Warburg Effect - a Consequence or the Cause of Carcinogenesis?


:Ever since its discovery (1924) the Warburg effect (aerobic glycolysis) remains an unresolved puzzle: why the aggressive cancer cells "prefer" to use the energetically highly inefficient method of burning the glucose at the cellular level? While in the course of the last 90 years several hypotheses have been suggested, to this date there is no clear explanation of this rather unusual effect. Even though it is commonly assumed that Warburg effect is a consequence of carcinogenesis, yet another hypothesis could be brought up that the cellular switch to aerobic glycolysis may represent the very point in time when a normal cell becomes cancerous. Furthermore, this switch may happen at the point where the fate of pyruvic acid is determined, caused by the inadequate supply of enzymes that promote citric as opposed to lactic acid cycle. Currently, few clinical observations, like low cancer incidence in Type 1 diabetes mellitus and increased cancer incidence in people on high carbohydrate diets might be called upon to support such hypothesis.


J Cancer


Journal of Cancer


Devic S




Has Abstract


2016-04-26 00:00:00












  • MiR-182 Is Associated with Growth, Migration and Invasion in Prostate Cancer via Suppression of FOXO1.

    abstract:BACKGROUND:MicroRNA (miRNA) have been shown to regulate gene expression in many cancers. MiR-182 has recently been found to be prognostic for patients treated with radical prostatectomy for prostate cancer. We sought to assess miR-182 as a prognostic marker and understand its role in prostate cancer progression and met...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Wallis CJ,Gordanpour A,Bendavid JS,Sugar L,Nam RK,Seth A

    更新日期:2015-10-25 00:00:00

  • Increased Reactive Oxygen Species and Distinct Oxidative Damage in Resveratrol-suppressed Glioblastoma Cells.

    abstract::Background and Aim: Glioblastoma multiforme (GBM) is a highly aggressive brain malignancy that lacks reliable treatments. Resveratrol possesses anti-cancer effects, but its activity against glioblastoma cells is variable for unknown reasons. One mechanism through which anti-cancer drugs exert their effects is oxidativ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Jia B,Zheng X,Wu ML,Tian XT,Song X,Liu YN,Li PN,Liu J

    更新日期:2021-01-01 00:00:00

  • Prognostic Value of Albumin/Globulin Ratio in Survival and Lymph Node Metastasis in Patients with Cancer: A Systematic Review and Meta-analysis.

    abstract::The impact of albumin to globulin ratio (AGR) on the prognosis of various human cancers has not been well established. Here, a systemic review and meta-analysis has been performed to comprehensively assess the relationships between AGR and lymph node metastasis (LNM) or overall survival (OS). Systematical search throu...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审


    authors: Chi J,Xie Q,Jia J,Liu X,Sun J,Chen J,Yi L

    更新日期:2018-06-12 00:00:00

  • Optimizing a 3D Culture System to Study the Interaction between Epithelial Breast Cancer and Its Surrounding Fibroblasts.

    abstract::Stromal fibroblasts are suggested to be a key determinant in the malignant progression of breast cancer. To find an in vitro culture model that best mimics the in vivo tumor microenvironment so we can study the effects of stromal fibroblasts on breast cancer progression, we evaluated several three-dimensional (3D) co-...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Li L,Lu Y

    更新日期:2011-01-01 00:00:00

  • Targeting hepatocarcinogenesis model in C56BL6 mice with pan-aurora kinase inhibitor Danusertib.

    abstract::Background: To elucidate the expression of Aurora kinases (AURK) and the anticancer effects of pan-aurora kinase inhibitor Danusertib in hepatocarcinogenesis model in C56Bl6 mice. Methods: Thirty mice C56Bl6 were randomly divided into Group A or control, Group B animals who underwent experimental hepatocarcinogenesis ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Gavriilidis P,Poutahidis T,Giakoustidis A,Makedou K,Angelopoulou K,Hardas A,Andreani P,Zacharioudaki A,Saridis G,Gargavanis A,Louri E,Antoniadis N,Karampela E,Psychalakis N,Michalopoulos A,Papalois A,Iliadis S,Mudan S,

