Neoadjuvant Chemoradiation Treatment for Resectable Esophago-Gastric Cancer: A Systematic Review and Meta-Analysis.

Abstract:

:Background: Neoadjuvant chemoradiation (CRT) remains controversial in the treatment of the oesophagus or gastro-oesophageal junction (GOJ) carcinomas. Methods: We conducted a meta-analysis to assess the efficacy and safety of Neoadjuvant CRT plus surgery comparing with neoadjuvant CT plus surgery or surgery alone. Feasible studies were searched from electronic databases. The outcomes of survival, R0 resection rate and adverse effects were analyzed. The outcomes were measured with relative risk (RR) and odds ratio(OR). Results: Seventeen records including 4095 patients were included. Neoadjuvant CRT improved 1-,2-,3-and 5-year survival. The relative risk (RR) [95% confidence interval (CI),P value] was respectively 1.08(1.03-1.14,0.002), 1.21(1.12-1.32,<0.00001),1.31(1.09-1.58,0.004),1.38(1.17-1.62, <0.001).In subgroup analysis, patients with squamous cell carcinoma benefited more survival advantage from neoadjuvant CRT than those with adenocarcinoma[1.23(1.15-1.33)vs1.11 (1.03-1.19)]. A significant advantage was observed in analysis of neoadjuvant CRT for PFS [1.32 (1.22-1.44),<0.00001]. Tests for DFS between neoadjuvant CRT and neoadjuvant CT or surgery alone were not statistically significant[1.06 (0.97-1.17,0.19)]. Neoadjuvant CRT was associated with higher R0 resection [2.58(1.75-3.82),<0.00001] and pCR rate [4.37(2.68-7.13),<0.00001]. Neoadjuvant CRT lowered the local recurrence rate [0.52(0.39-0.69),<0.00001] and didn't control distant metastasis rate[0.85(0.67-1.08),0.19].There was no evidence that neoadjuvant CRT increased the treatment-related mortality[1.27(0.95-1.71),0.11]. Neoadjuvant CRT plus surgery did not increase the risk of adverse events morbidity[1.14(0.99-1.32),0.08]. Conclusion: Patients with oesophagus or GOJ carcinomas can obtain a survival advantage from neoadjuvant CRT. The addition of radiation was efficacy and safe in range. However, these results need further high-quality prospective RCTs confirmation.

journal_name

J Cancer

journal_title

Journal of Cancer

authors

Meng X,Wang L,Zhao Y,Zhu B,Sun T,Zhang T,Gu X,Zheng Z

doi

10.7150/jca.25915

subject

Has Abstract

pub_date

2019-01-01 00:00:00

pages

192-204

issue

1

issn

1837-9664

pii

jcav10p0192

journal_volume

10

pub_type

杂志文章
  • Association of Body Mass Index Changes during Neoadjuvant Chemotherapy with Pathologic Complete Response and Clinical Outcomes in Patients with Locally Advanced Breast Cancer.

    abstract::The purpose of this study was to determine the association between body mass index (BMI) measurements (baseline BMI and changes in BMI during neoadjuvant systemic treatment [NST]) and clinical efficacy (pathologic complete response [pCR] rate and survival outcomes) in locally advanced breast cancer (LABC). We hypothes...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.10580

    authors: Kogawa T,Fouad TM,Wei C,Masuda H,Kai K,Fujii T,El-Zein R,Chavez-MacGregor M,Litton JK,Brewster A,Alvarez RH,Hortobagyi GN,Valero V,Theriault R,Ueno NT

    更新日期:2015-01-22 00:00:00

  • Risk Prediction for Early Mortality in Patients with Newly Diagnosed Primary CNS Lymphoma.

    abstract::Background: Overall survival of patients with primary CNS lymphoma (PCNSL) has improved since the introduction of immunochemotherapy. However, up to 10-15% of PCNSL patients still die shortly after diagnosis. In the present study, we aimed to investigate the risk factors of early mortality (death within 60 days after ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.32467

    authors: Lin CH,Yang CF,Yang HC,Fay LY,Yeh CM,Kuan AS,Wang HY,Gau JP,Hsiao LT,Chiou TJ,Chen PM,Liu YC,Ko PS,Liu JH,Liu CJ

    更新日期:2019-07-05 00:00:00

  • Biological functions and prognostic value of RNA Binding Proteins in clear cell Renal Cell Carcinoma.

