Fertility Sparing Management in Non-Epithelial Ovarian Cancer. Which Patients, What Procedure and What Outcome?

Abstract:

:Non epithelial ovarian tumors represent a small group of rare gynecological cancers but they have a high incidence in young childbearing women. The recent years fertility preservation surgeries have become a common practice in specific ovarian malignancies when the patients wish to maintain their fertility. Specific types of non-epithelial ovarian tumors can be managed with fertility sparing operations with a similar outcome to more radical intervention but due to the rarity of these tumors the extent of the operation remains in some cases controversial. Moreover, the reproductive outcome of the women that had these conservative operations seems to be very promising. In our review we try to summarize the data regarding the fertility sparing management of all types of non-epithelial ovarian cancers and what procedure should be performed in each case. Finally we have accumulated the data concerning the reproductive outcome of patients that had undergone this type of surgery.

journal_name

J Cancer

journal_title

Journal of Cancer

authors

Thomakos N,Malakasis A,Machairiotis N,Zarogoulidis P,Rodolakis A

doi

10.7150/jca.26674

subject

Has Abstract

pub_date

2018-11-24 00:00:00

pages

4659-4664

issue

24

issn

1837-9664

pii

jcav09p4659

journal_volume

9

pub_type

杂志文章,评审
  • Association of Body Mass Index Changes during Neoadjuvant Chemotherapy with Pathologic Complete Response and Clinical Outcomes in Patients with Locally Advanced Breast Cancer.

    abstract::The purpose of this study was to determine the association between body mass index (BMI) measurements (baseline BMI and changes in BMI during neoadjuvant systemic treatment [NST]) and clinical efficacy (pathologic complete response [pCR] rate and survival outcomes) in locally advanced breast cancer (LABC). We hypothes...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.10580

    authors: Kogawa T,Fouad TM,Wei C,Masuda H,Kai K,Fujii T,El-Zein R,Chavez-MacGregor M,Litton JK,Brewster A,Alvarez RH,Hortobagyi GN,Valero V,Theriault R,Ueno NT

    更新日期:2015-01-22 00:00:00

  • RAS/RAF mutations in tumor samples and cell-free DNA from plasma and bone marrow aspirates in multiple myeloma patients.

    abstract::Purpose: To evaluate the detection of gene mutations in bone marrow biopsy and circulating free DNA (cfDNA) from plasma in multiple myeloma (MM). Experimental design: We used cell-free DNA from plasma and bone marrow to test BRAF V600, KRAS G12/G13, NRAS G12/G13 and NRAS Q61 mutations using multiplex assays for drople...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.43729

    authors: Li Q,Huang HJ,Ma J,Wang Y,Cao Z,Karlin-Neumann G,Janku F,Liu Z

    更新日期:2020-03-15 00:00:00

  • Centromere Protein N Participates in Cellular Proliferation of Human Oral Cancer by Cell-Cycle Enhancement.

    abstract::Centromere protein N (CENP-N), an important member of the centromere protein family, is essential for kinetochore assembly and chromosome segregation; however, the relevance of CENP-N in cancers remains unknown. The aim of this study was to investigate CENP-N expression and its functional mechanisms in oral squamous c...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.32281

    authors: Oka N,Kasamatsu A,Endo-Sakamoto Y,Eizuka K,Wagai S,Koide-Ishida N,Miyamoto I,Iyoda M,Tanzawa H,Uzawa K

    更新日期:2019-06-09 00:00:00

  • MiR-93 Promotes Tumorigenesis and Metastasis of Non-Small Cell Lung Cancer Cells by Activating the PI3K/Akt Pathway via Inhibition of LKB1/PTEN/CDKN1A.

    abstract:BACKGROUND:Non-small cell lung cancer (NSCLC) accounts for approximately 85% of clinical lung cancer cases. MicroRNA-93 (miR-93) is an oncomiR in many types of human cancer, exerting pivotal effects in the development and progression of malignancies, including NSCLC. However, the mechanism underlying miR-93 involvement...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.17958

    authors: Li C,Lyu J,Meng QH

    更新日期:2017-03-07 00:00:00

  • High expression of calreticulin indicates poor prognosis and modulates cell migration and invasion via activating Stat3 in nasopharyngeal carcinoma.

