Effect of TTLL6 expression on CDDP sensitivity of EC109/CDDP cells in hypoxia/acidosis microenvironment.

abstract：:Clinical outcomes of checkpoint blockade immunotherapy on colorectal cancer (CRC) are influenced by mismatch repair (MMR) gene status, which is associated with distinct tumor immune infiltrates and systemic inflammatory response status. However, the prognostic value of PD-L1 expression and the systemic inflammatory re...

journal_title：Journal of Cancer

authors： Kong P,Wang J,Song Z,Liu S,He W,Jiang C,Xie Q,Yang L,Xia X,Xia L

更新日期：2019-04-05 00:00:00

abstract：:Background and aim: Silencing the expression of ACACA inhibits cell proliferation and induces apoptosis in prostate cancer LNCaP cells. However, the role of ACACA in other prostate cancer cells is not fully understood. Also, the effect of knocking down ACACA gene on mitochondria remains unclear. This study aimed to di...

journal_title：Journal of Cancer

authors： Zhang H,Liu S,Cai Z,Dong W,Ye J,Cai Z,Han Z,Liang Y,Zhuo Y,Luo Y,Zhu X,Deng Y,Zhang Y,Liu R,Feng Y,Lai J,Zhou R,Tan H,Zhong W

更新日期：2021-01-01 00:00:00

abstract：:Objectives: Platinum-based chemotherapy is first-line treatment for non-small cell lung cancer (NSCLC) patients. The efficacy is limited by drug resistance. Recent studies suggest that ATP7B, a copper efflux transporter, may be involved in platinum resistance. However, the clinical significance of ATP7B expression in ...

journal_title：Journal of Cancer

authors： Li YQ,Chen J,Yin JY,Liu ZQ,Li XP

更新日期：2018-09-08 00:00:00

abstract：:Purpose: The aberrant of fibroblast growth factors and their receptors (FGF/FGFR) is an emerging target in the treatment of solid tumors. This study aimed to explore the landscape of FGF/FGFR alterations in a large cohort of cancer patients. Material and Methods: The formalin-fixed paraffin-embedded specimens of cance...

journal_title：Journal of Cancer

authors： Zuo W,He Y,Li W,Wu H,Zhao Z,Zhang Y,Chen S,Yin Y

更新日期：2020-09-23 00:00:00

abstract：:Background: Given recent results indicating that diminished LKB1 expression in laryngeal cancer correlates with shorter survival. We aim to perform an analysis estimate the role of decreased liver kinase B1(LKB1) and in the prognostication of human laryngeal squamous cell carcinoma (LSCC). Methods: We conducted a retr...

journal_title：Journal of Cancer

authors： He SS,Chen Y,Wang HZ,Shen XM,Sun P,Dong J,Liao XB,Guo GF,Chen JG,Xia LP,Hu PL,Qiu HJ,Liu SS,Zhou YX,Wang W,Hu WH,Cai XY

更新日期：2017-09-30 00:00:00

abstract：:Cullin family proteins function as scaffolds to form numerous E3 ubiquitin ligases with RING proteins, adaptor proteins and substrate recognition receptors. These E3 ligases further recognize numerous substrates to participate in a variety of cellular processes, such as DNA damage and repair, cell death and cell cycle...

journal_title：Journal of Cancer

authors： Chen Z,Sui J,Zhang F,Zhang C

更新日期：2015-01-16 00:00:00

abstract：:Little is known about the possible oncogenic roles of genes encoding for the phosphatidylinositol 4-kinases, a family of enzymes that regulate an early step in phosphoinositide signalling. To address this issue, the mutational status of all four human phosphatidylinositol 4-kinases genes was analyzed across 852 breast...

journal_title：Journal of Cancer

authors： Waugh MG

更新日期：2014-10-28 00:00:00

abstract：PURPOSE:Triple-negative breast cancer (TNBC) has attracted more attention both clinically and experimentally because of its high-risk biological characteristics and lacking of effective treatment method. The purpose of this retrospective study was to find out the incidence of triple-negative breast cancer (TNBC) in all...

journal_title：Journal of Cancer

authors： Qiu J,Xue X,Hu C,Xu H,Kou D,Li R,Li M

更新日期：2016-01-01 00:00:00

abstract：:Cancer is a genetic disease where genetic variations cause abnormally functioning genes that appear to alter expression. Proteins, the final products of gene expression, determine the phenotypes and biological processes. Therefore, detecting gene expression levels can be used for cancer diagnosis, prognosis, and treat...

