Tailored Selection of First-Line Cisplatin-Based Chemotherapy in Patients with Metastatic Urothelial Carcinoma of Bladder.

abstract：:Background: In the various cancer, mast cells (MCs) infiltration is correlated with a worse prognosis. There is an increasing evidence that MCs and their mediators are participated in remodeling of the tumor microenvironment and facilitate tumor growth, epithelial-to-mesenchymal transition (EMT) and metastasis. Method...

journal_title：Journal of Cancer

authors： Qu J,Cheng T,Liu L,Heng J,Liu X,Sun Z,Wang W,Li K,Yang N

更新日期：2019-06-09 00:00:00

abstract：PURPOSE:To investigate prognostic impact of chemoradiotherapy-induced hemoglobin (Hb) decrease on treatment outcomes of endemic nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS:Eight hundred and fifteen non-metastatic NPC, receiving neoadjuvant chemotherapy followed by radiotherapy (NACT+RT group) or concomitant ...

journal_title：Journal of Cancer

authors： Liang XX,Li Q,Su Z,Lan XW,Ouyang PY,Mao YP,Shi DB,Deng WG,Cheng ZB,Wang SY,Xie FY

更新日期：2015-04-02 00:00:00

abstract：:The purpose of this study was to determine the association between body mass index (BMI) measurements (baseline BMI and changes in BMI during neoadjuvant systemic treatment [NST]) and clinical efficacy (pathologic complete response [pCR] rate and survival outcomes) in locally advanced breast cancer (LABC). We hypothes...

journal_title：Journal of Cancer

authors： Kogawa T,Fouad TM,Wei C,Masuda H,Kai K,Fujii T,El-Zein R,Chavez-MacGregor M,Litton JK,Brewster A,Alvarez RH,Hortobagyi GN,Valero V,Theriault R,Ueno NT

更新日期：2015-01-22 00:00:00

abstract：:Objective: Although previous studies suggest that previous pulmonary tuberculosis was associated with increased risk of lung cancer. It remains controversial whether pulmonary tuberculosis is a risk factor for lung cancer. Our study was aimed to examine the association between pulmonary tuberculosis and lung cancer ri...

journal_title：Journal of Cancer

authors： Oh CM,Roh YH,Lim D,Kong HJ,Cho H,Hwangbo B,Won YJ,Jung KW,Oh K

更新日期：2020-01-20 00:00:00

abstract：:Objective: This study aimed to evaluate the therapeutic response of hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) with diffusion kurtosis imaging (DKI). Methods: Forty-three patients with fifty-nine hepatic cancer nodules were recruited for this study. All patients were treated b...

journal_title：Journal of Cancer

authors： Yuan ZG,Wang ZY,Xia MY,Li FZ,Li Y,Shen Z,Wang XZ

更新日期：2020-02-10 00:00:00

abstract：:Recent studies indicated that long noncoding RNAs (lncRNAs) played important regulatory roles in carcinogenesis and cancer progression. However, the contribution of small nucleolar RNA host gene 20 (SNHG20) to cancer development remains largely unknown. The aim of the study is to investigate the expression of SNHG20 a...

journal_title：Journal of Cancer

authors： Zhang D,Cao C,Liu L,Wu D

更新日期：2016-03-19 00:00:00

abstract：:Objectives: Platinum-based chemotherapy is first-line treatment for non-small cell lung cancer (NSCLC) patients. The efficacy is limited by drug resistance. Recent studies suggest that ATP7B, a copper efflux transporter, may be involved in platinum resistance. However, the clinical significance of ATP7B expression in ...

journal_title：Journal of Cancer

authors： Li YQ,Chen J,Yin JY,Liu ZQ,Li XP

更新日期：2018-09-08 00:00:00

abstract：:PURPOSE: Chronic obstructive pulmonary disease (COPD) is associated with an increased cancer risk. We evaluated the chemopreventive effect of statins against all cancers in COPD patients and identified the statin with the strongest chemopreventive effect. PATIENTS AND METHODS: All patients diagnosed with COPD at healt...

journal_title：Journal of Cancer

authors： Chen CC,Hsu YP,Liu JC,Kao PF,Sung LC,Lin CF,Hao WR,Liu SH,Wu SY

更新日期：2016-09-13 00:00:00

abstract：:The growth of research in the field of exercise oncology has resulted in a large evidence base for the role of physical activity in preventing and managing cancer outcomes. Nonetheless, there remain many unanswered questions across the multidisciplinary field. This study aimed to determine the priority research questi...

journal_title：Journal of Cancer

authors： Morris M,Crank H,Loosemore M,Stevinson C

更新日期：2020-02-19 00:00:00

abstract：:Cancer is a genetic disease where genetic variations cause abnormally functioning genes that appear to alter expression. Proteins, the final products of gene expression, determine the phenotypes and biological processes. Therefore, detecting gene expression levels can be used for cancer diagnosis, prognosis, and treat...

