Expression of MMP-14 and prognosis in digestive system carcinoma: a meta-analysis and databases validation.

Abstract:

:Background: The Matrix metalloproteinase-14 (MMP-14) expression has been shown to be overexpressed in different cancers. However, there is no comprehensive quantitative evaluation of the MMP-14 prognostic value in digestive system carcinoma (DSC). The aim of this study is to explore the correlation between the MMP-14 expression and DSC prognosis.Methods: We conducted a meta-analysis to estimate the association strength between MMP-14 expression and prognosis. GEPIA and Kaplan Meier plotters were used to assess overall survival (OS), disease-free survival (DFS)/progression-free survival (PFS) in DSC patients and the differential expression of MMP-14 in DSC tissues and adjacent tissues. Results: A total of 20 studies including 2,519 patients with OS and 438 patients with DFS/PFS data were analyzed in evidence synthesis. Overall, the combined hazard ratio (HR) with 95% confidence interval (95% CI) was 1.98 (95%Cl: 1.77-2.22, P<0.001) for OS and 3.61 (95%Cl: 2.39-5.43, P<0.001) for DFS/PFS. For subgroup analyses, significant correlations were revealed between increased MMP-14 expression and poor OS in patients with gastric cancer (HR=2.21, 95%CI: 1.76-2.77, P<0.001), esophageal carcinoma (HR=2.01, 95%CI: 1.58-2.57, P<0.001), oral cancer (HR = 1.69, 95% CI: 1.30-2.20, P < 0.001) (HR=2.14, 95%CI 1.35-2.19, P<0.001) and hepatocarcinoma. In database verification analyses, the MMP-14 expression levels in normal tissues were significantly higher than that in DSC tissues, and significant associations were observed between high MMP-14 expression levels and poor prognosis. Conclusions: The high expression levels of MMP-14 might predict poor prognosis in DSC. Larger prospective clinical cohort studies are required to validate the prognostic role.

journal_name

J Cancer

journal_title

Journal of Cancer

authors

Duan F,Peng Z,Yin J,Yang Z,Shang J

doi

10.7150/jca.36469

subject

Has Abstract

pub_date

2020-01-01 00:00:00

pages

1141-1150

issue

5

issn

1837-9664

pii

jcav11p1141

journal_volume

11

pub_type

杂志文章
  • miRNA Biomarkers in Breast Cancer Detection and Management.

    abstract::Breast cancer is considered as a heterogeneous disease comprising various types of neoplasms, which involves different profile changes in both mRNA and micro-RNA (miRNA) expression. Extensive studies on mRNA expression in breast tumor have yielded some very interesting findings, some of which have been validated and u...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.2.116

    authors: Fu SW,Chen L,Man YG

    更新日期:2011-02-24 00:00:00

  • GDF15/GFRAL Pathway as a Metabolic Signature for Cachexia in Patients with Cancer.

    abstract::Cachexia is a metabolic mutiny that directly reduces life expectancy in chronic conditions such as cancer. The underlying mechanisms associated with cachexia involve inflammation, metabolism, and anorexia. Therefore, the need to identify cachexia biomarkers is warranted to better understand catabolism change and asses...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.50376

    authors: Ahmed DS,Isnard S,Lin J,Routy B,Routy JP

    更新日期:2021-01-01 00:00:00

  • Osteopontin is Critical for Hyperactive mTOR-Induced Tumorigenesis in Oral Squamous Cell Carcinoma.

    abstract::Mechanistic target of rapamycin (mTOR) plays a critical role in the development of oral squamous cell carcinoma (OSCC), but the underlying mechanisms remain poorly understood. Here we have demonstrated that the expression of osteopontin (OPN) was dramatically up-regulated in OSCC tissues and cell lines. Moreover, redu...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.18031

    authors: Gan N,Zou S,Hang W,Yang D,Zhang X,Yin Y

    更新日期:2017-05-12 00:00:00

  • Sorafenib Monotherapy Versus Sorafenib Combined with Regional Therapies for Hepatocellular Carcinoma Patients with Pulmonary Oligometastases: A Propensity Score-matched Analysis.