    abstract::Early detection and accurate evaluation were both critical to improving the prognosis of clear cell Renal Cell Carcinoma (ccRCC) patients. More importantly, RNA Binding Proteins (RBPs) play a vital role in the tumorigenesis and progression of numerous cancers. However, the relationship between RBPs and ccRCC is still ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.49175

    authors: Zhu Z,He A,Lin L,Xu C,Cai T,Lin J

    更新日期:2020-09-23 00:00:00

  • Diagnostic and prognostic biomarkers of Human Leukocyte Antigen complex for hepatitis B virus-related hepatocellular carcinoma.

    abstract::Background: Hepatitis B virus infection had been identified its relationship with liver diseases, including liver tumors. We aimed to explore diagnostic and prognostic values between the Human Leukocyte Antigen (HLA) complex and hepatocellular carcinoma (HCC). Methods: We used the GSE14520 dataset to explore diagnosti...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.29655

    authors: Wang XK,Liao XW,Yang CK,Yu TD,Liu ZQ,Gong YZ,Huang KT,Zeng XM,Han CY,Zhu GZ,Qin W,Peng T

    更新日期:2019-08-28 00:00:00

  • A novel seven-gene signature as Prognostic Biomarker in Hepatocellular Carcinoma.

    abstract:PURPOSE:Our study is designed to develop and certify a promising prognostic signature for hepatocellular carcinoma (HCC). Materials and methods: We retrospectively analyzed mRNA expression profiles and clinicopathological data fetched from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. We fo...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.44573

    authors: Xie H,Liu S,Zhang Z,Chen P,Tao Y

    更新日期:2020-07-31 00:00:00

  • Survival Benefit of Preoperative Versus Postoperative Radiotherapy in Metastatic Rectal Cancer Treated With Definitive Surgical Resection of Primary Tumor: A Population Based, Propensity Score-Matched Study.

    abstract::Preoperative chemoradiation followed by surgery has been recommended as a standard treatment for patients with stage II/III rectal cancer. However, the optimal sequencing of radiotherapy for metastatic rectal cancer remains unclear. Between 2004 and 2014, patients diagnosed with metastatic rectal cancer who underwent ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.28320

    authors: Luo D,Liu Q,Zhu J,Ma Y,Cai S,Li Q,Li X

    更新日期:2019-01-30 00:00:00

  • Hedgehog signaling pathway regulates ovarian cancer invasion and migration via adhesion molecule CD24.

    abstract::Hedgehog (Hh) signalling plays an important role in cancer; however, its mechanism in ovarian cancer migration and invasion remains unclear. In the present study, we aimed to clarify the effect of the Hh signalling pathway on ovarian cancer migration and invasion through the regulation of CD24 expression, both in vitr...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.17712

    authors: Zeng C,Chen T,Zhang Y,Chen Q

    更新日期:2017-02-25 00:00:00

  • MCMs expression in lung cancer: implication of prognostic significance.

    abstract::Minichromosome Maintenance (MCM) proteins play essential roles in various cancers. We previously reported that MCM7 could be a prognostic biomarker in non-small cell lung cancer (NSCLC). The purpose of current study is to explore roles of other MCM proteins in NSCLC and their correlation with clinico-pathologic parame...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.20777

    authors: Liu YZ,Wang BS,Jiang YY,Cao J,Hao JJ,Zhang Y,Xu X,Cai Y,Wang MR

    更新日期:2017-10-09 00:00:00

  • Ectopic Expression of Snail and Twist in Ph+ Leukemia Cells Upregulates CD44 Expression and Alters Their Differentiation Potential.

    abstract::Philadelphia chromosome-positive (Ph+) leukemia is characterized by reciprocal translocation between chromosomes 9 and 22. The resultant BCR/ABL fusion protein displays constitutive tyrosine kinase activity, leading to the induction of aberrant proliferation and neoplastic transformation. The bone marrow (BM) microenv...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.19633

    authors: Kidan N,Khamaisie H,Ruimi N,Roitman S,Eshel E,Dally N,Ruthardt M,Mahajna J

    更新日期:2017-10-23 00:00:00

  • A New and Safe Mode of Ventilation for Interventional Pulmonary Medicine: The Ease of Nasal Superimposed High Frequency Jet Ventilation.

