Abstract:
:The INT0116 trial was a milestone study and laid the foundation for the adjuvant radiotherapy (RT) associated to concurrent chemotherapy (CT) for the treatment of gastric cancer (GC) after gastrectomy. However, it is still controversial whether adding RT to CT could further benefit D2-dissected GC patients. The ARTIST trial indicated that the addition of RT to CT did not have a positive impact on disease-free survival (DFS). Nevertheless, in a subgroup of 396 patients with positive pathological lymph nodes, combined treatment with RT was superior to CT alone. A similar randomized Chinese trial confirmed the superiority of adding RT to CT in terms of DFS for patients with D2 lymphadenectomy. However, several previous randomized studies provided inconsistent results with the benefits of combined treatment of RT and CT. The inconsistent results of several studies may be due to the differences between tumor epidemiology, treatment policies, and treatment outcomes. During the past decade, major progress in accurate target delineation utilizing RT technology has been observed. However, even though the use of adjuvant RT doubled after the INT-0116 trial results became public, the fraction of patients receiving adjuvant RT was still low according to the SEER database. The low rate of adjuvant RT can partially be explained by concern over toxicity while undergoing RT. Several studies have also defined the specific location of locoregional recurrence for postoperative RT in GC, but these studies are still limited. A number of retrospective studies demonstrated that the most prevalent nodal recurrence was outside the D2 dissection field. In order to overcome the restricted nature of a retrospective study and provide more individual radiation field determination, additional large-scale prospective multicenter studies are required to evaluate the optimal RT target.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Xu J,Zhu J,Wei Qdoi
10.7150/jca.27335subject
Has Abstractpub_date
2019-01-01 00:00:00pages
458-466issue
2issn
1837-9664pii
jcav10p0458journal_volume
10pub_type
杂志文章,评审abstract::Background: Radiotherapy is a primary treatment strategy for patients with unresectable hepatocellular carcinoma (HCC); however, the prognostic factors among HCC patients who have received radiotherapy but not undergone surgery have not been systematically studied. Thus, the prognostic factors were investigated in thi...
journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2019-07-25 00:00:00
abstract::Taking into account the previously reported relationship between inflammation and carcinogenesis, and the scant amount of data concerning the role of neutrophil extracellular traps (NETs) in carcinogenesis, we decided to study the process of extracellular trap formation in patients with inflammation as well as in pati...
journal_title:Journal of Cancer
pub_type: 杂志文章
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journal_title:Journal of Cancer
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doi:10.7150/jca.9961
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journal_title:Journal of Cancer
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doi:10.7150/jca.49560
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journal_title:Journal of Cancer
pub_type: 杂志文章
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pub_type: 杂志文章,评审
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doi:10.7150/jca.26101
更新日期:2018-09-08 00:00:00
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journal_title:Journal of Cancer
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更新日期:2020-02-03 00:00:00
abstract::For hepatocellular carcinoma (HCC) patients with macrovascular invasion (MaVI), hepatectomy and transcatheter arterial chemoembolization (TACE) remain the main treatment options in Asia. However, which could achieve better survivals remains controversial. In present study, we conducted a meta-analysis to clarify the s...
journal_title:Journal of Cancer
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doi:10.7150/jca.20978
更新日期:2017-08-25 00:00:00
abstract::Cervical cancer is a commonly diagnosed cancer among females. Polymorphisms in pre-microRNAs have been demonstrated to play critical roles in cancer. However, the roles of pre-microRNA polymorphisms in the aetiology of cervical cancer have not been well documented. We genotyped eight pre-microRNA polymorphisms in 290 ...
journal_title:Journal of Cancer
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abstract::Background: Our previous study demonstrated that the peroxiredoxin 6 (PRDX6) protein was downregulated in squamous cervical cancer samples after neoadjuvant chemotherapy compared with the expression level before chemotherapy. However, the effect of PRDX6 on the biological behavior of cervical cancer is still uncertain...
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abstract::Early detection and accurate evaluation were both critical to improving the prognosis of clear cell Renal Cell Carcinoma (ccRCC) patients. More importantly, RNA Binding Proteins (RBPs) play a vital role in the tumorigenesis and progression of numerous cancers. However, the relationship between RBPs and ccRCC is still ...
journal_title:Journal of Cancer
pub_type: 杂志文章
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journal_title:Journal of Cancer
pub_type: 杂志文章
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abstract::Background: IgA antibodies against Epstein-Barr virus (EBV) capsid antigen (VCA) and nuclear antigen 1 (EBNA1) have been proposed to facilitate the diagnosis and early detection of nasopharyngeal carcinoma (NPC) in high-incidence regions. However, while new methodologies and new platforms for the detection of VCA-IgA ...
journal_title:Journal of Cancer
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pub_type: 杂志文章
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更新日期:2013-01-01 00:00:00
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journal_title:Journal of Cancer
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24568
更新日期:2018-04-19 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2019-05-12 00:00:00
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journal_title:Journal of Cancer
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journal_title:Journal of Cancer
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journal_title:Journal of Cancer
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