Anticancer Properties of Fenofibrate: A Repurposing Use.

abstract：:Objectives: For patients with multiple small-sized pulmonary cancers, a lobectomy can disrupt future therapeutic options for other lesions. It was recently reported that limited pulmonary resections were not inferior to lobectomy for the management of selected peripheral small-sized pulmonary adenocarcinomas. Patients...

journal_title：Journal of Cancer

authors： Nakagiri T,Nakayama T,Tokunaga T,Takenaka A,Kunoh H,Ishida H,Tomita Y,Nakatsuka SI,Nakamura H,Okami J,Higashiyama M

更新日期：2020-02-20 00:00:00

abstract：INTRODUCTION:Hürthle cell carcinoma (HCC) is a rare tumor that tends to metastasize to the lymph nodes. Some studies have correlated size of Hürthle cell tumors with the risk of malignancy. Whether the size of HCC correlates with the risk of lymph node (LN) metastases, to our knowledge has not been addressed. METHODS:...

journal_title：Journal of Cancer

authors： Guerrero MA,Suh I,Vriens MR,Shen WT,Gosnell J,Kebebew E,Duh QY,Clark OH

更新日期：2010-06-02 00:00:00

abstract：:Objective: Multiple reports have described the proportion of T-regulatory cells (Tregs) in peripheral blood (PB) and tissues in patients with gynecological cancers (GCs) with controversial results. Thus, the aim of this study was to investigate the proportion of Tregs and its prognostic survival role in GCs patients. ...

journal_title：Journal of Cancer

authors： Hu J,Wu X,Huang P,Teng F,Wang Y,Xue F

更新日期：2020-03-05 00:00:00

abstract：BACKGROUND:Statins are proposed as a chemoprevention agent for breast cancer due to their anti-inflammatory effect. The effects of lipophilic and hydrophilic statins on breast cancer risk might be different due to their different pharmacologic properties. Therefore, this study aimed to assess a casual-effect of lipophi...

journal_title：Journal of Cancer

authors： Anothaisintawee T,Udomsubpayakul U,McEvoy M,Lerdsitthichai P,Attia J,Thakkinstian A

更新日期：2016-06-06 00:00:00

abstract：:Background: HER2 serves as an important therapeutic target in gastroesophageal cancer. Differences in HER2 gene signal distribution patterns can be observed at the tissue level, but how it influences the HER2 amplification status has not been studied so far. Here, we investigated the link between HER2 amplification an...

journal_title：Journal of Cancer

authors： Jørgensen JT,Nielsen KB,Kjærsgaard G,Jepsen A,Mollerup J

更新日期：2017-06-01 00:00:00

abstract：:Various factors modulate the risk of hepatoblastoma. In this study, we aimed to investigate whether single nucleotide polymorphisms (SNPs) in the YTHDF1 gene could predispose to hepatoblastoma. We used TaqMan assay to genotype two YTHDF1 SNPs (rs6011668 C>T and rs6090311 A>G) in a Chinese population composed of 313 su...

journal_title：Journal of Cancer

authors： Luo Z,Li G,Wang M,Zhu J,Yang Z,Li Y,Zhang J,Xin Y,Li S,Li L,Zhuo Z,He J

更新日期：2020-06-28 00:00:00

abstract：:Aims: We previously demonstrated that a loss of lean body mass loss at one month after gastrectomy was an independent risk factor for the continuation of adjuvant chemotherapy with S-1. However, it is unclear whether or not lean body mass loss after gastrectomy leads to a poor survival through poor compliance to adjuv...

journal_title：Journal of Cancer

authors： Aoyama T,Yoshikawa T,Maezawa Y,Kano K,Numata M,Hara K,Komori K,Yamada T,Hayashi T,Sato T,Tamagawa H,Yukawa N,Rino Y,Masuda M,Ogata T,Cho H,Oshima T

更新日期：2019-05-28 00:00:00

abstract：:Purpose: The aberrant of fibroblast growth factors and their receptors (FGF/FGFR) is an emerging target in the treatment of solid tumors. This study aimed to explore the landscape of FGF/FGFR alterations in a large cohort of cancer patients. Material and Methods: The formalin-fixed paraffin-embedded specimens of cance...

journal_title：Journal of Cancer

authors： Zuo W,He Y,Li W,Wu H,Zhao Z,Zhang Y,Chen S,Yin Y

更新日期：2020-09-23 00:00:00

abstract：:Endometrial carcinoma (EC) is the most common malignant tumors in female derived from the endometrial epithelium. Several previous studies have described estrogen receptors (ER), progesterone Receptor (PR) and phosphatase and tensin homolog (PTEN) are associated with clinicopathological factors and prognosis in EC pat...

journal_title：Journal of Cancer

authors： Liang Y,Lin B,Ye Z,Chen S,Yu H,Chen C,Zhang X,Zhou K,Zeng J

更新日期：2020-01-13 00:00:00

abstract：:Objective: This study aimed to evaluate the therapeutic response of hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) with diffusion kurtosis imaging (DKI). Methods: Forty-three patients with fifty-nine hepatic cancer nodules were recruited for this study. All patients were treated b...

