Association of endothelial nitric oxide synthase (eNOS) polymorphisms with EGFR-mutated lung adenocarcinoma in Taiwan.

abstract：:Minichromosome Maintenance (MCM) proteins play essential roles in various cancers. We previously reported that MCM7 could be a prognostic biomarker in non-small cell lung cancer (NSCLC). The purpose of current study is to explore roles of other MCM proteins in NSCLC and their correlation with clinico-pathologic parame...

journal_title：Journal of Cancer

authors： Liu YZ,Wang BS,Jiang YY,Cao J,Hao JJ,Zhang Y,Xu X,Cai Y,Wang MR

更新日期：2017-10-09 00:00:00

abstract：:Chemo- and radio-therapy suffer from certain well-recognized drawbacks for lymphoma therapy. Passive immunotherapy with monoclonal antibody has improved outcome for patients with CD20+ B cell lymphoma, but not for T cell lymphoma. Therefore, novel treatment approaches are clearly required for T cell lymphoma. To date,...

journal_title：Journal of Cancer

authors： Gao D,Li W,Wang W,Cai Y,Wang Y,Luo X,Wei CC

更新日期：2017-09-15 00:00:00

abstract：:Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential enzyme in the base excision repair pathway. Epidemiological studies have suggested associations between APE1 rs1760944 polymorphism and cancer risk. This study was aimed to evaluate the relationship between APE1 rs1760944 polymorphism and cancer risk. We sear...

journal_title：Journal of Cancer

authors： Dai ZJ,Wang XJ,Kang AJ,Ma XB,Min WL,Lin S,Zhao Y,Yang PT,Wang M,Kang HF

更新日期：2014-03-13 00:00:00

abstract：:Esophageal cancer (EC) is a unique and heterogeneous disease diagnosed mostly at advanced stages. Altered glycans presented on cell surfaces are involved in the occurrence and development of malignancy. However, the effects of glycans on EC progression are largely unexplored. Here, a lectin array was utilized to detec...

journal_title：Journal of Cancer

authors： Xia M,Shao J,Qiao M,Luo Z,Deng X,Ke Q,Dong X,Shen L

更新日期：2020-06-01 00:00:00

abstract：:Mechanistic target of rapamycin (mTOR) plays a critical role in the development of oral squamous cell carcinoma (OSCC), but the underlying mechanisms remain poorly understood. Here we have demonstrated that the expression of osteopontin (OPN) was dramatically up-regulated in OSCC tissues and cell lines. Moreover, redu...

journal_title：Journal of Cancer

authors： Gan N,Zou S,Hang W,Yang D,Zhang X,Yin Y

更新日期：2017-05-12 00:00:00

abstract：:Objectives: Platinum-based chemotherapy is first-line treatment for non-small cell lung cancer (NSCLC) patients. The efficacy is limited by drug resistance. Recent studies suggest that ATP7B, a copper efflux transporter, may be involved in platinum resistance. However, the clinical significance of ATP7B expression in ...

journal_title：Journal of Cancer

authors： Li YQ,Chen J,Yin JY,Liu ZQ,Li XP

更新日期：2018-09-08 00:00:00

abstract：:Background: The Matrix metalloproteinase-14 (MMP-14) expression has been shown to be overexpressed in different cancers. However, there is no comprehensive quantitative evaluation of the MMP-14 prognostic value in digestive system carcinoma (DSC). The aim of this study is to explore the correlation between the MMP-14 ...

journal_title：Journal of Cancer

authors： Duan F,Peng Z,Yin J,Yang Z,Shang J

更新日期：2020-01-01 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is currently one of the most intractable malignancies with a typical scirrhous pattern in histology. Due to its abundant tumor stroma and scant vascularization, chemotherapeutic agents are considered inefficiently permeable to cancer nests, making it highly difficult to cure the...

