Abstract:
:Background: The incidence and mortality rate of gastric cancer has markedly declined over the past few decades, due to the progress and advances in the development of diagnostic and treatment regimens. However, there is still a large portion of patients who are first diagnosed during the advanced stage of gastric cancer when chemotherapy is needed. Unfortunately, resistance to chemotherapeutic agents is the most frequent occurrence during treatment, which indicates a need for the discovery of novel therapeutic anticancer drugs. Methods: The tumor-suppression effect of eight different cucurbitacins was evaluated in gastric cancer cell lines, and the Cucurbitacin E (CuE) showing the greatest effect was used in further studies to explore the mechanism and potential synergistic effect of Dox both in vitro and in vivo. Results: Compared with other cucurbitacins, CuE showed the greatest antiproliferative activity against the gastric cancer cell lines. Further investigations revealed that CuE suppressed the growth of gastric cancer cell lines through the induction of G2/M arrest and subsequent apoptosis by impairing AKt activation and reducing its expression in gastric cancer cells. Furthermore, our results indicate that CuE can significantly enhance the cytotoxicity of doxorubicin (Dox) both in vitro and in vivo. Conclusion: In summary, we present the first evidence of the efficacy of CuE for the inhibition of gastric cancer growth and the synergistic antitumorigenic effect of CuE and Dox, both in vitro and in vivo.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Si W,Lyu J,Liu Z,Wang C,Huang J,Jiang L,Ma Tdoi
10.7150/jca.31303subject
Has Abstractpub_date
2019-10-06 00:00:00pages
5843-5851issue
23issn
1837-9664pii
jcav10p5843journal_volume
10pub_type
杂志文章abstract::Background: Noninvasive stool-based DNA methylation testing emerges as a new approach for detecting colorectal cancer (CRC). However, its feasibility for early detection of CRC and precancerous lesions in the Chinese population remains inconclusive. Methods: In this study, we establish a possibilities screening method...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.50525
更新日期:2021-01-01 00:00:00
abstract::Purpose: To evaluate long-term survival trends after primary total laryngectomy (TL) for locally advanced laryngeal carcinoma (LC). Methods: A total of 2094 patients diagnosed with locally advanced LC and underwent primary TL (1992-2011, at least 5-year follow-up) in the Surveillance, Epidemiology, and End Results (SE...
journal_title:Journal of Cancer
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abstract::We hypothesised that the blood levels of immune cells would be related to the progression of colorectal cancer and regional lymph node metastasis. We investigated the association between the blood levels of immune cells and regional lymph node metastasis in colorectal cancer patients. Patients with American Joint Comm...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18230
更新日期:2017-05-10 00:00:00
abstract::Amplified in breast cancer 1 (AIB1) gene, a coactivator for steroid receptor, is frequently amplified in diverse cancers and is considered as an oncogene in tumorigenesis. However, the prognostic significance of AIB1 amplification in gliomas remains totally unclear. In this study, 115 gliomas and 16 benign meningiomas...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16069
更新日期:2016-10-22 00:00:00
abstract::Background: Growing data suggest that DNA damage repair and detoxification pathways play crucial roles in radiation-induced toxicities. To determine whether common functional single-nucleotide polymorphisms (SNPs) in candidate genes from these pathways can be used as predictors of radiation pneumonitis (RP), we conduc...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.20643
更新日期:2018-02-01 00:00:00
abstract::Background: Malignant biliary and/or pancreatic obstruction has often encountered in the advanced stages of periampullary and cholangicarcinomas. HabibTM Radiofrequency (RF) ablation has been successfully used in the management of various cancers of liver and pancreas. Percutaneous HPB probe (EMcision Ltd, London, UK)...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.23280
更新日期:2018-01-05 00:00:00
abstract::The incidence of colorectal cancer (CRC) ranks third among all cancers in China and improvements in screening for CRC have an important impact on prevention and control of the disease. Paraoxonase 1 (PON1) is a calcium ion-dependent hydrolase that is widely distributed in tissue. Its diagnostic value in colorectal can...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.45204
