Identification of Research Priorities in Exercise Oncology: A Consensus Study.

abstract：BACKGROUND:This study was performed to assess the impact of irradiation on the tissue penetration depth of doxorubicin delivered during Pressurized Intra-Peritoneal Aerosol Chemotherapy (PIPAC). METHODS:Fresh post mortem swine peritoneum was cut into 10 proportional sections. Except for 2 control samples, all received...

journal_title：Journal of Cancer

authors： Khosrawipour V,Giger-Pabst U,Khosrawipour T,Pour YH,Diaz-Carballo D,Förster E,Böse-Ribeiro H,Adamietz IA,Zieren J,Fakhrian K

更新日期：2016-05-07 00:00:00

abstract：:Background: Topoisomerase IIA (TOP2A) gene encodes DNA topoisomerase enzyme and has been reported that TOP2A is broadly expressed in many types of cancers. Our study aims to investigate the prognostic effect of TOP2A on lung adenocarcinoma (LUAD) and the potential molecular mechanism of TOP2A to tumorigenesis. Methods...

journal_title：Journal of Cancer

authors： Kou F,Sun H,Wu L,Li B,Zhang B,Wang X,Yang L

更新日期：2020-02-10 00:00:00

abstract：:Objective: To develop and validate a prediction model for the pathological complete response (pCR) to neoadjuvant chemotherapy (NCT) of triple-negative breast cancer (TNBC). Methods: We systematically searched Gene Expression Omnibus, ArrayExpress, and PubMed for the gene expression profiles of operable TNBC accessibl...

journal_title：Journal of Cancer

authors： Han Y,Wang J,Xu B

更新日期：2021-01-01 00:00:00

abstract：:Tissue-derived RNA, DNA and protein samples become more and more crucial for molecular detection in clinical research, personalized and targeted cancer therapy. This study evaluated how to biobanking colorectal tissues through examining the influences of cold ischemic time and freeze-thaw cycles on RNA, DNA and protei...

journal_title：Journal of Cancer

authors： Fan XJ,Huang Y,Wu PH,Yin XK,Yu XH,Fu XH,Feng LL,Wang YL,Yi HJ,Chen ZT,Yin JX,Zhang DL,Feng WX,Bai SM,Kim T,Mills GB,Lu YL,Wan XB,Wang L

更新日期：2019-08-27 00:00:00

abstract：:Objective: This study aimed to evaluate the efficacy and safety of doxorubicin-loaded drug-eluting beads transarterial chemoembolization (DEB-TACE) with CalliSpheres microspheres (CSM) in treating unresectable intrahepatic cholangiocarcinoma (ICC). Methods: 88 unresectable ICC patients who received DEB-TACE treatment ...

journal_title：Journal of Cancer

authors： Zhou TY,Zhou GH,Zhang YL,Nie CH,Zhu TY,Wang HL,Chen SQ,Wang BQ,Yu ZN,Wu LM,Zheng SS,Sun JH

更新日期：2020-05-18 00:00:00

abstract：:Metabolic syndrome has been previously identified as a risk factor for breast cancer and is increasingly a public health concern. This study aims to investigate the prevalence of metabolic syndrome and its components among primary breast cancer and control population. The clinical data of metabolic syndrome and its co...

journal_title：Journal of Cancer

authors： Wu YT,Luo QQ,Li X,Arshad B,Xu Z,Ran L,Zhao CX,Wu H,Shi YL,Chen HR,Li H,Li HY,Wu KN,Kong LQ

更新日期：2018-01-01 00:00:00

abstract：:Inhibition of aberrantly activated pathways cross-talking with hormone receptor (HR) improves response to endocrine therapy in patients with HR-positive advanced breast cancer. We performed a Pubmed database systematic review to ascertain the existence of a better clinical response when combining endocrine therapy wit...

journal_title：Journal of Cancer

authors： Grassadonia A,Caporale M,Tinari N,Zilli M,DeTursi M,Gamucci T,Vici P,Natoli C

