Increased Prevalence of Esophageal Cancer in Areas with High Levels of Nickel in Farm Soils.

abstract：:Background: CDK 4 and 6 inhibitors (CDK4/6i), which arrest unregulated cancer cell proliferation, show clinical efficacy in breast cancer. Unexpectedly, a patient treated on a CDK4/6i-based trial, as first-line therapy in metastatic breast cancer, developed rapid disease progression following discontinuation of study ...

journal_title：Journal of Cancer

authors： Bashour SI,Doostan I,Keyomarsi K,Valero V,Ueno NT,Brown PH,Litton JK,Koenig KB,Karuturi M,Abouharb S,Tripathy D,Moulder-Thompson SL,Ibrahim NK

更新日期：2017-07-05 00:00:00

abstract：:Background and Aim: Glioblastoma multiforme (GBM) is a highly aggressive brain malignancy that lacks reliable treatments. Resveratrol possesses anti-cancer effects, but its activity against glioblastoma cells is variable for unknown reasons. One mechanism through which anti-cancer drugs exert their effects is oxidativ...

journal_title：Journal of Cancer

authors： Jia B,Zheng X,Wu ML,Tian XT,Song X,Liu YN,Li PN,Liu J

更新日期：2021-01-01 00:00:00

abstract：:Accumulating evidence suggests that the malignant phenotypes of cancers are determined not only by the intrinsic properties of cancer cells but also by components in the tumor microenvironment (TME). In this study, we comprehensively characterized the TME of cutaneous melanoma (CM). As a result, tumor stage, tissue si...

journal_title：Journal of Cancer

authors： Wang P,Zhang X,Sun N,Zhao Z,He J

更新日期：2020-04-06 00:00:00

abstract：:The impact of albumin to globulin ratio (AGR) on the prognosis of various human cancers has not been well established. Here, a systemic review and meta-analysis has been performed to comprehensively assess the relationships between AGR and lymph node metastasis (LNM) or overall survival (OS). Systematical search throu...

journal_title：Journal of Cancer

authors： Chi J,Xie Q,Jia J,Liu X,Sun J,Chen J,Yi L

更新日期：2018-06-12 00:00:00

abstract：:Objectives: To investigate the effect of the concurrent use of trastuzumab and anthracycline-based neoadjuvant chemotherapy (NAC) for HER2-positive breast cancer in terms of pCR and cardiotoxicity. Methods: We systematically searched Pubmed, Embase, Cochrane and SinoMed databases from inception until 1 July 2017 for r...

journal_title：Journal of Cancer

authors： Wu YT,Xu Z,Arshad B,Wu JS,Zhang K,Wu H,Li X,Li H,Li YC,Wang ZL,Wu KN,Kong LQ

更新日期：2018-08-06 00:00:00

abstract：PURPOSE:Chemotherapy regimens containing anthracyclines and taxanes represent the landmark of neoadjuvant systemic therapy of breast cancer. In advanced breast cancer patients liposomal anthracyclines (LA) have shown similar efficacy and less cardiac toxicity when compared to conventional anthracyclines. We performed t...

journal_title：Journal of Cancer

authors： Vici P,Pizzuti L,Gamucci T,Sergi D,Conti F,Zampa G,Del Medico P,De Vita R,Pozzi M,Botti C,Di Filippo S,Tomao F,Sperduti I,Di Lauro L

更新日期：2014-04-25 00:00:00

abstract：:Mechanistic target of rapamycin (mTOR) plays a critical role in the development of oral squamous cell carcinoma (OSCC), but the underlying mechanisms remain poorly understood. Here we have demonstrated that the expression of osteopontin (OPN) was dramatically up-regulated in OSCC tissues and cell lines. Moreover, redu...

journal_title：Journal of Cancer

authors： Gan N,Zou S,Hang W,Yang D,Zhang X,Yin Y

更新日期：2017-05-12 00:00:00

abstract：:We examined the feasibility and safety of using paclitaxel and trastuzumab as maintenance therapy after high-dose chemotherapy (HDC) with autologous hematopoietic stem cell transplantation (AHST) for patients with HER2-positive metastatic breast cancer. Ten patients (9 women and 1 man) were enrolled in the study. The ...