journal_title：Journal of Cancer

authors： Narrandes S,Xu W

更新日期：2018-06-05 00:00:00

abstract：:Colorectal cancer (CRC) usually gives rise to transcoelomic spread and ultimately causes peritoneal carcinomatosis (PC). However, mechanism studies, especially the immunological basis of colorectal PC, are rarely revealed due to lack of a suitable PC model. Here we selected a mouse colorectal cancer cell line MC-38 fo...

journal_title：Journal of Cancer

authors： Shi R,Xiang W,Kang X,Zhang L,Wang J,Miao H,He F

更新日期：2019-01-01 00:00:00

abstract：AIM:The aim of our study was to compare clinical outcomes between elderly patients aged ≥75 years (elderly group, n=66) with intermediate hepatocellular carcinoma (HCC) undergoing transcatheter arterial chemoembolization (TACE) and younger patients aged <75 years (control group, n=84) with intermediate HCC undergoing T...

journal_title：Journal of Cancer

authors： Nishikawa H,Kita R,Kimura T,Ohara Y,Takeda H,Sakamoto A,Saito S,Nishijima N,Nasu A,Komekado H,Osaki Y

更新日期：2014-07-17 00:00:00

abstract：:Accumulating evidence suggests that the malignant phenotypes of cancers are determined not only by the intrinsic properties of cancer cells but also by components in the tumor microenvironment (TME). In this study, we comprehensively characterized the TME of cutaneous melanoma (CM). As a result, tumor stage, tissue si...

journal_title：Journal of Cancer

authors： Wang P,Zhang X,Sun N,Zhao Z,He J

更新日期：2020-04-06 00:00:00

abstract：:Background: We previously demonstrated that Proline rich 11 (PRR11) gene is associated with the development and progression of tongue squamous cell carcinoma (TSCC), but the underlying mechanism is unknown. This study aimed to investigate the molecular mechanism underlying oncogenic potential of PRR11 in TSCC cells. M...

journal_title：Journal of Cancer

authors： Wang C,Yu L,Ren X,Wu T,Chen X,Huang Y,Cheng B

更新日期：2019-06-02 00:00:00

abstract：:Background: Carbonic anhydrase 4 (CA4) maintains homeostasis of carbon dioxide and bicarbonate. It is suggested to be a potential prognostic biomarker, while the correlations between CA4 and different cancers are indistinct. Methods: Differential mRNA expression of CA4 among different cancers and corresponding normal ...

journal_title：Journal of Cancer

authors： Xu Y,Xu WH,Shi SN,Yang XL,Ren YR,Zhuang XY,Qu YY,Zhang HL,Zhang XF

更新日期：2020-08-25 00:00:00

abstract：:Background: Growing data suggest that DNA damage repair and detoxification pathways play crucial roles in radiation-induced toxicities. To determine whether common functional single-nucleotide polymorphisms (SNPs) in candidate genes from these pathways can be used as predictors of radiation pneumonitis (RP), we conduc...

journal_title：Journal of Cancer

authors： Du L,Yu W,Huang X,Zhao N,Liu F,Tong F,Zhang S,Niu B,Liu X,Xu S,Huang Y,Dai X,Xie C,Chen G,Cong X,Qu B

更新日期：2018-02-01 00:00:00

abstract：:Objectives: We aimed to investigate the interaction between fasting blood glucose and tumor embolus, and the potential mediation effect of fasting blood glucose on tumor embolus in predicting gastrointestinal tract cancer-specific mortality risk postoperatively. Methods and Results: 4330 patients were consecutively re...

journal_title：Journal of Cancer

authors： Hu D,Zhang X,Lin X,Zhang H,Xia Y,Lin J,Zheng X,Peng F,Niu W

更新日期：2020-01-01 00:00:00

abstract：:Junctional adhesion molecule B (JAM-B) is a multifunctional transmembrane protein that plays an important role in tumor progression. JAM-B is significantly upregulated in gastric cancer, melanoma cell metastasis and oral squamous cell carcinoma. JAM-2 may also function as a putative tumor suppressor in the progression...

journal_title：Journal of Cancer

authors： Zhang W,He R,Chen S,Zhang L,Cao G,Yang W,Li J

更新日期：2020-03-05 00:00:00

abstract：:Background/Aims: Autologous, tumor-derived, heat shock protein gp96 peptide complexes have antitumor potential. We conducted the first Phase II trial to evaluate the safety and efficacy of gp96 vaccination in adjuvant settings for patients with gastric cancer. Methods: We enrolled 73 consecutive patients from October ...

journal_title：Journal of Cancer

authors： Zhang K,Peng Z,Huang X,Qiao Z,Wang X,Wang N,Xi H,Cui J,Gao Y,Huang X,Gao H,Wei B,Chen L

更新日期：2017-07-02 00:00:00

abstract：:Inhibition of aberrantly activated pathways cross-talking with hormone receptor (HR) improves response to endocrine therapy in patients with HR-positive advanced breast cancer. We performed a Pubmed database systematic review to ascertain the existence of a better clinical response when combining endocrine therapy wit...

journal_title：Journal of Cancer

authors： Grassadonia A,Caporale M,Tinari N,Zilli M,DeTursi M,Gamucci T,Vici P,Natoli C

