Abstract:
:Establishing an applicable preclinical model is vital for translational cancer research. Patient-derived xenograft has been important preclinical model systems and widely used for cancer research. Patient-derived xenograft models that represent the tumors of the patients are necessary to better translate research discoveries and to test potential therapeutic approaches. However, research in this field is hampered by the limited engraftment rate. In this review, we go over a large number of researches on patient-derived xenograft transplantation and firstly systematically summarize the main factors in methodology to successfully establish models. These results will be applied to the development of patient-derived xenograft leading to better preclinical research.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Chen C,Lin W,Huang Y,Chen X,Wang H,Teng Ldoi
10.7150/jca.51749subject
Has Abstractpub_date
2021-01-01 00:00:00pages
28-37issue
1issn
1837-9664pii
jcav12p0028journal_volume
12pub_type
杂志文章,评审abstract::Background: Anti-EGFR therapies have been recommended for advanced colorectal cancer (CRC) with wild-type RAS and PIK3CA mutation. However, PIK3CA mutations are a poor prognostic marker and a negative predictor of response to anti-EGFR therapies in RAS wild-type CRC. Therefore, new and advanced treatment strategies ar...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19458
更新日期:2017-08-22 00:00:00
abstract::Endocrine resistance in hormone receptor positive breast cancer patients urges us to develop novel approaches such as inhibitors of the cyclin-dependent kinases (CDK) 4/6 to reverse its resistance. Nowadays, three selective CDK4/6 inhibitors (Palbociclib, Ribociclib and Abemaciclib) are approved by Federal Drug Admini...
journal_title:Journal of Cancer
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更新日期:2019-10-21 00:00:00
abstract::Background: Early gastric carcinoma (EGC) with pure signet ring cell carcinoma (pSRCC) has been reported to have favourable prognosis and low risk of lymph node metastasis (LNM). However, risk factors of LNM and clinicopathological features for early gastric mixed signet ring cell carcinoma (mSRCC) remain poorly inves...
journal_title:Journal of Cancer
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doi:10.7150/jca.29245
更新日期:2019-01-29 00:00:00
abstract::To explore the role of phospholipase D1 (PLD1) mRNA in transition of prostate cancer (PCa) cells to androgen independence, we used Arraystar Human LncRNA Microarray V3.0 to detect and compare the differential expression of PLD1 and its signaling pathway-related gene in standard androgen dependence prostate cancer (ADP...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26689
更新日期:2018-09-08 00:00:00
abstract::Purpose: Systemic therapy has often been used for patients with advanced hepatocellular carcinoma (HCC). However, due to drug resistance, the use of cytotoxic chemotherapy in the treatment of patients with advanced HCC has typically demonstrated low response rates. Secretory clusterin (sCLU) is expressed in aggressive...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.23849
更新日期:2018-04-06 00:00:00
abstract::Our results show that using an EBV-LCL feeder cell line, large numbers of pure populations of highly activated NK cells can be expanded ex vivo under GMP conditions. With the exception of thyroiditis and constitutional symptoms related to IL-2 therapy, infusions of up to 1 x 10(8) cells/kg of ex vivo expanded NK have ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.383
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abstract::Non-small cell lung cancer (NSCLC) is one of the most common types of aggressive cancer. The tumor tissue, which shows an active angiogenesis, is composed of neoplastic and stromal cells, and an abundant inflammatory infiltrate. Angiogenesis is important to support tumor growth, while infiltrating cells contribute to ...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.12286
更新日期:2015-08-07 00:00:00
abstract::Hepatocellular Carcinoma is a major healthcare problem, representing the third most common cause of cancer-related mortality worldwide. There are 130 million Hepatitis C virus infected patients worldwide who are at a high-risk for developing Hepatocellular Carcinoma. Due to the fact that reliable parameters and/or too...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.4280
更新日期:2012-01-01 00:00:00
abstract::MicroRNAs (miRNAs) have been extensively studied over the decades and have been proposed as potential molecular targets for cancer treatment. Studies have shown that miR-378 participates in numerous biological processes in various cancers; whereas miR-1827 has only been reported in pediatric glioma. The mechanism of h...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18188
更新日期:2018-01-01 00:00:00
abstract::The use of polyADPribose polymerase inhibitors in cancer treatment provides a unique opportunity to target DNA repair processes in cancer cells while leaving normal tissue intact. The PARP-1 enzyme repairs DNA single strand breaks (SSB). Therefore PARP-1 inhibition in BRCA1 negative cancers results in the formation of...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.21338
更新日期:2017-10-23 00:00:00
abstract::Background: Overall survival of patients with primary CNS lymphoma (PCNSL) has improved since the introduction of immunochemotherapy. However, up to 10-15% of PCNSL patients still die shortly after diagnosis. In the present study, we aimed to investigate the risk factors of early mortality (death within 60 days after ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.32467
更新日期:2019-07-05 00:00:00
abstract::Nasopharyngeal carcinoma (NPC), is one of the most common malignant tumor in southern China and southeast Asia. MYH10 is a coding gene of the NMMHC-IIB protein. Previous studies have shown that MYH10 expression was up-regulated in breast cancer, glioma and meningioma. Moreover, it was targeted by miR200 family. Howeve...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.40438
更新日期:2020-03-04 00:00:00
abstract::Purpose: Extremity soft tissue leiomyosarcoma (LMS) with metastasis is a rare disease with a poor prognosis. The purpose of our study was to define clinical features of extremity soft tissue LMS with metastasis as well as to identify multivariable predictors of survival. Methods: During 1973-2015, 239 patients with me...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29874
