Abstract:
PURPOSE:Urothelial carcinoma (UC) is a type of tumor, especially of the urinary bladder, that affects people worldwide. Clarification of its detailed tumor biology and discovery of potential targets for developing treatment strategies are imperative because of frequent recurrences and poor prognosis of advanced UCs. By data mining a published dataset of UC of bladder (UCB) transcriptome (GSE31684) from Gene Expression Omnibus, National Center of Biotechnology Information (GEO, NCBI), we identified that THBS2 was the most significantly upregulated gene among those related to structural molecule activity (GO:0005198). Therefore, we evaluated the clinical significance and prognostic impact of thrombospondin-2 (THBS2) protein, A.K.A. TSP2, which encoded by THBS2 gene. MATERIALS AND METHODS:THBS2 immunostaining was performed in 340 UCs of upper urinary tract (UC-UUTs) and 295 UCBs; subsequently, both groups were dichotomized into high- and low-expression subgroups. Moreover, statistical analyses were performed to correlate the association between THBS2 expression and clinicopathological parameters with two survival indexes: disease-specific survival (DSS) and metastasis-free survival (MeFS). RESULTS:High THBS2 immunoexpression was significantly associated with advanced primary tumor status, nodal metastasis, and vascular invasion in both UC-UUT and UCB groups (all P ≤ .001). In addition, THBS2 overexpression was linked to adverse DSS and MeFS in univariate analyses and served as an independent prognosticator indicating poor outcomes in both groups in multivariate analyses. CONCLUSION:THBS2 may play a crucial role in UC progression and may be a novel prognostic marker. Additional investigations to elucidate the molecular pathway are necessary for developing potential THBS2-targeted therapies for UCs.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Chang IW,Li CF,Lin VC,He HL,Liang PI,Wu WJ,Li CC,Huang CNdoi
10.7150/jca.15696subject
Has Abstractpub_date
2016-07-08 00:00:00pages
1541-9issue
11issn
1837-9664pii
jcav07p1541journal_volume
7pub_type
杂志文章abstract::Non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation inevitably have a relapse due to the occurrence of acquired resistance, resulting in treatment failure. However, little is known about the mechanisms of acquired resistance of NSCLC patients. Here, we elucidated the expre...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.35097
更新日期:2019-10-15 00:00:00
abstract::Globally, prostate cancer is the third most common cancer in the world, and the second most common cancer in men. However, rates for incidence and mortality vary considerably with race, ethnicity, and geography. Over 97 significantly mutated genes that have been identified in prostate cancer; however, a lack of genomi...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.48433
更新日期:2021-01-01 00:00:00
abstract::Purpose Increasing evidences revealed that cancer cells with the characteristics of epithelial-mesenchymal transition (EMT) or cancer stem cells (CSC) have high ability of progression, invasion, metastasis and chemoresistance. TWIST1 and BMI1 are crucial transcription factors required for EMT and CSC. Both TWIST1 and ...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.14031
更新日期:2016-05-25 00:00:00
abstract:BACKGROUND:Non-small cell lung cancer (NSCLC) accounts for approximately 85% of clinical lung cancer cases. MicroRNA-93 (miR-93) is an oncomiR in many types of human cancer, exerting pivotal effects in the development and progression of malignancies, including NSCLC. However, the mechanism underlying miR-93 involvement...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.17958
更新日期:2017-03-07 00:00:00
abstract::RBP7 is a member of the cellular retinol-binding protein (CRBP) family and previous data suggested a link between CRBPs and the malignant transformation of colon cancer cells. Here, we investigated the potential of RBP7 as a predictive biomarker for patients with colon cancer and determined its functional relevance fo...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.35180
更新日期:2019-08-27 00:00:00
abstract::Background: The programmed death 1 (PD1)/programmed death ligand 1 (PDL1) targeted therapies have gained positive outcomes in several tumors, but the evidence of the expression and prognosis value of PD1/PDL1 in high risk prostate cancer was rare. Methods: Immunohistochemical analysis of PDL1/PD1 expression by a valid...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.30384
更新日期:2019-06-02 00:00:00
abstract:UNLABELLED:The mechanism of progression from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) remains largely unknown. We compared gene expression in tumors with simultaneous DCIS and IDC to decipher how diverse proteins participate in the local invasive process.Twenty frozen tumor specimens with conc...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.4120