更新日期：2015-05-12 00:00:00

abstract：:Endometrium is the mucosal lining of the uterus which expressed a cyclic process of proliferation, secretion and scaling under the control of hormones secreted by the ovary, and it also plays an indispensable role in the embryo implantation, the constitution of fetal-maternal interface, and the maintaining of pregnanc...

journal_title：Journal of Cancer

authors： Yang S,Wang H,Li D,Li M

更新日期：2019-06-09 00:00:00

abstract：:The capture of peritoneal metastatic cancer stem cell of human gastric cancer (pMCSC-hGC) is important to further understand the mechanism of peritoneal metastasis in gastric cancer patients. Previously, cancer stem cells (CSCs) of gastric and rectal cancers were captured and identified. However, the bottleneck of cap...

journal_title：Journal of Cancer

authors： Chen XZ,Song XH,Chen XL,Li CC,Mo XM,Hu JK

更新日期：2017-09-16 00:00:00

abstract：:In the present study, we constructed the recombinant plasmid IL10-PEGFP-C1 and successfully transfected into human mesenchymal stem cells. After culturing for 72 h, the levels of IL6 and TNF-α in the supernatant of the MSCs-IL10 group were significantly lower than the vector group and the control group (17.6 ± 0.68vs7...

journal_title：Journal of Cancer

authors： Zhao C,Pu Y,Zhang H,Hu X,Zhang R,He S,Zhao Q,Mu B

更新日期：2020-07-09 00:00:00

abstract：OBJECTIVE:Most prostate cancers originate from the prostatic peripheral zone (PZ). We tested the hypothesis that the stromal cells from PZ and transitional zone (TZ) have differential effects on the ability of tumorigenesis. METHODS:Stromal cells isolated from the PZ and TZ of normal human prostates mixed with DU145 c...

journal_title：Journal of Cancer

authors： Peng Y,Chen Q,Gu M,Chen Y,Zhang M,Zhou J,Wang H,Gao Y,Li W,Wang Z,Cai Z

更新日期：2015-07-03 00:00:00

abstract：:Pancreatic ductal adenocarcinoma (PDAC) is currently one of the most intractable malignancies with a typical scirrhous pattern in histology. Due to its abundant tumor stroma and scant vascularization, chemotherapeutic agents are considered inefficiently permeable to cancer nests, making it highly difficult to cure the...

journal_title：Journal of Cancer

authors： Saito K,Sakaguchi M,Maruyama S,Iioka H,Putranto EW,Sumardika IW,Tomonobu N,Kawasaki T,Homma K,Kondo E

更新日期：2018-07-30 00:00:00

abstract：:Background: Heavy metal pollution in farm soils is a grave concern in Taiwan. Previously, we found the incidence of oral cancer (OC) correlated positively with levels of nickel and arsenic in farm soils. Many OC patients have a second malignancy, among which esophageal cancer (EC) is the most common one in Taiwan. Obj...

journal_title：Journal of Cancer

authors： Lee CP,Lee YH,Lian IB,Su CC

更新日期：2016-08-06 00:00:00

abstract：:Aim: BAP1 is frequently mutated in clear cell renal cell carcinoma (ccRCC) with a definitive role still unclear. Methods: In silico analysis of BAP1-mutant and wild-type gene enrichment and functional annotation in TCGA-KIRC dataset was performed. Target gene was studied based on functional clustering and was knowledg...

journal_title：Journal of Cancer

authors： Sun C,Zhao C,Li S,Wang J,Zhou Q,Sun J,Ding Q,Liu M,Ding G

更新日期：2018-10-01 00:00:00

abstract：:Background: IgA antibodies against Epstein-Barr virus (EBV) capsid antigen (VCA) and nuclear antigen 1 (EBNA1) have been proposed to facilitate the diagnosis and early detection of nasopharyngeal carcinoma (NPC) in high-incidence regions. However, while new methodologies and new platforms for the detection of VCA-IgA ...

