Transcriptional cofactor Mask2 is required for YAP-induced cell growth and migration in bladder cancer cell.

abstract：:The capture of peritoneal metastatic cancer stem cell of human gastric cancer (pMCSC-hGC) is important to further understand the mechanism of peritoneal metastasis in gastric cancer patients. Previously, cancer stem cells (CSCs) of gastric and rectal cancers were captured and identified. However, the bottleneck of cap...

journal_title：Journal of Cancer

authors： Chen XZ,Song XH,Chen XL,Li CC,Mo XM,Hu JK

更新日期：2017-09-16 00:00:00

abstract：:Background: Hepatitis B virus infection had been identified its relationship with liver diseases, including liver tumors. We aimed to explore diagnostic and prognostic values between the Human Leukocyte Antigen (HLA) complex and hepatocellular carcinoma (HCC). Methods: We used the GSE14520 dataset to explore diagnosti...

journal_title：Journal of Cancer

authors： Wang XK,Liao XW,Yang CK,Yu TD,Liu ZQ,Gong YZ,Huang KT,Zeng XM,Han CY,Zhu GZ,Qin W,Peng T

更新日期：2019-08-28 00:00:00

abstract：:Background: Colorectal cancer (CRC) remains to be one of the most common malignancies worldwide. Various studies have demonstrated that microRNAs (miRs) play a critical role in regulating cancer progression and sensitivity to chemoradiotherapy. miR-1 was found to be aberrantly expressed in CRC. However, it has not bee...

journal_title：Journal of Cancer

authors： Wu Y,Pu N,Su W,Yang X,Xing C

更新日期：2020-06-07 00:00:00

abstract：:Neural invasion (NI) is one of the important routes for local spread of gastric cancer (GC) correlated with poor prognosis. However, the exact cellular characteristics and molecular mechanisms of NI in GC are still unclear. Netrin-1(NTN1) as an axon guidance molecule was firstly found during neural system development....

journal_title：Journal of Cancer

authors： Yin K,Wang L,Xia Y,Dang S,Zhang X,He Z,Xu J,Shang M,Xu Z

更新日期：2019-06-02 00:00:00

abstract：:Breast cancer is considered as a heterogeneous disease comprising various types of neoplasms, which involves different profile changes in both mRNA and micro-RNA (miRNA) expression. Extensive studies on mRNA expression in breast tumor have yielded some very interesting findings, some of which have been validated and u...

journal_title：Journal of Cancer

authors： Fu SW,Chen L,Man YG

更新日期：2011-02-24 00:00:00

abstract：OBJECTIVE:With the survival rate of acute lymphoblastic leukemia (ALL) surpassing 90 percent within this decade, new research is emerging in the field of late effects. A review of the research investigating the relationship of treatment regimens for ALL to specific late effect deficits, underlying mechanisms, and possi...

journal_title：Journal of Cancer

authors： Bisen-Hersh EB,Hineline PN,Walker EA

更新日期：2011-01-01 00:00:00

abstract：PURPOSE:Triple-negative breast cancer (TNBC) has attracted more attention both clinically and experimentally because of its high-risk biological characteristics and lacking of effective treatment method. The purpose of this retrospective study was to find out the incidence of triple-negative breast cancer (TNBC) in all...

journal_title：Journal of Cancer

authors： Qiu J,Xue X,Hu C,Xu H,Kou D,Li R,Li M

更新日期：2016-01-01 00:00:00

abstract：:Fallopian tube epithelial cells (FTECs) are thought to be the origin of epithelial ovarian cancer. However, the effect of the hormones on FTECs is unknown, and therefore, this study explored this effect. We successfully derived FTECs from the fallopian tube epithelial layer and treated them with estradiol and progeste...

journal_title：Journal of Cancer

authors： Chang YH,Ding DC,Chu TY

更新日期：2019-06-02 00:00:00

abstract：:Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase and works as an oncogene in various cancers. Recently, PTK6 has been used as a therapeutic target for breast cancer patients in a clinical study. However, the prognostic value of PTK6 in bladder cancer (BC) remains vague. Therefore, we retrieved 3 inde...

journal_title：Journal of Cancer

authors： Xu XL,Ye YL,Wu ZM,He QM,Tan L,Xiao KH,Wu RY,Yu Y,Mai J,Li ZL,Peng XD,Huang Y,Li X,Zhang HL,Zhu XF,Qin ZK

更新日期：2017-09-27 00:00:00

abstract：:The INT0116 trial was a milestone study and laid the foundation for the adjuvant radiotherapy (RT) associated to concurrent chemotherapy (CT) for the treatment of gastric cancer (GC) after gastrectomy. However, it is still controversial whether adding RT to CT could further benefit D2-dissected GC patients. The ARTIST...

