Abstract:
:Tumor growth depends on angiogenesis, the growth of new blood vessels. Complement factor H (CFH) is a plasma glycoprotein that functions as a regulator of the complement system. The aim of this study is to delineate the role of CFH in angiogenesis. A conditional null allele of the Cfh gene was generated in C57BL/6J mice by flanking the exon 3 with loxP sites. The Cfhflox/flox mice were crossed with Rosa26-Cre mice to obtain the mice homozygotes of Cfh deletion (Cfh-/-). The Cfh-/- mice were examined by in vivo angiogenesis assays. Mouse endothelial cells were treated with media containing 5% of mouse plasma from the wildtype or Cfh-/- mice and assayed for proliferation, viability and migration. The Cfh-/- mice did not display any obvious abnormalities. They demonstrated a pro-angiogenic phenotype in matrigel plug assay, but not in aorta ring assay. In vitro, loss of Cfh in plasma does not affect proliferation or viability, but significantly increases migration of mouse endothelial cells. Our findings suggest that plasma CFH inhibits angiogenesis by reduction of endothelial cell migration. Thus the mutation of CFH might lead to excessive tumor angiogenesis.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Liu J,Hoh Jdoi
10.7150/jca.19452subject
Has Abstractpub_date
2017-07-15 00:00:00pages
2184-2190issue
12issn
1837-9664pii
jcav08p2184journal_volume
8pub_type
杂志文章abstract:INTRODUCTION:Bioimpedance is a measure of the electrical properties of biological tissues. In the last two decades bioimpedance has been successfully introduced in clinical diagnosis of cancer. It has been demonstrated that tumoral tissues often show lower bioimpedance values than healthy tissues. The aim of this work ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.11936
更新日期:2015-08-20 00:00:00
abstract::Purpose Neuroblastoma is an embryonic solid tumor derived from the progenitors of the sympathetic nervous system. More than half of the patients developed metastatic disease at the time of initial diagnosis and had poor outcome with current therapeutic approaches. In recent years, some obligate and facultative anaerob...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18776
更新日期:2017-06-03 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.11239
更新日期:2015-09-15 00:00:00
abstract::Purpose: Eukaryotic initiation factor 4A-3 (EIF4A3) is an RNA-binding protein (RBP) that is a core component of the exon junction complex (EJC). It has been identified as an important player in post-transcriptional regulation processes. Recently, investigations have focused on EIF4A3 dysfunction in carcinogenesis. The...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.27655
更新日期:2018-11-11 00:00:00
abstract::Colorectal cancer(CRC) is a prevalent malignancy in the world. There is growing evidence that microRNAs (miRNAs) as crucial modulator are in connection with many tumor-related diseases including CRC. Though miR-485-5p has been reported as an anti-oncogene in certain cancers, it remains unclear in CRC. In this research...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24918
更新日期:2018-06-23 00:00:00
abstract::Fallopian tube epithelial cells (FTECs) are thought to be the origin of epithelial ovarian cancer. However, the effect of the hormones on FTECs is unknown, and therefore, this study explored this effect. We successfully derived FTECs from the fallopian tube epithelial layer and treated them with estradiol and progeste...
journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2019-06-02 00:00:00
abstract::Stromal fibroblasts are suggested to be a key determinant in the malignant progression of breast cancer. To find an in vitro culture model that best mimics the in vivo tumor microenvironment so we can study the effects of stromal fibroblasts on breast cancer progression, we evaluated several three-dimensional (3D) co-...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.458
更新日期:2011-01-01 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18230
更新日期:2017-05-10 00:00:00
abstract::Glioblastoma multiforme (GBM) is commonly known as the most aggressive primary CNS tumor in adults. The mean survival of it is 14 to 15 months, following the standard therapy from surgery, chemotherapy, to radiotherapy. Efforts in recent decades have brought many novel therapies to light, however, with limitations. In...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
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更新日期:2019-08-27 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2019-10-17 00:00:00
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journal_title:Journal of Cancer
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更新日期:2019-09-07 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2019-06-09 00:00:00
abstract:BACKGROUND:Age-adjusted evaluations have explored the possible utility of (HPV test results in women with LSIL Pap. We investigated HPV test results and histopathologic follow-up results of LSIL patients from China's largest CAP-certified laboratory. METHODS:Patients with LSIL between 2011 and 2015 from the Guangzhou ...
journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2017-07-23 00:00:00
abstract::Oral cancer is one of the most frequent malignant diseases worldwide, and areca nut is a primary carcinogen causing this cancer in Southeast Asia. It has been widely reported that areca nut induced several cytotoxic effects in oral cells, including ROS generation, inflammation, tissue hypoxia, DNA damage, and cell inv...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
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更新日期:2019-07-08 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.292
更新日期:2011-01-01 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2020-02-03 00:00:00
abstract::Purpose: Extremity soft tissue leiomyosarcoma (LMS) with metastasis is a rare disease with a poor prognosis. The purpose of our study was to define clinical features of extremity soft tissue LMS with metastasis as well as to identify multivariable predictors of survival. Methods: During 1973-2015, 239 patients with me...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29874
更新日期:2019-05-21 00:00:00
abstract::Butyrate, a product of dietary fiber and a histone deacetylase inhibitor, induces apoptosis of colorectal cancer cells; this effect of butyrate is in part mediated by its ability to hyperactivate Wnt signaling, and may in part explain the preventive action of dietary fiber against colorectal cancer. However, the mecha...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.37864
更新日期:2020-01-01 00:00:00
abstract::Purpose: The early BCR-ABL1 reduction had the prognostic impact of the chronic-phase chronic myeloid leukemia (CML-CP) patients. This study was to find a more precise early prognosis index at 3 months in the patients with newly diagnosed CML-CP, especially for the patients with BCR-ABL1IS >10%. Methods: We retrospecti...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.38752
更新日期:2020-02-03 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.36
更新日期:2011-01-08 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.15779
更新日期:2016-09-13 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2019-06-02 00:00:00
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更新日期:2019-01-01 00:00:00
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journal_title:Journal of Cancer
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doi:10.7150/jca.8085
更新日期:2014-03-13 00:00:00
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journal_title:Journal of Cancer
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更新日期:2015-03-18 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2020-07-09 00:00:00
abstract::Non epithelial ovarian tumors represent a small group of rare gynecological cancers but they have a high incidence in young childbearing women. The recent years fertility preservation surgeries have become a common practice in specific ovarian malignancies when the patients wish to maintain their fertility. Specific t...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.26674
更新日期:2018-11-24 00:00:00
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journal_title:Journal of Cancer
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更新日期:2018-04-06 00:00:00
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更新日期:2017-07-20 00:00:00
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pub_type: 杂志文章
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更新日期:2020-03-04 00:00:00