Abstract:
:Background: Neoadjuvant chemoradiation (CRT) remains controversial in the treatment of the oesophagus or gastro-oesophageal junction (GOJ) carcinomas. Methods: We conducted a meta-analysis to assess the efficacy and safety of Neoadjuvant CRT plus surgery comparing with neoadjuvant CT plus surgery or surgery alone. Feasible studies were searched from electronic databases. The outcomes of survival, R0 resection rate and adverse effects were analyzed. The outcomes were measured with relative risk (RR) and odds ratio(OR). Results: Seventeen records including 4095 patients were included. Neoadjuvant CRT improved 1-,2-,3-and 5-year survival. The relative risk (RR) [95% confidence interval (CI),P value] was respectively 1.08(1.03-1.14,0.002), 1.21(1.12-1.32,<0.00001),1.31(1.09-1.58,0.004),1.38(1.17-1.62, <0.001).In subgroup analysis, patients with squamous cell carcinoma benefited more survival advantage from neoadjuvant CRT than those with adenocarcinoma[1.23(1.15-1.33)vs1.11 (1.03-1.19)]. A significant advantage was observed in analysis of neoadjuvant CRT for PFS [1.32 (1.22-1.44),<0.00001]. Tests for DFS between neoadjuvant CRT and neoadjuvant CT or surgery alone were not statistically significant[1.06 (0.97-1.17,0.19)]. Neoadjuvant CRT was associated with higher R0 resection [2.58(1.75-3.82),<0.00001] and pCR rate [4.37(2.68-7.13),<0.00001]. Neoadjuvant CRT lowered the local recurrence rate [0.52(0.39-0.69),<0.00001] and didn't control distant metastasis rate[0.85(0.67-1.08),0.19].There was no evidence that neoadjuvant CRT increased the treatment-related mortality[1.27(0.95-1.71),0.11]. Neoadjuvant CRT plus surgery did not increase the risk of adverse events morbidity[1.14(0.99-1.32),0.08]. Conclusion: Patients with oesophagus or GOJ carcinomas can obtain a survival advantage from neoadjuvant CRT. The addition of radiation was efficacy and safe in range. However, these results need further high-quality prospective RCTs confirmation.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Meng X,Wang L,Zhao Y,Zhu B,Sun T,Zhang T,Gu X,Zheng Zdoi
10.7150/jca.25915subject
Has Abstractpub_date
2019-01-01 00:00:00pages
192-204issue
1issn
1837-9664pii
jcav10p0192journal_volume
10pub_type
杂志文章abstract::Background: The effect of adjuvant chemotherapy on stage II colon cancer remains constantly controversial. Recently, however, several studies have reported the definite survival benefit of adjuvant chemotherapy (ACT) in T4 disease (stage IIB and IIC) among stage II colon cancer patients. The following study investigat...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.28917
更新日期:2019-01-29 00:00:00
abstract::Hepatocellular Carcinoma is a major healthcare problem, representing the third most common cause of cancer-related mortality worldwide. There are 130 million Hepatitis C virus infected patients worldwide who are at a high-risk for developing Hepatocellular Carcinoma. Due to the fact that reliable parameters and/or too...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.4280
更新日期:2012-01-01 00:00:00
abstract::Cisplatin-based chemotherapy is the foundation of treatment for major non-small cell lung cancer (NSCLC) patients. However, cisplatin resistance is still a challenging issue, and the molecular mechanisms underlying this resistance remain to be fully explored. CLEC4M, a Ca2+-dependent C-type lectin, has recently been f...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.30139
更新日期:2019-10-19 00:00:00
abstract::Cellular compartmentalization of biochemical processes in eukaryotic cells is critical for many functions including shuttling of reducing equivalents across membranes. Although coordination of metabolic flux between different organelles is vital for cell physiology, its impact on tumor cell survival is not well unders...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19373
更新日期:2017-07-05 00:00:00
abstract::Background: Immunotherapy including immune checkpoint blockade, cancer vaccines, and adoptive cell therapy. However, no immune therapies support ovarian cancer. It is not clear whether the neutrophils, the component of the immune system derived from umbilical cord blood play a role in inhibiting the progression of ova...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.41035
更新日期:2020-05-18 00:00:00
abstract::Background: Epithelioid trophoblastic tumors (ETTs) are the rarest type of gestational trophoblastic neoplasias. We investigated the clinical features, treatments, outcomes, and prognostic factors in patients with ETT, and explored potential therapeutic targets. Methods: We retrospectively analyzed the clinical featur...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.28134
更新日期:2019-01-01 00:00:00