    更新日期:2018-02-27 00:00:00

  • Paclitaxel and Trastuzumab as Maintenance Therapy in Patients with HER2-Positive Metastatic Breast Cancer Who Underwent High-Dose Chemotherapy and Autologous Hematopoietic Stem Cell Transplantation.

    abstract::We examined the feasibility and safety of using paclitaxel and trastuzumab as maintenance therapy after high-dose chemotherapy (HDC) with autologous hematopoietic stem cell transplantation (AHST) for patients with HER2-positive metastatic breast cancer. Ten patients (9 women and 1 man) were enrolled in the study. The ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Cheng YC,Rondón G,Anderlini P,Khouri IF,Champlin RE,Ueno NT

    更新日期:2013-09-27 00:00:00

  • miRNA Biomarkers in Breast Cancer Detection and Management.

    abstract::Breast cancer is considered as a heterogeneous disease comprising various types of neoplasms, which involves different profile changes in both mRNA and micro-RNA (miRNA) expression. Extensive studies on mRNA expression in breast tumor have yielded some very interesting findings, some of which have been validated and u...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Fu SW,Chen L,Man YG

    更新日期:2011-02-24 00:00:00

  • Inhibition of malignant human bladder cancer phenotypes through the down-regulation of the long non-coding RNA SNHG7.

    abstract::There is abundant evidence that long non-coding RNAs play important roles in the development of tumors. In the present study, our main aim was to explore the relationship between lncRNA SNHG7 and human bladder cancer cells, thus finding a novel target for bladder cancer therapy and diagnosis. Expression of lncRNA SNHG...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Xu C,Zhou J,Wang Y,Wang A,Su L,Liu S,Kang X

    更新日期:2019-01-01 00:00:00

  • Down-regulation of ACACA suppresses the malignant progression of Prostate Cancer through inhibiting mitochondrial potential.

    abstract::Background and aim: Silencing the expression of ACACA inhibits cell proliferation and induces apoptosis in prostate cancer LNCaP cells. However, the role of ACACA in other prostate cancer cells is not fully understood. Also, the effect of knocking down ACACA gene on mitochondria remains unclear. This study aimed to di...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Zhang H,Liu S,Cai Z,Dong W,Ye J,Cai Z,Han Z,Liang Y,Zhuo Y,Luo Y,Zhu X,Deng Y,Zhang Y,Liu R,Feng Y,Lai J,Zhou R,Tan H,Zhong W

    更新日期:2021-01-01 00:00:00

  • The tumor suppressive miR-302c-3p inhibits migration and invasion of hepatocellular carcinoma cells by targeting TRAF4.

    abstract::MicroRNAs (miRNAs) have been recognized as key regulators of tumorigenesis and progression. Serum miR-302c-3p expression is prominently deregulated in HCV-related hepatocellular carcinoma (HCC). However, the expression of miR-302c-3p and its functional role in HBV-related HCC are rarely investigated. In this study, we...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Yang L,Guo Y,Liu X,Wang T,Tong X,Lei K,Wang J,Huang D,Xu Q

    更新日期:2018-06-23 00:00:00

  • The combination of PKM2 overexpression and M2 macrophages infiltration confers a poor prognosis for PDAC patients.

    abstract::Macrophages play a critical role in the initiation and progression in various human solid tumors; however, their role and transformation in pancreatic ductal adenocarcinoma (PDAC) were still illusive. Here, immunohistochemistry was used to determine CD206 (specific marker of M2 macrophage) and PKM2 expression in PDAC ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Hu H,Tu W,Chen Y,Zhu M,Jin H,Huang T,Zou Z,Xia Q

    更新日期:2020-02-03 00:00:00

  • BCR-ABL1 transcript decline ratio combined BCR-ABL1IS as a precise predictor for imatinib response and outcome in the patients with chronic myeloid leukemia.