journal_title：Journal of Cancer

authors： Xu J,Zhu J,Wei Q

更新日期：2019-01-01 00:00:00

abstract：:Colorectal cancer (CRC) is an important health issue worldwide, accounting for the third place of cancer incidence. Chronic inflammation, as seen in Crohn's disease and ulcerative colitis, is the most important risk factor for developing CRC, as it favours neoplastic transformation by enhancing epithelial cell turnove...

journal_title：Journal of Cancer

authors： Figueroa-González G,García-Castillo V,Coronel-Hernández J,López-Urrutia E,León-Cabrera S,Arias-Romero LE,Terrazas LI,Rodríguez-Sosa M,Campos-Parra AD,Zúñiga-Calzada E,Lopez-Camarillo C,Morales-González F,Jacobo-Herrera NJ,Pérez

更新日期：2016-07-25 00:00:00

abstract：:Background/Aims: Autologous, tumor-derived, heat shock protein gp96 peptide complexes have antitumor potential. We conducted the first Phase II trial to evaluate the safety and efficacy of gp96 vaccination in adjuvant settings for patients with gastric cancer. Methods: We enrolled 73 consecutive patients from October ...

journal_title：Journal of Cancer

authors： Zhang K,Peng Z,Huang X,Qiao Z,Wang X,Wang N,Xi H,Cui J,Gao Y,Huang X,Gao H,Wei B,Chen L

更新日期：2017-07-02 00:00:00

abstract：:Background: Noninvasive stool-based DNA methylation testing emerges as a new approach for detecting colorectal cancer (CRC). However, its feasibility for early detection of CRC and precancerous lesions in the Chinese population remains inconclusive. Methods: In this study, we establish a possibilities screening method...

journal_title：Journal of Cancer

authors： Wang DY,He KX,Huang Y,Lou QQ,He T,Xu X

更新日期：2021-01-01 00:00:00

abstract：BACKGROUND:Neoadjuvant chemotherapy with concurrent docetaxel, doxorubicin and cyclophosphamide is commonly used for patients with locally advanced breast cancer. Epirubicin is another anthracycline used in breast cancer but the concurrent use of epirubicin and taxane is not well-established. We conducted a single inst...

journal_title：Journal of Cancer

authors： Yao X,Hosenpud J,Chitambar CR,Charlson J,Cheng YC

更新日期：2012-01-01 00:00:00

abstract：:Background: Immune cells recognize tumor antigens presented on major histocompatibility complex class I (MHC-I) molecule. Increase of MHC-I molecular expression makes tumor cells more susceptible to lysis by immune cells. Methods: Tumor lysate vaccine was prepared to damage glioma cells including cell lines and primar...

journal_title：Journal of Cancer

authors： Sun T,Li Y,Yang W,Wu H,Li X,Huang Y,Zhou Y,Du Z

更新日期：2019-09-07 00:00:00

abstract：:The incidence of colorectal cancer (CRC) ranks third among all cancers in China and improvements in screening for CRC have an important impact on prevention and control of the disease. Paraoxonase 1 (PON1) is a calcium ion-dependent hydrolase that is widely distributed in tissue. Its diagnostic value in colorectal can...

journal_title：Journal of Cancer

authors： Zhang J,Yang X,Wei L,Tan H,Chen J,Li W,Chan K,Su Y,Zhao L,Hu S,Zhong S,Xiao Y,Liu H

更新日期：2020-09-17 00:00:00

abstract：:Butyrate, a product of dietary fiber and a histone deacetylase inhibitor, induces apoptosis of colorectal cancer cells; this effect of butyrate is in part mediated by its ability to hyperactivate Wnt signaling, and may in part explain the preventive action of dietary fiber against colorectal cancer. However, the mecha...

journal_title：Journal of Cancer

authors： Bordonaro M

更新日期：2020-01-01 00:00:00

abstract：:Objectives: We aimed to investigate the interaction between fasting blood glucose and tumor embolus, and the potential mediation effect of fasting blood glucose on tumor embolus in predicting gastrointestinal tract cancer-specific mortality risk postoperatively. Methods and Results: 4330 patients were consecutively re...

journal_title：Journal of Cancer

authors： Hu D,Zhang X,Lin X,Zhang H,Xia Y,Lin J,Zheng X,Peng F,Niu W

更新日期：2020-01-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) cells exhibit multidrug resistance (MDR), but the underlying mechanisms remain unclear. Cancer cells that overexpress telomerase are resistant to chemotherapeutic drugs. This study aimed to determine the effects of mitochondrial translocation of telomerase on MDR in HCC cells. HepG2 cell...

journal_title：Journal of Cancer

authors： Yan J,Zhou Y,Chen D,Li L,Yang X,You Y,Ling X

更新日期：2015-01-05 00:00:00

abstract：:Cachexia is a common term for the wasting symptoms which may appear in almost every chronic illness, such as AIDS, tuberculosis, and cancer. Cancer cachexia (CCA) is a result of the interaction between the host and the tumor, mainly manifested in short-term wasting, malnutrition, and so on. Due to the chronic food sho...