journal_title：Journal of Cancer

authors： Yu X,Li F,Cheng W,Wu B,Fang H,Xia F,Gong Y,Yu W,Liao P,Cao Y,Yang F,Zhu H,Li J,Huang Y,Gan L,Zhang L,Lou Y,Ji M

更新日期：2020-10-18 00:00:00

abstract：:Human papillomavirus (HPV) is a DNA virus that infects epithelial cells and has been implicated in the development of cervical cancer. Few therapeutic strategies have been designed for the treatment of cervical intraepithelial neoplasia, a precursor of cervical cancer. In these early stages, the HPV E2 protein is the ...

journal_title：Journal of Cancer

authors： Bermúdez-Morales VH,Fierros-Zarate G,García-Meléndrez C,Alcocer-Gonzalez JM,Morales-Ortega A,Peralta-Zaragoza O,Torres-Poveda K,Burguete-García AI,Hernández-Márquez E,Madrid-Marina V

更新日期：2016-09-27 00:00:00

abstract：:Objective: Increasing evidence suggested that dysregulated small nucleolar RNAs (snoRNAs) were involved in tumor development. The roles of snoRNA 71A (SNORA71A) in the progression of non-small cell lung cancer (NSCLC) remained unclear. Methods: Dataset GSE19188 from Gene Expression Omnibus (GEO) database was downloade...

journal_title：Journal of Cancer

authors： Tang G,Zeng Z,Sun W,Li S,You C,Tang F,Peng S,Ma S,Luo Y,Xu J,Tian X,Zhang N,Gong Y,Xie C

更新日期：2019-05-21 00:00:00

abstract：BACKGROUND:Medullary thyroid cancer (MTC) commonly presents with lymph node (LN) metastases, and has a worse prognosis than papillary thyroid cancer (PTC). Tumor size and LN involvement have been shown to affect stage of disease; however, to our knowledge, ours is the first study that attempts to correlate anterior nec...

journal_title：Journal of Cancer

authors： Guerrero MA,Lindsay S,Suh I,Vriens MR,Khanafshar E,Shen WT,Gosnell J,Kebebew E,Duh QY,Clark OH

更新日期：2011-04-08 00:00:00

abstract：:Epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) have been widely used to treat non-small cell lung cancer (NSCLC) because they inhibit tumour growth and metastasis. However, the underlying mechanisms are not fully understood. Here, we investigate whether anti-lymphangiogenesis mechanisms cont...

journal_title：Journal of Cancer

authors： Zhang Y,Yang X,Liu H,Cai M,Shentu Y

更新日期：2020-01-01 00:00:00

abstract：:Background: The Matrix metalloproteinase-14 (MMP-14) expression has been shown to be overexpressed in different cancers. However, there is no comprehensive quantitative evaluation of the MMP-14 prognostic value in digestive system carcinoma (DSC). The aim of this study is to explore the correlation between the MMP-14 ...

journal_title：Journal of Cancer

authors： Duan F,Peng Z,Yin J,Yang Z,Shang J

更新日期：2020-01-01 00:00:00

abstract：:The incidence of colorectal cancer (CRC) ranks third among all cancers in China and improvements in screening for CRC have an important impact on prevention and control of the disease. Paraoxonase 1 (PON1) is a calcium ion-dependent hydrolase that is widely distributed in tissue. Its diagnostic value in colorectal can...

journal_title：Journal of Cancer

authors： Zhang J,Yang X,Wei L,Tan H,Chen J,Li W,Chan K,Su Y,Zhao L,Hu S,Zhong S,Xiao Y,Liu H

更新日期：2020-09-17 00:00:00

abstract：:Ever since its discovery (1924) the Warburg effect (aerobic glycolysis) remains an unresolved puzzle: why the aggressive cancer cells "prefer" to use the energetically highly inefficient method of burning the glucose at the cellular level? While in the course of the last 90 years several hypotheses have been suggested...

