Genes Regulating Epithelial Polarity Are Critical Suppressors of Esophageal Oncogenesis.

abstract：:Background: The genetic heterogeneity between primary and metastatic lesions has rarely studied. Purpose: This study aims to compare the mutation profiling of key cancer-related genes in primary lung cancers and their matched lymph nodes (LN) metastasis. Methods: The gene mutation profiling of both primary cancers and...

journal_title：Journal of Cancer

authors： Chen Y,Mao B,Peng X,Zhou Y,Xia K,Guo H,Jiang H,Wang G,Zhuang W

更新日期：2019-03-03 00:00:00

abstract：:Background: The Aldehyde dehydrogenase 2 (ALDH2) mutant genotypes contain an allele encoding defective ALDH2 with reduced efficacy of alcohol metabolism leading to accumulation of highly toxic and carcinogenic acetaldehyde. It can induce unpleasant "Asian flush syndrome" and associate with increased risk of cancers. H...

journal_title：Journal of Cancer

authors： Huang PH,Hu CC,Chien CH,Chen LW,Chien RN,Lin YS,Chao M,Lin CL,Yeh CT

更新日期：2019-10-03 00:00:00

abstract：:Background: Heavy metal pollution in farm soils is a grave concern in Taiwan. Previously, we found the incidence of oral cancer (OC) correlated positively with levels of nickel and arsenic in farm soils. Many OC patients have a second malignancy, among which esophageal cancer (EC) is the most common one in Taiwan. Obj...

journal_title：Journal of Cancer

authors： Lee CP,Lee YH,Lian IB,Su CC

更新日期：2016-08-06 00:00:00

abstract：:Objective: This study aimed to evaluate the therapeutic response of hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) with diffusion kurtosis imaging (DKI). Methods: Forty-three patients with fifty-nine hepatic cancer nodules were recruited for this study. All patients were treated b...

journal_title：Journal of Cancer

authors： Yuan ZG,Wang ZY,Xia MY,Li FZ,Li Y,Shen Z,Wang XZ

更新日期：2020-02-10 00:00:00

abstract：INTRODUCTION:Hürthle cell carcinoma (HCC) is a rare tumor that tends to metastasize to the lymph nodes. Some studies have correlated size of Hürthle cell tumors with the risk of malignancy. Whether the size of HCC correlates with the risk of lymph node (LN) metastases, to our knowledge has not been addressed. METHODS:...

journal_title：Journal of Cancer

authors： Guerrero MA,Suh I,Vriens MR,Shen WT,Gosnell J,Kebebew E,Duh QY,Clark OH

更新日期：2010-06-02 00:00:00

abstract：BACKGROUND:Mitochondria play crucial roles in cell signaling events, interorganellar communication, aging, cell proliferation and apoptosis, and mitochondrial impairment has been shown to accelerate or modulate cancer progression. Ubiquitous mitochondrial creatine kinase (uMtCK) is predominantly localized in the interm...

journal_title：Journal of Cancer

authors： Amamoto R,Uchiumi T,Yagi M,Monji K,Song Y,Oda Y,Shiota M,Yokomizo A,Naito S,Kang D

更新日期：2016-01-01 00:00:00

abstract：:Cancer is a leading cause of death throughout the world, and cancer therapy remains a big medical challenge in terms of both its therapeutic efficacy and safety. Therefore, to find out a safe anticancer drug has been long goal for oncologist and medical scientists. Among clinically used medicines with no or little tox...

journal_title：Journal of Cancer

authors： Lian X,Wang G,Zhou H,Zheng Z,Fu Y,Cai L

更新日期：2018-04-06 00:00:00

abstract：:Aim: BAP1 is frequently mutated in clear cell renal cell carcinoma (ccRCC) with a definitive role still unclear. Methods: In silico analysis of BAP1-mutant and wild-type gene enrichment and functional annotation in TCGA-KIRC dataset was performed. Target gene was studied based on functional clustering and was knowledg...

journal_title：Journal of Cancer

authors： Sun C,Zhao C,Li S,Wang J,Zhou Q,Sun J,Ding Q,Liu M,Ding G

更新日期：2018-10-01 00:00:00

abstract：:Background: To support cancer therapy, development of low cost library preparation techniques for targeted next generation sequencing (NGS) is needed. In this study we designed and tested a PCR-based library preparation panel with limited target area for sequencing the top 12 somatic mutation hot spots in colorectal c...

journal_title：Journal of Cancer

authors： Péterfia B,Kalmár A,Patai ÁV,Csabai I,Bodor A,Micsik T,Wichmann B,Egedi K,Hollósi P,Kovalszky I,Tulassay Z,Molnár B

更新日期：2017-01-12 00:00:00

abstract：BACKGROUND:Age-adjusted evaluations have explored the possible utility of (HPV test results in women with LSIL Pap. We investigated HPV test results and histopathologic follow-up results of LSIL patients from China's largest CAP-certified laboratory. METHODS:Patients with LSIL between 2011 and 2015 from the Guangzhou ...

