Abstract:
:Background: Proverbially, the incidence rate of papillary thyroid carcinoma (PTC) has increased year by year. Many long noncoding RNAs (lncRNAs) have been discovered having a relationship with tumor genesis tightly recently. Thanks to the previous researches, we found long intergenic noncoding RNA 00511 (LINC00511) is overexpressed and acts as an oncogene in non-small-cell lung cancer and breast cancer. However, the biological role and function of LINC00511 are still unclear in PTC. Methods: We got the expression of LINC00511 in PTC tissues and matched adjacent tissues, as well the cell lines (B-CPAP, KTC-1, and KTC-1) by way of quantitative real-time polymerase chain reaction (qRT-PCR). In vitro, we knocked down the LINC00511 with small interfering RNA in PTC cell lines and demonstrated the function of LINC00511 by Cell Counting Kit-8, cell colony formation, Transwell migration, Transwell invasion, apoptosis assays, and cell cycle assays. Then, we discovered several downstream proteins of LINC00511 using Western blotting. Results: We proved that LINC00511's expression in PTC tissues and cell lines is higher than the control. LINC00511 promoted cellular proliferation, migration, invasion, G1/S transition and reduced apoptosis in vitro experiment. Knocked-down of LINC00511 resulted in the reduction of histone methyltransferase enhancer of zeste homolog 2 (EZH2), cyclin-dependent kinase 2 (CDK2) and cyclin-dependent kinase 4 (CDK4). Conclusions: Our results certified the role and function of LINC00511 in PTC, and it could become a novel tumor therapeutic target.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Xiang J,Guan Y,Bhandari A,Xia E,Wen J,Wang Odoi
10.7150/jca.35364subject
Has Abstractpub_date
2020-01-01 00:00:00pages
450-459issue
2issn
1837-9664pii
jcav11p0450journal_volume
11pub_type
杂志文章abstract:PURPOSE:To evaluate acute hypersensitivity reactions at the UCSD Moores Cancer Center in San Diego, compare our findings to those reported previously in the literature, and examine the effectiveness of the objective grading scale as represented by the Common Terminology Criteria for Adverse Events (CTCAE). PATIENTS AN...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.153
更新日期:2011-03-10 00:00:00
abstract::Background: The genetic heterogeneity between primary and metastatic lesions has rarely studied. Purpose: This study aims to compare the mutation profiling of key cancer-related genes in primary lung cancers and their matched lymph nodes (LN) metastasis. Methods: The gene mutation profiling of both primary cancers and...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.28266
更新日期:2019-03-03 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a major malignancy of cancer-related mortality worldwide. Metastasis-associated in colon cancer-1 (MACC1) was suggested as a marker for vascular invasive HCC. This study investigated the MACC1 single-nucleotide polymorphisms (SNPs) to evaluate HCC susceptibility and clinicopathologica...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.38856
更新日期:2020-01-14 00:00:00
abstract::Objectives: Lung cancer in young adults is a distinct disease with particular socioeconomic implications. This study aimed to clarify the clinicopathological characteristics, best interventions, and outcomes of this distinctive entity. Methods: A retrospective review of patients with lung cancer was performed in our i...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.27490
更新日期:2019-06-09 00:00:00
abstract:BACKGROUND:Due to the lack of studies, it remains unclear whether the additional neoadjuvant chemotherapy (NACT) to concurrent chemoradiotherapy (CCRT) is superior to CCRT alone for locoregionally advanced nasopharyngeal carcinoma (NPC). The main objective of this Bayesian network meta-analysis was to determine the eff...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.11814
更新日期:2015-07-17 00:00:00
abstract::Background & Aims: Primary tumors of colorectal carcinoma (CRC) with liver metastasis might gain some liver-specific characteristics to adapt the liver micro-environment. This study aims to reveal potential liver-like transcriptional characteristics associated with the liver metastasis in primary colorectal carcinoma....