abstract::Objective: Both previous and recent literature showed long non-coding RNAs (lncRNAs) were crucial participants in multiple myeloma (MM) evolution. However, the dynamic regulation and mechanism of lncRNAs in MM progression was not fully understood. This study will explore the expression and effects of prostate cancer-a...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.35098
更新日期:2019-10-20 00:00:00
abstract::Globally, prostate cancer is the third most common cancer in the world, and the second most common cancer in men. However, rates for incidence and mortality vary considerably with race, ethnicity, and geography. Over 97 significantly mutated genes that have been identified in prostate cancer; however, a lack of genomi...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.48433
更新日期:2021-01-01 00:00:00
abstract::Background: The programmed death 1 (PD1)/programmed death ligand 1 (PDL1) targeted therapies have gained positive outcomes in several tumors, but the evidence of the expression and prognosis value of PD1/PDL1 in high risk prostate cancer was rare. Methods: Immunohistochemical analysis of PDL1/PD1 expression by a valid...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.30384
更新日期:2019-06-02 00:00:00
abstract::Aim: BAP1 is frequently mutated in clear cell renal cell carcinoma (ccRCC) with a definitive role still unclear. Methods: In silico analysis of BAP1-mutant and wild-type gene enrichment and functional annotation in TCGA-KIRC dataset was performed. Target gene was studied based on functional clustering and was knowledg...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26275
更新日期:2018-10-01 00:00:00
abstract::Background: Immune cells recognize tumor antigens presented on major histocompatibility complex class I (MHC-I) molecule. Increase of MHC-I molecular expression makes tumor cells more susceptible to lysis by immune cells. Methods: Tumor lysate vaccine was prepared to damage glioma cells including cell lines and primar...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.34471
更新日期:2019-09-07 00:00:00
abstract::Endocrine resistance in hormone receptor positive breast cancer patients urges us to develop novel approaches such as inhibitors of the cyclin-dependent kinases (CDK) 4/6 to reverse its resistance. Nowadays, three selective CDK4/6 inhibitors (Palbociclib, Ribociclib and Abemaciclib) are approved by Federal Drug Admini...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.33079
更新日期:2019-10-21 00:00:00
abstract::Transarterial chemoembolization (TACE) has been considered the standard treatment for intermediate-stage hepatocellular carcinoma according to BCLC algorithm. However, it has been unclear about the TACE-related predictive bio-markers and underlying molecular mechanisms. This investigation revealed that HCCs with highe...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.35631
更新日期:2020-01-01 00:00:00
abstract::Objectives: Platinum-based chemotherapy is first-line treatment for non-small cell lung cancer (NSCLC) patients. The efficacy is limited by drug resistance. Recent studies suggest that ATP7B, a copper efflux transporter, may be involved in platinum resistance. However, the clinical significance of ATP7B expression in ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26286
更新日期:2018-09-08 00:00:00
abstract::Macrophages play a critical role in the initiation and progression in various human solid tumors; however, their role and transformation in pancreatic ductal adenocarcinoma (PDAC) were still illusive. Here, immunohistochemistry was used to determine CD206 (specific marker of M2 macrophage) and PKM2 expression in PDAC ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.38981
更新日期:2020-02-03 00:00:00
abstract::Background/Purpose: In colon cancer (CC) patients preoperative (pre-op) levels of VEGF-A165 (VEGF) is a strong predictor for disease recurrence. Elevated postoperative (post-op) VEGF levels could have undesirable effects by enhancing tumor growth and metastasis formation. It has been suggested that thromboprophylaxis ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.20107
更新日期:2017-08-25 00:00:00
abstract::Aims: To compare the long-term prognosis of younger and elderly patients with combined hepatocellular-cholangiocarcinoma (CHC) who underwent curative resection between 1993 and 2014 at our center. Methods: Two hundred and thirteen patients who underwent liver resection for CHC were enrolled in our study. The overall s...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.23921
更新日期:2018-02-28 00:00:00
abstract::In this short communication we report a quick, cost-free method of purification of DNA fragments from agarose gel. Unlike those procedures that involve commercial kits, this method uses glass wool or absorbent cotton to filter agarose gel during a quick spinning-down of DNA, thus significantly simplifying the routine ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.4163
更新日期:2012-01-01 00:00:00