    abstract::We use pulmonary interventional procedures for the diagnosis of pulmonary diseases either for benign or malignant lesions. Flexible bronchoscopy with or without radial endobronchial ultrasound, convex-probe endobronchial ultrasound and electromagnetic navigation are procedures performed in centers with experience in d...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.23737

    authors: Hohenforst-Schmidt W,Zarogoulidis P,Huang H,Man YG,Laskou S,Koulouris C,Giannakidis D,Mantalobas S,Florou MC,Amaniti A,Steinheimer M,Sinha A,Freitag L,Turner JF,Browning R,Vogl T,Roman A,Benhassen N,Kesisoglou I,Sap

    更新日期:2018-02-12 00:00:00

  • VEGFR-2 Inhibitor Apatinib Hinders Endothelial Cells Progression Triggered by Irradiated Gastric Cancer Cells-derived Exosomes.

    abstract::Background: Radiotherapy is a standard treatment for a significant fraction of cancer patients. Nonetheless, to this day radiation resistance is a key impediment in gastric cancer (GC) treatment. Moreover, GC is characterized by its substantial neo-angiogenesis, driven by high levels of vascular endothelial growth fac...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.25370

    authors: Li G,Lin H,Tian R,Zhao P,Huang Y,Pang X,Zhao L,Cao B

    更新日期:2018-10-18 00:00:00

  • CD68- and CD163-positive tumor infiltrating macrophages in non-metastatic breast cancer: a retrospective study and meta-analysis.

    abstract::Studies have indicated the significance of tumor associated macrophages (TAMs) in breast cancer; however, inconsistent results still exist. We retrospectively reviewed the macrophage distribution in 1579 breast cancer specimens with anti-CD68 or anti-CD163 immunohistochemical staining, and further analyzed the overall...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.33914

    authors: Ni C,Yang L,Xu Q,Yuan H,Wang W,Xia W,Gong D,Zhang W,Yu K

    更新日期:2019-07-23 00:00:00

  • Chloroma/Granulocytic sarcoma: abdominal & pelvic presentation of acute myelogenous leukemia.

    abstract::There is limited literature documenting granulocytic sarcoma of the colon. We report a case of a 28 year-old female with a colonic granulocystic sarcoma of the colon as a complication of AML, as it is an important consideration with surgical management of typhilitis. ...

    journal_title:Journal of Cancer

    pub_type:

    doi:10.7150/jca.1.98

    authors: Tsikitis VL,Corning C,Henderson J,Rose J

    更新日期:2010-07-14 00:00:00

  • MiR-182 Is Associated with Growth, Migration and Invasion in Prostate Cancer via Suppression of FOXO1.

    abstract:BACKGROUND:MicroRNA (miRNA) have been shown to regulate gene expression in many cancers. MiR-182 has recently been found to be prognostic for patients treated with radical prostatectomy for prostate cancer. We sought to assess miR-182 as a prognostic marker and understand its role in prostate cancer progression and met...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.13176

    authors: Wallis CJ,Gordanpour A,Bendavid JS,Sugar L,Nam RK,Seth A

    更新日期:2015-10-25 00:00:00

  • Myeloid-derived suppressor cells interact with tumors in terms of myelopoiesis, tumorigenesis and immunosuppression: thick as thieves.

    abstract::Tumor progression is often associated with chronic inflammation in the tumor microenvironment, which is mediated by numerous cytokines, chemokines and growth factors produced by cancer and stroma cells. All these mediators support tumor development and immunosuppression in autocrine and/or paracrine ways. Neutralizati...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.5047

    authors: Sevko A,Umansky V

    更新日期:2013-01-01 00:00:00

  • Anti-inflammatory and Antitumor Activity of a Triple Therapy for a Colitis-Related Colorectal Cancer.

    abstract::Colorectal cancer (CRC) is an important health issue worldwide, accounting for the third place of cancer incidence. Chronic inflammation, as seen in Crohn's disease and ulcerative colitis, is the most important risk factor for developing CRC, as it favours neoplastic transformation by enhancing epithelial cell turnove...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.13123

    authors: Figueroa-González G,García-Castillo V,Coronel-Hernández J,López-Urrutia E,León-Cabrera S,Arias-Romero LE,Terrazas LI,Rodríguez-Sosa M,Campos-Parra AD,Zúñiga-Calzada E,Lopez-Camarillo C,Morales-González F,Jacobo-Herrera NJ,Pérez

    更新日期:2016-07-25 00:00:00

  • Antitumor Activity of TAK-285, an Investigational, Non-Pgp Substrate HER2/EGFR Kinase Inhibitor, in Cultured Tumor Cells, Mouse and Rat Xenograft Tumors, and in an HER2-Positive Brain Metastasis Model.

