Abstract:
:The process of neoplastic transformation of the colon involves a progression through hyperproliferative epithelium through the aberrant crypt foci→small adenoma→large adenoma→invasive cancer→metastatic disease. These are orchestrated by sequential genetic and epigenetic events which provide the underpinnings of cellular alterations such as early induction in proliferation/suppression of apoptosis, along with the late stage increase in invasiveness. Colorectal cancer (CRC) averages 49-111 mutations per tumor encompassing 10-15 critical signaling pathways[1]. Accumulating such a high number of mutations requires a fertile mutational field, which is the hallmark of colon carcinogenesis.While genetic susceptibility to colorectal cancer is well-known, at least half of the risk is believed to be due to exogeneous factors (e.g., obesity, diet, exercise). Understanding these risk factors represents a promising mode of tailoring screening modality and intensity. However, previous attempts using these factors (i.e., NCI risk calculator) have only been modestly successful with an area under receiver operating characteristics (ROC) curve (AUC) of just 0.61. One of the most important concepts is that risk is the interaction between these genetic and environmental components and is driven by the variety of polymorphisms. Thus, predicting risk is difficult given the complexity. On the other hand, the colonic mucosa represents the end product of the complex interplay between these multiple factors. The power of field carcinogenesis is that it reflects this interplay between genetics and environment.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Backman V,Roy HKdoi
10.7150/jca.5838subject
Has Abstractpub_date
2013-01-01 00:00:00pages
251-61issue
3issn
1837-9664pii
jcav04p0251journal_volume
4pub_type
杂志文章abstract::Background: Noninvasive stool-based DNA methylation testing emerges as a new approach for detecting colorectal cancer (CRC). However, its feasibility for early detection of CRC and precancerous lesions in the Chinese population remains inconclusive. Methods: In this study, we establish a possibilities screening method...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.50525
更新日期:2021-01-01 00:00:00
abstract::Ovarian cancer, cervical cancer and endometrial cancer are three relatively common malignant cancers of the female reproductive system. Despite improvements in female genital tract cancer detection and development of new therapeutic approaches, there are still poor prognoses and some do not respond to therapeutic patt...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.44727
更新日期:2020-10-21 00:00:00
abstract::Dihydroorotate dehydrogenase (DHODH) is a rate-limiting enzyme in the de novo biosynthesis pathway of pyrimidines. Inhibition of this enzyme impedes cancer cell proliferation but the exact mechanisms of action of these inhibitors in cancer cells are poorly understood. In this study, we showed that cancer cells, namely...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.14835
更新日期:2017-09-05 00:00:00
abstract::Background and Aim: Glioblastoma multiforme (GBM) is a highly aggressive brain malignancy that lacks reliable treatments. Resveratrol possesses anti-cancer effects, but its activity against glioblastoma cells is variable for unknown reasons. One mechanism through which anti-cancer drugs exert their effects is oxidativ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.45489
更新日期:2021-01-01 00:00:00
abstract::Yes-associated protein (YAP) is a transcriptional coactivator that promotes cell proliferation, migration, and tissue homeostasis in colorectal cancer (CRC). Here, we established 5-Fu resistant CRC cell line (SW620R) and examined the role of YAP in chemotherapy resistance. We showed that YAP promoted cell proliferatio...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.44775
更新日期:2020-07-11 00:00:00
abstract::Objectives: For patients with multiple small-sized pulmonary cancers, a lobectomy can disrupt future therapeutic options for other lesions. It was recently reported that limited pulmonary resections were not inferior to lobectomy for the management of selected peripheral small-sized pulmonary adenocarcinomas. Patients...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.35026
更新日期:2020-02-20 00:00:00
abstract::Long non-coding RNAs (lncRNAs) have been considered as biomarkers for the carcinogenesis and development of various cancers. However, the prognostic significance of lncRNAs in renal cell carcinoma (RCC) remains unclear. This study aimed to determine the predictive ability of lncRNAs in clear cell RCC (ccRCC). Among th...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.40421
更新日期:2020-04-27 00:00:00
