Abstract：
:Background: We performed a meta-analysis to evaluate the risk of immune-related colitis associated with PD1/PD-L1 inhibitors as compared to chemotherapy in solid tumor patients. Methods: Eligible studies were identified through a comprehensive search of multiple databases and included solid tumor patients in randomized controlled trials (RCTs) with PD-1/PD-L1 inhibitors. The data was analyzed by Stata version 12.0 software. Results: After exclusion of ineligible studies, 11 clinical trials were considered eligible for the meta-analysis, including 5751 patients. Compared with chemotherapy, the risk ratios (RRs) of all-grade colitis were significant for the PD-1 inhibitor subgroup (RR 2.69, 95% confidence interval (CI): 1.15-6.29, p=0.023), and for pembrolizumab subgroup (RR 3.17, 95% CI: 1.08-9.37, p=0.037), but not for nivolumab treatment and PD-L1 inhibitor (atezolizumab) treatment (RR 2.05, 95% CI: 0.52-8.13, p=0.305; RR 4.75,95% CI: 0.56-40.50, p=0.154, respectively). The RR of all-grade colitis was significant for PD-1/PD-L1 inhibitor in NSCLC (RR 4.34, 95% CI: 1.37-13.82, p=0.013), and not significant in melanoma (RR 2.11, 95% CI: 0.54-8.34, p=0.285). Moreover, the RRs of all-grade diarrhea were significant for the PD-1 inhibitor subgroup (RR 0.61, 95% CI: 0.44-0.83, p=0.002), for the nivolumab subgroup (RR 0.54, 95% CI: 0.34-0.87, p=0.012), and for atezolizumab subgroup (RR 0.48, 95% CI: 0.25-0.89, p=0.021). The RR of high-grade diarrhea was significant for atezolizumab subgroup (RR 0.34, 95% CI: 0.12-0.94, p=0.037). Conclusions: Our meta-analysis demonstrates that compared with chemotherapy, pembrolizumab may result in a higher risk of all-grade immune-mediated colitis. PD-1/PD-L1 inhibitor treatment in NSCLC patients, but not in melanoma patients, increases the risk of all-grade colitis incidence.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Su Q,Zhang X,Shen X,Hou Y,Sun Z,Gao ZHdoi
10.7150/jca.24200subject
Has Abstractpub_date
2018-04-12 00:00:00pages
1614-1622issue
9issn
1837-9664pii
jcav09p1614journal_volume
9pub_type
杂志文章abstract：:Tumor growth depends on angiogenesis, the growth of new blood vessels. Complement factor H (CFH) is a plasma glycoprotein that functions as a regulator of the complement system. The aim of this study is to delineate the role of CFH in angiogenesis. A conditional null allele of the Cfh gene was generated in C57BL/6J mi...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.19452
更新日期：2017-07-15 00:00:00
abstract：:Aims: To compare the long-term prognosis of younger and elderly patients with combined hepatocellular-cholangiocarcinoma (CHC) who underwent curative resection between 1993 and 2014 at our center. Methods: Two hundred and thirteen patients who underwent liver resection for CHC were enrolled in our study. The overall s...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.23921
更新日期：2018-02-28 00:00:00
abstract：:The impact of albumin to globulin ratio (AGR) on the prognosis of various human cancers has not been well established. Here, a systemic review and meta-analysis has been performed to comprehensively assess the relationships between AGR and lymph node metastasis (LNM) or overall survival (OS). Systematical search throu...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.24889
更新日期：2018-06-12 00:00:00
abstract：:Aim: BAP1 is frequently mutated in clear cell renal cell carcinoma (ccRCC) with a definitive role still unclear. Methods: In silico analysis of BAP1-mutant and wild-type gene enrichment and functional annotation in TCGA-KIRC dataset was performed. Target gene was studied based on functional clustering and was knowledg...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.26275
更新日期：2018-10-01 00:00:00
abstract：:Objective: Emerging evidence suggests that calreticulin (CALR) has great impacts on the tumor formation and progression of various cancers, but the role of CALR remains controversial. We investigated the expression and clinical significance of CALR in nasopharyngeal carcinoma (NPC). Methods: Immunohistochemistry was u...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.35362
更新日期：2019-08-29 00:00:00
abstract：BACKGROUND:Neoadjuvant chemotherapy with concurrent docetaxel, doxorubicin and cyclophosphamide is commonly used for patients with locally advanced breast cancer. Epirubicin is another anthracycline used in breast cancer but the concurrent use of epirubicin and taxane is not well-established. We conducted a single inst...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.3980
更新日期：2012-01-01 00:00:00
abstract：PURPOSE:We conducted a meta-analysis to evaluate and compare the short- and long-term results of laparoscopy-assisted colectomy (LAC) and open colectomy (OC) for colon cancer. METHODS:We searched MEDLINE, EMBASE, Science Citation Index, and Cochrane Controlled Trial Register for relevant papers published between Janua...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.3621