更新日期:2012-01-01 00:00:00
abstract:BACKGROUND:MALAT-1 is significantly overexpressed in various cancers, suggesting that it might be a potential biomarker of cancer. METHODS:A meta-analysis was performed using microarray data obtained via the Affymetrix Human Genome U133 Plus 2.0 platform found in the Gene Expression Omnibus (GEO) database and data obt...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.14663
更新日期:2016-05-20 00:00:00
abstract::Background: The predictive roles of secreted protein acidic and rich in cysteine (SPARC) in pancreatic ductal adenocarcinoma (PDAC) patients after curative resection have not been clarified. We investigated the correlations between the SPARC expression and the postoperative prognosis. Methods: We retrospectively analy...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.28660
更新日期:2019-01-01 00:00:00
abstract::Background: Cancers may arise from cells with dysregulated telomeric functions due to shorten telomere length. We and others previously found that short leukocyte telomere length was associated with markedly evaluated risk of esophageal squamous cell carcinoma (ESCC). Hence, we hypothesized that single nucleotide poly...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.45165
更新日期:2020-06-23 00:00:00
abstract::Tissue-derived RNA, DNA and protein samples become more and more crucial for molecular detection in clinical research, personalized and targeted cancer therapy. This study evaluated how to biobanking colorectal tissues through examining the influences of cold ischemic time and freeze-thaw cycles on RNA, DNA and protei...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29372
更新日期:2019-08-27 00:00:00
abstract::Hepatocellular carcinoma (HCC) is a major malignancy of cancer-related mortality worldwide. Metastasis-associated in colon cancer-1 (MACC1) was suggested as a marker for vascular invasive HCC. This study investigated the MACC1 single-nucleotide polymorphisms (SNPs) to evaluate HCC susceptibility and clinicopathologica...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.38856
更新日期:2020-01-14 00:00:00
abstract::Colorectal cancer is a commonly diagnosed malignancy and also the major cause of death worldwide. Chemotherapy is the primary therapy for advanced colorectal cancer. Although oxaliplatin has potential effect in colorectal cancer therapy, the molecular mechanisms involved in its cytotoxic effects are not well elucidate...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24474
更新日期:2018-05-22 00:00:00
abstract::Hepatocellular Carcinoma is a major healthcare problem, representing the third most common cause of cancer-related mortality worldwide. There are 130 million Hepatitis C virus infected patients worldwide who are at a high-risk for developing Hepatocellular Carcinoma. Due to the fact that reliable parameters and/or too...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.4280
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:Our study is designed to develop and certify a promising prognostic signature for hepatocellular carcinoma (HCC). Materials and methods: We retrospectively analyzed mRNA expression profiles and clinicopathological data fetched from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. We fo...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.44573
更新日期:2020-07-31 00:00:00
abstract:BACKGROUND:This study was performed to assess the impact of irradiation on the tissue penetration depth of doxorubicin delivered during Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC). METHODS:Fresh post mortem swine peritoneum was cut into 10 proportional sections. Except for 2 control samples, all received...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.14714
更新日期:2016-05-07 00:00:00
abstract:: Purpose: Differentiated thyroid cancer (DTC) accounts for approximately 95% of thyroid carcinomas. In the metastatic RAI-refractory disease, chemotherapy has very limited efficacy and is associated with substantial toxicity. With increasing knowledge of the molecular patho...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.22318
更新日期:2018-01-01 00:00:00
abstract:BACKGROUND:Mitochondria play crucial roles in cell signaling events, interorganellar communication, aging, cell proliferation and apoptosis, and mitochondrial impairment has been shown to accelerate or modulate cancer progression. Ubiquitous mitochondrial creatine kinase (uMtCK) is predominantly localized in the interm...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.13207
更新日期:2016-01-01 00:00:00
