Abstract:
:Melanoma is the most aggressive and treatment-resistant form of skin cancer. Curcumol is a Chinese medicinal herb traditionally used as a cancer remedy. However, the molecular mechanisms underlying the anticancer activity of curcumol in melanoma remains largely unknown. In the present study, we observed that Curcumol decreased mouse melanoma B16 cell proliferation and migration. The xenograft tumor assay showed that curcumol reduced melanoma volume and lung metastasis. Curcumol upregulated the expression of E-cadherin and downregulated the expression of N-cadherin, MMP2 and MMP9 in mouse melanoma B16 cell. Western blot analysis revealed that curcumol reduced the translocation of p65 to the nucleus and decreased p-ERK. Furthermore, curcumol attenuated c-MET, P13K and p-AKT protein expression and upregulated miR-152-3p gene expression. The dual-luciferase reporter assay indicated that c-MET was a target gene of miR-152-3p. Reduced expression of miR-152-3p partially attenuated the effect of curcumol on mouse melanoma B16 cell proliferation and migration. The decrease in c-MET, P13K and p-AKT protein expression following curcumol treatment in mouse melanoma B16 cells was notably attenuated by the miR-152-3p inhibitor. Taken together, our findings suggested that curcumol attenuated melanoma progression and concomitantly suppressed ERK/NF-κB signaling and promoted miR-152-3p expression to inactivate the c-MET/PI3K/AKT signaling pathway.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Ning N,Liu S,Liu X,Tian Z,Jiang Y,Yu N,Tan B,Feng H,Feng X,Zou Ldoi
10.7150/jca.38624subject
Has Abstractpub_date
2020-01-14 00:00:00pages
1679-1692issue
7issn
1837-9664pii
jcav11p1679journal_volume
11pub_type
杂志文章abstract::Purpose: We explored the influence of age on clinicopathologic features and survival of patients with M0 gastric cancer (GC). Methods: 16856 GC patients from Surveillance, Epidemiology and End Results (SEER) database and 1037 GC patients from Chinese multiple centers were enrolled in the U.S. and Chinese cohort, respe...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.22085
更新日期:2018-03-08 00:00:00
abstract::Objective: Both previous and recent literature showed long non-coding RNAs (lncRNAs) were crucial participants in multiple myeloma (MM) evolution. However, the dynamic regulation and mechanism of lncRNAs in MM progression was not fully understood. This study will explore the expression and effects of prostate cancer-a...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.35098
更新日期:2019-10-20 00:00:00
abstract:BACKGROUND:Neoadjuvant chemotherapy with concurrent docetaxel, doxorubicin and cyclophosphamide is commonly used for patients with locally advanced breast cancer. Epirubicin is another anthracycline used in breast cancer but the concurrent use of epirubicin and taxane is not well-established. We conducted a single inst...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.3980
更新日期:2012-01-01 00:00:00
abstract::Early detection and accurate evaluation were both critical to improving the prognosis of clear cell Renal Cell Carcinoma (ccRCC) patients. More importantly, RNA Binding Proteins (RBPs) play a vital role in the tumorigenesis and progression of numerous cancers. However, the relationship between RBPs and ccRCC is still ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.49175
更新日期:2020-09-23 00:00:00
abstract::The process of neoplastic transformation of the colon involves a progression through hyperproliferative epithelium through the aberrant crypt foci→small adenoma→large adenoma→invasive cancer→metastatic disease. These are orchestrated by sequential genetic and epigenetic events which provide the underpinnings of cellul...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.5838
更新日期:2013-01-01 00:00:00
abstract::Background: The Aldehyde dehydrogenase 2 (ALDH2) mutant genotypes contain an allele encoding defective ALDH2 with reduced efficacy of alcohol metabolism leading to accumulation of highly toxic and carcinogenic acetaldehyde. It can induce unpleasant "Asian flush syndrome" and associate with increased risk of cancers. H...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.33221
更新日期:2019-10-03 00:00:00
abstract::MicroRNAs (miRNAs) have been recognized as key regulators of tumorigenesis and progression. Serum miR-302c-3p expression is prominently deregulated in HCV-related hepatocellular carcinoma (HCC). However, the expression of miR-302c-3p and its functional role in HBV-related HCC are rarely investigated. In this study, we...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25569
更新日期:2018-06-23 00:00:00
abstract::Dihydroorotate dehydrogenase (DHODH) is a rate-limiting enzyme in the de novo biosynthesis pathway of pyrimidines. Inhibition of this enzyme impedes cancer cell proliferation but the exact mechanisms of action of these inhibitors in cancer cells are poorly understood. In this study, we showed that cancer cells, namely...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.14835
更新日期:2017-09-05 00:00:00
abstract:OBJECTIVE:The main aim of this study was to study swith of the ovarian cancer cell to a calcifying phenotype in the formation of calcification in ovarian cancer, and to offer some help for ovarian cancer's diagnosis and differentiation therapy. METHODS:The mineralization of ovarian cancer cell lines SKOV3 was induced ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.22932
更新日期:2018-02-28 00:00:00
abstract::Background: Carbonic anhydrase 4 (CA4) maintains homeostasis of carbon dioxide and bicarbonate. It is suggested to be a potential prognostic biomarker, while the correlations between CA4 and different cancers are indistinct. Methods: Differential mRNA expression of CA4 among different cancers and corresponding normal ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.46902
更新日期:2020-08-25 00:00:00
abstract::The 21-gene recurrence score (RS) is increasingly being used for patients with early stage, hormone receptor-positive, Her-2-negative breast cancer. However, these results are largely from populations with infiltrating ductal carcinoma (IDC). The clinical value of RS testing in mucinous carcinoma has not been well inv...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.27291
更新日期:2018-08-06 00:00:00
abstract:BACKGROUND:Mitochondria play crucial roles in cell signaling events, interorganellar communication, aging, cell proliferation and apoptosis, and mitochondrial impairment has been shown to accelerate or modulate cancer progression. Ubiquitous mitochondrial creatine kinase (uMtCK) is predominantly localized in the interm...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.13207
