Surgical Treatment of Combined Hepatocellular-Cholangiocarcinoma is as Effective in Elderly Patients as it is in Younger Patients: A Propensity Score Matching Analysis.

abstract：:Preoperative chemoradiation followed by surgery has been recommended as a standard treatment for patients with stage II/III rectal cancer. However, the optimal sequencing of radiotherapy for metastatic rectal cancer remains unclear. Between 2004 and 2014, patients diagnosed with metastatic rectal cancer who underwent ...

journal_title：Journal of Cancer

authors： Luo D,Liu Q,Zhu J,Ma Y,Cai S,Li Q,Li X

更新日期：2019-01-30 00:00:00

abstract：:Our previous studies have demonstrated that the compound fuling granule (CFG), a traditional Chinese medicine, suppresses ovarian cancer cell growth, migration and metastasis. However, the underlying mechanisms remain to be fully elucidated. In this study, we found that CFG could induce mitochondrial fragmentation, mi...

journal_title：Journal of Cancer

authors： Ruan S,Zhang Z,Tian X,Huang D,Liu W,Yang B,Shen M,Tao F

更新日期：2018-09-08 00:00:00

abstract：:Objectives: For patients with multiple small-sized pulmonary cancers, a lobectomy can disrupt future therapeutic options for other lesions. It was recently reported that limited pulmonary resections were not inferior to lobectomy for the management of selected peripheral small-sized pulmonary adenocarcinomas. Patients...

journal_title：Journal of Cancer

authors： Nakagiri T,Nakayama T,Tokunaga T,Takenaka A,Kunoh H,Ishida H,Tomita Y,Nakatsuka SI,Nakamura H,Okami J,Higashiyama M

更新日期：2020-02-20 00:00:00

abstract：:Accumulating evidence suggests that the malignant phenotypes of cancers are determined not only by the intrinsic properties of cancer cells but also by components in the tumor microenvironment (TME). In this study, we comprehensively characterized the TME of cutaneous melanoma (CM). As a result, tumor stage, tissue si...

journal_title：Journal of Cancer

authors： Wang P,Zhang X,Sun N,Zhao Z,He J

更新日期：2020-04-06 00:00:00

abstract：:Cancer-testis (CT) genes played important roles in the progression of malignant tumors and were recognized as promising therapeutic targets. However, the roles of genetic variants in CT genes in lung cancer susceptibility have not been well depicted. This study aimed to evaluate the associations between genetic varian...

journal_title：Journal of Cancer

authors： Li Z,Tang J,Wen W,Wu W,Wang J,Xu J,Yu Y,He Z,Pan X,Wei H,Zhu Y,Hu S,Cao J,Shen H,Que J,Wang W,Zhu Q,Chen L

更新日期：2020-02-03 00:00:00

abstract：:Colorectal cancer (CRC) usually gives rise to transcoelomic spread and ultimately causes peritoneal carcinomatosis (PC). However, mechanism studies, especially the immunological basis of colorectal PC, are rarely revealed due to lack of a suitable PC model. Here we selected a mouse colorectal cancer cell line MC-38 fo...

journal_title：Journal of Cancer

authors： Shi R,Xiang W,Kang X,Zhang L,Wang J,Miao H,He F

更新日期：2019-01-01 00:00:00

abstract：:Endometrial carcinoma (EC) is the most common malignant tumors in female derived from the endometrial epithelium. Several previous studies have described estrogen receptors (ER), progesterone Receptor (PR) and phosphatase and tensin homolog (PTEN) are associated with clinicopathological factors and prognosis in EC pat...

journal_title：Journal of Cancer

authors： Liang Y,Lin B,Ye Z,Chen S,Yu H,Chen C,Zhang X,Zhou K,Zeng J

更新日期：2020-01-13 00:00:00

abstract：:Neural invasion (NI) is one of the important routes for local spread of gastric cancer (GC) correlated with poor prognosis. However, the exact cellular characteristics and molecular mechanisms of NI in GC are still unclear. Netrin-1(NTN1) as an axon guidance molecule was firstly found during neural system development....

journal_title：Journal of Cancer

authors： Yin K,Wang L,Xia Y,Dang S,Zhang X,He Z,Xu J,Shang M,Xu Z

更新日期：2019-06-02 00:00:00

abstract：:Inhibition of aberrantly activated pathways cross-talking with hormone receptor (HR) improves response to endocrine therapy in patients with HR-positive advanced breast cancer. We performed a Pubmed database systematic review to ascertain the existence of a better clinical response when combining endocrine therapy wit...

journal_title：Journal of Cancer

authors： Grassadonia A,Caporale M,Tinari N,Zilli M,DeTursi M,Gamucci T,Vici P,Natoli C

更新日期：2015-05-12 00:00:00

abstract：: Purpose: Differentiated thyroid cancer (DTC) accounts for approximately 95% of thyroid carcinomas. In the metastatic RAI-refractory disease, chemotherapy has very limited efficacy and is associated with substantial toxicity. With increasing knowledge of the molecular patho...