abstract::Minichromosome Maintenance (MCM) proteins play essential roles in various cancers. We previously reported that MCM7 could be a prognostic biomarker in non-small cell lung cancer (NSCLC). The purpose of current study is to explore roles of other MCM proteins in NSCLC and their correlation with clinico-pathologic parame...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.20777
更新日期:2017-10-09 00:00:00
abstract::Clinical outcomes of checkpoint blockade immunotherapy on colorectal cancer (CRC) are influenced by mismatch repair (MMR) gene status, which is associated with distinct tumor immune infiltrates and systemic inflammatory response status. However, the prognostic value of PD-L1 expression and the systemic inflammatory re...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25187
更新日期:2019-04-05 00:00:00
abstract::Background: Malnutrition and systemic inflammatory response are frequently associated with prognosis in patients with several types of cancer, including renal cell carcinoma (RCC). The study is aimed to investigate the ability of preoperative serum albumin to globulin ratio (AGR) to predict the long-term mortality of ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16525
更新日期:2017-01-15 00:00:00
abstract::Ever since its discovery (1924) the Warburg effect (aerobic glycolysis) remains an unresolved puzzle: why the aggressive cancer cells "prefer" to use the energetically highly inefficient method of burning the glucose at the cellular level? While in the course of the last 90 years several hypotheses have been suggested...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.14274
更新日期:2016-04-26 00:00:00
abstract::Background: Protein kinase C zeta/lambda (PKCζ/λ) is a family of protein kinase enzymes that contributes to cell proliferation and regulation, which are important for cancer development. PKCζ/λ has been shown to be an important regulator of tumorigenesis in intestinal cancer. The phosphorylated form of PKCζ/λ, p-PKCζ/...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.20983
更新日期:2017-09-20 00:00:00
abstract::The capture of peritoneal metastatic cancer stem cell of human gastric cancer (pMCSC-hGC) is important to further understand the mechanism of peritoneal metastasis in gastric cancer patients. Previously, cancer stem cells (CSCs) of gastric and rectal cancers were captured and identified. However, the bottleneck of cap...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.21669
更新日期:2017-09-16 00:00:00
abstract::Apurinic/apyrimidinic endonuclease 1 (APE1) is an essential enzyme in the base excision repair pathway. Epidemiological studies have suggested associations between APE1 rs1760944 polymorphism and cancer risk. This study was aimed to evaluate the relationship between APE1 rs1760944 polymorphism and cancer risk. We sear...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.8085
更新日期:2014-03-13 00:00:00
abstract::Background: CDK 4 and 6 inhibitors (CDK4/6i), which arrest unregulated cancer cell proliferation, show clinical efficacy in breast cancer. Unexpectedly, a patient treated on a CDK4/6i-based trial, as first-line therapy in metastatic breast cancer, developed rapid disease progression following discontinuation of study ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18196
更新日期:2017-07-05 00:00:00
abstract::Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. However, science has not yet been able to substantially improve the prognosis of lung cancer patients. Accumulating evidence suggests that microRNAs (miRNAs) are key players in the regulation of tumor development and metastasis....
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16961
更新日期:2017-06-30 00:00:00
abstract::Objectives: We aimed to investigate the interaction between fasting blood glucose and tumor embolus, and the potential mediation effect of fasting blood glucose on tumor embolus in predicting gastrointestinal tract cancer-specific mortality risk postoperatively. Methods and Results: 4330 patients were consecutively re...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.34843
更新日期:2020-01-01 00:00:00
abstract::Chemo- and radio-therapy suffer from certain well-recognized drawbacks for lymphoma therapy. Passive immunotherapy with monoclonal antibody has improved outcome for patients with CD20+ B cell lymphoma, but not for T cell lymphoma. Therefore, novel treatment approaches are clearly required for T cell lymphoma. To date,...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.20015
更新日期:2017-09-15 00:00:00
abstract::Cellular compartmentalization of biochemical processes in eukaryotic cells is critical for many functions including shuttling of reducing equivalents across membranes. Although coordination of metabolic flux between different organelles is vital for cell physiology, its impact on tumor cell survival is not well unders...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19373
更新日期:2017-07-05 00:00:00