journal_title：Journal of Cancer

authors： Cheng YC,Rondón G,Anderlini P,Khouri IF,Champlin RE,Ueno NT

更新日期：2013-09-27 00:00:00

abstract：:GOAL: To investigate the HPV prevalence and characterize the expression of potential molecular surrogate markers of HPV infection in esophageal squamous cell carcinoma. MATERIALS AND METHODS: The prevalence of HPV in individuals with and without esophageal cancer (EC) was determined by using multiplex PCR; p16 and p53...

journal_title：Journal of Cancer

authors： Pastrez PRA,Mariano VS,da Costa AM,Silva EM,Scapulatempo-Neto C,Guimarães DP,Fava G,Neto SAZ,Nunes EM,Sichero L,Villa LL,Syrjanen KJ,Longatto-Filho A

更新日期：2017-04-09 00:00:00

abstract：:Background: Malnutrition and systemic inflammatory response are frequently associated with prognosis in patients with several types of cancer, including renal cell carcinoma (RCC). The study is aimed to investigate the ability of preoperative serum albumin to globulin ratio (AGR) to predict the long-term mortality of ...

journal_title：Journal of Cancer

authors： He X,Guo S,Chen D,Yang G,Chen X,Zhang Y,He Q,Qin Z,Liu Z,Xue Y,Zhang M,Liu R,Zhou F,Han H,Yao K

更新日期：2017-01-15 00:00:00

abstract：:Aims: We previously demonstrated that a loss of lean body mass loss at one month after gastrectomy was an independent risk factor for the continuation of adjuvant chemotherapy with S-1. However, it is unclear whether or not lean body mass loss after gastrectomy leads to a poor survival through poor compliance to adjuv...

journal_title：Journal of Cancer

authors： Aoyama T,Yoshikawa T,Maezawa Y,Kano K,Numata M,Hara K,Komori K,Yamada T,Hayashi T,Sato T,Tamagawa H,Yukawa N,Rino Y,Masuda M,Ogata T,Cho H,Oshima T

更新日期：2019-05-28 00:00:00

abstract：:Glioblastoma multiforme (GBM) is commonly known as the most aggressive primary CNS tumor in adults. The mean survival of it is 14 to 15 months, following the standard therapy from surgery, chemotherapy, to radiotherapy. Efforts in recent decades have brought many novel therapies to light, however, with limitations. In...

journal_title：Journal of Cancer

authors： Zhang H,Wang R,Yu Y,Liu J,Luo T,Fan F

更新日期：2019-08-27 00:00:00

abstract：INTRODUCTION:Bioimpedance is a measure of the electrical properties of biological tissues. In the last two decades bioimpedance has been successfully introduced in clinical diagnosis of cancer. It has been demonstrated that tumoral tissues often show lower bioimpedance values than healthy tissues. The aim of this work ...

journal_title：Journal of Cancer

authors： Tatullo M,Marrelli M,Amantea M,Paduano F,Santacroce L,Gentile S,Scacco S

更新日期：2015-08-20 00:00:00

abstract：:Breast cancer therapy has improved following the development of drugs with specific molecular targets, exemplified by inhibitors of human epidermal growth factor receptor-2 (HER2) or epidermal growth factor receptor (EGFR) such as trastuzumab and lapatinib. However, these drugs have little effect on brain metastasis d...

journal_title：Journal of Cancer

authors： Nakayama A,Takagi S,Yusa T,Yaguchi M,Hayashi A,Tamura T,Kawakita Y,Ishikawa T,Ohta Y

更新日期：2013-08-16 00:00:00

abstract：:Hepatocellular carcinoma (HCC) cells exhibit multidrug resistance (MDR), but the underlying mechanisms remain unclear. Cancer cells that overexpress telomerase are resistant to chemotherapeutic drugs. This study aimed to determine the effects of mitochondrial translocation of telomerase on MDR in HCC cells. HepG2 cell...

