Abstract:
:Glioblastoma multiforme (GBM) is commonly known as the most aggressive primary CNS tumor in adults. The mean survival of it is 14 to 15 months, following the standard therapy from surgery, chemotherapy, to radiotherapy. Efforts in recent decades have brought many novel therapies to light, however, with limitations. In this paper, authors reviewed current treatments for GBM besides surgery. In the past decades, only radiotherapy, temozolomide (TMZ), and tumor treating field (TTF) were approved by FDA. Though promising in preclinical experiments, therapeutic effects of other novel treatments including BNCT, anti-angiogenic therapy, immunotherapy, epigenetic therapy, oncolytic virus therapy, and gene therapy are still either uncertain or discouraging in clinical results. In this review, we went through current clinical trials, underlying causes, and future therapy designs to present neurosurgeons and researchers a sketch of this field.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Zhang H,Wang R,Yu Y,Liu J,Luo T,Fan Fdoi
10.7150/jca.32475subject
Has Abstractpub_date
2019-08-27 00:00:00pages
4793-4806issue
20issn
1837-9664pii
jcav10p4793journal_volume
10pub_type
杂志文章,评审abstract::Accumulating evidence suggests that the malignant phenotypes of cancers are determined not only by the intrinsic properties of cancer cells but also by components in the tumor microenvironment (TME). In this study, we comprehensively characterized the TME of cutaneous melanoma (CM). As a result, tumor stage, tissue si...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.44413
更新日期:2020-04-06 00:00:00
abstract::Objective: As a member of the N-myc downregulated gene family, N-Myc downstream-regulated gene 2 (NDRG2) contributes to tumorigenesis of various types of cancer. The expression status of NDRG2 in colorectal cancer (CRC) and its prognostic value remain to be elucidated. The goal of this study was to determine the expre...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.31382
更新日期:2019-06-09 00:00:00
abstract::Background and aim: Silencing the expression of ACACA inhibits cell proliferation and induces apoptosis in prostate cancer LNCaP cells. However, the role of ACACA in other prostate cancer cells is not fully understood. Also, the effect of knocking down ACACA gene on mitochondria remains unclear. This study aimed to di...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.49560
更新日期:2021-01-01 00:00:00
abstract::Peroxisome proliferator-activated receptor gamma (PPARγ), a member of the nuclear receptor superfamily, participates in multiple physiological and pathological processes. Extensive studies have revealed the relationship between PPARγ and various tumors. However, the expression and function of PPARγ in bladder cancer s...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.42663
更新日期:2020-04-06 00:00:00
abstract::Background: In the various cancer, mast cells (MCs) infiltration is correlated with a worse prognosis. There is an increasing evidence that MCs and their mediators are participated in remodeling of the tumor microenvironment and facilitate tumor growth, epithelial-to-mesenchymal transition (EMT) and metastasis. Method...
