Abstract:
:Introduction: Preoperative risk stratification is crucial for clinical treatment of endometrial cancer (EC). This study aimed to establish a model based on magnetic resonance imaging (MRI) and clinical factors for risk classification of EC. Materials and Methods: A total of 102 patients with pathologically proven Stage I EC were included. Preoperative MRI examinations were performed in all the patients. 720 radiomic features were extracted from T2-weighted images. Least absolute shrinkage and selection operator (LASSO) regression model was performed to reduce irrelevant features. Logistic regression was used to build clinical, radiomic and combined predictive models. A nomogram was developed for clinical application. Results: The radiomic model has a better performance than the model based on clinical and conventional MRI characteristics [AUC of 0.946 (95% CI: 0.882-0.973) vs AUC of 0.756 (95% CI: 0.65, 0.86)]. The combined model consisting of radiomic features and tumor size showed the best predictive performance in the training cohort with AUC of 0.955 in the training and 0.889 in the validation cohorts. Conclusions: MRI-based radiomic model has great potential in prediction of low-risk ECs.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Chen J,Gu H,Fan W,Wang Y,Chen S,Chen X,Wang Zdoi
10.7150/jca.50872subject
Has Abstractpub_date
2021-01-01 00:00:00pages
726-734issue
3issn
1837-9664pii
jcav12p0726journal_volume
12pub_type
杂志文章abstract::Objective: To measure hematologic parameters derived from the white blood cell (WBC) count and differential count (DC) as prognostic factors for survival in patients with stage IB and IIA cervical cancer. Methods: We retrospectively examined demographic, clinicopathologic, and laboratory parameters in a cohort of 233 ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.22234
更新日期:2018-01-01 00:00:00
abstract::Cancer is a leading cause of death throughout the world, and cancer therapy remains a big medical challenge in terms of both its therapeutic efficacy and safety. Therefore, to find out a safe anticancer drug has been long goal for oncologist and medical scientists. Among clinically used medicines with no or little tox...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.24488
更新日期:2018-04-06 00:00:00
abstract::Triple negative breast cancer (TNBC) is characterized by distinctive biological features that confer an aggressive clinical behavior. In TNBC patients, the absence of well-defined driver pathways such as hormonal receptor expression or hyperactivation of the human epidermal growth factor receptor 2 (HER2) significantl...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.35109
更新日期:2019-10-12 00:00:00
abstract::Endocrine resistance in hormone receptor positive breast cancer patients urges us to develop novel approaches such as inhibitors of the cyclin-dependent kinases (CDK) 4/6 to reverse its resistance. Nowadays, three selective CDK4/6 inhibitors (Palbociclib, Ribociclib and Abemaciclib) are approved by Federal Drug Admini...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.33079
更新日期:2019-10-21 00:00:00
abstract::Hedgehog (Hh) signalling plays an important role in cancer; however, its mechanism in ovarian cancer migration and invasion remains unclear. In the present study, we aimed to clarify the effect of the Hh signalling pathway on ovarian cancer migration and invasion through the regulation of CD24 expression, both in vitr...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.17712
更新日期:2017-02-25 00:00:00
abstract::Colorectal cancer (CRC) is considered to be closely associated with alteration of intestinal microorganisms. The purpose of present study was to investigate the distribution of gut microbiota in the distinction of microbiota dysbiosis between two disease syndromes called Zheng-Qi-Kui-Xu(ZQKX) and Xie-Du-Yong-Sheng (XD...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.50318
更新日期:2020-10-23 00:00:00
abstract::Esophageal cancer is an aggressive disease featured by early lymphatic and hematogenous dissemination, and is the sixth leading cause of cancer-related deaths worldwide. The proper formation of apicobasal polarity is essential for normal epithelium physiology and tissue homeostasis, while loss of polarity is a hallmar...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.11709
更新日期:2015-06-11 00:00:00
abstract::Colorectal cancer(CRC) is a prevalent malignancy in the world. There is growing evidence that microRNAs (miRNAs) as crucial modulator are in connection with many tumor-related diseases including CRC. Though miR-485-5p has been reported as an anti-oncogene in certain cancers, it remains unclear in CRC. In this research...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24918
更新日期:2018-06-23 00:00:00
abstract::We studied combinatorial interactions of two phytochemicals, curcumin and silymarin, in their action against cancer cell proliferation. Curcumin is the major component of the spice turmeric. Silymarin is a bioactive component of milk thistle used as a protective supplement against liver disease. We studied antiprolife...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.15690
更新日期:2016-06-23 00:00:00
abstract:BACKGROUND:MicroRNA (miRNA) have been shown to regulate gene expression in many cancers. MiR-182 has recently been found to be prognostic for patients treated with radical prostatectomy for prostate cancer. We sought to assess miR-182 as a prognostic marker and understand its role in prostate cancer progression and met...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.13176
更新日期:2015-10-25 00:00:00
abstract::Little is known about the possible oncogenic roles of genes encoding for the phosphatidylinositol 4-kinases, a family of enzymes that regulate an early step in phosphoinositide signalling. To address this issue, the mutational status of all four human phosphatidylinositol 4-kinases genes was analyzed across 852 breast...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.9794