journal_title：Journal of Cancer

authors： Yan J,Zhou Y,Chen D,Li L,Yang X,You Y,Ling X

更新日期：2015-01-05 00:00:00

abstract：PURPOSE:Urothelial carcinoma (UC) is a type of tumor, especially of the urinary bladder, that affects people worldwide. Clarification of its detailed tumor biology and discovery of potential targets for developing treatment strategies are imperative because of frequent recurrences and poor prognosis of advanced UCs. By...

journal_title：Journal of Cancer

authors： Chang IW,Li CF,Lin VC,He HL,Liang PI,Wu WJ,Li CC,Huang CN

更新日期：2016-07-08 00:00:00

abstract：:Background: The Matrix metalloproteinase-14 (MMP-14) expression has been shown to be overexpressed in different cancers. However, there is no comprehensive quantitative evaluation of the MMP-14 prognostic value in digestive system carcinoma (DSC). The aim of this study is to explore the correlation between the MMP-14 ...

journal_title：Journal of Cancer

authors： Duan F,Peng Z,Yin J,Yang Z,Shang J

更新日期：2020-01-01 00:00:00

abstract：PURPOSE:Methotrexate, vinblastine, doxorubicin plus cisplatin (MVAC) and gemcitabine plus cisplatin (GC) are both effective first-line chemotherapy. We explore the responsive variables of MVAC and GC for patients with metastatic urothelial carcinoma of bladder (mUCB). MATERIALS AND METHODS:Patients who were initially ...

journal_title：Journal of Cancer

authors： Hsieh MC,Huang CH,Chiang PH,Chen YY,Tang Y,Su YL

更新日期：2016-06-27 00:00:00

abstract：:Distant metastasis is the primary cause of cancer-related death among patients with colorectal cancer (CRC), and the discovery of novel therapeutic targets by further exploring the molecular mechanisms of CRC metastasis is therefore urgently needed. We previously illustrated that CDC27 overexpression promoted prolifer...

journal_title：Journal of Cancer

authors： Qiu L,Tan X,Lin J,Liu RY,Chen S,Geng R,Wu J,Huang W

更新日期：2017-08-21 00:00:00

abstract：:Objectives: LncRNA associated with microvascular invasion in hepatocellular carcinoma (lncRNA MVIH) is a newly discovered long non-coding RNA that aberrantly up-regulates and holds prognostic value in various tumors. The aim of the review and meta-analysis is to assess its prognostic potential and functions in maligna...

journal_title：Journal of Cancer

authors： Zhang Y,Lin S,Yang X,Zhang X

更新日期：2019-02-26 00:00:00

abstract：:Background: Anti-EGFR therapies have been recommended for advanced colorectal cancer (CRC) with wild-type RAS and PIK3CA mutation. However, PIK3CA mutations are a poor prognostic marker and a negative predictor of response to anti-EGFR therapies in RAS wild-type CRC. Therefore, new and advanced treatment strategies ar...

journal_title：Journal of Cancer

authors： Kim JS,Kim JE,Kim K,Lee J,Park JO,Lim HY,Park YS,Kang WK,Kim ST

更新日期：2017-08-22 00:00:00

abstract：:The authors retrospectively examined the contralateral prophylactic mastectomy (CPM) rate among 100 women with ductal carcinoma in situ who are BRCA negative. Of 100 women with ductal carcinoma in situ, 31 elected contralateral prophylactic mastectomy (CPM). Factors associated with increased likelihood of undergoing c...

journal_title：Journal of Cancer

authors： Elsayegh N,Profato J,Barrera AM,Lin H,Kuerer HM,Ardic C,Litton JK,Tripathy D,Arun BK

更新日期：2015-05-23 00:00:00

abstract：OBJECTIVE:The main aim of this study was to study swith of the ovarian cancer cell to a calcifying phenotype in the formation of calcification in ovarian cancer, and to offer some help for ovarian cancer's diagnosis and differentiation therapy. METHODS:The mineralization of ovarian cancer cell lines SKOV3 was induced ...