journal_title:Journal of Cancer
pub_type: 杂志文章,收录出版
doi:10.7150/jca.29953
更新日期:2019-06-09 00:00:00
abstract::Melanoma is the most aggressive and treatment-resistant form of skin cancer. Curcumol is a Chinese medicinal herb traditionally used as a cancer remedy. However, the molecular mechanisms underlying the anticancer activity of curcumol in melanoma remains largely unknown. In the present study, we observed that Curcumol ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.38624
更新日期:2020-01-14 00:00:00
abstract::Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human malignancies. The metabolomic approaches are developed to discover the novel biomarkers of PDAC. Methods: 550 preoperative, postoperative PDAC and normal controls (NCs) serums were employed to characterize metabolic alterations in ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.41250
更新日期:2020-05-19 00:00:00
abstract:PURPOSE:Triple-negative breast cancer (TNBC) has attracted more attention both clinically and experimentally because of its high-risk biological characteristics and lacking of effective treatment method. The purpose of this retrospective study was to find out the incidence of triple-negative breast cancer (TNBC) in all...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.10944
更新日期:2016-01-01 00:00:00
abstract::Colon cancer is one of the most common types of gastrointestinal cancers and the fourth cause of cancer death worldwide. To discover novel diagnostic biomarkers for colon cancer and investigate potential mechanisms of oncogenesis, quantitative proteomic approach using iTRAQ-tagging and 2D-LC-MS/MS was performed to cha...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.17192
更新日期:2017-02-11 00:00:00
abstract::Non epithelial ovarian tumors represent a small group of rare gynecological cancers but they have a high incidence in young childbearing women. The recent years fertility preservation surgeries have become a common practice in specific ovarian malignancies when the patients wish to maintain their fertility. Specific t...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.26674
更新日期:2018-11-24 00:00:00
abstract::GOAL: To investigate the HPV prevalence and characterize the expression of potential molecular surrogate markers of HPV infection in esophageal squamous cell carcinoma. MATERIALS AND METHODS: The prevalence of HPV in individuals with and without esophageal cancer (EC) was determined by using multiplex PCR; p16 and p53...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.17080
更新日期:2017-04-09 00:00:00
abstract::Non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation inevitably have a relapse due to the occurrence of acquired resistance, resulting in treatment failure. However, little is known about the mechanisms of acquired resistance of NSCLC patients. Here, we elucidated the expre...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.35097
更新日期:2019-10-15 00:00:00
abstract::Hepatocellular Carcinoma is a major healthcare problem, representing the third most common cause of cancer-related mortality worldwide. There are 130 million Hepatitis C virus infected patients worldwide who are at a high-risk for developing Hepatocellular Carcinoma. Due to the fact that reliable parameters and/or too...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.4280
更新日期:2012-01-01 00:00:00
abstract::The use of polyADPribose polymerase inhibitors in cancer treatment provides a unique opportunity to target DNA repair processes in cancer cells while leaving normal tissue intact. The PARP-1 enzyme repairs DNA single strand breaks (SSB). Therefore PARP-1 inhibition in BRCA1 negative cancers results in the formation of...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.21338
更新日期:2017-10-23 00:00:00
abstract::Cancer is a genetic disease where genetic variations cause abnormally functioning genes that appear to alter expression. Proteins, the final products of gene expression, determine the phenotypes and biological processes. Therefore, detecting gene expression levels can be used for cancer diagnosis, prognosis, and treat...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.24744
更新日期:2018-06-05 00:00:00
abstract::Oral cancer is one of the most frequent malignant diseases worldwide, and areca nut is a primary carcinogen causing this cancer in Southeast Asia. It has been widely reported that areca nut induced several cytotoxic effects in oral cells, including ROS generation, inflammation, tissue hypoxia, DNA damage, and cell inv...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.29765
更新日期:2019-07-08 00:00:00
abstract::Background: Epithelioid trophoblastic tumors (ETTs) are the rarest type of gestational trophoblastic neoplasias. We investigated the clinical features, treatments, outcomes, and prognostic factors in patients with ETT, and explored potential therapeutic targets. Methods: We retrospectively analyzed the clinical featur...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.28134
更新日期:2019-01-01 00:00:00
