Surgery plus chemotherapy improves survival of patients with extremity soft tissue leiomyosarcoma and metastasis at presentation.

abstract：BACKGROUND:Neoadjuvant chemotherapy with concurrent docetaxel, doxorubicin and cyclophosphamide is commonly used for patients with locally advanced breast cancer. Epirubicin is another anthracycline used in breast cancer but the concurrent use of epirubicin and taxane is not well-established. We conducted a single inst...

journal_title：Journal of Cancer

authors： Yao X,Hosenpud J,Chitambar CR,Charlson J,Cheng YC

更新日期：2012-01-01 00:00:00

abstract：:Purpose: This study aimed to comprehensively investigate the differential expression and prognostic indicators of the tripartite motif-containing (TRIM) gene family in non-small cell lung cancer (NSCLC). Methods: The Cancer Genome Atlas (TCGA) Research Network and three datasets from Gene Expression Omnibus (GEO) data...

journal_title：Journal of Cancer

authors： Han X,Huang C,Qu X,Liu S,Yang X,Wang Y,Bie F,Liu Q,Du J

更新日期：2019-01-29 00:00:00

abstract：:Background: Bevacizumab combined with chemotherapy is still one of the standard options for treatment of advanced non-small cell lung cancer (NSCLC) patients without driver mutations. Serum inflammatory factors, representing the systemic immune status, are shown to have complicated relationships with tumor angiogenesi...

journal_title：Journal of Cancer

authors： Li B,Wang S,Li C,Guo M,Xu Y,Sun X,Yu J,Wang L

更新日期：2019-08-28 00:00:00

abstract：:Background: Immune cells recognize tumor antigens presented on major histocompatibility complex class I (MHC-I) molecule. Increase of MHC-I molecular expression makes tumor cells more susceptible to lysis by immune cells. Methods: Tumor lysate vaccine was prepared to damage glioma cells including cell lines and primar...

journal_title：Journal of Cancer

authors： Sun T,Li Y,Yang W,Wu H,Li X,Huang Y,Zhou Y,Du Z

更新日期：2019-09-07 00:00:00

abstract：:Background: Surgery for pancreatic cancer with liver metastases (PCL) is not recommended in the international guidelines, and investigation of its clinical significance in patients with PCL is very limited. This study explored whether surgery, especially synchronous resection of the primary tumor and liver metastases ...

journal_title：Journal of Cancer

authors： Su BB,Bai DS,Yu JQ,Zhang C,Jin SJ,Zhou BH,Jiang GQ

更新日期：2021-01-01 00:00:00

abstract：:Aim: BAP1 is frequently mutated in clear cell renal cell carcinoma (ccRCC) with a definitive role still unclear. Methods: In silico analysis of BAP1-mutant and wild-type gene enrichment and functional annotation in TCGA-KIRC dataset was performed. Target gene was studied based on functional clustering and was knowledg...

journal_title：Journal of Cancer

authors： Sun C,Zhao C,Li S,Wang J,Zhou Q,Sun J,Ding Q,Liu M,Ding G

更新日期：2018-10-01 00:00:00

abstract：:Globally, prostate cancer is the third most common cancer in the world, and the second most common cancer in men. However, rates for incidence and mortality vary considerably with race, ethnicity, and geography. Over 97 significantly mutated genes that have been identified in prostate cancer; however, a lack of genomi...

journal_title：Journal of Cancer

authors： Zeng T,Fedeli MA,Tanda F,Wang Y,Yang D,Xue B,Jia L,Palmieri G,Sechi LA,Kelvin DJ

更新日期：2021-01-01 00:00:00

abstract：:Chemo- and radio-therapy suffer from certain well-recognized drawbacks for lymphoma therapy. Passive immunotherapy with monoclonal antibody has improved outcome for patients with CD20+ B cell lymphoma, but not for T cell lymphoma. Therefore, novel treatment approaches are clearly required for T cell lymphoma. To date,...