journal_title：Journal of Cancer

authors： Saito K,Sakaguchi M,Maruyama S,Iioka H,Putranto EW,Sumardika IW,Tomonobu N,Kawasaki T,Homma K,Kondo E

更新日期：2018-07-30 00:00:00

abstract：BACKGROUND:Statins are proposed as a chemoprevention agent for breast cancer due to their anti-inflammatory effect. The effects of lipophilic and hydrophilic statins on breast cancer risk might be different due to their different pharmacologic properties. Therefore, this study aimed to assess a casual-effect of lipophi...

journal_title：Journal of Cancer

authors： Anothaisintawee T,Udomsubpayakul U,McEvoy M,Lerdsitthichai P,Attia J,Thakkinstian A

更新日期：2016-06-06 00:00:00

abstract：:Background: Radiotherapy is a standard treatment for a significant fraction of cancer patients. Nonetheless, to this day radiation resistance is a key impediment in gastric cancer (GC) treatment. Moreover, GC is characterized by its substantial neo-angiogenesis, driven by high levels of vascular endothelial growth fac...

journal_title：Journal of Cancer

authors： Li G,Lin H,Tian R,Zhao P,Huang Y,Pang X,Zhao L,Cao B

更新日期：2018-10-18 00:00:00

abstract：:Endometrial carcinoma (EC) is the most common malignant tumors in female derived from the endometrial epithelium. Several previous studies have described estrogen receptors (ER), progesterone Receptor (PR) and phosphatase and tensin homolog (PTEN) are associated with clinicopathological factors and prognosis in EC pat...

journal_title：Journal of Cancer

authors： Liang Y,Lin B,Ye Z,Chen S,Yu H,Chen C,Zhang X,Zhou K,Zeng J

更新日期：2020-01-13 00:00:00

abstract：:Objective: To investigate the development of bronchoscopy in China and compare it with its application in the early 21st century. Methods: The data collection was based on questionnaires. Three hundred and nineteen hospitals, which distributed across 30 provinces and 130 cities, were included in the study. Data about ...

journal_title：Journal of Cancer

authors： Shi D,Li F,Wang K,Kong C,Huang H,Li Q,Jin F,Hu C,Wang C,Shi H,Hu Z,Dong Y,Ning Y,Tsakiridis K,Sapalidis K,Kosmidis C,Vagionas A,Hohenforst-Schmidt W,Freitag L,Turner JF,Drevelegas K,Perdikouri EI,Kovacevic T,

更新日期：2020-07-20 00:00:00

abstract：:Colorectal cancer is a commonly diagnosed malignancy and also the major cause of death worldwide. Chemotherapy is the primary therapy for advanced colorectal cancer. Although oxaliplatin has potential effect in colorectal cancer therapy, the molecular mechanisms involved in its cytotoxic effects are not well elucidate...

journal_title：Journal of Cancer

authors： Evert J,Pathak S,Sun XF,Zhang H

更新日期：2018-05-22 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs), which are an important component of the tumor microenvironment, have been identified in the blood circulation of patients with cancer metastasis, and metastatic cancer cells can recruit circulating CAFs. However, primary carcinoma sites usually regulate the behavior of metastatic ...

journal_title：Journal of Cancer

authors： Zhang YF,Zhou YZ,Zhang B,Huang SF,Li PP,He XM,Cao GD,Kang MX,Dong X,Wu YL

更新日期：2019-07-23 00:00:00

abstract：:Chemotherapy resistance represents a major obstacle for the treatment of patients with breast cancer (BC) and greatly restricts the therapeutic effect of the first-line chemotherapeutic agent doxorubicin (DOX). The present study aimed to investigate the feasibility of the recombinant dual-target murine double minute 2...

journal_title：Journal of Cancer

authors： Fan Y,Ma K,Jing J,Wang C,Hu Y,Shi Y,Li E,Geng Q

更新日期：2020-01-01 00:00:00

abstract：:Background/Purpose: In colon cancer (CC) patients preoperative (pre-op) levels of VEGF-A165 (VEGF) is a strong predictor for disease recurrence. Elevated postoperative (post-op) VEGF levels could have undesirable effects by enhancing tumor growth and metastasis formation. It has been suggested that thromboprophylaxis ...