journal_title：Journal of Cancer

authors： Devic S

更新日期：2016-04-26 00:00:00

abstract：:Background & Aims: Primary tumors of colorectal carcinoma (CRC) with liver metastasis might gain some liver-specific characteristics to adapt the liver micro-environment. This study aims to reveal potential liver-like transcriptional characteristics associated with the liver metastasis in primary colorectal carcinoma....

journal_title：Journal of Cancer

authors： Cheng J,Song X,Ao L,Chen R,Chi M,Guo Y,Zhang J,Li H,Zhao W,Guo Z,Wang X

更新日期：2018-04-06 00:00:00

abstract：PURPOSE:To evaluate acute hypersensitivity reactions at the UCSD Moores Cancer Center in San Diego, compare our findings to those reported previously in the literature, and examine the effectiveness of the objective grading scale as represented by the Common Terminology Criteria for Adverse Events (CTCAE). PATIENTS AN...

journal_title：Journal of Cancer

authors： Demoor PA,Matusov Y,Kelly C,Kolan S,Barnachea L,Bazhenova LA

更新日期：2011-03-10 00:00:00

abstract：:Background. Esophageal cancer is ranked in the top ten of diagnosed tumors worldwide. Even though improvements in survival could be noticed over the last years, prognosis remains poor. ETS translocation variant 1 (ETV1) is a member of a family of transcription factors and is phosphorylated by mitogen-activated protein...

journal_title：Journal of Cancer

authors： Jomrich G,Maroske F,Stieger J,Preusser M,Ilhan-Mutlu A,Winkler D,Kristo I,Paireder M,Schoppmann SF

更新日期：2018-01-01 00:00:00

abstract：:Esophageal cancer (EC) is a unique and heterogeneous disease diagnosed mostly at advanced stages. Altered glycans presented on cell surfaces are involved in the occurrence and development of malignancy. However, the effects of glycans on EC progression are largely unexplored. Here, a lectin array was utilized to detec...

journal_title：Journal of Cancer

authors： Xia M,Shao J,Qiao M,Luo Z,Deng X,Ke Q,Dong X,Shen L

更新日期：2020-06-01 00:00:00

abstract：:Objectives: Platinum-based chemotherapy is first-line treatment for non-small cell lung cancer (NSCLC) patients. The efficacy is limited by drug resistance. Recent studies suggest that ATP7B, a copper efflux transporter, may be involved in platinum resistance. However, the clinical significance of ATP7B expression in ...

journal_title：Journal of Cancer

authors： Li YQ,Chen J,Yin JY,Liu ZQ,Li XP

更新日期：2018-09-08 00:00:00

abstract：:Hepatocellular Carcinoma is a major healthcare problem, representing the third most common cause of cancer-related mortality worldwide. There are 130 million Hepatitis C virus infected patients worldwide who are at a high-risk for developing Hepatocellular Carcinoma. Due to the fact that reliable parameters and/or too...

journal_title：Journal of Cancer

authors： Abdalla MA,Haj-Ahmad Y

更新日期：2012-01-01 00:00:00

abstract：:Objectives: PD-1 and PD-L1 overexpression in malignant tumors in response to radiotherapy is correlated with a poor prognosis. Human papilloma virus (HPV) infection impacts intrinsic radiosensitivity of head and neck cancers (HNCs). Herein, this study aims to determine PD-1/PD-L1 expression differences in tumors with ...

journal_title：Journal of Cancer

authors： Lyu X,Zhang M,Li G,Jiang Y,Qiao Q

更新日期：2019-01-29 00:00:00

abstract：:RBP7 is a member of the cellular retinol-binding protein (CRBP) family and previous data suggested a link between CRBPs and the malignant transformation of colon cancer cells. Here, we investigated the potential of RBP7 as a predictive biomarker for patients with colon cancer and determined its functional relevance fo...

journal_title：Journal of Cancer

authors： Elmasry M,Brandl L,Engel J,Jung A,Kirchner T,Horst D

更新日期：2019-08-27 00:00:00