    abstract::Purpose: The early BCR-ABL1 reduction had the prognostic impact of the chronic-phase chronic myeloid leukemia (CML-CP) patients. This study was to find a more precise early prognosis index at 3 months in the patients with newly diagnosed CML-CP, especially for the patients with BCR-ABL1IS >10%. Methods: We retrospecti...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Cai Z,Jia X,Zi J,Song H,Wang S,McGrath M,Zhao L,Song C,Ge Z

    更新日期:2020-02-03 00:00:00

  • Factors associated with improvement in symptoms and quality of life for first-line EGFR-tyrosine kinase inhibitor treatment in patients with EGFR-mutated non-small-cell lung cancer - A multicenter prospective SMILE study.

    abstract::Introduction: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are a standard first-line treatment for advanced EGFR-mutated NSCLC patients. Factors associated with symptoms and quality of life (QOL) improvements have not been investigated. Methods: We conducted a multicenter, prospective study ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Wei YF,Huang WT,Liu TC,Shieh JM,Chian CF,Wu MF,Chang CC,Lin CH,Ko JC,Lin CM,Hsia TC

    更新日期:2019-07-10 00:00:00

  • Differences and similarities in the phenomenon of NETs formation in oral inflammation and in oral squamous cell carcinoma.

    abstract::Taking into account the previously reported relationship between inflammation and carcinogenesis, and the scant amount of data concerning the role of neutrophil extracellular traps (NETs) in carcinogenesis, we decided to study the process of extracellular trap formation in patients with inflammation as well as in pati...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Garley M,Dziemiańczyk-Pakieła D,Grubczak K,Surażyński A,Dąbrowska D,Ratajczak-Wrona W,Sawicka-Powierza J,Borys J,Moniuszko M,Pałka JA,Jabłońska E

    更新日期:2018-04-30 00:00:00

  • Incidence and Impact of Lymph Node Metastases in Advanced Ovarian Cancer: Implications for Surgical Treatment.

    abstract::Background: This study aimed to clarify the impact of node involvement (affected to resected nodes) in optimally cytoreduced (residual tumour ≤1cm) stage IIIC/IV ovarian cancer. Methods: 108 consecutive patients with primary stage IIIC/IV ovarian cancer underwent stage-related surgery and got adjuvant platinum-based c...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Bachmann C,Bachmann R,Fend F,Wallwiener D

    更新日期:2016-11-09 00:00:00

  • Evaluation of Detection Methods and Values of Circulating Vascular Endothelial Growth Factor in Lung Cancer.

    abstract::Lung cancer is the deadliest cancer in the world. Angiogenesis plays a crucial role of the incidence, progression, and metastasis in lung cancer. Angiogenesis inhibitors are used to treat non-small cell lung cancer (NSCLC) patients, and the molecular biomarkers are also being assessed to predict treatment response/the...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审


    authors: Guo S,Martin MG,Tian C,Cui J,Wang L,Wu S,Gu W

    更新日期:2018-03-22 00:00:00

  • Combined Preoperative LMR and CA125 for Prognostic Assessment of Ovarian Cancer.

    abstract::Objectives: To investigate the role of inflammation-related factors, lymphocyte-to-monocyte ratio (LMR) alone and combined detection with cancer antigen 125 (CA125), in the prognostic assessment of ovarian cancer (OC). Methods: A retrospective clinicopathologic review was performed. The receiver-operating characterist...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Tang Y,Hu HQ,Tang FX,Lin D,Shen R,Deng L,Tang YL,Deng LH,Zhou M,Li J,Su B,Xu F

    更新日期:2020-03-04 00:00:00

  • Spatial and temporal fracture pattern in breast and gynecologic cancer survivors.

    abstract:OBJECTIVE(S):To assess skeletal wide fracture location and time of fracture after cancer treatment Study Design: One hundred thirty-nine women diagnosed with breast or gynecologic cancer between 2003 and 2012 that subsequently had a radiologic diagnosis of fracture were identified retrospectively using electronic medic...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Hui SK,Arentsen L,Wilcox A,Shanley R,Yee D,Ghebre R