    abstract::Objective: Emerging evidence suggests that calreticulin (CALR) has great impacts on the tumor formation and progression of various cancers, but the role of CALR remains controversial. We investigated the expression and clinical significance of CALR in nasopharyngeal carcinoma (NPC). Methods: Immunohistochemistry was u...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.35362

    authors: Han Y,Liao Q,Wang H,Rao S,Yi P,Tang L,Tian Y,Oyang L,Wang H,Shi Y,Zhou Y

    更新日期:2019-08-29 00:00:00

  • Whole-exome Sequencing of Prostate Cancer in Sardinian Identify Recurrent UDP-glucuronosyltransferase Amplifications.

    abstract::Globally, prostate cancer is the third most common cancer in the world, and the second most common cancer in men. However, rates for incidence and mortality vary considerably with race, ethnicity, and geography. Over 97 significantly mutated genes that have been identified in prostate cancer; however, a lack of genomi...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.48433

    authors: Zeng T,Fedeli MA,Tanda F,Wang Y,Yang D,Xue B,Jia L,Palmieri G,Sechi LA,Kelvin DJ

    更新日期:2021-01-01 00:00:00

  • A Study on Effect of Oxaliplatin in MicroRNA Expression in Human Colon Cancer.

    abstract::Colorectal cancer is a commonly diagnosed malignancy and also the major cause of death worldwide. Chemotherapy is the primary therapy for advanced colorectal cancer. Although oxaliplatin has potential effect in colorectal cancer therapy, the molecular mechanisms involved in its cytotoxic effects are not well elucidate...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.24474

    authors: Evert J,Pathak S,Sun XF,Zhang H

    更新日期:2018-05-22 00:00:00

  • Identifying DCN and HSPD1 as Potential Biomarkers in Colon Cancer Using 2D-LC-MS/MS Combined with iTRAQ Technology.

    abstract::Colon cancer is one of the most common types of gastrointestinal cancers and the fourth cause of cancer death worldwide. To discover novel diagnostic biomarkers for colon cancer and investigate potential mechanisms of oncogenesis, quantitative proteomic approach using iTRAQ-tagging and 2D-LC-MS/MS was performed to cha...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.17192

    authors: Li G,Li M,Liang X,Xiao Z,Zhang P,Shao M,Peng F,Chen Y,Li Y,Chen Z

    更新日期:2017-02-11 00:00:00

  • Monocytosis as a prognostic factor for survival in stage IB and IIA cervical cancer.

    abstract::Objective: To measure hematologic parameters derived from the white blood cell (WBC) count and differential count (DC) as prognostic factors for survival in patients with stage IB and IIA cervical cancer. Methods: We retrospectively examined demographic, clinicopathologic, and laboratory parameters in a cohort of 233 ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.22234

    authors: Eo WK,Kwon BS,Kim KH,Kim HY,Kim HB,Koh SB,Chun S,Ji YI,Lee JY,Namkung J,Kwon S

    更新日期:2018-01-01 00:00:00

  • Prognostic Value of Albumin/Globulin Ratio in Survival and Lymph Node Metastasis in Patients with Cancer: A Systematic Review and Meta-analysis.

    abstract::The impact of albumin to globulin ratio (AGR) on the prognosis of various human cancers has not been well established. Here, a systemic review and meta-analysis has been performed to comprehensively assess the relationships between AGR and lymph node metastasis (LNM) or overall survival (OS). Systematical search throu...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.24889

    authors: Chi J,Xie Q,Jia J,Liu X,Sun J,Chen J,Yi L

    更新日期:2018-06-12 00:00:00

  • Non-pegylated liposomal Doxorubicin-cyclophosphamide in sequential regimens with taxanes as neoadjuvant chemotherapy in breast cancer patients.