journal_title：Journal of Cancer

authors： Yuan ZG,Wang ZY,Xia MY,Li FZ,Li Y,Shen Z,Wang XZ

更新日期：2020-02-10 00:00:00

abstract：:The authors retrospectively examined the contralateral prophylactic mastectomy (CPM) rate among 100 women with ductal carcinoma in situ who are BRCA negative. Of 100 women with ductal carcinoma in situ, 31 elected contralateral prophylactic mastectomy (CPM). Factors associated with increased likelihood of undergoing c...

journal_title：Journal of Cancer

authors： Elsayegh N,Profato J,Barrera AM,Lin H,Kuerer HM,Ardic C,Litton JK,Tripathy D,Arun BK

更新日期：2015-05-23 00:00:00

abstract：:Background: To identify associated risk factors and develop a predictive nomogram for the early death of metastatic gastric cancer patients. Methods: A total of 4575 patients in the SEER cohort and 220 patients in the Chinese cohort diagnosed with metastatic gastric cancer in our Cancer Center were obtained. Univariat...

journal_title：Journal of Cancer

authors： Zhu Y,Fang X,Wang L,Zhang T,Yu D

更新日期：2020-07-14 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the sixth most common cancer, and the third most common cause of cancer related death worldwide. The multi-kinase inhibitor Sorafenib represents the only systemic treatment option until today, and results from clinical trials with allosteric mTOR inhibitors were sobering. Since the PI...

journal_title：Journal of Cancer

authors： Ewald F,Nörz D,Grottke A,Bach J,Herzberger C,Hofmann BT,Nashan B,Jücker M

更新日期：2015-09-16 00:00:00

abstract：:Circular RNAs (circRNAs), as a type of tissue specific RNA with more stable structure than linear RNAs, was poorly understood on its correlation with gastric cancer (GC). In this review, we outline the synthesis and characteristics of circRNAs and generalize their categories and functions. Through comprehensive analys...

journal_title：Journal of Cancer

authors： Fang X,Wen J,Sun M,Yuan Y,Xu Q

更新日期：2019-10-15 00:00:00

abstract：:Purpose: This study aimed to comprehensively investigate the differential expression and prognostic indicators of the tripartite motif-containing (TRIM) gene family in non-small cell lung cancer (NSCLC). Methods: The Cancer Genome Atlas (TCGA) Research Network and three datasets from Gene Expression Omnibus (GEO) data...

journal_title：Journal of Cancer

authors： Han X,Huang C,Qu X,Liu S,Yang X,Wang Y,Bie F,Liu Q,Du J

更新日期：2019-01-29 00:00:00

abstract：:Background: miRNAs dysregulate in hepatocellular carcinoma (HCC), showing promise for diagnostic biomarkers which may be found through exploration of differentially expressed miRNAs when comparing HCC and normal liver tissues. Materials and Methods: In the present research, candidate miRNAs were selected and verified ...

journal_title：Journal of Cancer

authors： Ji J,Chen H,Liu XP,Wang YH,Luo CL,Zhang WW,Xie W,Wang FB

更新日期：2018-09-08 00:00:00

abstract：:Taking into account the previously reported relationship between inflammation and carcinogenesis, and the scant amount of data concerning the role of neutrophil extracellular traps (NETs) in carcinogenesis, we decided to study the process of extracellular trap formation in patients with inflammation as well as in pati...

journal_title：Journal of Cancer

authors： Garley M,Dziemiańczyk-Pakieła D,Grubczak K,Surażyński A,Dąbrowska D,Ratajczak-Wrona W,Sawicka-Powierza J,Borys J,Moniuszko M,Pałka JA,Jabłońska E

更新日期：2018-04-30 00:00:00

abstract：PURPOSE:To evaluate acute hypersensitivity reactions at the UCSD Moores Cancer Center in San Diego, compare our findings to those reported previously in the literature, and examine the effectiveness of the objective grading scale as represented by the Common Terminology Criteria for Adverse Events (CTCAE). PATIENTS AN...

journal_title：Journal of Cancer

authors： Demoor PA,Matusov Y,Kelly C,Kolan S,Barnachea L,Bazhenova LA

更新日期：2011-03-10 00:00:00

abstract：:Background: We previously demonstrated that Proline rich 11 (PRR11) gene is associated with the development and progression of tongue squamous cell carcinoma (TSCC), but the underlying mechanism is unknown. This study aimed to investigate the molecular mechanism underlying oncogenic potential of PRR11 in TSCC cells. M...

journal_title：Journal of Cancer

authors： Wang C,Yu L,Ren X,Wu T,Chen X,Huang Y,Cheng B

更新日期：2019-06-02 00:00:00

abstract：:Ovarian cancer is a highly lethal malignancy in the female reproductive system. Platinum drugs, represented by cisplatin, are the first-line chemotherapeutic agents for treatment of various malignancies including ovarian cancer, but drug resistance leads to chemotherapy failure. MicroRNAs emerged as promising molecule...

