Abstract:
:Objective: Pancreatic cancer (PC) is a malignant tumor with limited therapeutic choices and extremely poor prognosis. Personalized therapy based on gene alternations is a promising choice. Considering tumor heterogeneity, the practice of ctDNA analysis has drawn the attention. Here, we try to assess the applicability of ctDNA in PC. Methods and materials: Next generation sequencing (NGS) was performed from blood samples of 223 PC patients and tissue sample of 564 PC patients. Genomic data from the TCGA database were also utilized. In addition, two cases received personalized treatment based on ctDNA sequencing results were reported. Results: Based on ctDNA sequencing, the genomic features of PC was revealed. Totally, 68.2% of patients detected at least one reportable genomic alteration (GA) from ctDNA. The frequently altered genes were KRAS (53.5%), followed by TP53 (52.8%), and CDKN2A (15.1%). Cell cycle control (8%) and DNA damage response (8%) pathways enriched the most mutated genes. Compared with mutations from tissue samples and a tissue-genomic database, similar frequencies of GAs were detected from ctDNA. The first two highest frequent mutation of genes were the same, but some of mutated genes were inclined to be observed in ctDNA, like AR. And two cases who received personalized therapy achieved better clinical benefit. Conclusion: Blood-source ctDNA sequencing could be regarded as a meaningful complement to tissue testing, and might guide clinically therapeutic regimen.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Li H,Di Y,Li J,Jiang Y,He H,Yao L,Gu J,Lu J,Song J,Chen S,Cai S,Jin C,Yuan Z,Fu Ddoi
10.7150/jca.43087subject
Has Abstractpub_date
2020-04-27 00:00:00pages
4316-4323issue
15issn
1837-9664pii
jcav11p4316journal_volume
11pub_type
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更新日期:2019-03-03 00:00:00
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journal_title:Journal of Cancer
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journal_title:Journal of Cancer
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