journal_title：Journal of Cancer

authors： Wen J,Zhao Z,Huang L,Li L,Li J,Zeng Y,Wu J,Miao Y

更新日期：2018-02-28 00:00:00

abstract：:Human papillomavirus (HPV) is a DNA virus that infects epithelial cells and has been implicated in the development of cervical cancer. Few therapeutic strategies have been designed for the treatment of cervical intraepithelial neoplasia, a precursor of cervical cancer. In these early stages, the HPV E2 protein is the ...

journal_title：Journal of Cancer

authors： Bermúdez-Morales VH,Fierros-Zarate G,García-Meléndrez C,Alcocer-Gonzalez JM,Morales-Ortega A,Peralta-Zaragoza O,Torres-Poveda K,Burguete-García AI,Hernández-Márquez E,Madrid-Marina V

更新日期：2016-09-27 00:00:00

abstract：:Cellular compartmentalization of biochemical processes in eukaryotic cells is critical for many functions including shuttling of reducing equivalents across membranes. Although coordination of metabolic flux between different organelles is vital for cell physiology, its impact on tumor cell survival is not well unders...

journal_title：Journal of Cancer

authors： Zhang B,Tornmalm J,Widengren J,Vakifahmetoglu-Norberg H,Norberg E

更新日期：2017-07-05 00:00:00

abstract：:Background: Esophageal squamous cell carcinoma (ESCC) has been having a high mortality rate in China. Most patients are diagnosed in advanced stages, leading to the poor prognosis and low 5-year survival rate. Detection of precancerous lesions or early cancers is the key to improving this situation. Although previous ...

journal_title：Journal of Cancer

authors： Sun Y,Zhang T,Wu W,Zhao D,Zhang N,Cui Y,Liu Y,Gu J,Lu P,Xue F,Yu J,Wang J

更新日期：2019-06-02 00:00:00

abstract：:Thyroid transcription factor-1 (TTF-1) is overexpressed in up to 95% of primary lung adenocarcinoma while negative for almost all squamous cell carcinomas. TTF-1 expression has been investigated as a prognostic factor in non-small-cell lung cancer (NSCLC) with conflicting results. We conducted this meta-analysis to ga...

journal_title：Journal of Cancer

authors： Kim JH,Kim HS,Kim BJ,Han B,Choi DR,Kwon JH

更新日期：2018-10-20 00:00:00

abstract：:Minichromosome Maintenance (MCM) proteins play essential roles in various cancers. We previously reported that MCM7 could be a prognostic biomarker in non-small cell lung cancer (NSCLC). The purpose of current study is to explore roles of other MCM proteins in NSCLC and their correlation with clinico-pathologic parame...

journal_title：Journal of Cancer

authors： Liu YZ,Wang BS,Jiang YY,Cao J,Hao JJ,Zhang Y,Xu X,Cai Y,Wang MR

更新日期：2017-10-09 00:00:00

abstract：:Objective: Pancreatic cancer (PC) is a malignant tumor with limited therapeutic choices and extremely poor prognosis. Personalized therapy based on gene alternations is a promising choice. Considering tumor heterogeneity, the practice of ctDNA analysis has drawn the attention. Here, we try to assess the applicability ...

journal_title：Journal of Cancer

authors： Li H,Di Y,Li J,Jiang Y,He H,Yao L,Gu J,Lu J,Song J,Chen S,Cai S,Jin C,Yuan Z,Fu D

更新日期：2020-04-27 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is a major malignancy of cancer-related mortality worldwide. Metastasis-associated in colon cancer-1 (MACC1) was suggested as a marker for vascular invasive HCC. This study investigated the MACC1 single-nucleotide polymorphisms (SNPs) to evaluate HCC susceptibility and clinicopathologica...

journal_title：Journal of Cancer

authors： Lin CH,Hsieh MJ,Lee HL,Yang SF,Su SC,Lee WJ,Chou YE

更新日期：2020-01-14 00:00:00