abstract::Background: To elucidate the expression of Aurora kinases (AURK) and the anticancer effects of pan-aurora kinase inhibitor Danusertib in hepatocarcinogenesis model in C56Bl6 mice. Methods: Thirty mice C56Bl6 were randomly divided into Group A or control, Group B animals who underwent experimental hepatocarcinogenesis ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.22329
更新日期:2018-02-27 00:00:00
abstract::Glioblastoma multiforme (GBM) is commonly known as the most aggressive primary CNS tumor in adults. The mean survival of it is 14 to 15 months, following the standard therapy from surgery, chemotherapy, to radiotherapy. Efforts in recent decades have brought many novel therapies to light, however, with limitations. In...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.32475
更新日期:2019-08-27 00:00:00
abstract::Trend analysis is the analysis using statistical models to estimate and predict potential trends over time, space or any independent continuous-variable. It has been widely used in epidemiology and public health, but much less so in clinical oncology and basic cancer research. Methodological imitations of the chosen s...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.43521
更新日期:2020-03-04 00:00:00
abstract::Cancer-associated fibroblasts (CAFs), which are an important component of the tumor microenvironment, have been identified in the blood circulation of patients with cancer metastasis, and metastatic cancer cells can recruit circulating CAFs. However, primary carcinoma sites usually regulate the behavior of metastatic ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.27590
更新日期:2019-07-23 00:00:00
abstract::Hepatocellular carcinoma (HCC) is the sixth most common tumor worldwide. The relationship between the gene methylation accumulation and HCC has been widely studied. In our study, we used the Sequenom EpiTYPER assay to investigate the methylation levels of the RASA3 in 164 HCC samples and paired adjacent non-cancerous ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24567
更新日期:2018-05-25 00:00:00
abstract::Aims: We previously demonstrated that a loss of lean body mass loss at one month after gastrectomy was an independent risk factor for the continuation of adjuvant chemotherapy with S-1. However, it is unclear whether or not lean body mass loss after gastrectomy leads to a poor survival through poor compliance to adjuv...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.30697
更新日期:2019-05-28 00:00:00
abstract::The 21-gene recurrence score (RS) is increasingly being used for patients with early stage, hormone receptor-positive, Her-2-negative breast cancer. However, these results are largely from populations with infiltrating ductal carcinoma (IDC). The clinical value of RS testing in mucinous carcinoma has not been well inv...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.27291
更新日期:2018-08-06 00:00:00
abstract::Despite advancement in the treatment of diffuse large B-cell lymphoma (DLBCL), many patients tend to relapse or become refractory after initial therapy. Therefore, it is essential to identify novel therapeutic targets and drugs, understand the molecular pathogenesis mechanism of DLBCL, and find ways to prevent and tre...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.48310
更新日期:2021-01-01 00:00:00
abstract::Background: Topoisomerase IIA (TOP2A) gene encodes DNA topoisomerase enzyme and has been reported that TOP2A is broadly expressed in many types of cancers. Our study aims to investigate the prognostic effect of TOP2A on lung adenocarcinoma (LUAD) and the potential molecular mechanism of TOP2A to tumorigenesis. Methods...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.41415
更新日期:2020-02-10 00:00:00
abstract::Even with the technological advances of dose-escalated IMRT with the addition of the latest image guidance technologies, local failures still occur. The combination of MRI-based imaging techniques can yield quantitative information that reflects on the biological properties of prostatic tissues. These techniques provi...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.5419
更新日期:2013-01-01 00:00:00
abstract:BACKGROUND:Mathematical models can be useful tools in exploring disease trends and health consequences of interventions in a population over time. Most cancers, in particular cervical cancer, have long incubation periods. The time from acquisition of HPV infection to development of invasive cancer can be up to two deca...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.4161
更新日期:2012-01-01 00:00:00