journal_title：Journal of Cancer

authors： Zheng B,Yang H,Li Z,Wei G,You J,Liang X,Zhao C

更新日期：2017-07-23 00:00:00

abstract：:Tumor progression is often associated with chronic inflammation in the tumor microenvironment, which is mediated by numerous cytokines, chemokines and growth factors produced by cancer and stroma cells. All these mediators support tumor development and immunosuppression in autocrine and/or paracrine ways. Neutralizati...

journal_title：Journal of Cancer

authors： Sevko A,Umansky V

更新日期：2013-01-01 00:00:00

abstract：:Cancer-testis (CT) genes played important roles in the progression of malignant tumors and were recognized as promising therapeutic targets. However, the roles of genetic variants in CT genes in lung cancer susceptibility have not been well depicted. This study aimed to evaluate the associations between genetic varian...

journal_title：Journal of Cancer

authors： Li Z,Tang J,Wen W,Wu W,Wang J,Xu J,Yu Y,He Z,Pan X,Wei H,Zhu Y,Hu S,Cao J,Shen H,Que J,Wang W,Zhu Q,Chen L

更新日期：2020-02-03 00:00:00

abstract：:Background: To elucidate the expression of Aurora kinases (AURK) and the anticancer effects of pan-aurora kinase inhibitor Danusertib in hepatocarcinogenesis model in C56Bl6 mice. Methods: Thirty mice C56Bl6 were randomly divided into Group A or control, Group B animals who underwent experimental hepatocarcinogenesis ...

journal_title：Journal of Cancer

authors： Gavriilidis P,Poutahidis T,Giakoustidis A,Makedou K,Angelopoulou K,Hardas A,Andreani P,Zacharioudaki A,Saridis G,Gargavanis A,Louri E,Antoniadis N,Karampela E,Psychalakis N,Michalopoulos A,Papalois A,Iliadis S,Mudan S,

更新日期：2018-02-27 00:00:00

abstract：:Non epithelial ovarian tumors represent a small group of rare gynecological cancers but they have a high incidence in young childbearing women. The recent years fertility preservation surgeries have become a common practice in specific ovarian malignancies when the patients wish to maintain their fertility. Specific t...

journal_title：Journal of Cancer

authors： Thomakos N,Malakasis A,Machairiotis N,Zarogoulidis P,Rodolakis A

更新日期：2018-11-24 00:00:00

abstract：BACKGROUND:This study was performed to assess the impact of irradiation on the tissue penetration depth of doxorubicin delivered during Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC). METHODS:Fresh post mortem swine peritoneum was cut into 10 proportional sections. Except for 2 control samples, all received...

journal_title：Journal of Cancer

authors： Khosrawipour V,Giger-Pabst U,Khosrawipour T,Pour YH,Diaz-Carballo D,Förster E,Böse-Ribeiro H,Adamietz IA,Zieren J,Fakhrian K

更新日期：2016-05-07 00:00:00

abstract：:Objective: To investigate the development of bronchoscopy in China and compare it with its application in the early 21st century. Methods: The data collection was based on questionnaires. Three hundred and nineteen hospitals, which distributed across 30 provinces and 130 cities, were included in the study. Data about ...

journal_title：Journal of Cancer

authors： Shi D,Li F,Wang K,Kong C,Huang H,Li Q,Jin F,Hu C,Wang C,Shi H,Hu Z,Dong Y,Ning Y,Tsakiridis K,Sapalidis K,Kosmidis C,Vagionas A,Hohenforst-Schmidt W,Freitag L,Turner JF,Drevelegas K,Perdikouri EI,Kovacevic T,

更新日期：2020-07-20 00:00:00

abstract：:Endocrine resistance in hormone receptor positive breast cancer patients urges us to develop novel approaches such as inhibitors of the cyclin-dependent kinases (CDK) 4/6 to reverse its resistance. Nowadays, three selective CDK4/6 inhibitors (Palbociclib, Ribociclib and Abemaciclib) are approved by Federal Drug Admini...

journal_title：Journal of Cancer

authors： Chen X,Xu D,Li X,Zhang J,Xu W,Hou J,Zhang W,Tang J

更新日期：2019-10-21 00:00:00

abstract：:Levels of plasma cell-free DNA (cfDNA) of a large series of children with classical Hodgkin lymphoma (cHL) were evaluated and analyzed at diagnosis and during chemotherapy treatment in relation with clinical characteristics. CfDNA levels in cHL patients were significantly higher compared with controls (p=0.002). CfDNA...

journal_title：Journal of Cancer

authors： Primerano S,Burnelli R,Carraro E,Pillon M,Elia C,Farruggia P,Sala A,Vinti L,Buffardi S,Basso G,Mascarin M,Mussolin L

更新日期：2016-01-12 00:00:00

abstract：:Background: Malignant biliary and/or pancreatic obstruction has often encountered in the advanced stages of periampullary and cholangicarcinomas. HabibTM Radiofrequency (RF) ablation has been successfully used in the management of various cancers of liver and pancreas. Percutaneous HPB probe (EMcision Ltd, London, UK)...