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.23017
更新日期:2018-04-06 00:00:00
abstract::Background: The use of PCI in early operable patients with small cell lung cancer (SCLC) is still controversial. Therefore, we conducted a systematic review with meta-analysis to investigate the effects of PCI in resected SCLC patients. Methods: Relevant studies were identified from PubMed and EMBASE databases, the po...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.21465
更新日期:2018-01-01 00:00:00
abstract::In this article, the use of different types of thermotherapies to treat breast cancer is reviewed. While hyperthermia is most commonly used as an adjuvant in combination with radiotherapy, chemotherapy, targeted therapy or cryotherapy to enhance the therapeutic effect of these therapies, thermoablation is usually carr...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.8693
更新日期:2014-05-29 00:00:00
abstract::Lung cancer is the deadliest cancer in the world. Angiogenesis plays a crucial role of the incidence, progression, and metastasis in lung cancer. Angiogenesis inhibitors are used to treat non-small cell lung cancer (NSCLC) patients, and the molecular biomarkers are also being assessed to predict treatment response/the...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.22020
更新日期:2018-03-22 00:00:00
abstract::Background: Esophageal squamous cell carcinoma (ESCC) has been having a high mortality rate in China. Most patients are diagnosed in advanced stages, leading to the poor prognosis and low 5-year survival rate. Detection of precancerous lesions or early cancers is the key to improving this situation. Although previous ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29979
更新日期:2019-06-02 00:00:00
abstract::Background: Radiotherapy is a standard treatment for a significant fraction of cancer patients. Nonetheless, to this day radiation resistance is a key impediment in gastric cancer (GC) treatment. Moreover, GC is characterized by its substantial neo-angiogenesis, driven by high levels of vascular endothelial growth fac...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25370
更新日期:2018-10-18 00:00:00
abstract::Nasopharyngeal carcinoma (NPC), is one of the most common malignant tumor in southern China and southeast Asia. MYH10 is a coding gene of the NMMHC-IIB protein. Previous studies have shown that MYH10 expression was up-regulated in breast cancer, glioma and meningioma. Moreover, it was targeted by miR200 family. Howeve...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.40438
更新日期:2020-03-04 00:00:00
abstract::Background: In the various cancer, mast cells (MCs) infiltration is correlated with a worse prognosis. There is an increasing evidence that MCs and their mediators are participated in remodeling of the tumor microenvironment and facilitate tumor growth, epithelial-to-mesenchymal transition (EMT) and metastasis. Method...
journal_title:Journal of Cancer
pub_type: 杂志文章,收录出版
doi:10.7150/jca.29953
更新日期:2019-06-09 00:00:00
abstract::Objectives: We aimed to investigate the interaction between fasting blood glucose and tumor embolus, and the potential mediation effect of fasting blood glucose on tumor embolus in predicting gastrointestinal tract cancer-specific mortality risk postoperatively. Methods and Results: 4330 patients were consecutively re...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.34843
更新日期:2020-01-01 00:00:00
abstract::Purpose: This study aimed to identify the survival benefit and safety of alternative dosage schedules for sunitinib in metastatic renal cell carcinoma. Materials and Methods: Clinicopathologic and survival data of patients treated with sunitinib as first-line therapy were retrospectively reviewed. Patients were classi...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25693
更新日期:2018-09-07 00:00:00
abstract::Background: Identification of new predictive markers in melanoma is of great clinical importance. This study was aimed to analyze association between selected common variants in the cancer susceptibility genes and melanoma progression at the time of diagnosis. Material and Method: The study included 243 consecutive pa...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26404
更新日期:2018-08-06 00:00:00
abstract::Objective: Emerging evidence suggests that calreticulin (CALR) has great impacts on the tumor formation and progression of various cancers, but the role of CALR remains controversial. We investigated the expression and clinical significance of CALR in nasopharyngeal carcinoma (NPC). Methods: Immunohistochemistry was u...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.35362
更新日期:2019-08-29 00:00:00
abstract:BACKGROUND:The 2010 guidelines by ASCO-CAP have mandated that breast cancer specimens with ≥1% positively staining cells by immunohistochemistry should be considered Estrogen Receptor (ER) positive. This has led to a subclass of low-ER positive (1-10%) breast cancers. We have examined the biology and clinical behavior ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.7668