abstract::Background: The Matrix metalloproteinase-14 (MMP-14) expression has been shown to be overexpressed in different cancers. However, there is no comprehensive quantitative evaluation of the MMP-14 prognostic value in digestive system carcinoma (DSC). The aim of this study is to explore the correlation between the MMP-14 ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.36469
更新日期:2020-01-01 00:00:00
abstract::Little is known about the possible oncogenic roles of genes encoding for the phosphatidylinositol 4-kinases, a family of enzymes that regulate an early step in phosphoinositide signalling. To address this issue, the mutational status of all four human phosphatidylinositol 4-kinases genes was analyzed across 852 breast...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.9794
更新日期:2014-10-28 00:00:00
abstract::Purpose: The objective of the study was to evaluate the important role played by androgen and insulin in the development of endometrial carcinoma (EC), and their combined effect on EC risk. Methods: We enrolled 510 type I EC patients and 510 age-, time-, and nationality-matched subjects into this study. Metabolic and ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.46391
更新日期:2020-07-25 00:00:00
abstract::Purpose: We examined the effect of GV1001 in castration castration-resistant prostate cancer (CRPC) cell growth and invasion and explored the potential molecular mechanisms of action. Materials and Methods: The in vitro anti-cancer effects of GV1001 in CRPC cells were examined using cell viability assay, TUNEL assay, ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.34859
更新日期:2019-10-17 00:00:00
abstract::Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human malignancies. The metabolomic approaches are developed to discover the novel biomarkers of PDAC. Methods: 550 preoperative, postoperative PDAC and normal controls (NCs) serums were employed to characterize metabolic alterations in ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.41250
更新日期:2020-05-19 00:00:00
abstract::Melanoma is the most aggressive and treatment-resistant form of skin cancer. Curcumol is a Chinese medicinal herb traditionally used as a cancer remedy. However, the molecular mechanisms underlying the anticancer activity of curcumol in melanoma remains largely unknown. In the present study, we observed that Curcumol ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.38624
更新日期:2020-01-14 00:00:00
abstract::Inhibition of aberrantly activated pathways cross-talking with hormone receptor (HR) improves response to endocrine therapy in patients with HR-positive advanced breast cancer. We performed a Pubmed database systematic review to ascertain the existence of a better clinical response when combining endocrine therapy wit...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.11566
更新日期:2015-05-12 00:00:00
abstract:BACKGROUND:MicroRNA (miRNA) have been shown to regulate gene expression in many cancers. MiR-182 has recently been found to be prognostic for patients treated with radical prostatectomy for prostate cancer. We sought to assess miR-182 as a prognostic marker and understand its role in prostate cancer progression and met...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.13176
更新日期:2015-10-25 00:00:00
abstract::Macrophages play a critical role in the initiation and progression in various human solid tumors; however, their role and transformation in pancreatic ductal adenocarcinoma (PDAC) were still illusive. Here, immunohistochemistry was used to determine CD206 (specific marker of M2 macrophage) and PKM2 expression in PDAC ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.38981
更新日期:2020-02-03 00:00:00
abstract::Background: The genetic heterogeneity between primary and metastatic lesions has rarely studied. Purpose: This study aims to compare the mutation profiling of key cancer-related genes in primary lung cancers and their matched lymph nodes (LN) metastasis. Methods: The gene mutation profiling of both primary cancers and...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.28266
更新日期:2019-03-03 00:00:00
abstract::Purpose: We retrospectively collected consecutive survival data of lung adenosquamous cell carcinoma (ASC) patients with brain metastasis (BM) in our institute and discussed the factors related to prognosis of these patients. Patients and Methods: A total of 42 patients diagnosed as lung ASC with BM between July 1, 20...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.27441
更新日期:2018-09-08 00:00:00
abstract:BACKGROUND:Medullary thyroid cancer (MTC) commonly presents with lymph node (LN) metastases, and has a worse prognosis than papillary thyroid cancer (PTC). Tumor size and LN involvement have been shown to affect stage of disease; however, to our knowledge, ours is the first study that attempts to correlate anterior nec...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.200
更新日期:2011-04-08 00:00:00