journal_title：Journal of Cancer

authors： Mizandari M,Kumar J,Pai M,Chikovani T,Azrumelashvili T,Reccia I,Habib N

更新日期：2018-01-05 00:00:00

abstract：:Butyrate, a product of dietary fiber and a histone deacetylase inhibitor, induces apoptosis of colorectal cancer cells; this effect of butyrate is in part mediated by its ability to hyperactivate Wnt signaling, and may in part explain the preventive action of dietary fiber against colorectal cancer. However, the mecha...

journal_title：Journal of Cancer

authors： Bordonaro M

更新日期：2020-01-01 00:00:00

abstract：:Ovarian cancer, cervical cancer and endometrial cancer are three relatively common malignant cancers of the female reproductive system. Despite improvements in female genital tract cancer detection and development of new therapeutic approaches, there are still poor prognoses and some do not respond to therapeutic patt...

journal_title：Journal of Cancer

authors： Zhu DL,Tuo XM,Rong Y,Zhang K,Guo Y

更新日期：2020-10-21 00:00:00

abstract：:Objective: To measure hematologic parameters derived from the white blood cell (WBC) count and differential count (DC) as prognostic factors for survival in patients with stage IB and IIA cervical cancer. Methods: We retrospectively examined demographic, clinicopathologic, and laboratory parameters in a cohort of 233 ...

journal_title：Journal of Cancer

authors： Eo WK,Kwon BS,Kim KH,Kim HY,Kim HB,Koh SB,Chun S,Ji YI,Lee JY,Namkung J,Kwon S

更新日期：2018-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) cells exhibit multidrug resistance (MDR), but the underlying mechanisms remain unclear. Cancer cells that overexpress telomerase are resistant to chemotherapeutic drugs. This study aimed to determine the effects of mitochondrial translocation of telomerase on MDR in HCC cells. HepG2 cell...

journal_title：Journal of Cancer

authors： Yan J,Zhou Y,Chen D,Li L,Yang X,You Y,Ling X

更新日期：2015-01-05 00:00:00

abstract：:Objectives: LncRNA associated with microvascular invasion in hepatocellular carcinoma (lncRNA MVIH) is a newly discovered long non-coding RNA that aberrantly up-regulates and holds prognostic value in various tumors. The aim of the review and meta-analysis is to assess its prognostic potential and functions in maligna...

journal_title：Journal of Cancer

authors： Zhang Y,Lin S,Yang X,Zhang X

更新日期：2019-02-26 00:00:00

abstract：:Mechanistic target of rapamycin (mTOR) plays a critical role in the development of oral squamous cell carcinoma (OSCC), but the underlying mechanisms remain poorly understood. Here we have demonstrated that the expression of osteopontin (OPN) was dramatically up-regulated in OSCC tissues and cell lines. Moreover, redu...

journal_title：Journal of Cancer

authors： Gan N,Zou S,Hang W,Yang D,Zhang X,Yin Y

更新日期：2017-05-12 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been widely used to treat non-small cell lung cancer (NSCLC) because they inhibit tumour growth and metastasis. However, the underlying mechanisms are not fully understood. Here, we investigate whether anti-lymphangiogenesis mechanisms cont...

journal_title：Journal of Cancer

authors： Zhang Y,Yang X,Liu H,Cai M,Shentu Y

更新日期：2020-01-01 00:00:00

abstract：:Ovarian carcinoma is the most lethal gynecological malignancy worldwide. Recent advance in genomic/epigenomic researches will impact on our prevention, detection and intervention on ovarian carcinoma. Detection of germline mutations in BRCA1/BRCA2, mismatch repair genes, and other genes in the homologous recombination...

journal_title：Journal of Cancer

authors： Dong A,Lu Y,Lu B

更新日期：2016-07-05 00:00:00

abstract：:Objectives: Chordomas are slow-growing malignancies that commonly affect vital neurological structures. These neoplasms are highly resistant to current chemotherapeutic regimens and often recur after surgical intervention. Therefore, there is an urgent need to identify molecular targets and more robust drugs to improv...

journal_title：Journal of Cancer

authors： Shen S,Dean DC,Yu Z,Hornicek F,Kan Q,Duan Z

更新日期：2020-01-01 00:00:00

abstract：:Background: The predictive roles of secreted protein acidic and rich in cysteine (SPARC) in pancreatic ductal adenocarcinoma (PDAC) patients after curative resection have not been clarified. We investigated the correlations between the SPARC expression and the postoperative prognosis. Methods: We retrospectively analy...

journal_title：Journal of Cancer

authors： Murakawa M,Aoyama T,Miyagi Y,Kobayashi S,Ueno M,Morimoto M,Numata M,Yamamoto N,Tamagawa H,Yukawa N,Rino Y,Masuda M,Morinaga S

更新日期：2019-01-01 00:00:00

abstract：:Chemo- and radio-therapy suffer from certain well-recognized drawbacks for lymphoma therapy. Passive immunotherapy with monoclonal antibody has improved outcome for patients with CD20+ B cell lymphoma, but not for T cell lymphoma. Therefore, novel treatment approaches are clearly required for T cell lymphoma. To date,...

journal_title：Journal of Cancer

authors： Gao D,Li W,Wang W,Cai Y,Wang Y,Luo X,Wei CC

更新日期：2017-09-15 00:00:00