abstract::Tripartite motif-containing 67 (TRIM67), an E3 ubiquitin ligase, belongs to the TRIM protein family. The relationship between TRIM67 and tumorigenesis is not fully clear. Here, we elucidated TRIM67 function in non-small cell lung cancer (NSCLC). TRIM67 immunostaining results were correlated with clinicopathological fe...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.38286
更新日期:2020-01-01 00:00:00
abstract::Background: HER2 serves as an important therapeutic target in gastroesophageal cancer. Differences in HER2 gene signal distribution patterns can be observed at the tissue level, but how it influences the HER2 amplification status has not been studied so far. Here, we investigated the link between HER2 amplification an...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.17878
更新日期:2017-06-01 00:00:00
abstract::Background: To identify associated risk factors and develop a predictive nomogram for the early death of metastatic gastric cancer patients. Methods: A total of 4575 patients in the SEER cohort and 220 patients in the Chinese cohort diagnosed with metastatic gastric cancer in our Cancer Center were obtained. Univariat...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.46563
更新日期:2020-07-14 00:00:00
abstract:BACKGROUND:Age-adjusted evaluations have explored the possible utility of (HPV test results in women with LSIL Pap. We investigated HPV test results and histopathologic follow-up results of LSIL patients from China's largest CAP-certified laboratory. METHODS:Patients with LSIL between 2011 and 2015 from the Guangzhou ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19421
更新日期:2017-07-23 00:00:00
abstract::Colorectal cancer (CRC) is considered to be closely associated with alteration of intestinal microorganisms. The purpose of present study was to investigate the distribution of gut microbiota in the distinction of microbiota dysbiosis between two disease syndromes called Zheng-Qi-Kui-Xu(ZQKX) and Xie-Du-Yong-Sheng (XD...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.50318
更新日期:2020-10-23 00:00:00
abstract::Dihydroorotate dehydrogenase (DHODH) is a rate-limiting enzyme in the de novo biosynthesis pathway of pyrimidines. Inhibition of this enzyme impedes cancer cell proliferation but the exact mechanisms of action of these inhibitors in cancer cells are poorly understood. In this study, we showed that cancer cells, namely...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.14835
更新日期:2017-09-05 00:00:00
abstract::Philadelphia chromosome-positive (Ph+) leukemia is characterized by reciprocal translocation between chromosomes 9 and 22. The resultant BCR/ABL fusion protein displays constitutive tyrosine kinase activity, leading to the induction of aberrant proliferation and neoplastic transformation. The bone marrow (BM) microenv...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19633
更新日期:2017-10-23 00:00:00
abstract::We studied combinatorial interactions of two phytochemicals, curcumin and silymarin, in their action against cancer cell proliferation. Curcumin is the major component of the spice turmeric. Silymarin is a bioactive component of milk thistle used as a protective supplement against liver disease. We studied antiprolife...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.15690
更新日期:2016-06-23 00:00:00
abstract::Colorectal cancer (CRC) is the fifth leading cause of cancer-related death in China. The incidence of Chinese CRC has increased dramatically with the changes of dietary and lifestyle. However, the genetic landscape of Chinese colorectal cancer mutation is still poorly understood. In this study, we have performed whole...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.37017
更新日期:2020-01-01 00:00:00
abstract:BACKGROUND:We conducted this pooled analysis to investigate the impact of RECIST 1.1 on the selection of target lesions and classification of tumor response, in comparison with RECIST 1.0. Methods : We searched MEDLINE and EMBASE for articles with terms of RECIST 1.0 or RECIST 1.1. We looked into all abstracts and virt...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.11316
更新日期:2015-02-25 00:00:00
abstract::Objective: Liposarcoma is a mesenchymal malignant tumor characterized by adipocyte differentiation which is divided into four subtypes with different prognosis. Accurate histopathological diagnosis is essential for precise treatment. Perilipins, including PLIN1, PLIN2, PLIN3, PLIN4, PLIN5, is a family of lipid droplet...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.41736
更新日期:2020-04-07 00:00:00
abstract::Objective: Chemotherapy is a major therapeutic method for bladder urothelial carcinoma (BUC), which can effectively improve the prognosis of BUC patients, but the chemoresistance often leads to chemotherapy failure. This study will research the regulatory roles and molecular mechanism of miR-101-3p in BUC chemoresista...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.33117
更新日期:2019-06-02 00:00:00
abstract:BACKGROUND:The 2010 guidelines by ASCO-CAP have mandated that breast cancer specimens with ≥1% positively staining cells by immunohistochemistry should be considered Estrogen Receptor (ER) positive. This has led to a subclass of low-ER positive (1-10%) breast cancers. We have examined the biology and clinical behavior ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.7668
更新日期:2014-01-23 00:00:00