    abstract:PURPOSE:Chemotherapy regimens containing anthracyclines and taxanes represent the landmark of neoadjuvant systemic therapy of breast cancer. In advanced breast cancer patients liposomal anthracyclines (LA) have shown similar efficacy and less cardiac toxicity when compared to conventional anthracyclines. We performed t...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.9132

    authors: Vici P,Pizzuti L,Gamucci T,Sergi D,Conti F,Zampa G,Del Medico P,De Vita R,Pozzi M,Botti C,Di Filippo S,Tomao F,Sperduti I,Di Lauro L

    更新日期:2014-04-25 00:00:00

  • Effect of Lipophilic and Hydrophilic Statins on Breast Cancer Risk in Thai Women: A Cross-sectional Study.

    abstract:BACKGROUND:Statins are proposed as a chemoprevention agent for breast cancer due to their anti-inflammatory effect. The effects of lipophilic and hydrophilic statins on breast cancer risk might be different due to their different pharmacologic properties. Therefore, this study aimed to assess a casual-effect of lipophi...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.14941

    authors: Anothaisintawee T,Udomsubpayakul U,McEvoy M,Lerdsitthichai P,Attia J,Thakkinstian A

    更新日期:2016-06-06 00:00:00

  • Efficacy of Chemiluminescence Immunoassays on VCA-IgA and EBNA1-IgA Antibodies of Epstein-Barr Virus in Diagnosing Nasopharyngeal Carcinoma.

    abstract::Background: IgA antibodies against Epstein-Barr virus (EBV) capsid antigen (VCA) and nuclear antigen 1 (EBNA1) have been proposed to facilitate the diagnosis and early detection of nasopharyngeal carcinoma (NPC) in high-incidence regions. However, while new methodologies and new platforms for the detection of VCA-IgA ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.47260

    authors: Yu X,Li F,Cheng W,Wu B,Fang H,Xia F,Gong Y,Yu W,Liao P,Cao Y,Yang F,Zhu H,Li J,Huang Y,Gan L,Zhang L,Lou Y,Ji M

    更新日期:2020-10-18 00:00:00

  • Role of Chemokines in Non-Small Cell Lung Cancer: Angiogenesis and Inflammation.

    abstract::Non-small cell lung cancer (NSCLC) is one of the most common types of aggressive cancer. The tumor tissue, which shows an active angiogenesis, is composed of neoplastic and stromal cells, and an abundant inflammatory infiltrate. Angiogenesis is important to support tumor growth, while infiltrating cells contribute to ...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.12286

    authors: Rivas-Fuentes S,Salgado-Aguayo A,Pertuz Belloso S,Gorocica Rosete P,Alvarado-Vásquez N,Aquino-Jarquin G

    更新日期:2015-08-07 00:00:00

  • Ki67 Proliferation Index as a Histopathological Predictive and Prognostic Parameter of Oral Mucosal Melanoma in Patients without Distant Metastases.

    abstract::Background: To investigate the relationship between clinical and histopathological characteristics and overall survival of patients with oral mucosal melanoma (OMM) without distal metastasis in order to provide predictive prognostic information of OMM. Methods: Ki67 expression was assessed by immunohistochemistry in 1...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.20935

    authors: Ma X,Wu Y,Zhang T,Song H,Jv H,Guo W,Ren G

    更新日期:2017-10-17 00:00:00

  • Small Nucleolar RNA 71A Promotes Lung Cancer Cell Proliferation, Migration and Invasion via MAPK/ERK Pathway.

    abstract::Objective: Increasing evidence suggested that dysregulated small nucleolar RNAs (snoRNAs) were involved in tumor development. The roles of snoRNA 71A (SNORA71A) in the progression of non-small cell lung cancer (NSCLC) remained unclear. Methods: Dataset GSE19188 from Gene Expression Omnibus (GEO) database was downloade...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.31077

    authors: Tang G,Zeng Z,Sun W,Li S,You C,Tang F,Peng S,Ma S,Luo Y,Xu J,Tian X,Zhang N,Gong Y,Xie C

    更新日期:2019-05-21 00:00:00

  • Overexpression and biological function of PRDX6 in human cervical cancer.