    abstract::Breast cancer therapy has improved following the development of drugs with specific molecular targets, exemplified by inhibitors of human epidermal growth factor receptor-2 (HER2) or epidermal growth factor receptor (EGFR) such as trastuzumab and lapatinib. However, these drugs have little effect on brain metastasis d...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.6689

    authors: Nakayama A,Takagi S,Yusa T,Yaguchi M,Hayashi A,Tamura T,Kawakita Y,Ishikawa T,Ohta Y

    更新日期:2013-08-16 00:00:00

  • Pulmonary Tuberculosis is Associated with Elevated Risk of Lung cancer in Korea: The Nationwide Cohort Study.

    abstract::Objective: Although previous studies suggest that previous pulmonary tuberculosis was associated with increased risk of lung cancer. It remains controversial whether pulmonary tuberculosis is a risk factor for lung cancer. Our study was aimed to examine the association between pulmonary tuberculosis and lung cancer ri...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.37022

    authors: Oh CM,Roh YH,Lim D,Kong HJ,Cho H,Hwangbo B,Won YJ,Jung KW,Oh K

    更新日期:2020-01-20 00:00:00

  • microRNA-485-5p Functions as a Tumor Suppressor in Colorectal Cancer Cells by Targeting CD147.

    abstract::Colorectal cancer(CRC) is a prevalent malignancy in the world. There is growing evidence that microRNAs (miRNAs) as crucial modulator are in connection with many tumor-related diseases including CRC. Though miR-485-5p has been reported as an anti-oncogene in certain cancers, it remains unclear in CRC. In this research...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.24918

    authors: Hu XX,Xu XN,He BS,Sun HL,Xu T,Liu XX,Chen XX,Zeng KX,Wang SK,Pan YQ

    更新日期:2018-06-23 00:00:00

  • Should EMT of Cancer Cells Be Understood as Epithelial-Myeloid Transition?

    abstract::Cancer cells express epithelial markers, and when progressing in malignancy they may express markers of the mesenchymal cell type. Therefore an epithelial-mesenchymal transition of the cancer cells is assumed. However the mesenchymal markers can equally well be interpreted as myeloid markers since they are common in b...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.8242

    authors: Schramm HM

    更新日期:2014-01-15 00:00:00

  • Tyrosine Kinase Inhibitors for the Elderly.

    abstract::Until few years ago non-specific cytotoxic agents were considered the tip of the arrow as first line treatment for lung cancer. However; age > 75 was considered a major drawback for this kind of therapy. Few exceptions were made by doctors based on the performance status of the patient. The side effects of these agent...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.14819

    authors: Hohenforst-Schmidt W,Zarogoulidis P,Steinheimer M,Benhassen N,Tsiouda T,Baka S,Yarmus L,Stratakos G,Organtzis J,Pataka A,Tsakiridis K,Karapantzos I,Karapantzou C,Darwiche K,Zissimopoulos A,Pitsiou G,Zarogoulidis K,Man Y

    更新日期:2016-03-21 00:00:00

  • Improved Long-Term Clinical Outcomes And Safety Profile Of Sunitinib Dosing Schedule With 4/2 Switched To 2/1 In Patients With Metastatic Renal Cell Carcinoma.

    abstract::Purpose: This study aimed to identify the survival benefit and safety of alternative dosage schedules for sunitinib in metastatic renal cell carcinoma. Materials and Methods: Clinicopathologic and survival data of patients treated with sunitinib as first-line therapy were retrospectively reviewed. Patients were classi...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.25693

    authors: Zhang X,Sun G,Zhao J,Shu K,Zhao P,Liu J,Yang Y,Tang Q,Chen J,Shen P,Wang J,Zeng H

    更新日期:2018-09-07 00:00:00

  • Association of endothelial nitric oxide synthase (eNOS) polymorphisms with EGFR-mutated lung adenocarcinoma in Taiwan.

    abstract::EGFR mutation of Non-small cell lung cancers (NSCLC) was predominantly seen in Asian population and it was considered as a predictor of responsiveness. Eendothelial nitric oxide synthase (eNOS) plays a vital role in chronic inflammation and carcinogenesis. In this study, we aimed to explore the association between the...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.25824

    authors: Huang CY,Hsieh MJ,Wu WJ,Chiang WL,Liu TC,Yang SF,Tsao TC

    更新日期:2018-06-15 00:00:00

  • Rapid Breast Cancer Disease Progression Following Cyclin Dependent Kinase 4 and 6 Inhibitor Discontinuation.