    abstract::Background: Sorafenib has been recommended as the standard therapy for advanced HCC with extrahepatic metastasis. The purpose of this retrospective study was to investigate the difference in overall survival (OS) between treatments with sorafenib combined with regional therapies versus sorafenib monotherapy in hepatoc...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.24568

    authors: Chen J,Lu S,Zhang Y,Xu L,Chen J,Wang J,Chen M,Zhang R,Zhou Z

    更新日期:2018-04-19 00:00:00

  • Effects of mitochondrial translocation of telomerase on drug resistance in hepatocellular carcinoma cells.

    abstract::Hepatocellular carcinoma (HCC) cells exhibit multidrug resistance (MDR), but the underlying mechanisms remain unclear. Cancer cells that overexpress telomerase are resistant to chemotherapeutic drugs. This study aimed to determine the effects of mitochondrial translocation of telomerase on MDR in HCC cells. HepG2 cell...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.10419

    authors: Yan J,Zhou Y,Chen D,Li L,Yang X,You Y,Ling X

    更新日期:2015-01-05 00:00:00

  • Prognostic Value of Albumin/Globulin Ratio in Survival and Lymph Node Metastasis in Patients with Cancer: A Systematic Review and Meta-analysis.

    abstract::The impact of albumin to globulin ratio (AGR) on the prognosis of various human cancers has not been well established. Here, a systemic review and meta-analysis has been performed to comprehensively assess the relationships between AGR and lymph node metastasis (LNM) or overall survival (OS). Systematical search throu...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.24889

    authors: Chi J,Xie Q,Jia J,Liu X,Sun J,Chen J,Yi L

    更新日期:2018-06-12 00:00:00

  • Risk Factors of Lymph Node Metastasis in Patients with Early Pure and Mixed Signet Ring Cell Gastric Carcinomas.

    abstract::Background: Early gastric carcinoma (EGC) with pure signet ring cell carcinoma (pSRCC) has been reported to have favourable prognosis and low risk of lymph node metastasis (LNM). However, risk factors of LNM and clinicopathological features for early gastric mixed signet ring cell carcinoma (mSRCC) remain poorly inves...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.29245

    authors: Hu Q,Dekusaah R,Cao S,Pang T,Wang Y,Zhang B,Lv Y,Zhang X,Ling T,Zhuge Y,Wang L,Zou X,Zhang W,Huang Q,Xu G

    更新日期:2019-01-29 00:00:00

  • VEGFR-2 Inhibitor Apatinib Hinders Endothelial Cells Progression Triggered by Irradiated Gastric Cancer Cells-derived Exosomes.

    abstract::Background: Radiotherapy is a standard treatment for a significant fraction of cancer patients. Nonetheless, to this day radiation resistance is a key impediment in gastric cancer (GC) treatment. Moreover, GC is characterized by its substantial neo-angiogenesis, driven by high levels of vascular endothelial growth fac...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.25370

    authors: Li G,Lin H,Tian R,Zhao P,Huang Y,Pang X,Zhao L,Cao B

    更新日期:2018-10-18 00:00:00

  • Risk factors for discontinuation of s-1 adjuvant chemotherapy for gastric cancer.

    abstract:PURPOSE:The aim of this study was to clarify the risk factors for discontinuing tegafur/gimeracil/oteracil potassium (S-1) adjuvant chemotherapy following gastrectomy in patients with gastric cancer. METHODS:We retrospectively investigated patients with curatively-resected gastric cancer who received S-1 adjuvant chem...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.11189

    authors: Kawazoe H,Shimasaki M,Ueno M,Sumikawa S,Takatori S,Namba H,Yoshida M,Sato K,Kojima Y,Watanabe Y,Moriguchi T,Tanaka A,Araki H

    更新日期:2015-03-18 00:00:00

  • Decreased KPNB1 Expression is Induced by PLK1 Inhibition and Leads to Apoptosis in Lung Adenocarcinoma.