journal_title：Journal of Cancer

authors： Xiang Y,Chen YJ,Yan YB,Liu Y,Qiu J,Tan RQ,Tian Q,Guan L,Niu SS,Xin HW

更新日期：2020-03-13 00:00:00

abstract：:Ever since its discovery (1924) the Warburg effect (aerobic glycolysis) remains an unresolved puzzle: why the aggressive cancer cells "prefer" to use the energetically highly inefficient method of burning the glucose at the cellular level? While in the course of the last 90 years several hypotheses have been suggested...

journal_title：Journal of Cancer

authors： Devic S

更新日期：2016-04-26 00:00:00

abstract：:Background: Neoadjuvant chemoradiation (CRT) remains controversial in the treatment of the oesophagus or gastro-oesophageal junction (GOJ) carcinomas. Methods: We conducted a meta-analysis to assess the efficacy and safety of Neoadjuvant CRT plus surgery comparing with neoadjuvant CT plus surgery or surgery alone. Fea...

journal_title：Journal of Cancer

authors： Meng X,Wang L,Zhao Y,Zhu B,Sun T,Zhang T,Gu X,Zheng Z

更新日期：2019-01-01 00:00:00

abstract：:Lung cancer is a major cause of death worldwide, with lung adenocarcinoma being the most frequently diagnosed subtype in Japan. Finding the target of an anticancer drug can improve lung adenocarcinoma treatments. Polo-like kinase 1 (PLK1) is an essential mitotic kinase in mitotic progression, and PLK1 inhibition induc...

journal_title：Journal of Cancer

authors： Sekimoto N,Suzuki Y,Sugano S

更新日期：2017-11-06 00:00:00

abstract：:Objective: To measure hematologic parameters derived from the white blood cell (WBC) count and differential count (DC) as prognostic factors for survival in patients with stage IB and IIA cervical cancer. Methods: We retrospectively examined demographic, clinicopathologic, and laboratory parameters in a cohort of 233 ...

journal_title：Journal of Cancer

authors： Eo WK,Kwon BS,Kim KH,Kim HY,Kim HB,Koh SB,Chun S,Ji YI,Lee JY,Namkung J,Kwon S

更新日期：2018-01-01 00:00:00

abstract：:Lung cancer is the most common malignancy in China and is associated with a poor survival rate amongst Han Chinese. The high mortality is largely attributed to late-stage diagnosis, when treatment is largely ineffective. Identification of genetic variants could potentially assist with earlier diagnosis and thus more e...

journal_title：Journal of Cancer

authors： Hu W,Tang CH,Chen HT,Zhao J,Jin L,Kang L,Wu Y,Ying P,Wang CQ,Su CM

更新日期：2019-06-02 00:00:00

abstract：:Recent studies indicated that long noncoding RNAs (lncRNAs) played important regulatory roles in carcinogenesis and cancer progression. However, the contribution of small nucleolar RNA host gene 20 (SNHG20) to cancer development remains largely unknown. The aim of the study is to investigate the expression of SNHG20 a...

journal_title：Journal of Cancer

authors： Zhang D,Cao C,Liu L,Wu D

更新日期：2016-03-19 00:00:00

abstract：:Background: The purpose of this study was to examine and compare the prognostic value of different immunization-based scoring systems in patients with soft tissue sarcoma (STS). Methods: We conducted a retrospective study evaluating a cohort of 165 patients diagnosed with STS between July 2007 and July 2014. The relat...

journal_title：Journal of Cancer

authors： Jiang SS,Jiang L,Weng DS,Li YF,Pan QZ,Zhao JJ,Tang Y,Zhou ZW,Xia JC

更新日期：2017-02-25 00:00:00

abstract：:The use of polyADPribose polymerase inhibitors in cancer treatment provides a unique opportunity to target DNA repair processes in cancer cells while leaving normal tissue intact. The PARP-1 enzyme repairs DNA single strand breaks (SSB). Therefore PARP-1 inhibition in BRCA1 negative cancers results in the formation of...

journal_title：Journal of Cancer

authors： Bourton EC,Ahorner PA,Plowman PN,Zahir SA,Al-Ali H,Parris CN

更新日期：2017-10-23 00:00:00

abstract：:Aims: To compare the long-term prognosis of younger and elderly patients with combined hepatocellular-cholangiocarcinoma (CHC) who underwent curative resection between 1993 and 2014 at our center. Methods: Two hundred and thirteen patients who underwent liver resection for CHC were enrolled in our study. The overall s...

journal_title：Journal of Cancer

authors： Tao CY,Liu WR,Jin L,Tang Z,Tian MX,Jiang XF,Wang H,Zhou PY,Fang Y,Ding ZB,Peng YF,Dai Z,Qiu SJ,Zhou J,Fan J,Shi YH

更新日期：2018-02-28 00:00:00

abstract：:The process of neoplastic transformation of the colon involves a progression through hyperproliferative epithelium through the aberrant crypt foci→small adenoma→large adenoma→invasive cancer→metastatic disease. These are orchestrated by sequential genetic and epigenetic events which provide the underpinnings of cellul...

journal_title：Journal of Cancer

authors： Backman V,Roy HK

更新日期：2013-01-01 00:00:00