journal_title：Journal of Cancer

authors： Wang J,Wang Y,Tong M,Pan H,Li D

更新日期：2019-01-01 00:00:00

abstract：PURPOSE:The current study examined quality of life, progression of disease, and survival rate during chemotherapy in newly diagnosed non-small cell lung cancer (NSCLC) patients with depression (n=48) and without depression (n=78). Further, the study explored the hypothesis that the survival benefit resulted from the ch...

journal_title：Journal of Cancer

authors： Chen J,Li W,Cui L,Qian Y,Zhu Y,Gu H,Chen G,Shen Y,Liu Y

更新日期：2015-09-15 00:00:00

abstract：:Aim: Skin cutaneous melanoma (SKCM) is one of the most life-threatening malignancies damaging human health. APOBEC3G (A3G) has been found in several cancers; however, the role of A3G in SKCM is rarely studied. This study aimed to investigate the expression of A3G in tumor tissue and its prognostic value in SKCM patien...

journal_title：Journal of Cancer

authors： Han W,Xu J,Shen GL

更新日期：2020-07-06 00:00:00

abstract：:Colorectal cancer (CRC) is considered to be closely associated with alteration of intestinal microorganisms. The purpose of present study was to investigate the distribution of gut microbiota in the distinction of microbiota dysbiosis between two disease syndromes called Zheng-Qi-Kui-Xu(ZQKX) and Xie-Du-Yong-Sheng (XD...

journal_title：Journal of Cancer

authors： Wang P,Ding S,Sun L,Feng Y,Guo K,Zhu Y,Huang D,Ruan S

更新日期：2020-10-23 00:00:00

abstract：:Background: The most common metastatic site in cervical cancers is lung. The aim of this study is to identify cervical cancer patients with high risk for developing lung metastasis and further explore their prognosis. Materials and Methods: At first, patients diagnosed with cervical cancer from 2010 to 2015 were ident...

journal_title：Journal of Cancer

authors： Chen X,Chen L,Zhu H,Tao J

更新日期：2020-08-08 00:00:00

abstract：:Purpose: To design an alternative workflow for cancer-risk assessment to predict distant metastasis (DM) of nasopharyngeal carcinoma (NPC). Methods: We enrolled 234 patients with non-disseminated NPC and a family history of cancer who underwent intensity-modulated radiotherapy and concurrent chemo-radiotherapy with/wi...

journal_title：Journal of Cancer

authors： Zhang W,Chen Y,Chen L,Liu X,Sun Y,Li Y,Ma J

更新日期：2017-07-20 00:00:00

abstract：:Objective: Chemotherapy is a major therapeutic method for bladder urothelial carcinoma (BUC), which can effectively improve the prognosis of BUC patients, but the chemoresistance often leads to chemotherapy failure. This study will research the regulatory roles and molecular mechanism of miR-101-3p in BUC chemoresista...

journal_title：Journal of Cancer

authors： Li B,Xie D,Zhang H

更新日期：2019-06-02 00:00:00

abstract：:EGFR mutation of Non-small cell lung cancers (NSCLC) was predominantly seen in Asian population and it was considered as a predictor of responsiveness. Eendothelial nitric oxide synthase (eNOS) plays a vital role in chronic inflammation and carcinogenesis. In this study, we aimed to explore the association between the...

journal_title：Journal of Cancer

authors： Huang CY,Hsieh MJ,Wu WJ,Chiang WL,Liu TC,Yang SF,Tsao TC

更新日期：2018-06-15 00:00:00

abstract：:Pokemon, also known as leukemia/lymphoma-related factor (LRF) is a pro-oncogenic protein highly expressed in several cancers. There have been few in vitro and animal studies about its malignant biological behavior and function, however, its role especially in prostate cancer has not been completely elucidated. Therefo...

journal_title：Journal of Cancer

authors： Jiang F,Zheng Q,Chang L,Li X,Wang X,Gu X

更新日期：2019-04-21 00:00:00

abstract：:Amplified in breast cancer 1 (AIB1) gene, a coactivator for steroid receptor, is frequently amplified in diverse cancers and is considered as an oncogene in tumorigenesis. However, the prognostic significance of AIB1 amplification in gliomas remains totally unclear. In this study, 115 gliomas and 16 benign meningiomas...

journal_title：Journal of Cancer

authors： Chen L,Wang C,Zhang X,Gao K,Liu R,Shi B,Hou P

更新日期：2016-10-22 00:00:00

abstract：:Purpose: The aberrant of fibroblast growth factors and their receptors (FGF/FGFR) is an emerging target in the treatment of solid tumors. This study aimed to explore the landscape of FGF/FGFR alterations in a large cohort of cancer patients. Material and Methods: The formalin-fixed paraffin-embedded specimens of cance...

journal_title：Journal of Cancer

authors： Zuo W,He Y,Li W,Wu H,Zhao Z,Zhang Y,Chen S,Yin Y

更新日期：2020-09-23 00:00:00