journal_title：Journal of Cancer

authors： Mitsis M,Koliou P,Bali C,Ntounousi E,Tatsis V,Nousias V,Lianos GD,Vartholomatos G,Nastos D

更新日期：2017-08-25 00:00:00

abstract：:Purpose: This study aimed to identify the survival benefit and safety of alternative dosage schedules for sunitinib in metastatic renal cell carcinoma. Materials and Methods: Clinicopathologic and survival data of patients treated with sunitinib as first-line therapy were retrospectively reviewed. Patients were classi...

journal_title：Journal of Cancer

authors： Zhang X,Sun G,Zhao J,Shu K,Zhao P,Liu J,Yang Y,Tang Q,Chen J,Shen P,Wang J,Zeng H

更新日期：2018-09-07 00:00:00

abstract：BACKGROUND:The 2010 guidelines by ASCO-CAP have mandated that breast cancer specimens with ≥1% positively staining cells by immunohistochemistry should be considered Estrogen Receptor (ER) positive. This has led to a subclass of low-ER positive (1-10%) breast cancers. We have examined the biology and clinical behavior ...

journal_title：Journal of Cancer

authors： Prabhu JS,Korlimarla A,Desai K,Alexander A,Raghavan R,Anupama C,Dendukuri N,Manjunath S,Correa M,Raman N,Kalamdani A,Prasad M,Gopinath KS,Srinath BS,Sridhar TS

更新日期：2014-01-23 00:00:00

abstract：:To explore the role of phospholipase D1 (PLD1) mRNA in transition of prostate cancer (PCa) cells to androgen independence, we used Arraystar Human LncRNA Microarray V3.0 to detect and compare the differential expression of PLD1 and its signaling pathway-related gene in standard androgen dependence prostate cancer (ADP...

journal_title：Journal of Cancer

authors： Zhou W,Shi K,Ji L,Wu R,Chen Y,Tu H,Zhou B,Wang Z,Zhang M

更新日期：2018-09-08 00:00:00

abstract：:Cancer is a leading cause of death throughout the world, and cancer therapy remains a big medical challenge in terms of both its therapeutic efficacy and safety. Therefore, to find out a safe anticancer drug has been long goal for oncologist and medical scientists. Among clinically used medicines with no or little tox...

journal_title：Journal of Cancer

authors： Lian X,Wang G,Zhou H,Zheng Z,Fu Y,Cai L

更新日期：2018-04-06 00:00:00

abstract：:Background: The study of CTLA-4 inhibitors has been one of the hot spots in the field of tumor immunotherapy. As the most immunogenic subtype of breast cancer, Triple negative breast cancer (TNBC) has a great potential in the treatment strategy. The aim of this study was to explore the relevant genes and pathways of C...

journal_title：Journal of Cancer

authors： Peng Z,Su P,Yang Y,Yao X,Zhang Y,Jin F,Yang B

更新日期：2020-09-09 00:00:00

abstract：BACKGROUND:This study was performed to assess the impact of irradiation on the tissue penetration depth of doxorubicin delivered during Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC). METHODS:Fresh post mortem swine peritoneum was cut into 10 proportional sections. Except for 2 control samples, all received...

journal_title：Journal of Cancer

authors： Khosrawipour V,Giger-Pabst U,Khosrawipour T,Pour YH,Diaz-Carballo D,Förster E,Böse-Ribeiro H,Adamietz IA,Zieren J,Fakhrian K

更新日期：2016-05-07 00:00:00

abstract：:Purpose: We examined the effect of GV1001 in castration castration-resistant prostate cancer (CRPC) cell growth and invasion and explored the potential molecular mechanisms of action. Materials and Methods: The in vitro anti-cancer effects of GV1001 in CRPC cells were examined using cell viability assay, TUNEL assay, ...