    abstract::Lung cancer is a major cause of death worldwide, with lung adenocarcinoma being the most frequently diagnosed subtype in Japan. Finding the target of an anticancer drug can improve lung adenocarcinoma treatments. Polo-like kinase 1 (PLK1) is an essential mitotic kinase in mitotic progression, and PLK1 inhibition induc...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.21802

    authors: Sekimoto N,Suzuki Y,Sugano S

    更新日期:2017-11-06 00:00:00

  • Inhibition of Tumor Lymphangiogenesis is an Important Part that EGFR-TKIs Play in the Treatment of NSCLC.

    abstract::Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been widely used to treat non-small cell lung cancer (NSCLC) because they inhibit tumour growth and metastasis. However, the underlying mechanisms are not fully understood. Here, we investigate whether anti-lymphangiogenesis mechanisms cont...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.35448

    authors: Zhang Y,Yang X,Liu H,Cai M,Shentu Y

    更新日期:2020-01-01 00:00:00

  • Lung cancer in young adults aged 35 years or younger: A full-scale analysis and review.

    abstract::Objectives: Lung cancer in young adults is a distinct disease with particular socioeconomic implications. This study aimed to clarify the clinicopathological characteristics, best interventions, and outcomes of this distinctive entity. Methods: A retrospective review of patients with lung cancer was performed in our i...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.27490

    authors: Liu B,Quan X,Xu C,Lv J,Li C,Dong L,Liu M

    更新日期:2019-06-09 00:00:00

  • Consistency Analysis of Programmed Death-Ligand 1 Expression between Primary and Metastatic Non-Small Cell Lung Cancer: A Retrospective Study.

    abstract::Background: Programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer (NSCLC) is considered as a predictive biomarker of anti-PD-1/PD-L1 cancer therapies. However, the correlation of PD-L1 expression status between the primary and paired metastatic NSCLC is still not clear. The current study aims to a...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.34793

    authors: Luo L,Luo X,Chen W,Liang C,Yao S,Huang W,Liu C,Ge Y,Lin X,Li Z

    更新日期:2020-01-01 00:00:00

  • Adjuvant Radiochemotherapy versus Chemotherapy Alone for Gastric Cancer: Implications for Target Definition.

    abstract::The INT0116 trial was a milestone study and laid the foundation for the adjuvant radiotherapy (RT) associated to concurrent chemotherapy (CT) for the treatment of gastric cancer (GC) after gastrectomy. However, it is still controversial whether adding RT to CT could further benefit D2-dissected GC patients. The ARTIST...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.27335

    authors: Xu J,Zhu J,Wei Q

    更新日期:2019-01-01 00:00:00

  • Current Practice Patterns Regarding the Conduct of Thyroidectomy and Parathyroidectomy amongst Surgeons - A Survey Study.

    abstract:BACKGROUND:Heterogeneity of surgical care exists among surgeons regarding the conduct of thyroidectomy and parathyroidectomy. AIM:To identify the current patterns of technical conduct of operation amongst surgeons performing thyroidectomy or parathyroidectomy. METHODS:A survey was designed and beta-tested on five sur...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.4452

    authors: Henry L,Helou L,Solomon N,Chang A,Libutti S,Stojadinovic A

    更新日期:2012-01-01 00:00:00

  • microRNA-485-5p Functions as a Tumor Suppressor in Colorectal Cancer Cells by Targeting CD147.

    abstract::Colorectal cancer(CRC) is a prevalent malignancy in the world. There is growing evidence that microRNAs (miRNAs) as crucial modulator are in connection with many tumor-related diseases including CRC. Though miR-485-5p has been reported as an anti-oncogene in certain cancers, it remains unclear in CRC. In this research...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.24918

    authors: Hu XX,Xu XN,He BS,Sun HL,Xu T,Liu XX,Chen XX,Zeng KX,Wang SK,Pan YQ

    更新日期:2018-06-23 00:00:00

  • Prognostic Impact of Thrombospodin-2 (THBS2) Overexpression on Patients with Urothelial Carcinomas of Upper Urinary Tracts and Bladders.