    abstract::Background: Our previous study demonstrated that the peroxiredoxin 6 (PRDX6) protein was downregulated in squamous cervical cancer samples after neoadjuvant chemotherapy compared with the expression level before chemotherapy. However, the effect of PRDX6 on the biological behavior of cervical cancer is still uncertain...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.39892

    authors: Hu X,Lu E,Pan C,Xu Y,Zhu X

    更新日期:2020-02-10 00:00:00

  • Multi-Parametric MRI-Directed Focal Salvage Permanent Interstitial Brachytherapy for Locally Recurrent Adenocarcinoma of the Prostate: A Novel Approach.

    abstract::Even with the technological advances of dose-escalated IMRT with the addition of the latest image guidance technologies, local failures still occur. The combination of MRI-based imaging techniques can yield quantitative information that reflects on the biological properties of prostatic tissues. These techniques provi...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.5419

    authors: Wallace T,Avital I,Stojadinovic A,Brücher BL,Cote E,Yu J

    更新日期:2013-01-01 00:00:00

  • Development and validation of a nomogram for predicting cancer-specific survival in patients with Wilms' tumor.

    abstract::Purpose: The objective of this study was to develop and validate a nomogram for predicting the cancer-specific survival (CSS) in patients with Wilms' tumor (WT). Methods: Patients with WT diagnosed between 2002 and 2015 in the Surveillance, Epidemiology, and End Results (SEER) database were divided randomly into train...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.32741

    authors: Pan Z,You H,Bu Q,Feng X,Zhao F,Li Y,Lyu J

    更新日期:2019-08-28 00:00:00

  • Anticancer Properties of Fenofibrate: A Repurposing Use.

    abstract::Cancer is a leading cause of death throughout the world, and cancer therapy remains a big medical challenge in terms of both its therapeutic efficacy and safety. Therefore, to find out a safe anticancer drug has been long goal for oncologist and medical scientists. Among clinically used medicines with no or little tox...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.24488

    authors: Lian X,Wang G,Zhou H,Zheng Z,Fu Y,Cai L

    更新日期:2018-04-06 00:00:00

  • Activation or suppression of the immune response mediators in biliary tract cancer (BTC) patients: a systematic review and meta-analysis.

    abstract::Background: Infiltration of immune cells and immune microenvironment determine the proliferative activity of the tumor and metastasis. The aim of this study was to analyze the influence of activation or suppression of the immune response mediators on the prognosis of biliary tract cancer (BTC). Methods: We searched Pu...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.16774

    authors: Wang Y,Ding M,Zhang Q,Wang J,Yang X,Zhou F,Li L,Yuan Z,Jin H,Qian Q

    更新日期:2017-01-01 00:00:00

  • Effect of targeted agents on the endocrine response of breast cancer in the neoadjuvant setting: a systematic review.

    abstract::Inhibition of aberrantly activated pathways cross-talking with hormone receptor (HR) improves response to endocrine therapy in patients with HR-positive advanced breast cancer. We performed a Pubmed database systematic review to ascertain the existence of a better clinical response when combining endocrine therapy wit...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.11566

    authors: Grassadonia A,Caporale M,Tinari N,Zilli M,DeTursi M,Gamucci T,Vici P,Natoli C

    更新日期:2015-05-12 00:00:00

  • Perspectives of breast cancer thermotherapies.

    abstract::In this article, the use of different types of thermotherapies to treat breast cancer is reviewed. While hyperthermia is most commonly used as an adjuvant in combination with radiotherapy, chemotherapy, targeted therapy or cryotherapy to enhance the therapeutic effect of these therapies, thermoablation is usually carr...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.8693

    authors: Alphandéry E

    更新日期:2014-05-29 00:00:00

  • Long-term aspirin use for primary cancer prevention: An updated systematic review and subgroup meta-analysis of 29 randomized clinical trials.