更新日期:2016-01-01 00:00:00
abstract::The highly conserved Hippo signaling pathway is an important pathway involved in tumorigenesis and development. In previous studies, YAP, the transcription coactivator of Hippo pathway, is found to be highly expressed in many clinical bladder cancer samples. To investigate the function of YAP and its cofactor Mask2 in...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16438
更新日期:2016-10-23 00:00:00
abstract:BACKGROUND:We conducted this pooled analysis to investigate the impact of RECIST 1.1 on the selection of target lesions and classification of tumor response, in comparison with RECIST 1.0. Methods : We searched MEDLINE and EMBASE for articles with terms of RECIST 1.0 or RECIST 1.1. We looked into all abstracts and virt...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.11316
更新日期:2015-02-25 00:00:00
abstract::Our results show that using an EBV-LCL feeder cell line, large numbers of pure populations of highly activated NK cells can be expanded ex vivo under GMP conditions. With the exception of thyroiditis and constitutional symptoms related to IL-2 therapy, infusions of up to 1 x 10(8) cells/kg of ex vivo expanded NK have ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.383
更新日期:2011-01-01 00:00:00
abstract::Background: Radiotherapy is a primary treatment strategy for patients with unresectable hepatocellular carcinoma (HCC); however, the prognostic factors among HCC patients who have received radiotherapy but not undergone surgery have not been systematically studied. Thus, the prognostic factors were investigated in thi...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.30365
更新日期:2019-07-25 00:00:00
abstract::Cullin family proteins function as scaffolds to form numerous E3 ubiquitin ligases with RING proteins, adaptor proteins and substrate recognition receptors. These E3 ligases further recognize numerous substrates to participate in a variety of cellular processes, such as DNA damage and repair, cell death and cell cycle...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.11076
更新日期:2015-01-16 00:00:00
abstract::Background: The incidence and mortality rate of gastric cancer has markedly declined over the past few decades, due to the progress and advances in the development of diagnostic and treatment regimens. However, there is still a large portion of patients who are first diagnosed during the advanced stage of gastric canc...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.31303
更新日期:2019-10-06 00:00:00
abstract::Peroxisome proliferator-activated receptor gamma (PPARγ), a member of the nuclear receptor superfamily, participates in multiple physiological and pathological processes. Extensive studies have revealed the relationship between PPARγ and various tumors. However, the expression and function of PPARγ in bladder cancer s...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.42663
更新日期:2020-04-06 00:00:00
abstract::Fallopian tube epithelial cells (FTECs) are thought to be the origin of epithelial ovarian cancer. However, the effect of the hormones on FTECs is unknown, and therefore, this study explored this effect. We successfully derived FTECs from the fallopian tube epithelial layer and treated them with estradiol and progeste...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.30588
更新日期:2019-06-02 00:00:00
abstract::Colorectal cancer (CRC) is considered to be closely associated with alteration of intestinal microorganisms. The purpose of present study was to investigate the distribution of gut microbiota in the distinction of microbiota dysbiosis between two disease syndromes called Zheng-Qi-Kui-Xu(ZQKX) and Xie-Du-Yong-Sheng (XD...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.50318
更新日期:2020-10-23 00:00:00
abstract::Until few years ago non-specific cytotoxic agents were considered the tip of the arrow as first line treatment for lung cancer. However; age > 75 was considered a major drawback for this kind of therapy. Few exceptions were made by doctors based on the performance status of the patient. The side effects of these agent...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.14819
更新日期:2016-03-21 00:00:00
abstract::Purpose: Systemic therapy has often been used for patients with advanced hepatocellular carcinoma (HCC). However, due to drug resistance, the use of cytotoxic chemotherapy in the treatment of patients with advanced HCC has typically demonstrated low response rates. Secretory clusterin (sCLU) is expressed in aggressive...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.23849
更新日期:2018-04-06 00:00:00
abstract::Background: CDK 4 and 6 inhibitors (CDK4/6i), which arrest unregulated cancer cell proliferation, show clinical efficacy in breast cancer. Unexpectedly, a patient treated on a CDK4/6i-based trial, as first-line therapy in metastatic breast cancer, developed rapid disease progression following discontinuation of study ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18196
更新日期:2017-07-05 00:00:00
abstract::Endometrial and ovarian cancers are two most common cancers affecting women in their post-menopausal years. To date, there are no simple biochemical tests to detect these cancers at early stages. Our previous study has demonstrated that the activity of total proprotein convertases (PCs) is significantly increased in u...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16331
更新日期:2016-08-12 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24238
更新日期:2018-04-30 00:00:00
abstract::Colorectal cancer is a commonly diagnosed malignancy and also the major cause of death worldwide. Chemotherapy is the primary therapy for advanced colorectal cancer. Although oxaliplatin has potential effect in colorectal cancer therapy, the molecular mechanisms involved in its cytotoxic effects are not well elucidate...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24474
更新日期:2018-05-22 00:00:00
abstract::Objective: Pancreatic cancer (PC) is a malignant tumor with limited therapeutic choices and extremely poor prognosis. Personalized therapy based on gene alternations is a promising choice. Considering tumor heterogeneity, the practice of ctDNA analysis has drawn the attention. Here, we try to assess the applicability ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.43087
更新日期:2020-04-27 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.200
更新日期:2011-04-08 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2017-05-10 00:00:00