    更新日期:2015-01-01 00:00:00

  • Centromere Protein N Participates in Cellular Proliferation of Human Oral Cancer by Cell-Cycle Enhancement.

    abstract::Centromere protein N (CENP-N), an important member of the centromere protein family, is essential for kinetochore assembly and chromosome segregation; however, the relevance of CENP-N in cancers remains unknown. The aim of this study was to investigate CENP-N expression and its functional mechanisms in oral squamous c...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Oka N,Kasamatsu A,Endo-Sakamoto Y,Eizuka K,Wagai S,Koide-Ishida N,Miyamoto I,Iyoda M,Tanzawa H,Uzawa K

    更新日期:2019-06-09 00:00:00

  • The JAM-B/c-src/MMP9 pathway is associated with progression and regulates the invasion of pancreatic cancer.

    abstract::Junctional adhesion molecule B (JAM-B) is a multifunctional transmembrane protein that plays an important role in tumor progression. JAM-B is significantly upregulated in gastric cancer, melanoma cell metastasis and oral squamous cell carcinoma. JAM-2 may also function as a putative tumor suppressor in the progression...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Zhang W,He R,Chen S,Zhang L,Cao G,Yang W,Li J

    更新日期:2020-03-05 00:00:00

  • The Expression of Perilipin Family Proteins can be used as Diagnostic Markers of Liposarcoma and to Differentiate Subtypes.

    abstract::Objective: Liposarcoma is a mesenchymal malignant tumor characterized by adipocyte differentiation which is divided into four subtypes with different prognosis. Accurate histopathological diagnosis is essential for precise treatment. Perilipins, including PLIN1, PLIN2, PLIN3, PLIN4, PLIN5, is a family of lipid droplet...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Zhang Q,Zhang P,Li B,Dang H,Jiang J,Meng L,Zhang H,Zhang Y,Wang X,Li Q,Wang Y,Liu C,Li F

    更新日期:2020-04-07 00:00:00

  • Risk factors for discontinuation of s-1 adjuvant chemotherapy for gastric cancer.

    abstract:PURPOSE:The aim of this study was to clarify the risk factors for discontinuing tegafur/gimeracil/oteracil potassium (S-1) adjuvant chemotherapy following gastrectomy in patients with gastric cancer. METHODS:We retrospectively investigated patients with curatively-resected gastric cancer who received S-1 adjuvant chem...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Kawazoe H,Shimasaki M,Ueno M,Sumikawa S,Takatori S,Namba H,Yoshida M,Sato K,Kojima Y,Watanabe Y,Moriguchi T,Tanaka A,Araki H

    更新日期:2015-03-18 00:00:00

  • Hypoxia Inducible Factor-1alpha (HIF-1A) plays different roles in Gallbladder Cancer and Normal Gallbladder Tissues.

    abstract::Purpose: Hypoxia-inducible factor-1alpha (HIF-1A) is a transcription factor that plays an "angiogenic switch" role especially under hypoxia microenvironment in solid tumor. However, the functions and clinical significance of HIF-1A in gallbladder cancer (GBC) are still controversial, and it has not been studied in nor...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Wu Y,Meng D,You Y,Sun R,Fu M,Yan Q,Zhang S,Fang Z,Bao J,Li Y

    更新日期:2021-01-01 00:00:00

  • Tumor Suppressor LKB1 inhibits both the mRNA Expression and the Amplification of hTERC by the Phosphorylation of YAP in Lung Cancer Cells.

    abstract::Liver kinase B1 (LKB1) is a critical tumor suppressor that is frequently mutated in human cancers. LKB1 has serine/threonine protein kinase activity, which regulates gene expression by phosphorylation of Yes-Associated protein (YAP). The phosphorylation-dependent YAP shuttling is critically important intracellular mec...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: He L,Wu MZ,Wang XB,Qiu XS,Wang EH,Wu GP