journal_title：Journal of Cancer

authors： Gao D,Li W,Wang W,Cai Y,Wang Y,Luo X,Wei CC

更新日期：2017-09-15 00:00:00

abstract：:Objective: Liposarcoma is a mesenchymal malignant tumor characterized by adipocyte differentiation which is divided into four subtypes with different prognosis. Accurate histopathological diagnosis is essential for precise treatment. Perilipins, including PLIN1, PLIN2, PLIN3, PLIN4, PLIN5, is a family of lipid droplet...

journal_title：Journal of Cancer

authors： Zhang Q,Zhang P,Li B,Dang H,Jiang J,Meng L,Zhang H,Zhang Y,Wang X,Li Q,Wang Y,Liu C,Li F

更新日期：2020-04-07 00:00:00

abstract：:Introduction: Preoperative risk stratification is crucial for clinical treatment of endometrial cancer (EC). This study aimed to establish a model based on magnetic resonance imaging (MRI) and clinical factors for risk classification of EC. Materials and Methods: A total of 102 patients with pathologically proven Stag...

journal_title：Journal of Cancer

authors： Chen J,Gu H,Fan W,Wang Y,Chen S,Chen X,Wang Z

更新日期：2021-01-01 00:00:00

abstract：:RBP7 is a member of the cellular retinol-binding protein (CRBP) family and previous data suggested a link between CRBPs and the malignant transformation of colon cancer cells. Here, we investigated the potential of RBP7 as a predictive biomarker for patients with colon cancer and determined its functional relevance fo...

journal_title：Journal of Cancer

authors： Elmasry M,Brandl L,Engel J,Jung A,Kirchner T,Horst D

更新日期：2019-08-27 00:00:00

abstract：:Background/Aims: Autologous, tumor-derived, heat shock protein gp96 peptide complexes have antitumor potential. We conducted the first Phase II trial to evaluate the safety and efficacy of gp96 vaccination in adjuvant settings for patients with gastric cancer. Methods: We enrolled 73 consecutive patients from October ...

journal_title：Journal of Cancer

authors： Zhang K,Peng Z,Huang X,Qiao Z,Wang X,Wang N,Xi H,Cui J,Gao Y,Huang X,Gao H,Wei B,Chen L

更新日期：2017-07-02 00:00:00

abstract：:As a crucial event involved in the metastasis and relapse of esophageal cancer, c-Met overexpression has been considered as one of the culprits responsible for the failure in patients who received radiochemotherapy. Since c-Met has been confirmed to be pivotal for cell survival, proliferation and migration, little is ...

journal_title：Journal of Cancer

authors： Chen GZ,Dai WS,Zhu HC,Song HM,Yang X,Wang YD,Min H,Lu Q,Liu S,Sun XC,Zeng XN

更新日期：2017-03-12 00:00:00

abstract：:Background: The genetic heterogeneity between primary and metastatic lesions has rarely studied. Purpose: This study aims to compare the mutation profiling of key cancer-related genes in primary lung cancers and their matched lymph nodes (LN) metastasis. Methods: The gene mutation profiling of both primary cancers and...

journal_title：Journal of Cancer

authors： Chen Y,Mao B,Peng X,Zhou Y,Xia K,Guo H,Jiang H,Wang G,Zhuang W

更新日期：2019-03-03 00:00:00

abstract：:Purpose: The early BCR-ABL1 reduction had the prognostic impact of the chronic-phase chronic myeloid leukemia (CML-CP) patients. This study was to find a more precise early prognosis index at 3 months in the patients with newly diagnosed CML-CP, especially for the patients with BCR-ABL1IS >10%. Methods: We retrospecti...

journal_title：Journal of Cancer

authors： Cai Z,Jia X,Zi J,Song H,Wang S,McGrath M,Zhao L,Song C,Ge Z

更新日期：2020-02-03 00:00:00

abstract：:EGFR mutation of Non-small cell lung cancers (NSCLC) was predominantly seen in Asian population and it was considered as a predictor of responsiveness. Eendothelial nitric oxide synthase (eNOS) plays a vital role in chronic inflammation and carcinogenesis. In this study, we aimed to explore the association between the...