journal_title：Journal of Cancer

authors： Narrandes S,Xu W

更新日期：2018-06-05 00:00:00

abstract：:Angiogenesis, a highly regulated process, is exploited by tumors like breast cancer to ensure a constant supply of oxygen and nutrients and is key for tumor survival and progression. Estrogen and alcohol independently have been observed to contribute to angiogenesis in breast cancer but their combinatorial effects hav...

journal_title：Journal of Cancer

authors： Maniyar R,Chakraborty S,Suriano R

更新日期：2018-10-06 00:00:00

abstract：:The INT0116 trial was a milestone study and laid the foundation for the adjuvant radiotherapy (RT) associated to concurrent chemotherapy (CT) for the treatment of gastric cancer (GC) after gastrectomy. However, it is still controversial whether adding RT to CT could further benefit D2-dissected GC patients. The ARTIST...

journal_title：Journal of Cancer

authors： Xu J,Zhu J,Wei Q

更新日期：2019-01-01 00:00:00

abstract：:Objectives: Chordomas are slow-growing malignancies that commonly affect vital neurological structures. These neoplasms are highly resistant to current chemotherapeutic regimens and often recur after surgical intervention. Therefore, there is an urgent need to identify molecular targets and more robust drugs to improv...

journal_title：Journal of Cancer

authors： Shen S,Dean DC,Yu Z,Hornicek F,Kan Q,Duan Z

更新日期：2020-01-01 00:00:00

abstract：:Background: Uterine cervical cancer (UCC) is a common malignant tumor in women. We conducted this work to provide a though description on the patterns of distant metastases and to investigate the relevant factors for prognosis of UCC patients based on a large population. Patients and methods: UCC patients with FIGO st...

journal_title：Journal of Cancer

authors： Zhang Y,Guo Y,Zhou X,Wang X,Wang X

更新日期：2020-01-14 00:00:00

abstract：:Objective: Pancreatic cancer (PC) is a malignant tumor with limited therapeutic choices and extremely poor prognosis. Personalized therapy based on gene alternations is a promising choice. Considering tumor heterogeneity, the practice of ctDNA analysis has drawn the attention. Here, we try to assess the applicability ...

journal_title：Journal of Cancer

authors： Li H,Di Y,Li J,Jiang Y,He H,Yao L,Gu J,Lu J,Song J,Chen S,Cai S,Jin C,Yuan Z,Fu D

更新日期：2020-04-27 00:00:00

abstract：:Objective: To investigate the development of bronchoscopy in China and compare it with its application in the early 21st century. Methods: The data collection was based on questionnaires. Three hundred and nineteen hospitals, which distributed across 30 provinces and 130 cities, were included in the study. Data about ...

journal_title：Journal of Cancer

authors： Shi D,Li F,Wang K,Kong C,Huang H,Li Q,Jin F,Hu C,Wang C,Shi H,Hu Z,Dong Y,Ning Y,Tsakiridis K,Sapalidis K,Kosmidis C,Vagionas A,Hohenforst-Schmidt W,Freitag L,Turner JF,Drevelegas K,Perdikouri EI,Kovacevic T,

更新日期：2020-07-20 00:00:00

abstract：:Thyroid transcription factor-1 (TTF-1) is overexpressed in up to 95% of primary lung adenocarcinoma while negative for almost all squamous cell carcinomas. TTF-1 expression has been investigated as a prognostic factor in non-small-cell lung cancer (NSCLC) with conflicting results. We conducted this meta-analysis to ga...

journal_title：Journal of Cancer

authors： Kim JH,Kim HS,Kim BJ,Han B,Choi DR,Kwon JH

更新日期：2018-10-20 00:00:00

abstract：:Background: Malignant biliary and/or pancreatic obstruction has often encountered in the advanced stages of periampullary and cholangicarcinomas. HabibTM Radiofrequency (RF) ablation has been successfully used in the management of various cancers of liver and pancreas. Percutaneous HPB probe (EMcision Ltd, London, UK)...

journal_title：Journal of Cancer

authors： Mizandari M,Kumar J,Pai M,Chikovani T,Azrumelashvili T,Reccia I,Habib N

更新日期：2018-01-05 00:00:00

abstract：:Aims: We previously demonstrated that a loss of lean body mass loss at one month after gastrectomy was an independent risk factor for the continuation of adjuvant chemotherapy with S-1. However, it is unclear whether or not lean body mass loss after gastrectomy leads to a poor survival through poor compliance to adjuv...