    abstract::Background: CDK 4 and 6 inhibitors (CDK4/6i), which arrest unregulated cancer cell proliferation, show clinical efficacy in breast cancer. Unexpectedly, a patient treated on a CDK4/6i-based trial, as first-line therapy in metastatic breast cancer, developed rapid disease progression following discontinuation of study ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.18196

    authors: Bashour SI,Doostan I,Keyomarsi K,Valero V,Ueno NT,Brown PH,Litton JK,Koenig KB,Karuturi M,Abouharb S,Tripathy D,Moulder-Thompson SL,Ibrahim NK

    更新日期:2017-07-05 00:00:00

  • Spatial and temporal fracture pattern in breast and gynecologic cancer survivors.

    abstract:OBJECTIVE(S):To assess skeletal wide fracture location and time of fracture after cancer treatment Study Design: One hundred thirty-nine women diagnosed with breast or gynecologic cancer between 2003 and 2012 that subsequently had a radiologic diagnosis of fracture were identified retrospectively using electronic medic...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.10288

    authors: Hui SK,Arentsen L,Wilcox A,Shanley R,Yee D,Ghebre R

    更新日期:2015-01-01 00:00:00

  • The tumor suppressive miR-302c-3p inhibits migration and invasion of hepatocellular carcinoma cells by targeting TRAF4.

    abstract::MicroRNAs (miRNAs) have been recognized as key regulators of tumorigenesis and progression. Serum miR-302c-3p expression is prominently deregulated in HCV-related hepatocellular carcinoma (HCC). However, the expression of miR-302c-3p and its functional role in HBV-related HCC are rarely investigated. In this study, we...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.25569

    authors: Yang L,Guo Y,Liu X,Wang T,Tong X,Lei K,Wang J,Huang D,Xu Q

    更新日期:2018-06-23 00:00:00

  • Carbonic Anhydrase 4 serves as a Clinicopathological Biomarker for Outcomes and Immune Infiltration in Renal Cell Carcinoma, Lower Grade Glioma, Lung Adenocarcinoma and Uveal Melanoma.

    abstract::Background: Carbonic anhydrase 4 (CA4) maintains homeostasis of carbon dioxide and bicarbonate. It is suggested to be a potential prognostic biomarker, while the correlations between CA4 and different cancers are indistinct. Methods: Differential mRNA expression of CA4 among different cancers and corresponding normal ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.46902

    authors: Xu Y,Xu WH,Shi SN,Yang XL,Ren YR,Zhuang XY,Qu YY,Zhang HL,Zhang XF

    更新日期:2020-08-25 00:00:00

  • Surgery plus chemotherapy improves survival of patients with extremity soft tissue leiomyosarcoma and metastasis at presentation.

    abstract::Purpose: Extremity soft tissue leiomyosarcoma (LMS) with metastasis is a rare disease with a poor prognosis. The purpose of our study was to define clinical features of extremity soft tissue LMS with metastasis as well as to identify multivariable predictors of survival. Methods: During 1973-2015, 239 patients with me...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.29874

    authors: Qian SJ,Wu JQ,Wang Z,Zhang B

    更新日期:2019-05-21 00:00:00

  • Cullin family proteins and tumorigenesis: genetic association and molecular mechanisms.

    abstract::Cullin family proteins function as scaffolds to form numerous E3 ubiquitin ligases with RING proteins, adaptor proteins and substrate recognition receptors. These E3 ligases further recognize numerous substrates to participate in a variety of cellular processes, such as DNA damage and repair, cell death and cell cycle...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.11076

    authors: Chen Z,Sui J,Zhang F,Zhang C

    更新日期:2015-01-16 00:00:00

  • Prognostic Factors among Brain Metastases in Newly Diagnosed Ovary Cancer: A Large Real-world Study.

    abstract::Background: Population-based data on the prognosis of brain metastases at initial diagnosis of ovary cancer (OCBM) are currently lacking. Besides, the effective treatment for OCBM patients is still controversial now. The study aimed to explore the prognostic factors among OCBM. Methods: We retrospectively reviewed the...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.44494

    authors: Xi S,Li Z,Guo Q,Lin W,Liang X,Ma L

    更新日期:2020-05-18 00:00:00