更新日期:2020-09-17 00:00:00
abstract::Background: miRNAs dysregulate in hepatocellular carcinoma (HCC), showing promise for diagnostic biomarkers which may be found through exploration of differentially expressed miRNAs when comparing HCC and normal liver tissues. Materials and Methods: In the present research, candidate miRNAs were selected and verified ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26101
更新日期:2018-09-08 00:00:00
abstract::Background: Infiltration of immune cells and immune microenvironment determine the proliferative activity of the tumor and metastasis. The aim of this study was to analyze the influence of activation or suppression of the immune response mediators on the prognosis of biliary tract cancer (BTC). Methods: We searched Pu...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16774
更新日期:2017-01-01 00:00:00
abstract::Metabolic syndrome has been previously identified as a risk factor for breast cancer and is increasingly a public health concern. This study aims to investigate the prevalence of metabolic syndrome and its components among primary breast cancer and control population. The clinical data of metabolic syndrome and its co...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.22968
更新日期:2018-01-01 00:00:00
abstract::We use pulmonary interventional procedures for the diagnosis of pulmonary diseases either for benign or malignant lesions. Flexible bronchoscopy with or without radial endobronchial ultrasound, convex-probe endobronchial ultrasound and electromagnetic navigation are procedures performed in centers with experience in d...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.23737
更新日期:2018-02-12 00:00:00
abstract::Background: To investigate the relationship between clinical and histopathological characteristics and overall survival of patients with oral mucosal melanoma (OMM) without distal metastasis in order to provide predictive prognostic information of OMM. Methods: Ki67 expression was assessed by immunohistochemistry in 1...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.20935
更新日期:2017-10-17 00:00:00
abstract::MicroRNA-519d (miR-519d) has been reported to play important roles in tumor development and progression in multiple cancers, either as tumor suppressor or tumor promotor. However, the expression level, biological function and molecular mechanisms of miR-519d in oral squamous cell carcinoma (OSCC) remain unclear. There...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.31825
更新日期:2019-06-02 00:00:00
abstract::Purpose: Several new treatment options for patients with metastatic castration resistant prostate cancer (mCRPC) have been approved within the last years - among them cabazitaxel (CAB), abiraterone acetate, enzalutamide, and radium-223. The aim of this study was to assess factors predictive for efficacy of CAB. Method...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.17644
更新日期:2017-02-11 00:00:00
abstract:BACKGROUND:Age-adjusted evaluations have explored the possible utility of (HPV test results in women with LSIL Pap. We investigated HPV test results and histopathologic follow-up results of LSIL patients from China's largest CAP-certified laboratory. METHODS:Patients with LSIL between 2011 and 2015 from the Guangzhou ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19421
更新日期:2017-07-23 00:00:00
abstract::Butyrate, a product of dietary fiber and a histone deacetylase inhibitor, induces apoptosis of colorectal cancer cells; this effect of butyrate is in part mediated by its ability to hyperactivate Wnt signaling, and may in part explain the preventive action of dietary fiber against colorectal cancer. However, the mecha...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.37864
更新日期:2020-01-01 00:00:00
abstract::Background: Surgery for pancreatic cancer with liver metastases (PCL) is not recommended in the international guidelines, and investigation of its clinical significance in patients with PCL is very limited. This study explored whether surgery, especially synchronous resection of the primary tumor and liver metastases ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.51218
更新日期:2021-01-01 00:00:00
abstract::MPHOSPH1, which is one of the kinesin superfamily proteins, has been reported to play an essential role in the carcinogenesis and progression of several kinds of cancers. MPHOSPH1 has also been suggested to be involved in STAT3 phosphorylation in hepatocellular carcinoma. However, the biological behavior of MPHOSPH1 i...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25279
更新日期:2018-10-31 00:00:00