    更新日期:2019-06-09 00:00:00

  • The Expression of Ubiquitous Mitochondrial Creatine Kinase Is Downregulated as Prostate Cancer Progression.

    abstract:BACKGROUND:Mitochondria play crucial roles in cell signaling events, interorganellar communication, aging, cell proliferation and apoptosis, and mitochondrial impairment has been shown to accelerate or modulate cancer progression. Ubiquitous mitochondrial creatine kinase (uMtCK) is predominantly localized in the interm...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Amamoto R,Uchiumi T,Yagi M,Monji K,Song Y,Oda Y,Shiota M,Yokomizo A,Naito S,Kang D

    更新日期:2016-01-01 00:00:00

  • Association between SNPs in Long Non-coding RNAs and the Risk of Female Breast Cancer in a Chinese Population.

    abstract::Long non-coding RNAs (LncRNAs) have been reported to be involved in tumorigenesis and tumor progression. Single nucleotide polymorphisms (SNPs) in the lncRNAs also play a vital role in carcinogenesis. The aim of this study was to assess the relationships between the four selected tagSNPs (rs944289, rs3787016, rs145631...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Xu T,Hu XX,Liu XX,Wang HJ,Lin K,Pan YQ,Sun HL,Peng HX,Chen XX,Wang SK,He BS

    更新日期:2017-04-09 00:00:00

  • Mast cells induce epithelial-to-mesenchymal transition and migration in non-small cell lung cancer through IL-8/Wnt/β-catenin pathway.

    abstract::Background: In the various cancer, mast cells (MCs) infiltration is correlated with a worse prognosis. There is an increasing evidence that MCs and their mediators are participated in remodeling of the tumor microenvironment and facilitate tumor growth, epithelial-to-mesenchymal transition (EMT) and metastasis. Method...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,收录出版


    authors: Qu J,Cheng T,Liu L,Heng J,Liu X,Sun Z,Wang W,Li K,Yang N

    更新日期:2019-06-09 00:00:00

  • Impact of Cold Ischemic Time and Freeze-Thaw Cycles on RNA, DNA and Protein Quality in Colorectal Cancer Tissues Biobanking.

    abstract::Tissue-derived RNA, DNA and protein samples become more and more crucial for molecular detection in clinical research, personalized and targeted cancer therapy. This study evaluated how to biobanking colorectal tissues through examining the influences of cold ischemic time and freeze-thaw cycles on RNA, DNA and protei...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Fan XJ,Huang Y,Wu PH,Yin XK,Yu XH,Fu XH,Feng LL,Wang YL,Yi HJ,Chen ZT,Yin JX,Zhang DL,Feng WX,Bai SM,Kim T,Mills GB,Lu YL,Wan XB,Wang L

    更新日期:2019-08-27 00:00:00

  • Chloroma/Granulocytic sarcoma: abdominal & pelvic presentation of acute myelogenous leukemia.

    abstract::There is limited literature documenting granulocytic sarcoma of the colon. We report a case of a 28 year-old female with a colonic granulocystic sarcoma of the colon as a complication of AML, as it is an important consideration with surgical management of typhilitis. ...

    journal_title:Journal of Cancer



    authors: Tsikitis VL,Corning C,Henderson J,Rose J

    更新日期:2010-07-14 00:00:00

  • Blood-based Genomic Profiling of Circulating Tumor DNA from Patients with Advanced Pancreatic Cancer and its Value to Guide Clinical Treatment.

    abstract::Objective: Pancreatic cancer (PC) is a malignant tumor with limited therapeutic choices and extremely poor prognosis. Personalized therapy based on gene alternations is a promising choice. Considering tumor heterogeneity, the practice of ctDNA analysis has drawn the attention. Here, we try to assess the applicability ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Li H,Di Y,Li J,Jiang Y,He H,Yao L,Gu J,Lu J,Song J,Chen S,Cai S,Jin C,Yuan Z,Fu D

    更新日期:2020-04-27 00:00:00