journal_title：Journal of Cancer

authors： Park YH,Jung AR,Kim GE,Kim MY,Sung JW,Shin D,Cho HJ,Ha US,Hong SH,Kim SW,Lee JY

更新日期：2019-10-17 00:00:00

abstract：:Background: Neoadjuvant chemoradiation (CRT) remains controversial in the treatment of the oesophagus or gastro-oesophageal junction (GOJ) carcinomas. Methods: We conducted a meta-analysis to assess the efficacy and safety of Neoadjuvant CRT plus surgery comparing with neoadjuvant CT plus surgery or surgery alone. Fea...

journal_title：Journal of Cancer

authors： Meng X,Wang L,Zhao Y,Zhu B,Sun T,Zhang T,Gu X,Zheng Z

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND AND AIMS:We compared clinicopathologic data and long-term clinical outcomes among patients with non-B and non-C hepatocellular carcinoma (NBNC-HCC) who underwent curative resection (group A, n=129), those with hepatitis B virus-related HCC (group B, n=62) and those with hepatitis C virus-related HCC (group C...

journal_title：Journal of Cancer

authors： Nishikawa H,Arimoto A,Wakasa T,Kita R,Kimura T,Osaki Y

更新日期：2013-07-18 00:00:00

abstract：:Junctional adhesion molecule B (JAM-B) is a multifunctional transmembrane protein that plays an important role in tumor progression. JAM-B is significantly upregulated in gastric cancer, melanoma cell metastasis and oral squamous cell carcinoma. JAM-2 may also function as a putative tumor suppressor in the progression...

journal_title：Journal of Cancer

authors： Zhang W,He R,Chen S,Zhang L,Cao G,Yang W,Li J

更新日期：2020-03-05 00:00:00

abstract：:Macrophages play a critical role in the initiation and progression in various human solid tumors; however, their role and transformation in pancreatic ductal adenocarcinoma (PDAC) were still illusive. Here, immunohistochemistry was used to determine CD206 (specific marker of M2 macrophage) and PKM2 expression in PDAC ...

journal_title：Journal of Cancer

authors： Hu H,Tu W,Chen Y,Zhu M,Jin H,Huang T,Zou Z,Xia Q

更新日期：2020-02-03 00:00:00

abstract：:MPHOSPH1, which is one of the kinesin superfamily proteins, has been reported to play an essential role in the carcinogenesis and progression of several kinds of cancers. MPHOSPH1 has also been suggested to be involved in STAT3 phosphorylation in hepatocellular carcinoma. However, the biological behavior of MPHOSPH1 i...

journal_title：Journal of Cancer

authors： Abe T,Kohashi K,Takemoto J,Kinoshita F,Eto M,Oda Y

更新日期：2018-10-31 00:00:00

abstract：:Long non-coding RNAs (LncRNAs) have been reported to be involved in tumorigenesis and tumor progression. Single nucleotide polymorphisms (SNPs) in the lncRNAs also play a vital role in carcinogenesis. The aim of this study was to assess the relationships between the four selected tagSNPs (rs944289, rs3787016, rs145631...

journal_title：Journal of Cancer

authors： Xu T,Hu XX,Liu XX,Wang HJ,Lin K,Pan YQ,Sun HL,Peng HX,Chen XX,Wang SK,He BS

更新日期：2017-04-09 00:00:00

abstract：:Background: To identify associated risk factors and develop a predictive nomogram for the early death of metastatic gastric cancer patients. Methods: A total of 4575 patients in the SEER cohort and 220 patients in the Chinese cohort diagnosed with metastatic gastric cancer in our Cancer Center were obtained. Univariat...

journal_title：Journal of Cancer

authors： Zhu Y,Fang X,Wang L,Zhang T,Yu D

更新日期：2020-07-14 00:00:00