journal_title：Journal of Cancer

authors： Huang CY,Hsieh MJ,Wu WJ,Chiang WL,Liu TC,Yang SF,Tsao TC

更新日期：2018-06-15 00:00:00

abstract：:Purpose: Systemic therapy has often been used for patients with advanced hepatocellular carcinoma (HCC). However, due to drug resistance, the use of cytotoxic chemotherapy in the treatment of patients with advanced HCC has typically demonstrated low response rates. Secretory clusterin (sCLU) is expressed in aggressive...

journal_title：Journal of Cancer

authors： Wang X,Zou F,Zhong J,Yue L,Wang F,Wei H,Yang G,Jin T,Dong X,Li J,Xiu P

更新日期：2018-04-06 00:00:00

abstract：:Background: Radiotherapy is a primary treatment strategy for patients with unresectable hepatocellular carcinoma (HCC); however, the prognostic factors among HCC patients who have received radiotherapy but not undergone surgery have not been systematically studied. Thus, the prognostic factors were investigated in thi...

journal_title：Journal of Cancer

authors： Zhang L,Yan L,Niu H,Ma J,Yuan BY,Chen YH,Zhuang Y,Hu Y,Zeng ZC,Xiang ZL

更新日期：2019-07-25 00:00:00

abstract：:Objectives: Lung cancer in young adults is a distinct disease with particular socioeconomic implications. This study aimed to clarify the clinicopathological characteristics, best interventions, and outcomes of this distinctive entity. Methods: A retrospective review of patients with lung cancer was performed in our i...

journal_title：Journal of Cancer

authors： Liu B,Quan X,Xu C,Lv J,Li C,Dong L,Liu M

更新日期：2019-06-09 00:00:00

abstract：:Objective: Both previous and recent literature showed long non-coding RNAs (lncRNAs) were crucial participants in multiple myeloma (MM) evolution. However, the dynamic regulation and mechanism of lncRNAs in MM progression was not fully understood. This study will explore the expression and effects of prostate cancer-a...

journal_title：Journal of Cancer

authors： Shen X,Shen P,Yang Q,Yin Q,Wang F,Cong H,Wang X,Ju S

更新日期：2019-10-20 00:00:00

abstract：PURPOSE:We conducted a meta-analysis to evaluate and compare the short- and long-term results of laparoscopy-assisted colectomy (LAC) and open colectomy (OC) for colon cancer. METHODS:We searched MEDLINE, EMBASE, Science Citation Index, and Cochrane Controlled Trial Register for relevant papers published between Janua...

journal_title：Journal of Cancer

authors： Ohtani H,Tamamori Y,Arimoto Y,Nishiguchi Y,Maeda K,Hirakawa K

更新日期：2012-01-01 00:00:00

abstract：:Purpose: Aim of this study was to comprehensively analyze BRCA1-associated protein-1 (BAP1) somatic mutation in clear cell renal cell carcinoma (ccRCC) and explore potential therapeutic pathways and molecules. Patients and methods: In this study, we analyzed 445 ccRCC cases from The Cancer Genome Atlas (TCGA). Compreh...

journal_title：Journal of Cancer

authors： Jin S,Wu J,Zhu Y,Gu W,Wan F,Xiao W,Dai B,Zhang H,Shi G,Shen Y,Zhu Y,Ye D

更新日期：2018-10-18 00:00:00

abstract：BACKGROUND:Mathematical models can be useful tools in exploring disease trends and health consequences of interventions in a population over time. Most cancers, in particular cervical cancer, have long incubation periods. The time from acquisition of HPV infection to development of invasive cancer can be up to two deca...