更新日期：2012-01-01 00:00:00
abstract：:Objectives: To investigate the effect of the concurrent use of trastuzumab and anthracycline-based neoadjuvant chemotherapy (NAC) for HER2-positive breast cancer in terms of pCR and cardiotoxicity. Methods: We systematically searched Pubmed, Embase, Cochrane and SinoMed databases from inception until 1 July 2017 for r...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.24701
更新日期：2018-08-06 00:00:00
abstract：:Purpose: Eukaryotic initiation factor 4A-3 (EIF4A3) is an RNA-binding protein (RBP) that is a core component of the exon junction complex (EJC). It has been identified as an important player in post-transcriptional regulation processes. Recently, investigations have focused on EIF4A3 dysfunction in carcinogenesis. The...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.27655
更新日期：2018-11-11 00:00:00
abstract：:Increasing studies indicate that long noncoding RNA (lncRNA) plays a critical role in aerobic glycolysis of various tumors. However, the contribution of lncRNA in gastric cancer (GC) cell glycolysis is still poorly understood. The objective of this research was to investigate the functional role and mechanism of lncRN...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.48365
更新日期：2020-08-27 00:00:00
abstract：:Early detection and accurate evaluation were both critical to improving the prognosis of clear cell Renal Cell Carcinoma (ccRCC) patients. More importantly, RNA Binding Proteins (RBPs) play a vital role in the tumorigenesis and progression of numerous cancers. However, the relationship between RBPs and ccRCC is still ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.49175
更新日期：2020-09-23 00:00:00
abstract：:Dysbindin has been reported to be correlated with several malignancies. However, the clinical significance and biological role of dysbindin in epithelial ovarian cancer remains largely unknown. Here we demonstrated that the mRNA and protein levels of dysbindin were significantly upregulated in EOC tissues compared wit...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.39269
更新日期：2020-02-21 00:00:00
abstract：:Objective: Liposarcoma is a mesenchymal malignant tumor characterized by adipocyte differentiation which is divided into four subtypes with different prognosis. Accurate histopathological diagnosis is essential for precise treatment. Perilipins, including PLIN1, PLIN2, PLIN3, PLIN4, PLIN5, is a family of lipid droplet...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.41736
更新日期：2020-04-07 00:00:00
abstract：:Mechanistic target of rapamycin (mTOR) plays a critical role in the development of oral squamous cell carcinoma (OSCC), but the underlying mechanisms remain poorly understood. Here we have demonstrated that the expression of osteopontin (OPN) was dramatically up-regulated in OSCC tissues and cell lines. Moreover, redu...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.18031
更新日期：2017-05-12 00:00:00
abstract：:Cervical cancer is a commonly diagnosed cancer among females. Polymorphisms in pre-microRNAs have been demonstrated to play critical roles in cancer. However, the roles of pre-microRNA polymorphisms in the aetiology of cervical cancer have not been well documented. We genotyped eight pre-microRNA polymorphisms in 290 ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.39636
更新日期：2020-02-03 00:00:00
abstract：BACKGROUND:MALAT-1 is significantly overexpressed in various cancers, suggesting that it might be a potential biomarker of cancer. METHODS:A meta-analysis was performed using microarray data obtained via the Affymetrix Human Genome U133 Plus 2.0 platform found in the Gene Expression Omnibus (GEO) database and data obt...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.14663
更新日期：2016-05-20 00:00:00
abstract：:Ovarian cancer, cervical cancer and endometrial cancer are three relatively common malignant cancers of the female reproductive system. Despite improvements in female genital tract cancer detection and development of new therapeutic approaches, there are still poor prognoses and some do not respond to therapeutic patt...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.44727
更新日期：2020-10-21 00:00:00
abstract：:Background: Heavy metal pollution in farm soils is a grave concern in Taiwan. Previously, we found the incidence of oral cancer (OC) correlated positively with levels of nickel and arsenic in farm soils. Many OC patients have a second malignancy, among which esophageal cancer (EC) is the most common one in Taiwan. Obj...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.15441
更新日期：2016-08-06 00:00:00