    abstract:PURPOSE:Urothelial carcinoma (UC) is a type of tumor, especially of the urinary bladder, that affects people worldwide. Clarification of its detailed tumor biology and discovery of potential targets for developing treatment strategies are imperative because of frequent recurrences and poor prognosis of advanced UCs. By...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.15696

    authors: Chang IW,Li CF,Lin VC,He HL,Liang PI,Wu WJ,Li CC,Huang CN

    更新日期:2016-07-08 00:00:00

  • Increased Reactive Oxygen Species and Distinct Oxidative Damage in Resveratrol-suppressed Glioblastoma Cells.

    abstract::Background and Aim: Glioblastoma multiforme (GBM) is a highly aggressive brain malignancy that lacks reliable treatments. Resveratrol possesses anti-cancer effects, but its activity against glioblastoma cells is variable for unknown reasons. One mechanism through which anti-cancer drugs exert their effects is oxidativ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.45489

    authors: Jia B,Zheng X,Wu ML,Tian XT,Song X,Liu YN,Li PN,Liu J

    更新日期:2021-01-01 00:00:00

  • Characterization of the Role of the Malate Dehydrogenases to Lung Tumor Cell Survival.

    abstract::Cellular compartmentalization of biochemical processes in eukaryotic cells is critical for many functions including shuttling of reducing equivalents across membranes. Although coordination of metabolic flux between different organelles is vital for cell physiology, its impact on tumor cell survival is not well unders...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.19373

    authors: Zhang B,Tornmalm J,Widengren J,Vakifahmetoglu-Norberg H,Norberg E

    更新日期:2017-07-05 00:00:00

  • Bioimpedance Detection of Oral Lichen Planus Used as Preneoplastic Model.

    abstract:INTRODUCTION:Bioimpedance is a measure of the electrical properties of biological tissues. In the last two decades bioimpedance has been successfully introduced in clinical diagnosis of cancer. It has been demonstrated that tumoral tissues often show lower bioimpedance values than healthy tissues. The aim of this work ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.11936

    authors: Tatullo M,Marrelli M,Amantea M,Paduano F,Santacroce L,Gentile S,Scacco S

    更新日期:2015-08-20 00:00:00

  • Overexpression of PTK6 predicts poor prognosis in bladder cancer patients.

    abstract::Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase and works as an oncogene in various cancers. Recently, PTK6 has been used as a therapeutic target for breast cancer patients in a clinical study. However, the prognostic value of PTK6 in bladder cancer (BC) remains vague. Therefore, we retrieved 3 inde...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.21318

    authors: Xu XL,Ye YL,Wu ZM,He QM,Tan L,Xiao KH,Wu RY,Yu Y,Mai J,Li ZL,Peng XD,Huang Y,Li X,Zhang HL,Zhu XF,Qin ZK

    更新日期:2017-09-27 00:00:00

  • Prognostic Impact of TTF-1 Expression in Non-Squamous Non-Small-Cell Lung Cancer: A Meta-Analysis.

    abstract::Thyroid transcription factor-1 (TTF-1) is overexpressed in up to 95% of primary lung adenocarcinoma while negative for almost all squamous cell carcinomas. TTF-1 expression has been investigated as a prognostic factor in non-small-cell lung cancer (NSCLC) with conflicting results. We conducted this meta-analysis to ga...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.26830

    authors: Kim JH,Kim HS,Kim BJ,Han B,Choi DR,Kwon JH

    更新日期:2018-10-20 00:00:00

  • Fibrinogen and C-reactive protein score is a prognostic index for patients with hepatocellular carcinoma undergoing curative resection: a prognostic nomogram study.

    abstract::Background: While curative resection is the established strategy for Hepatocellular carcinoma (HCC) patients, the prognosis still remains poor, and the efficiency of existing prediction models is unsatisfactory. Therefore, we aimed to develop a credible and easy-to-use prognostic index for patients with HCC undergoing...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.22246

    authors: Gan W,Yi Y,Fu Y,Huang J,Lu Z,Jing C,Fan J,Zhou J,Qiu S

    更新日期:2018-01-01 00:00:00

  • Radical Nephrectomy with or without Lymph Node Dissection for pT3 Renal Cell Carcinoma: A Propensity Score-based Analysis.