    abstract::Background and objective: Long-term aspirin use for the primary prevention of cancer remains controversial, and variations in the effect of aspirin use on cancer outcomes by aspirin dose, follow-up duration, or study population have never been systematically evaluated. The objective of this study was to evaluate the e...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.49001

    authors: Wu Q,Yao X,Chen H,Liu Z,Li T,Fan X,Zhang G,Yu L,Chen M,Xu C,Zhang R,Chen B,Sui X,Leung EL

    更新日期:2020-09-14 00:00:00

  • Hyperactivation of IL-6/STAT3 pathway leaded to the poor prognosis of post-TACE HCCs by HIF-1α/SNAI1 axis-induced epithelial to mesenchymal transition.

    abstract::Transarterial chemoembolization (TACE) has been considered the standard treatment for intermediate-stage hepatocellular carcinoma according to BCLC algorithm. However, it has been unclear about the TACE-related predictive bio-markers and underlying molecular mechanisms. This investigation revealed that HCCs with highe...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.35631

    authors: Gai X,Zhou P,Xu M,Liu Z,Zheng X,Liu Q

    更新日期:2020-01-01 00:00:00

  • Human Stromal Cells in the Peripheral Zone of the Prostate Promote Tumorigenesis of Prostatic Cancer Stem Cells through Up-regulation of C-Kit Expression.

    abstract:OBJECTIVE:Most prostate cancers originate from the prostatic peripheral zone (PZ). We tested the hypothesis that the stromal cells from PZ and transitional zone (TZ) have differential effects on the ability of tumorigenesis. METHODS:Stromal cells isolated from the PZ and TZ of normal human prostates mixed with DU145 c...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.9961

    authors: Peng Y,Chen Q,Gu M,Chen Y,Zhang M,Zhou J,Wang H,Gao Y,Li W,Wang Z,Cai Z

    更新日期:2015-07-03 00:00:00

  • Cullin family proteins and tumorigenesis: genetic association and molecular mechanisms.

    abstract::Cullin family proteins function as scaffolds to form numerous E3 ubiquitin ligases with RING proteins, adaptor proteins and substrate recognition receptors. These E3 ligases further recognize numerous substrates to participate in a variety of cellular processes, such as DNA damage and repair, cell death and cell cycle...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.11076

    authors: Chen Z,Sui J,Zhang F,Zhang C

    更新日期:2015-01-16 00:00:00

  • Genomic/Epigenomic Alterations in Ovarian Carcinoma: Translational Insight into Clinical Practice.

    abstract::Ovarian carcinoma is the most lethal gynecological malignancy worldwide. Recent advance in genomic/epigenomic researches will impact on our prevention, detection and intervention on ovarian carcinoma. Detection of germline mutations in BRCA1/BRCA2, mismatch repair genes, and other genes in the homologous recombination...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审

    doi:10.7150/jca.15556

    authors: Dong A,Lu Y,Lu B

    更新日期:2016-07-05 00:00:00

  • Effects of MACC1 polymorphisms on hepatocellular carcinoma development and clinical characteristics.

    abstract::Hepatocellular carcinoma (HCC) is a major malignancy of cancer-related mortality worldwide. Metastasis-associated in colon cancer-1 (MACC1) was suggested as a marker for vascular invasive HCC. This study investigated the MACC1 single-nucleotide polymorphisms (SNPs) to evaluate HCC susceptibility and clinicopathologica...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.38856

    authors: Lin CH,Hsieh MJ,Lee HL,Yang SF,Su SC,Lee WJ,Chou YE

    更新日期:2020-01-14 00:00:00

  • Effects of mitochondrial translocation of telomerase on drug resistance in hepatocellular carcinoma cells.

    abstract::Hepatocellular carcinoma (HCC) cells exhibit multidrug resistance (MDR), but the underlying mechanisms remain unclear. Cancer cells that overexpress telomerase are resistant to chemotherapeutic drugs. This study aimed to determine the effects of mitochondrial translocation of telomerase on MDR in HCC cells. HepG2 cell...

    journal_title:Journal of Cancer

    pub_type: 杂志文章

    doi:10.7150/jca.10419

    authors: Yan J,Zhou Y,Chen D,Li L,Yang X,You Y,Ling X

    更新日期:2015-01-05 00:00:00