journal_title：Journal of Cancer

authors： Balmelli C,Railic N,Siano M,Feuerlein K,Cathomas R,Cristina V,Güthner C,Zimmermann S,Weidner S,Pless M,Stenner F,Rothschild SI

更新日期：2018-01-01 00:00:00

abstract：:Purpose: The early BCR-ABL1 reduction had the prognostic impact of the chronic-phase chronic myeloid leukemia (CML-CP) patients. This study was to find a more precise early prognosis index at 3 months in the patients with newly diagnosed CML-CP, especially for the patients with BCR-ABL1IS >10%. Methods: We retrospecti...

journal_title：Journal of Cancer

authors： Cai Z,Jia X,Zi J,Song H,Wang S,McGrath M,Zhao L,Song C,Ge Z

更新日期：2020-02-03 00:00:00

abstract：:Esophageal cancer is an aggressive disease featured by early lymphatic and hematogenous dissemination, and is the sixth leading cause of cancer-related deaths worldwide. The proper formation of apicobasal polarity is essential for normal epithelium physiology and tissue homeostasis, while loss of polarity is a hallmar...

journal_title：Journal of Cancer

authors： Li XM,Wang H,Zhu LL,Zhao RZ,Ji HL

更新日期：2015-06-11 00:00:00

abstract：OBJECTIVE:The expression of DACH1 was frequently lost in human breast cancer, which significantly correlated with poor prognosis. Herein, we aim to investigate its underlying mechanisms. METHODS:The expression of miR-217 was detected by Taqman PCR. The mRNA and protein level of DACH1 were investigated by real time PCR...

journal_title：Journal of Cancer

authors： Zhang Q,Yuan Y,Cui J,Xiao T,Jiang D

更新日期：2015-01-01 00:00:00

abstract：AIM:The aim of our study was to compare clinical outcomes between elderly patients aged ≥75 years (elderly group, n=66) with intermediate hepatocellular carcinoma (HCC) undergoing transcatheter arterial chemoembolization (TACE) and younger patients aged <75 years (control group, n=84) with intermediate HCC undergoing T...

journal_title：Journal of Cancer

authors： Nishikawa H,Kita R,Kimura T,Ohara Y,Takeda H,Sakamoto A,Saito S,Nishijima N,Nasu A,Komekado H,Osaki Y

更新日期：2014-07-17 00:00:00

abstract：:Junctional adhesion molecule B (JAM-B) is a multifunctional transmembrane protein that plays an important role in tumor progression. JAM-B is significantly upregulated in gastric cancer, melanoma cell metastasis and oral squamous cell carcinoma. JAM-2 may also function as a putative tumor suppressor in the progression...

journal_title：Journal of Cancer

authors： Zhang W,He R,Chen S,Zhang L,Cao G,Yang W,Li J

更新日期：2020-03-05 00:00:00

abstract：:Objective: This study aimed to evaluate the therapeutic response of hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) with diffusion kurtosis imaging (DKI). Methods: Forty-three patients with fifty-nine hepatic cancer nodules were recruited for this study. All patients were treated b...

journal_title：Journal of Cancer

authors： Yuan ZG,Wang ZY,Xia MY,Li FZ,Li Y,Shen Z,Wang XZ

更新日期：2020-02-10 00:00:00

abstract：:Lung cancer is the most common malignancy in China and is associated with a poor survival rate amongst Han Chinese. The high mortality is largely attributed to late-stage diagnosis, when treatment is largely ineffective. Identification of genetic variants could potentially assist with earlier diagnosis and thus more e...

journal_title：Journal of Cancer

authors： Hu W,Tang CH,Chen HT,Zhao J,Jin L,Kang L,Wu Y,Ying P,Wang CQ,Su CM

更新日期：2019-06-02 00:00:00

abstract：BACKGROUND:Statins are proposed as a chemoprevention agent for breast cancer due to their anti-inflammatory effect. The effects of lipophilic and hydrophilic statins on breast cancer risk might be different due to their different pharmacologic properties. Therefore, this study aimed to assess a casual-effect of lipophi...

journal_title：Journal of Cancer

authors： Anothaisintawee T,Udomsubpayakul U,McEvoy M,Lerdsitthichai P,Attia J,Thakkinstian A

更新日期：2016-06-06 00:00:00

abstract：:Objectives: LncRNA associated with microvascular invasion in hepatocellular carcinoma (lncRNA MVIH) is a newly discovered long non-coding RNA that aberrantly up-regulates and holds prognostic value in various tumors. The aim of the review and meta-analysis is to assess its prognostic potential and functions in maligna...

journal_title：Journal of Cancer

authors： Zhang Y,Lin S,Yang X,Zhang X

更新日期：2019-02-26 00:00:00

abstract：:Hedgehog (Hh) signalling plays an important role in cancer; however, its mechanism in ovarian cancer migration and invasion remains unclear. In the present study, we aimed to clarify the effect of the Hh signalling pathway on ovarian cancer migration and invasion through the regulation of CD24 expression, both in vitr...