journal_title：Journal of Cancer

authors： Lee SL,Tameru AM

更新日期：2012-01-01 00:00:00

abstract：:Background and aim: Understanding the molecular biological mechanisms underlying laryngeal squamous cell carcinoma (LSCC) invasion and metastasis is crucial for diagnosis, treatment, and prognosis. We aimed to examine the expression of the tumor suppressor microRNA-204-5p (miR-204-5p) and its target gene, forkhead box...

journal_title：Journal of Cancer

authors： Gao W,Wu Y,He X,Zhang C,Zhu M,Chen B,Liu Q,Qu X,Li W,Wen S,Wang B

更新日期：2017-07-21 00:00:00

abstract：:Centromere protein N (CENP-N), an important member of the centromere protein family, is essential for kinetochore assembly and chromosome segregation; however, the relevance of CENP-N in cancers remains unknown. The aim of this study was to investigate CENP-N expression and its functional mechanisms in oral squamous c...

journal_title：Journal of Cancer

authors： Oka N,Kasamatsu A,Endo-Sakamoto Y,Eizuka K,Wagai S,Koide-Ishida N,Miyamoto I,Iyoda M,Tanzawa H,Uzawa K

更新日期：2019-06-09 00:00:00

abstract：:Purpose: Hypoxia-inducible factor-1alpha (HIF-1A) is a transcription factor that plays an "angiogenic switch" role especially under hypoxia microenvironment in solid tumor. However, the functions and clinical significance of HIF-1A in gallbladder cancer (GBC) are still controversial, and it has not been studied in nor...

journal_title：Journal of Cancer

authors： Wu Y,Meng D,You Y,Sun R,Fu M,Yan Q,Zhang S,Fang Z,Bao J,Li Y

更新日期：2021-01-01 00:00:00

abstract：:Until few years ago non-specific cytotoxic agents were considered the tip of the arrow as first line treatment for lung cancer. However; age > 75 was considered a major drawback for this kind of therapy. Few exceptions were made by doctors based on the performance status of the patient. The side effects of these agent...

journal_title：Journal of Cancer

authors： Hohenforst-Schmidt W,Zarogoulidis P,Steinheimer M,Benhassen N,Tsiouda T,Baka S,Yarmus L,Stratakos G,Organtzis J,Pataka A,Tsakiridis K,Karapantzos I,Karapantzou C,Darwiche K,Zissimopoulos A,Pitsiou G,Zarogoulidis K,Man Y

更新日期：2016-03-21 00:00:00

abstract：:Oncogenic activation of the ETS Related Gene (ERG) in humans was originally identified in subsets of Ewing sarcomas, myeloid leukemias and, recently, in the majority of prostate cancers. Expression of human ERG protein and consequently its functions in normal and disease states needs to be better understood in light o...

journal_title：Journal of Cancer

authors： Mohamed AA,Tan SH,Mikhalkevich N,Ponniah S,Vasioukhin V,Bieberich CJ,Sesterhenn IA,Dobi A,Srivastava S,Sreenath TL

更新日期：2010-10-25 00:00:00

abstract：:Ovarian cancer, cervical cancer and endometrial cancer are three relatively common malignant cancers of the female reproductive system. Despite improvements in female genital tract cancer detection and development of new therapeutic approaches, there are still poor prognoses and some do not respond to therapeutic patt...

journal_title：Journal of Cancer

authors： Zhu DL,Tuo XM,Rong Y,Zhang K,Guo Y

更新日期：2020-10-21 00:00:00

abstract：:Colorectal cancer (CRC) is considered to be closely associated with alteration of intestinal microorganisms. The purpose of present study was to investigate the distribution of gut microbiota in the distinction of microbiota dysbiosis between two disease syndromes called Zheng-Qi-Kui-Xu(ZQKX) and Xie-Du-Yong-Sheng (XD...

journal_title：Journal of Cancer

authors： Wang P,Ding S,Sun L,Feng Y,Guo K,Zhu Y,Huang D,Ruan S

更新日期：2020-10-23 00:00:00