Abstract:
:Endometrial and ovarian cancers are two most common cancers affecting women in their post-menopausal years. To date, there are no simple biochemical tests to detect these cancers at early stages. Our previous study has demonstrated that the activity of total proprotein convertases (PCs) is significantly increased in uterine lavage at all stages of endometrial cancer, suggesting uterine lavage which can be obtained relatively non-invasively may provide a simple tool for the detection of endometrial cancer. However, uterine lavage may also contain ovarian-derived factors, and PCs are also reported to be up-regulated in ovarian cancer. In this study we determined whether increases in uterine lavage PC activity are specific to endometrial cancer or are also associated with ovarian cancer. PC activity was detected in all uterine lavages examined but no difference was found between women with and without ovarian cancer. On the other hand, the PC activity was significantly higher in post-menopausal endometrial cancer patients, consistent with our previous report. These results suggest that measuring total PC activity in uterine lavage is a useful tool to detect endometrial cancer specifically.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Heng S,Stephens AN,Jobling TW,Nie Gdoi
10.7150/jca.16331subject
Has Abstractpub_date
2016-08-12 00:00:00pages
1812-1814issue
13issn
1837-9664pii
jcav07p1812journal_volume
7pub_type
杂志文章abstract::Hepatocellular carcinoma (HCC) is the sixth most common cancer, and the third most common cause of cancer related death worldwide. The multi-kinase inhibitor Sorafenib represents the only systemic treatment option until today, and results from clinical trials with allosteric mTOR inhibitors were sobering. Since the PI...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.12452
更新日期:2015-09-16 00:00:00
abstract::Early detection and accurate evaluation were both critical to improving the prognosis of clear cell Renal Cell Carcinoma (ccRCC) patients. More importantly, RNA Binding Proteins (RBPs) play a vital role in the tumorigenesis and progression of numerous cancers. However, the relationship between RBPs and ccRCC is still ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.49175
更新日期:2020-09-23 00:00:00
abstract::Dysbindin has been reported to be correlated with several malignancies. However, the clinical significance and biological role of dysbindin in epithelial ovarian cancer remains largely unknown. Here we demonstrated that the mRNA and protein levels of dysbindin were significantly upregulated in EOC tissues compared wit...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.39269
更新日期:2020-02-21 00:00:00
abstract::Background: Docetaxel (DOC), or Taxotere, is an anthracycline antibiotic used to treat multiple types of cancer. It is a first-line chemotherapy treatment for patients with metastasized, hormone-resistant prostate cancer (PCa) or for patients with high-risk, localized PCa that could benefit from early chemotherapy tre...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26681
更新日期:2018-11-11 00:00:00
abstract::Junctional adhesion molecule B (JAM-B) is a multifunctional transmembrane protein that plays an important role in tumor progression. JAM-B is significantly upregulated in gastric cancer, melanoma cell metastasis and oral squamous cell carcinoma. JAM-2 may also function as a putative tumor suppressor in the progression...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.40953
更新日期:2020-03-05 00:00:00
abstract::Purpose: Extremity soft tissue leiomyosarcoma (LMS) with metastasis is a rare disease with a poor prognosis. The purpose of our study was to define clinical features of extremity soft tissue LMS with metastasis as well as to identify multivariable predictors of survival. Methods: During 1973-2015, 239 patients with me...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29874
更新日期:2019-05-21 00:00:00
abstract::Taking into account the previously reported relationship between inflammation and carcinogenesis, and the scant amount of data concerning the role of neutrophil extracellular traps (NETs) in carcinogenesis, we decided to study the process of extracellular trap formation in patients with inflammation as well as in pati...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24238
更新日期:2018-04-30 00:00:00
abstract::Mechanistic target of rapamycin (mTOR) plays a critical role in the development of oral squamous cell carcinoma (OSCC), but the underlying mechanisms remain poorly understood. Here we have demonstrated that the expression of osteopontin (OPN) was dramatically up-regulated in OSCC tissues and cell lines. Moreover, redu...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18031
更新日期:2017-05-12 00:00:00
abstract::Background: Epithelial-mesenchymal transition (EMT) plays an important role in the invasion and migration during cancer metastasis. Wnt3a is one of the ligands in canonical Wnt/β-catenin signaling pathway, which contributes to the carcinogenesis and progression of lung cancer cell lines. The aim of this study was to e...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18560
更新日期:2017-08-02 00:00:00
abstract::Objective: Chemotherapy is a major therapeutic method for bladder urothelial carcinoma (BUC), which can effectively improve the prognosis of BUC patients, but the chemoresistance often leads to chemotherapy failure. This study will research the regulatory roles and molecular mechanism of miR-101-3p in BUC chemoresista...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.33117
更新日期:2019-06-02 00:00:00
abstract::Objective: This study aimed to evaluate the therapeutic response of hepatocellular carcinoma (HCC) after transcatheter arterial chemoembolization (TACE) with diffusion kurtosis imaging (DKI). Methods: Forty-three patients with fifty-nine hepatic cancer nodules were recruited for this study. All patients were treated b...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.32491
更新日期:2020-02-10 00:00:00
abstract::Purpose: Systemic therapy has often been used for patients with advanced hepatocellular carcinoma (HCC). However, due to drug resistance, the use of cytotoxic chemotherapy in the treatment of patients with advanced HCC has typically demonstrated low response rates. Secretory clusterin (sCLU) is expressed in aggressive...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.23849
更新日期:2018-04-06 00:00:00
abstract::Objectives: We aimed to investigate the interaction between fasting blood glucose and tumor embolus, and the potential mediation effect of fasting blood glucose on tumor embolus in predicting gastrointestinal tract cancer-specific mortality risk postoperatively. Methods and Results: 4330 patients were consecutively re...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.34843
更新日期:2020-01-01 00:00:00