    abstract:OBJECTIVES:To study whether radical nephrectomy (RN) with lymph node dissection (LND) can benefit pT3 renal cell carcinoma (RCC) patients versus no LND under the 2018 American Joint Committee on Cancer TNM classification system. Subjects/Patients and Methods: We performed a retrospective cohort study of clinicopatholog...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.30375

    authors: Li P,Peng C,Gu L,Xie Y,Nie W,Zhang Y,Xuan Y,Shen D,Du S,Tang L,Yao Y,Fan Y,Ma X,Zhang X

    更新日期:2019-05-26 00:00:00

  • The Expression of Ubiquitous Mitochondrial Creatine Kinase Is Downregulated as Prostate Cancer Progression.

    abstract:BACKGROUND:Mitochondria play crucial roles in cell signaling events, interorganellar communication, aging, cell proliferation and apoptosis, and mitochondrial impairment has been shown to accelerate or modulate cancer progression. Ubiquitous mitochondrial creatine kinase (uMtCK) is predominantly localized in the interm...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.13207

    authors: Amamoto R,Uchiumi T,Yagi M,Monji K,Song Y,Oda Y,Shiota M,Yokomizo A,Naito S,Kang D

    更新日期:2016-01-01 00:00:00

  • Activation or suppression of the immune response mediators in biliary tract cancer (BTC) patients: a systematic review and meta-analysis.

    abstract::Background: Infiltration of immune cells and immune microenvironment determine the proliferative activity of the tumor and metastasis. The aim of this study was to analyze the influence of activation or suppression of the immune response mediators on the prognosis of biliary tract cancer (BTC). Methods: We searched Pu...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.16774

    authors: Wang Y,Ding M,Zhang Q,Wang J,Yang X,Zhou F,Li L,Yuan Z,Jin H,Qian Q

    更新日期:2017-01-01 00:00:00

  • Differences and similarities in the phenomenon of NETs formation in oral inflammation and in oral squamous cell carcinoma.

    abstract::Taking into account the previously reported relationship between inflammation and carcinogenesis, and the scant amount of data concerning the role of neutrophil extracellular traps (NETs) in carcinogenesis, we decided to study the process of extracellular trap formation in patients with inflammation as well as in pati...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.24238

    authors: Garley M,Dziemiańczyk-Pakieła D,Grubczak K,Surażyński A,Dąbrowska D,Ratajczak-Wrona W,Sawicka-Powierza J,Borys J,Moniuszko M,Pałka JA,Jabłońska E

    更新日期:2018-04-30 00:00:00

  • Development and validation of a nomogram for predicting cancer-specific survival in patients with Wilms' tumor.

    abstract::Purpose: The objective of this study was to develop and validate a nomogram for predicting the cancer-specific survival (CSS) in patients with Wilms' tumor (WT). Methods: Patients with WT diagnosed between 2002 and 2015 in the Surveillance, Epidemiology, and End Results (SEER) database were divided randomly into train...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.32741

    authors: Pan Z,You H,Bu Q,Feng X,Zhao F,Li Y,Lyu J

    更新日期:2019-08-28 00:00:00

  • Surgery plus chemotherapy improves survival of patients with extremity soft tissue leiomyosarcoma and metastasis at presentation.

    abstract::Purpose: Extremity soft tissue leiomyosarcoma (LMS) with metastasis is a rare disease with a poor prognosis. The purpose of our study was to define clinical features of extremity soft tissue LMS with metastasis as well as to identify multivariable predictors of survival. Methods: During 1973-2015, 239 patients with me...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.29874

    authors: Qian SJ,Wu JQ,Wang Z,Zhang B

    更新日期:2019-05-21 00:00:00

  • Transcriptional cofactor Mask2 is required for YAP-induced cell growth and migration in bladder cancer cell.

    abstract::The highly conserved Hippo signaling pathway is an important pathway involved in tumorigenesis and development. In previous studies, YAP, the transcription coactivator of Hippo pathway, is found to be highly expressed in many clinical bladder cancer samples. To investigate the function of YAP and its cofactor Mask2 in...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.16438

    authors: Dong L,Lin F,Wu W,Huang W,Cai Z

    更新日期:2016-10-23 00:00:00