更新日期:2014-01-23 00:00:00
abstract::The incidence of colorectal cancer (CRC) ranks third among all cancers in China and improvements in screening for CRC have an important impact on prevention and control of the disease. Paraoxonase 1 (PON1) is a calcium ion-dependent hydrolase that is widely distributed in tissue. Its diagnostic value in colorectal can...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.45204
更新日期:2020-09-17 00:00:00
abstract::Purpose: To design an alternative workflow for cancer-risk assessment to predict distant metastasis (DM) of nasopharyngeal carcinoma (NPC). Methods: We enrolled 234 patients with non-disseminated NPC and a family history of cancer who underwent intensity-modulated radiotherapy and concurrent chemo-radiotherapy with/wi...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19611
更新日期:2017-07-20 00:00:00
abstract::Aim: BAP1 is frequently mutated in clear cell renal cell carcinoma (ccRCC) with a definitive role still unclear. Methods: In silico analysis of BAP1-mutant and wild-type gene enrichment and functional annotation in TCGA-KIRC dataset was performed. Target gene was studied based on functional clustering and was knowledg...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26275
更新日期:2018-10-01 00:00:00
abstract:PURPOSE:Methotrexate, vinblastine, doxorubicin plus cisplatin (MVAC) and gemcitabine plus cisplatin (GC) are both effective first-line chemotherapy. We explore the responsive variables of MVAC and GC for patients with metastatic urothelial carcinoma of bladder (mUCB). MATERIALS AND METHODS:Patients who were initially ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.15213
更新日期:2016-06-27 00:00:00
abstract::Background and aim: Understanding the molecular biological mechanisms underlying laryngeal squamous cell carcinoma (LSCC) invasion and metastasis is crucial for diagnosis, treatment, and prognosis. We aimed to examine the expression of the tumor suppressor microRNA-204-5p (miR-204-5p) and its target gene, forkhead box...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19470
更新日期:2017-07-21 00:00:00
abstract::Galectins are the member of soluble proteins that bind with β-galactoside containing glycans. These proteins have been considered to be associated in various important events such as different types of cancers. It has been found that galectins could contribute to neoplastic transformation or regulate cell growth, cell...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.23628
更新日期:2018-11-25 00:00:00
abstract::Background: The Gustave Roussy Immune Score (GRIm-Score) was initially reported to select patients for immunotherapy. Therefore, the purpose of the current retrospective study was to determine whether GRIm-Score, a novel nutritional and inflammatory-based prognostic score, is a useful prognostic marker in patients wit...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.37898
更新日期:2020-01-01 00:00:00
abstract::Pokemon, also known as leukemia/lymphoma-related factor (LRF) is a pro-oncogenic protein highly expressed in several cancers. There have been few in vitro and animal studies about its malignant biological behavior and function, however, its role especially in prostate cancer has not been completely elucidated. Therefo...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29471
更新日期:2019-04-21 00:00:00
abstract::Establishing an applicable preclinical model is vital for translational cancer research. Patient-derived xenograft has been important preclinical model systems and widely used for cancer research. Patient-derived xenograft models that represent the tumors of the patients are necessary to better translate research disc...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.51749
更新日期:2021-01-01 00:00:00
abstract::Esophageal cancer is an aggressive disease featured by early lymphatic and hematogenous dissemination, and is the sixth leading cause of cancer-related deaths worldwide. The proper formation of apicobasal polarity is essential for normal epithelium physiology and tissue homeostasis, while loss of polarity is a hallmar...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.11709
更新日期:2015-06-11 00:00:00
abstract::Non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation inevitably have a relapse due to the occurrence of acquired resistance, resulting in treatment failure. However, little is known about the mechanisms of acquired resistance of NSCLC patients. Here, we elucidated the expre...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.35097
更新日期:2019-10-15 00:00:00
abstract::Background: We performed a meta-analysis to evaluate the risk of immune-related colitis associated with PD1/PD-L1 inhibitors as compared to chemotherapy in solid tumor patients. Methods: Eligible studies were identified through a comprehensive search of multiple databases and included solid tumor patients in randomize...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24200
更新日期:2018-04-12 00:00:00