abstract::Introduction: Epidermal growth factor receptor-tyrosine kinase inhibitors (EGFR-TKIs) are a standard first-line treatment for advanced EGFR-mutated NSCLC patients. Factors associated with symptoms and quality of life (QOL) improvements have not been investigated. Methods: We conducted a multicenter, prospective study ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.30507
更新日期:2019-07-10 00:00:00
abstract::MPHOSPH1, which is one of the kinesin superfamily proteins, has been reported to play an essential role in the carcinogenesis and progression of several kinds of cancers. MPHOSPH1 has also been suggested to be involved in STAT3 phosphorylation in hepatocellular carcinoma. However, the biological behavior of MPHOSPH1 i...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.25279
更新日期:2018-10-31 00:00:00
abstract::Background: Growing data suggest that DNA damage repair and detoxification pathways play crucial roles in radiation-induced toxicities. To determine whether common functional single-nucleotide polymorphisms (SNPs) in candidate genes from these pathways can be used as predictors of radiation pneumonitis (RP), we conduc...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.20643
更新日期:2018-02-01 00:00:00
abstract::Objective: To enquire into the clinical significance and potential molecular mechanism of microRNA (miRNA)-196b-5p in hepatocellular carcinoma (HCC). Methods: Quantitative reverse transcription and polymerase chain reaction (qRT-PCR) were utilized to examine miR-196b-5p expression level in 67 HCC paraffin embedded tis...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29293
更新日期:2019-08-29 00:00:00
abstract::Purpose: To evaluate the detection of gene mutations in bone marrow biopsy and circulating free DNA (cfDNA) from plasma in multiple myeloma (MM). Experimental design: We used cell-free DNA from plasma and bone marrow to test BRAF V600, KRAS G12/G13, NRAS G12/G13 and NRAS Q61 mutations using multiplex assays for drople...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.43729
更新日期:2020-03-15 00:00:00
abstract::Transforming growth factor β1 (TGF-β1) plays an important role in tumor initiation and development by inducing epithelial-mesenchymal Transition (EMT). Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is a long noncoding RNA (lncRNA) that contributes to the invasion and metastasis of tumors, including e...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.48426
更新日期:2020-10-04 00:00:00
abstract::In 2006, a remarkable collaboration between University of Texas MD Anderson Cancer Center clinicians and Texas and New Mexico State legislators led to the formation of a dedicated IBC Research Program and Clinic at MD Anderson. This initiative provided funding and infrastructure to foster coordination of an IBC World ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.21200
更新日期:2017-10-09 00:00:00
abstract::Non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation inevitably have a relapse due to the occurrence of acquired resistance, resulting in treatment failure. However, little is known about the mechanisms of acquired resistance of NSCLC patients. Here, we elucidated the expre...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.35097
更新日期:2019-10-15 00:00:00
abstract::Colorectal cancer is a commonly diagnosed malignancy and also the major cause of death worldwide. Chemotherapy is the primary therapy for advanced colorectal cancer. Although oxaliplatin has potential effect in colorectal cancer therapy, the molecular mechanisms involved in its cytotoxic effects are not well elucidate...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24474
更新日期:2018-05-22 00:00:00
abstract:PURPOSE:Our study is designed to develop and certify a promising prognostic signature for hepatocellular carcinoma (HCC). Materials and methods: We retrospectively analyzed mRNA expression profiles and clinicopathological data fetched from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) datasets. We fo...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.44573
更新日期:2020-07-31 00:00:00
abstract:PURPOSE:The current study examined quality of life, progression of disease, and survival rate during chemotherapy in newly diagnosed non-small cell lung cancer (NSCLC) patients with depression (n=48) and without depression (n=78). Further, the study explored the hypothesis that the survival benefit resulted from the ch...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.11239
更新日期:2015-09-15 00:00:00
abstract::Cancer is a leading cause of death throughout the world, and cancer therapy remains a big medical challenge in terms of both its therapeutic efficacy and safety. Therefore, to find out a safe anticancer drug has been long goal for oncologist and medical scientists. Among clinically used medicines with no or little tox...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.24488
更新日期:2018-04-06 00:00:00
abstract::We hypothesised that the blood levels of immune cells would be related to the progression of colorectal cancer and regional lymph node metastasis. We investigated the association between the blood levels of immune cells and regional lymph node metastasis in colorectal cancer patients. Patients with American Joint Comm...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18230
更新日期:2017-05-10 00:00:00
abstract:BACKGROUND:There is often a finite progression-free interval of time between one systemic therapy and the next when treating patients with advanced cancer. While it appears that progression-free survival (PFS) between systemic therapies tends to get shorter for a number of factors, there has not been a formal evaluatio...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.3.7
更新日期:2012-01-01 00:00:00
abstract:PURPOSE:We conducted a meta-analysis to evaluate and compare the short- and long-term results of laparoscopic colorectal surgery (LCRS) and conventional open surgery (OCRS) for colorectal cancer (CRC). METHODS:We searched relevant papers published between January 1990 and May 2011. We analyzed the outcomes of each typ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.425
更新日期:2011-01-01 00:00:00
abstract::Inhibition of aberrantly activated pathways cross-talking with hormone receptor (HR) improves response to endocrine therapy in patients with HR-positive advanced breast cancer. We performed a Pubmed database systematic review to ascertain the existence of a better clinical response when combining endocrine therapy wit...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.11566
更新日期:2015-05-12 00:00:00
abstract::Background: The incidence and mortality rate of gastric cancer has markedly declined over the past few decades, due to the progress and advances in the development of diagnostic and treatment regimens. However, there is still a large portion of patients who are first diagnosed during the advanced stage of gastric canc...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.31303
更新日期:2019-10-06 00:00:00