Abstract:
:Objectives: We aimed to investigate the interaction between fasting blood glucose and tumor embolus, and the potential mediation effect of fasting blood glucose on tumor embolus in predicting gastrointestinal tract cancer-specific mortality risk postoperatively. Methods and Results: 4330 patients were consecutively recruited between January 2000 and December 2010, with annual follow-up ending in December 2015. The median follow-up time was 48.6 months. Two optimal cutoff points for fasting blood glucose (6.11 and 11.69 mmol/L) were identified. Patients with fasting blood glucose <6.11 mmol/L and negative tumor embolus had the best survival, and the worst survival was seen in patients with fasting blood glucose >11.69 mmol/L and positive tumor embolus. The risk was highest for patients with fasting blood glucose >11.69 mmol/L and positive tumor embolus (adjusted HR: 11.91, 95% CI: 9.13 to 15.52). Using the Sobel-Goodman mediation test, the proportion of total effect conferred by tumor embolus that was mediated by fasting blood glucose was estimated to be 45.3%. Conclusions: Our findings indicate a synergistic interaction between fasting blood glucose and tumor embolus in predicting the postoperative prognosis of gastrointestinal tract cancer.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Hu D,Zhang X,Lin X,Zhang H,Xia Y,Lin J,Zheng X,Peng F,Niu Wdoi
10.7150/jca.34843subject
Has Abstractpub_date
2020-01-01 00:00:00pages
867-873issue
4issn
1837-9664pii
jcav11p0867journal_volume
11pub_type
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journal_title:Journal of Cancer
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journal_title:Journal of Cancer
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doi:10.7150/jca.29245
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更新日期:2015-09-01 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2019-01-29 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.27335
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journal_title:Journal of Cancer
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journal_title:Journal of Cancer
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journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.8693
更新日期:2014-05-29 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.35362
更新日期:2019-08-29 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.33720
更新日期:2020-01-13 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.5838
更新日期:2013-01-01 00:00:00
abstract::Objective: First, to evaluate the sensitivity and positive predictive value (PPV) of intra-operative frozen section (FS) diagnosis in borderline ovarian tumors (BOTs), and to explore the factors affecting the diagnostic accuracy. Second, to assess the clinical outcomes of misdiagnosed BOT patients. Methods: We perform...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25883
更新日期:2018-07-16 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.7235
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journal_title:Journal of Cancer
pub_type: 杂志文章
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journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2019-05-26 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.425
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abstract::Human papillomavirus (HPV) is a DNA virus that infects epithelial cells and has been implicated in the development of cervical cancer. Few therapeutic strategies have been designed for the treatment of cervical intraepithelial neoplasia, a precursor of cervical cancer. In these early stages, the HPV E2 protein is the ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.15536
更新日期:2016-09-27 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29933
更新日期:2019-05-12 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16069
更新日期:2016-10-22 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.31077
更新日期:2019-05-21 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.5047
更新日期:2013-01-01 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19452
更新日期:2017-07-15 00:00:00