更新日期：2015-05-12 00:00:00

abstract：:Cancer is a leading cause of death throughout the world, and cancer therapy remains a big medical challenge in terms of both its therapeutic efficacy and safety. Therefore, to find out a safe anticancer drug has been long goal for oncologist and medical scientists. Among clinically used medicines with no or little tox...

journal_title：Journal of Cancer

authors： Lian X,Wang G,Zhou H,Zheng Z,Fu Y,Cai L

更新日期：2018-04-06 00:00:00

abstract：:Endometrial carcinoma (EC) is the most common malignant tumors in female derived from the endometrial epithelium. Several previous studies have described estrogen receptors (ER), progesterone Receptor (PR) and phosphatase and tensin homolog (PTEN) are associated with clinicopathological factors and prognosis in EC pat...

journal_title：Journal of Cancer

authors： Liang Y,Lin B,Ye Z,Chen S,Yu H,Chen C,Zhang X,Zhou K,Zeng J

更新日期：2020-01-13 00:00:00

abstract：:Objective: Increasing evidence suggested that dysregulated small nucleolar RNAs (snoRNAs) were involved in tumor development. The roles of snoRNA 71A (SNORA71A) in the progression of non-small cell lung cancer (NSCLC) remained unclear. Methods: Dataset GSE19188 from Gene Expression Omnibus (GEO) database was downloade...

journal_title：Journal of Cancer

authors： Tang G,Zeng Z,Sun W,Li S,You C,Tang F,Peng S,Ma S,Luo Y,Xu J,Tian X,Zhang N,Gong Y,Xie C

更新日期：2019-05-21 00:00:00

abstract：:Background: Immunotherapy including immune checkpoint blockade, cancer vaccines, and adoptive cell therapy. However, no immune therapies support ovarian cancer. It is not clear whether the neutrophils, the component of the immune system derived from umbilical cord blood play a role in inhibiting the progression of ova...

journal_title：Journal of Cancer

authors： Liu Q,Yang W,Luo N,Liu J,Wu Y,Ding J,Li C,Cheng Z

更新日期：2020-05-18 00:00:00

abstract：:Establishing an applicable preclinical model is vital for translational cancer research. Patient-derived xenograft has been important preclinical model systems and widely used for cancer research. Patient-derived xenograft models that represent the tumors of the patients are necessary to better translate research disc...

journal_title：Journal of Cancer

authors： Chen C,Lin W,Huang Y,Chen X,Wang H,Teng L

更新日期：2021-01-01 00:00:00

abstract：PURPOSE:Our study is designed to develop and certify a promising prognostic signature for hepatocellular carcinoma (HCC). Materials and methods: We retrospectively analyzed mRNA expression profiles and clinicopathological data fetched from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. We fo...

journal_title：Journal of Cancer

authors： Xie H,Liu S,Zhang Z,Chen P,Tao Y

更新日期：2020-07-31 00:00:00

abstract：PURPOSE:Urothelial carcinoma (UC) is a type of tumor, especially of the urinary bladder, that affects people worldwide. Clarification of its detailed tumor biology and discovery of potential targets for developing treatment strategies are imperative because of frequent recurrences and poor prognosis of advanced UCs. By...

journal_title：Journal of Cancer

authors： Chang IW,Li CF,Lin VC,He HL,Liang PI,Wu WJ,Li CC,Huang CN

更新日期：2016-07-08 00:00:00

abstract：:Purpose: The objective of this study was to develop and validate a nomogram for predicting the cancer-specific survival (CSS) in patients with Wilms' tumor (WT). Methods: Patients with WT diagnosed between 2002 and 2015 in the Surveillance, Epidemiology, and End Results (SEER) database were divided randomly into train...

journal_title：Journal of Cancer

authors： Pan Z,You H,Bu Q,Feng X,Zhao F,Li Y,Lyu J

更新日期：2019-08-28 00:00:00

abstract：:Background/Purpose: In colon cancer (CC) patients preoperative (pre-op) levels of VEGF-A165 (VEGF) is a strong predictor for disease recurrence. Elevated postoperative (post-op) VEGF levels could have undesirable effects by enhancing tumor growth and metastasis formation. It has been suggested that thromboprophylaxis ...

journal_title：Journal of Cancer

authors： Mitsis M,Koliou P,Bali C,Ntounousi E,Tatsis V,Nousias V,Lianos GD,Vartholomatos G,Nastos D

更新日期：2017-08-25 00:00:00

abstract：:MicroRNAs (miRNAs) have been recognized as key regulators of tumorigenesis and progression. Serum miR-302c-3p expression is prominently deregulated in HCV-related hepatocellular carcinoma (HCC). However, the expression of miR-302c-3p and its functional role in HBV-related HCC are rarely investigated. In this study, we...

journal_title：Journal of Cancer

authors： Yang L,Guo Y,Liu X,Wang T,Tong X,Lei K,Wang J,Huang D,Xu Q

更新日期：2018-06-23 00:00:00