

    abstract::Background: We previously demonstrated that Proline rich 11 (PRR11) gene is associated with the development and progression of tongue squamous cell carcinoma (TSCC), but the underlying mechanism is unknown. This study aimed to investigate the molecular mechanism underlying oncogenic potential of PRR11 in TSCC cells. M...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.29265

    authors: Wang C,Yu L,Ren X,Wu T,Chen X,Huang Y,Cheng B

    更新日期:2019-06-02 00:00:00

  • High serum Androgen and Insulin concentrations increase the tendency of Endometrial Carcinoma.

    abstract::Purpose: The objective of the study was to evaluate the important role played by androgen and insulin in the development of endometrial carcinoma (EC), and their combined effect on EC risk. Methods: We enrolled 510 type I EC patients and 510 age-, time-, and nationality-matched subjects into this study. Metabolic and ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.46391

    authors: Teng F,Ma X,Yu X,Yan Y,Zhao J,Gao J,Gao C,Wang Y,Tian W,Xue F

    更新日期:2020-07-25 00:00:00

  • Prognostic value of MET copy number gain in non-small-cell lung cancer: an updated meta-analysis.

    abstract::The alterations of MET have been detected in non-small-cell lung cancer (NSCLC). However, the prognostic impact of MET gene copy number gain (CNG) has not been consistent among studies. We performed this meta-analysis to evaluate the prognostic value of high MET CNG in patients with NSCLC. A systematic computerized se...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.24980

    authors: Kim JH,Kim HS,Kim BJ

    更新日期:2018-04-23 00:00:00

  • MicroRNA-101-3p advances cisplatin sensitivity in bladder urothelial carcinoma through targeted silencing EZH2.

    abstract::Objective: Chemotherapy is a major therapeutic method for bladder urothelial carcinoma (BUC), which can effectively improve the prognosis of BUC patients, but the chemoresistance often leads to chemotherapy failure. This study will research the regulatory roles and molecular mechanism of miR-101-3p in BUC chemoresista...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.33117

    authors: Li B,Xie D,Zhang H

    更新日期:2019-06-02 00:00:00

  • Downregulation of miR-1 in colorectal cancer promotes radioresistance and aggressive phenotypes.

    abstract::Background: Colorectal cancer (CRC) remains to be one of the most common malignancies worldwide. Various studies have demonstrated that microRNAs (miRs) play a critical role in regulating cancer progression and sensitivity to chemoradiotherapy. miR-1 was found to be aberrantly expressed in CRC. However, it has not bee...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.44753

    authors: Wu Y,Pu N,Su W,Yang X,Xing C

    更新日期:2020-06-07 00:00:00

  • Impact of Cold Ischemic Time and Freeze-Thaw Cycles on RNA, DNA and Protein Quality in Colorectal Cancer Tissues Biobanking.

    abstract::Tissue-derived RNA, DNA and protein samples become more and more crucial for molecular detection in clinical research, personalized and targeted cancer therapy. This study evaluated how to biobanking colorectal tissues through examining the influences of cold ischemic time and freeze-thaw cycles on RNA, DNA and protei...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.29372

    authors: Fan XJ,Huang Y,Wu PH,Yin XK,Yu XH,Fu XH,Feng LL,Wang YL,Yi HJ,Chen ZT,Yin JX,Zhang DL,Feng WX,Bai SM,Kim T,Mills GB,Lu YL,Wan XB,Wang L

    更新日期:2019-08-27 00:00:00

  • Prognostic Impact of Thrombospodin-2 (THBS2) Overexpression on Patients with Urothelial Carcinomas of Upper Urinary Tracts and Bladders.

    abstract:PURPOSE:Urothelial carcinoma (UC) is a type of tumor, especially of the urinary bladder, that affects people worldwide. Clarification of its detailed tumor biology and discovery of potential targets for developing treatment strategies are imperative because of frequent recurrences and poor prognosis of advanced UCs. By...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.15696

    authors: Chang IW,Li CF,Lin VC,He HL,Liang PI,Wu WJ,Li CC,Huang CN

    更新日期:2016-07-08 00:00:00

  • Stromal mesenchymal stem cells facilitate pancreatic cancer progression by regulating specific secretory molecules through mutual cellular interaction.

    abstract::Pancreatic ductal adenocarcinoma (PDAC) is currently one of the most intractable malignancies with a typical scirrhous pattern in histology. Due to its abundant tumor stroma and scant vascularization, chemotherapeutic agents are considered inefficiently permeable to cancer nests, making it highly difficult to cure the...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.24415

    authors: Saito K,Sakaguchi M,Maruyama S,Iioka H,Putranto EW,Sumardika IW,Tomonobu N,Kawasaki T,Homma K,Kondo E

    更新日期:2018-07-30 00:00:00

  • Clinicopathological Significance and Antitumor Effect of MPHOSPH1 in Testicular Germ Cell Tumor.

    abstract::MPHOSPH1, which is one of the kinesin superfamily proteins, has been reported to play an essential role in the carcinogenesis and progression of several kinds of cancers. MPHOSPH1 has also been suggested to be involved in STAT3 phosphorylation in hepatocellular carcinoma. However, the biological behavior of MPHOSPH1 i...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.25279

    authors: Abe T,Kohashi K,Takemoto J,Kinoshita F,Eto M,Oda Y

    更新日期:2018-10-31 00:00:00