journal_title：Journal of Cancer

authors： Zeng C,Chen T,Zhang Y,Chen Q

更新日期：2017-02-25 00:00:00

abstract：:Cullin family proteins function as scaffolds to form numerous E3 ubiquitin ligases with RING proteins, adaptor proteins and substrate recognition receptors. These E3 ligases further recognize numerous substrates to participate in a variety of cellular processes, such as DNA damage and repair, cell death and cell cycle...

journal_title：Journal of Cancer

authors： Chen Z,Sui J,Zhang F,Zhang C

更新日期：2015-01-16 00:00:00

abstract：:Background: We performed a meta-analysis to evaluate the risk of immune-related colitis associated with PD1/PD-L1 inhibitors as compared to chemotherapy in solid tumor patients. Methods: Eligible studies were identified through a comprehensive search of multiple databases and included solid tumor patients in randomize...

journal_title：Journal of Cancer

authors： Su Q,Zhang X,Shen X,Hou Y,Sun Z,Gao ZH

更新日期：2018-04-12 00:00:00

abstract：:Distant metastasis is the primary cause of cancer-related death among patients with colorectal cancer (CRC), and the discovery of novel therapeutic targets by further exploring the molecular mechanisms of CRC metastasis is therefore urgently needed. We previously illustrated that CDC27 overexpression promoted prolifer...

journal_title：Journal of Cancer

authors： Qiu L,Tan X,Lin J,Liu RY,Chen S,Geng R,Wu J,Huang W

更新日期：2017-08-21 00:00:00

abstract：:Objective: Chemotherapy is a major therapeutic method for bladder urothelial carcinoma (BUC), which can effectively improve the prognosis of BUC patients, but the chemoresistance often leads to chemotherapy failure. This study will research the regulatory roles and molecular mechanism of miR-101-3p in BUC chemoresista...

journal_title：Journal of Cancer

authors： Li B,Xie D,Zhang H

更新日期：2019-06-02 00:00:00

abstract：:Colon cancer is one of the most common types of gastrointestinal cancers and the fourth cause of cancer death worldwide. To discover novel diagnostic biomarkers for colon cancer and investigate potential mechanisms of oncogenesis, quantitative proteomic approach using iTRAQ-tagging and 2D-LC-MS/MS was performed to cha...

journal_title：Journal of Cancer

authors： Li G,Li M,Liang X,Xiao Z,Zhang P,Shao M,Peng F,Chen Y,Li Y,Chen Z

更新日期：2017-02-11 00:00:00

abstract：:Background: Carbonic anhydrase 4 (CA4) maintains homeostasis of carbon dioxide and bicarbonate. It is suggested to be a potential prognostic biomarker, while the correlations between CA4 and different cancers are indistinct. Methods: Differential mRNA expression of CA4 among different cancers and corresponding normal ...

journal_title：Journal of Cancer

authors： Xu Y,Xu WH,Shi SN,Yang XL,Ren YR,Zhuang XY,Qu YY,Zhang HL,Zhang XF

更新日期：2020-08-25 00:00:00

abstract：:Pokemon, also known as leukemia/lymphoma-related factor (LRF) is a pro-oncogenic protein highly expressed in several cancers. There have been few in vitro and animal studies about its malignant biological behavior and function, however, its role especially in prostate cancer has not been completely elucidated. Therefo...

journal_title：Journal of Cancer

authors： Jiang F,Zheng Q,Chang L,Li X,Wang X,Gu X

更新日期：2019-04-21 00:00:00

abstract：:Background: CDK 4 and 6 inhibitors (CDK4/6i), which arrest unregulated cancer cell proliferation, show clinical efficacy in breast cancer. Unexpectedly, a patient treated on a CDK4/6i-based trial, as first-line therapy in metastatic breast cancer, developed rapid disease progression following discontinuation of study ...

journal_title：Journal of Cancer

authors： Bashour SI,Doostan I,Keyomarsi K,Valero V,Ueno NT,Brown PH,Litton JK,Koenig KB,Karuturi M,Abouharb S,Tripathy D,Moulder-Thompson SL,Ibrahim NK

更新日期：2017-07-05 00:00:00

abstract：:Objectives: Lung cancer in young adults is a distinct disease with particular socioeconomic implications. This study aimed to clarify the clinicopathological characteristics, best interventions, and outcomes of this distinctive entity. Methods: A retrospective review of patients with lung cancer was performed in our i...

journal_title：Journal of Cancer

authors： Liu B,Quan X,Xu C,Lv J,Li C,Dong L,Liu M

更新日期：2019-06-09 00:00:00

abstract：:The process of neoplastic transformation of the colon involves a progression through hyperproliferative epithelium through the aberrant crypt foci→small adenoma→large adenoma→invasive cancer→metastatic disease. These are orchestrated by sequential genetic and epigenetic events which provide the underpinnings of cellul...

journal_title：Journal of Cancer

authors： Backman V,Roy HK

更新日期：2013-01-01 00:00:00