abstract：BACKGROUND:Non-small cell lung cancer (NSCLC) accounts for approximately 85% of clinical lung cancer cases. MicroRNA-93 (miR-93) is an oncomiR in many types of human cancer, exerting pivotal effects in the development and progression of malignancies, including NSCLC. However, the mechanism underlying miR-93 involvement...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.17958
更新日期：2017-03-07 00:00:00
abstract：:EGFR mutation of Non-small cell lung cancers (NSCLC) was predominantly seen in Asian population and it was considered as a predictor of responsiveness. Eendothelial nitric oxide synthase (eNOS) plays a vital role in chronic inflammation and carcinogenesis. In this study, we aimed to explore the association between the...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.25824
更新日期：2018-06-15 00:00:00
abstract：:Background: Neoadjuvant chemoradiation (CRT) remains controversial in the treatment of the oesophagus or gastro-oesophageal junction (GOJ) carcinomas. Methods: We conducted a meta-analysis to assess the efficacy and safety of Neoadjuvant CRT plus surgery comparing with neoadjuvant CT plus surgery or surgery alone. Fea...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.25915
更新日期：2019-01-01 00:00:00
abstract：BACKGROUND AND PURPOSE:There is increasing evidence that the presence of an inflammation-based prognostic score (modified Glasgow prognostic score, mGPS) is associated with survival in patients with advanced cancer. This study aimed to assess whether the mGPS has prognostic value in patients with thoracic esophageal sq...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.9569
更新日期：2014-09-06 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is a major malignancy of cancer-related mortality worldwide. Metastasis-associated in colon cancer-1 (MACC1) was suggested as a marker for vascular invasive HCC. This study investigated the MACC1 single-nucleotide polymorphisms (SNPs) to evaluate HCC susceptibility and clinicopathologica...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.38856
更新日期：2020-01-14 00:00:00
abstract：:Background: Immunotherapy including immune checkpoint blockade, cancer vaccines, and adoptive cell therapy. However, no immune therapies support ovarian cancer. It is not clear whether the neutrophils, the component of the immune system derived from umbilical cord blood play a role in inhibiting the progression of ova...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.41035
更新日期：2020-05-18 00:00:00
abstract：:Objective: The applicability of the linear quadratic (LQ) model to local control (LC) modeling after hypofractionated radiotherapy to treat lung cancer is highly debated. To date, the differences in predicted outcomes between the LQ model and other radiobiological models, which are characterized by additional dose mod...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.33001
更新日期：2019-08-08 00:00:00
abstract：:Metabolic syndrome has been previously identified as a risk factor for breast cancer and is increasingly a public health concern. This study aims to investigate the prevalence of metabolic syndrome and its components among primary breast cancer and control population. The clinical data of metabolic syndrome and its co...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.22968
更新日期：2018-01-01 00:00:00
abstract：:Background: To support cancer therapy, development of low cost library preparation techniques for targeted next generation sequencing (NGS) is needed. In this study we designed and tested a PCR-based library preparation panel with limited target area for sequencing the top 12 somatic mutation hot spots in colorectal c...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.16037
更新日期：2017-01-12 00:00:00
abstract：:Until few years ago non-specific cytotoxic agents were considered the tip of the arrow as first line treatment for lung cancer. However; age > 75 was considered a major drawback for this kind of therapy. Few exceptions were made by doctors based on the performance status of the patient. The side effects of these agent...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.14819
更新日期：2016-03-21 00:00:00
abstract：:Non-small cell lung cancer (NSCLC) is the leading cause of cancer-related death worldwide. However, science has not yet been able to substantially improve the prognosis of lung cancer patients. Accumulating evidence suggests that microRNAs (miRNAs) are key players in the regulation of tumor development and metastasis....
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.16961
更新日期：2017-06-30 00:00:00
abstract：:Background: Radiotherapy is a primary treatment strategy for patients with unresectable hepatocellular carcinoma (HCC); however, the prognostic factors among HCC patients who have received radiotherapy but not undergone surgery have not been systematically studied. Thus, the prognostic factors were investigated in thi...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.30365
更新日期：2019-07-25 00:00:00