abstract::Purpose: The present study aims to explore the potential mechanisms contributing to prostate cancer (PCa), screen the hub genes, and identify potential biomarkers and correlated pathways of PCa progression. Methods: The PCa gene expression profile GSE3325 was operated to analyze the differentially expressed genes (DEG...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29571
更新日期:2019-02-23 00:00:00
abstract::Colorectal cancer (CRC) is the fifth leading cause of cancer-related death in China. The incidence of Chinese CRC has increased dramatically with the changes of dietary and lifestyle. However, the genetic landscape of Chinese colorectal cancer mutation is still poorly understood. In this study, we have performed whole...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.37017
更新日期:2020-01-01 00:00:00
abstract::Objectives: PD-1 and PD-L1 overexpression in malignant tumors in response to radiotherapy is correlated with a poor prognosis. Human papilloma virus (HPV) infection impacts intrinsic radiosensitivity of head and neck cancers (HNCs). Herein, this study aims to determine PD-1/PD-L1 expression differences in tumors with ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.27199
更新日期:2019-01-29 00:00:00
abstract::Purpose Increasing evidences revealed that cancer cells with the characteristics of epithelial-mesenchymal transition (EMT) or cancer stem cells (CSC) have high ability of progression, invasion, metastasis and chemoresistance. TWIST1 and BMI1 are crucial transcription factors required for EMT and CSC. Both TWIST1 and ...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.14031
更新日期:2016-05-25 00:00:00
abstract::Philadelphia chromosome-positive (Ph+) leukemia is characterized by reciprocal translocation between chromosomes 9 and 22. The resultant BCR/ABL fusion protein displays constitutive tyrosine kinase activity, leading to the induction of aberrant proliferation and neoplastic transformation. The bone marrow (BM) microenv...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19633
更新日期:2017-10-23 00:00:00
abstract::Triple negative breast cancer (TNBC) is characterized by distinctive biological features that confer an aggressive clinical behavior. In TNBC patients, the absence of well-defined driver pathways such as hormonal receptor expression or hyperactivation of the human epidermal growth factor receptor 2 (HER2) significantl...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.35109
更新日期:2019-10-12 00:00:00
abstract::Background: Lung carcinoma is the leading cause of malignant tumor related mortality in China in recent decades, and the development of new and effective therapies for patients with advanced lung carcinoma is needed. We recently found that fluorofenidone (FD), a newly developed pyridine compound, reduced the activatio...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18040
更新日期:2017-07-04 00:00:00
abstract::Background: Colorectal cancer (CRC) remains to be one of the most common malignancies worldwide. Various studies have demonstrated that microRNAs (miRs) play a critical role in regulating cancer progression and sensitivity to chemoradiotherapy. miR-1 was found to be aberrantly expressed in CRC. However, it has not bee...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.44753
更新日期:2020-06-07 00:00:00
abstract::Early detection and accurate evaluation were both critical to improving the prognosis of clear cell Renal Cell Carcinoma (ccRCC) patients. More importantly, RNA Binding Proteins (RBPs) play a vital role in the tumorigenesis and progression of numerous cancers. However, the relationship between RBPs and ccRCC is still ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.49175
更新日期:2020-09-23 00:00:00
abstract::Aims: We previously demonstrated that a loss of lean body mass loss at one month after gastrectomy was an independent risk factor for the continuation of adjuvant chemotherapy with S-1. However, it is unclear whether or not lean body mass loss after gastrectomy leads to a poor survival through poor compliance to adjuv...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.30697
更新日期:2019-05-28 00:00:00
abstract::Oncogenic activation of the ETS Related Gene (ERG) in humans was originally identified in subsets of Ewing sarcomas, myeloid leukemias and, recently, in the majority of prostate cancers. Expression of human ERG protein and consequently its functions in normal and disease states needs to be better understood in light o...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.1.197
更新日期:2010-10-25 00:00:00
abstract::Background: Carbonic anhydrase 4 (CA4) maintains homeostasis of carbon dioxide and bicarbonate. It is suggested to be a potential prognostic biomarker, while the correlations between CA4 and different cancers are indistinct. Methods: Differential mRNA expression of CA4 among different cancers and corresponding normal ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.46902
更新日期:2020-08-25 00:00:00