更新日期:2014-10-28 00:00:00
abstract::Objective: Increasing evidence suggested that dysregulated small nucleolar RNAs (snoRNAs) were involved in tumor development. The roles of snoRNA 71A (SNORA71A) in the progression of non-small cell lung cancer (NSCLC) remained unclear. Methods: Dataset GSE19188 from Gene Expression Omnibus (GEO) database was downloade...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.31077
更新日期:2019-05-21 00:00:00
abstract::Background: Immunotherapy including immune checkpoint blockade, cancer vaccines, and adoptive cell therapy. However, no immune therapies support ovarian cancer. It is not clear whether the neutrophils, the component of the immune system derived from umbilical cord blood play a role in inhibiting the progression of ova...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.41035
更新日期:2020-05-18 00:00:00
abstract::Amplified in breast cancer 1 (AIB1) gene, a coactivator for steroid receptor, is frequently amplified in diverse cancers and is considered as an oncogene in tumorigenesis. However, the prognostic significance of AIB1 amplification in gliomas remains totally unclear. In this study, 115 gliomas and 16 benign meningiomas...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16069
更新日期:2016-10-22 00:00:00
abstract::Background and aim: Understanding the molecular biological mechanisms underlying laryngeal squamous cell carcinoma (LSCC) invasion and metastasis is crucial for diagnosis, treatment, and prognosis. We aimed to examine the expression of the tumor suppressor microRNA-204-5p (miR-204-5p) and its target gene, forkhead box...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19470
更新日期:2017-07-21 00:00:00
abstract::Colorectal cancer (CRC) is an important health issue worldwide, accounting for the third place of cancer incidence. Chronic inflammation, as seen in Crohn's disease and ulcerative colitis, is the most important risk factor for developing CRC, as it favours neoplastic transformation by enhancing epithelial cell turnove...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.13123
更新日期:2016-07-25 00:00:00
abstract::For unresectable Hepatocellular carcinoma (HCC), chemotherapy is still an important treatment strategy. Oxaliplatin (Oxa) is an effective treatment of HCC after sorafenib treatment failure. However, the intrinsic or acquired resistance of Oxa affected the chemotherapeutic sensitivity. By analyzing the data of GEO Data...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25909
更新日期:2018-10-10 00:00:00
abstract::Background: IgA antibodies against Epstein-Barr virus (EBV) capsid antigen (VCA) and nuclear antigen 1 (EBNA1) have been proposed to facilitate the diagnosis and early detection of nasopharyngeal carcinoma (NPC) in high-incidence regions. However, while new methodologies and new platforms for the detection of VCA-IgA ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.47260
更新日期:2020-10-18 00:00:00
abstract::Purpose: The aberrant of fibroblast growth factors and their receptors (FGF/FGFR) is an emerging target in the treatment of solid tumors. This study aimed to explore the landscape of FGF/FGFR alterations in a large cohort of cancer patients. Material and Methods: The formalin-fixed paraffin-embedded specimens of cance...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.49269
更新日期:2020-09-23 00:00:00
abstract::Endometrium is the mucosal lining of the uterus which expressed a cyclic process of proliferation, secretion and scaling under the control of hormones secreted by the ovary, and it also plays an indispensable role in the embryo implantation, the constitution of fetal-maternal interface, and the maintaining of pregnanc...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.31742
更新日期:2019-06-09 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.24889
更新日期:2018-06-12 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.116
更新日期:2011-02-24 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18135
更新日期:2017-03-12 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19373
更新日期:2017-07-05 00:00:00
abstract::Purpose: We retrospectively collected consecutive survival data of lung adenosquamous cell carcinoma (ASC) patients with brain metastasis (BM) in our institute and discussed the factors related to prognosis of these patients. Patients and Methods: A total of 42 patients diagnosed as lung ASC with BM between July 1, 20...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.27441
更新日期:2018-09-08 00:00:00
abstract::Recent studies indicated that long noncoding RNAs (lncRNAs) played important regulatory roles in carcinogenesis and cancer progression. However, the contribution of small nucleolar RNA host gene 20 (SNHG20) to cancer development remains largely unknown. The aim of the study is to investigate the expression of SNHG20 a...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.13822
更新日期:2016-03-19 00:00:00
abstract::Cisplatin chemoresistance is a clinical obstacle in the treatment of gastric cancer (GC). Enhanced DNA repair capacity may lead to cisplatin resistance. However, the detailed molecular mechanism of GC cisplatin resistance specifically involving nucleotide excision repair (NER) is not clear. However, the mechanism thro...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25814
更新日期:2019-01-29 00:00:00
abstract::Ovarian carcinoma is the most lethal gynecological malignancy worldwide. Recent advance in genomic/epigenomic researches will impact on our prevention, detection and intervention on ovarian carcinoma. Detection of germline mutations in BRCA1/BRCA2, mismatch repair genes, and other genes in the homologous recombination...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.15556
更新日期:2016-07-05 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.49001
更新日期:2020-09-14 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.30230
更新日期:2019-06-02 00:00:00