更新日期:2019-05-21 00:00:00
abstract::Objective: Emerging evidence suggests that calreticulin (CALR) has great impacts on the tumor formation and progression of various cancers, but the role of CALR remains controversial. We investigated the expression and clinical significance of CALR in nasopharyngeal carcinoma (NPC). Methods: Immunohistochemistry was u...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.35362
更新日期:2019-08-29 00:00:00
abstract::Background: Most hepatocellular carcinoma (HCC) patients have undergone a progression from chronic hepatitis, then liver cirrhosis (LC), and finally to carcinoma. The objective of this study was to elucidate risk factors to predict HCC development for cirrhosis patients. Methods: Multiple methylated specific PCR (MSP)...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24024
更新日期:2018-06-04 00:00:00
abstract:PURPOSE:The aim of this study was to clarify the risk factors for discontinuing tegafur/gimeracil/oteracil potassium (S-1) adjuvant chemotherapy following gastrectomy in patients with gastric cancer. METHODS:We retrospectively investigated patients with curatively-resected gastric cancer who received S-1 adjuvant chem...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.11189
更新日期:2015-03-18 00:00:00
abstract::Background: Colorectal cancer (CRC) has been reconsidered as a heterogeneous disease. Among advances of genomic analysis in CRC, the sidedness of tumors (left-sided colon vs. right-sided colon) and microsatellite instability (MSI)-high (H) tumors have been highlighted. Methods: We analyzed 153 CRC patients who were av...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18286
更新日期:2017-08-23 00:00:00
abstract::Background: We performed a meta-analysis to evaluate the risk of immune-related colitis associated with PD1/PD-L1 inhibitors as compared to chemotherapy in solid tumor patients. Methods: Eligible studies were identified through a comprehensive search of multiple databases and included solid tumor patients in randomize...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24200
更新日期:2018-04-12 00:00:00
abstract::Hedgehog (Hh) signalling plays an important role in cancer; however, its mechanism in ovarian cancer migration and invasion remains unclear. In the present study, we aimed to clarify the effect of the Hh signalling pathway on ovarian cancer migration and invasion through the regulation of CD24 expression, both in vitr...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.17712
更新日期:2017-02-25 00:00:00
abstract::Objective: The purpose of this study was to evaluate the efficacy and feasibility of the R.E.N.A.L. Nephrometry Score to postoperatively predict high-grade clear-cell renal carcinoma (ccRCC). Methods: The study included 288 patients diagnosed with ccRCC who had complete CT/CTA data and R.E.N.A.L. Nephrometry Scores an...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.21189
更新日期:2017-10-17 00:00:00
abstract::Preoperative chemoradiation followed by surgery has been recommended as a standard treatment for patients with stage II/III rectal cancer. However, the optimal sequencing of radiotherapy for metastatic rectal cancer remains unclear. Between 2004 and 2014, patients diagnosed with metastatic rectal cancer who underwent ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.28320
更新日期:2019-01-30 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
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journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2019-06-02 00:00:00
abstract::MPHOSPH1, which is one of the kinesin superfamily proteins, has been reported to play an essential role in the carcinogenesis and progression of several kinds of cancers. MPHOSPH1 has also been suggested to be involved in STAT3 phosphorylation in hepatocellular carcinoma. However, the biological behavior of MPHOSPH1 i...
journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2018-10-31 00:00:00
abstract::Recent studies indicated that long noncoding RNAs (lncRNAs) played important regulatory roles in carcinogenesis and cancer progression. However, the contribution of small nucleolar RNA host gene 20 (SNHG20) to cancer development remains largely unknown. The aim of the study is to investigate the expression of SNHG20 a...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.13822
更新日期:2016-03-19 00:00:00
abstract::Metabolic syndrome has been previously identified as a risk factor for breast cancer and is increasingly a public health concern. This study aims to investigate the prevalence of metabolic syndrome and its components among primary breast cancer and control population. The clinical data of metabolic syndrome and its co...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.22968
更新日期:2018-01-01 00:00:00
abstract::Red blood cell distribution width (RDW) has been recently demonstrated to be a predictor of inflammation. High pretreatment RDW level is associated with poor survival outcomes in various malignancies, although the results are controversial. We aimed to investigate the prognostic role of RDW. A systematic literature se...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.31598
更新日期:2019-07-10 00:00:00
abstract::Objective: This study aimed to evaluate the efficacy and safety of doxorubicin-loaded drug-eluting beads transarterial chemoembolization (DEB-TACE) with CalliSpheres microspheres (CSM) in treating unresectable intrahepatic cholangiocarcinoma (ICC). Methods: 88 unresectable ICC patients who received DEB-TACE treatment ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.39410
更新日期:2020-05-18 00:00:00
abstract::Hepatocellular carcinoma (HCC) cells exhibit multidrug resistance (MDR), but the underlying mechanisms remain unclear. Cancer cells that overexpress telomerase are resistant to chemotherapeutic drugs. This study aimed to determine the effects of mitochondrial translocation of telomerase on MDR in HCC cells. HepG2 cell...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.10419
更新日期:2015-01-05 00:00:00
abstract::Purpose: The early BCR-ABL1 reduction had the prognostic impact of the chronic-phase chronic myeloid leukemia (CML-CP) patients. This study was to find a more precise early prognosis index at 3 months in the patients with newly diagnosed CML-CP, especially for the patients with BCR-ABL1IS >10%. Methods: We retrospecti...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.38752
更新日期:2020-02-03 00:00:00