Abstract:
:Pokemon, also known as leukemia/lymphoma-related factor (LRF) is a pro-oncogenic protein highly expressed in several cancers. There have been few in vitro and animal studies about its malignant biological behavior and function, however, its role especially in prostate cancer has not been completely elucidated. Therefore, in this study, we identified that Pokemon is overexpressed in human prostate cancer tissue samples, and its suppression inhibits proliferation of prostate cancer cells, along with promotion of apoptosis. Furthermore, to explore the mechanism by which Pokemon promotes tumor progression, we observed that it binds to the promoter of STRN4 (striatin 4), a downstream target, and subsequently regulates its expression. In conclusion, our study indicated that Pokemon through stimulation of STRN4 expression promotes prostate tumor progression via a Pokemon /STRN4 axis.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Jiang F,Zheng Q,Chang L,Li X,Wang X,Gu Xdoi
10.7150/jca.29471subject
Has Abstractpub_date
2019-04-21 00:00:00pages
1833-1845issue
8issn
1837-9664pii
jcav10p1833journal_volume
10pub_type
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更新日期:2019-10-22 00:00:00
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更新日期:2019-08-29 00:00:00
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