abstract::Objective: Increasing evidence suggested that dysregulated small nucleolar RNAs (snoRNAs) were involved in tumor development. The roles of snoRNA 71A (SNORA71A) in the progression of non-small cell lung cancer (NSCLC) remained unclear. Methods: Dataset GSE19188 from Gene Expression Omnibus (GEO) database was downloade...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.31077
更新日期:2019-05-21 00:00:00
abstract::Aim: BAP1 is frequently mutated in clear cell renal cell carcinoma (ccRCC) with a definitive role still unclear. Methods: In silico analysis of BAP1-mutant and wild-type gene enrichment and functional annotation in TCGA-KIRC dataset was performed. Target gene was studied based on functional clustering and was knowledg...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26275
更新日期:2018-10-01 00:00:00
abstract:BACKGROUND:Mitochondria play crucial roles in cell signaling events, interorganellar communication, aging, cell proliferation and apoptosis, and mitochondrial impairment has been shown to accelerate or modulate cancer progression. Ubiquitous mitochondrial creatine kinase (uMtCK) is predominantly localized in the interm...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.13207
更新日期:2016-01-01 00:00:00
abstract::Traditional chemotherapy and radiotherapy for cancer treatment face serious challenges such as drug resistance and toxic side effects. Complementary / Alternative medicine is increasingly being practiced worldwide due to its safety beneficial therapeutic effects. We hypothesized that a super combination (SC) of known ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.7235
更新日期:2013-11-14 00:00:00
abstract::To explore the role of phospholipase D1 (PLD1) mRNA in transition of prostate cancer (PCa) cells to androgen independence, we used Arraystar Human LncRNA Microarray V3.0 to detect and compare the differential expression of PLD1 and its signaling pathway-related gene in standard androgen dependence prostate cancer (ADP...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26689
更新日期:2018-09-08 00:00:00
abstract::Background: Heavy metal pollution in farm soils is a grave concern in Taiwan. Previously, we found the incidence of oral cancer (OC) correlated positively with levels of nickel and arsenic in farm soils. Many OC patients have a second malignancy, among which esophageal cancer (EC) is the most common one in Taiwan. Obj...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.15441
更新日期:2016-08-06 00:00:00
abstract::Objectives: This study aims to evaluate influence factors for adjuvant chemotherapy regimen choice on the basis of trastuzumab in older human epidermal growth factor receptor 2 (HER2)-positive breast cancer under multi-disciplinary team (MDT) modality. Materials and Methods: HER2-positive breast cancer patients aged ≥...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.39509
更新日期:2020-02-14 00:00:00
abstract::The authors retrospectively examined the contralateral prophylactic mastectomy (CPM) rate among 100 women with ductal carcinoma in situ who are BRCA negative. Of 100 women with ductal carcinoma in situ, 31 elected contralateral prophylactic mastectomy (CPM). Factors associated with increased likelihood of undergoing c...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.11710
更新日期:2015-05-23 00:00:00
abstract::Endometrial carcinoma (EC) is the most common malignant tumors in female derived from the endometrial epithelium. Several previous studies have described estrogen receptors (ER), progesterone Receptor (PR) and phosphatase and tensin homolog (PTEN) are associated with clinicopathological factors and prognosis in EC pat...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.33720
更新日期:2020-01-13 00:00:00
abstract::Cancer cells express epithelial markers, and when progressing in malignancy they may express markers of the mesenchymal cell type. Therefore an epithelial-mesenchymal transition of the cancer cells is assumed. However the mesenchymal markers can equally well be interpreted as myeloid markers since they are common in b...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.8242
更新日期:2014-01-15 00:00:00
abstract::Background: The genetic heterogeneity between primary and metastatic lesions has rarely studied. Purpose: This study aims to compare the mutation profiling of key cancer-related genes in primary lung cancers and their matched lymph nodes (LN) metastasis. Methods: The gene mutation profiling of both primary cancers and...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.28266
更新日期:2019-03-03 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.9961
更新日期:2015-07-03 00:00:00