journal_title：Journal of Cancer

authors： Aoyama T,Yoshikawa T,Maezawa Y,Kano K,Numata M,Hara K,Komori K,Yamada T,Hayashi T,Sato T,Tamagawa H,Yukawa N,Rino Y,Masuda M,Ogata T,Cho H,Oshima T

更新日期：2019-05-28 00:00:00

abstract：:Background: Hepatitis B virus infection had been identified its relationship with liver diseases, including liver tumors. We aimed to explore diagnostic and prognostic values between the Human Leukocyte Antigen (HLA) complex and hepatocellular carcinoma (HCC). Methods: We used the GSE14520 dataset to explore diagnosti...

journal_title：Journal of Cancer

authors： Wang XK,Liao XW,Yang CK,Yu TD,Liu ZQ,Gong YZ,Huang KT,Zeng XM,Han CY,Zhu GZ,Qin W,Peng T

更新日期：2019-08-28 00:00:00

abstract：:RBP7 is a member of the cellular retinol-binding protein (CRBP) family and previous data suggested a link between CRBPs and the malignant transformation of colon cancer cells. Here, we investigated the potential of RBP7 as a predictive biomarker for patients with colon cancer and determined its functional relevance fo...

journal_title：Journal of Cancer

authors： Elmasry M,Brandl L,Engel J,Jung A,Kirchner T,Horst D

更新日期：2019-08-27 00:00:00

abstract：:Purpose: We retrospectively collected consecutive survival data of lung adenosquamous cell carcinoma (ASC) patients with brain metastasis (BM) in our institute and discussed the factors related to prognosis of these patients. Patients and Methods: A total of 42 patients diagnosed as lung ASC with BM between July 1, 20...

journal_title：Journal of Cancer

authors： Pan F,Cui S,Wang W,Gu A,Jiang L

更新日期：2018-09-08 00:00:00

abstract：PURPOSE:To investigate prognostic impact of chemoradiotherapy-induced hemoglobin (Hb) decrease on treatment outcomes of endemic nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS:Eight hundred and fifteen non-metastatic NPC, receiving neoadjuvant chemotherapy followed by radiotherapy (NACT+RT group) or concomitant ...

journal_title：Journal of Cancer

authors： Liang XX,Li Q,Su Z,Lan XW,Ouyang PY,Mao YP,Shi DB,Deng WG,Cheng ZB,Wang SY,Xie FY

更新日期：2015-04-02 00:00:00

abstract：:Background: Infiltration of immune cells and immune microenvironment determine the proliferative activity of the tumor and metastasis. The aim of this study was to analyze the influence of activation or suppression of the immune response mediators on the prognosis of biliary tract cancer (BTC). Methods: We searched Pu...

journal_title：Journal of Cancer

authors： Wang Y,Ding M,Zhang Q,Wang J,Yang X,Zhou F,Li L,Yuan Z,Jin H,Qian Q

更新日期：2017-01-01 00:00:00

abstract：:Objectives: This study aims to evaluate influence factors for adjuvant chemotherapy regimen choice on the basis of trastuzumab in older human epidermal growth factor receptor 2 (HER2)-positive breast cancer under multi-disciplinary team (MDT) modality. Materials and Methods: HER2-positive breast cancer patients aged ≥...

journal_title：Journal of Cancer

authors： Fang Y,Wang Z,Wu J,Huang O,He J,Zhu L,Chen W,Li Y,Chen X,Shen K

更新日期：2020-02-14 00:00:00

abstract：:Background: Most hepatocellular carcinoma (HCC) patients have undergone a progression from chronic hepatitis, then liver cirrhosis (LC), and finally to carcinoma. The objective of this study was to elucidate risk factors to predict HCC development for cirrhosis patients. Methods: Multiple methylated specific PCR (MSP)...

journal_title：Journal of Cancer

authors： Huang Y,Wei L,Zhao RC,Liang WB,Zhang J,Ding XQ,Li ZL,Sun CJ,Li B,Liu QY,He JY,Yu XQ,Gao B,Chen MM,Sun AM,Qin Y

更新日期：2018-06-04 00:00:00

abstract：OBJECTIVE:The main aim of this study was to study swith of the ovarian cancer cell to a calcifying phenotype in the formation of calcification in ovarian cancer, and to offer some help for ovarian cancer's diagnosis and differentiation therapy. METHODS:The mineralization of ovarian cancer cell lines SKOV3 was induced ...

journal_title：Journal of Cancer

authors： Wen J,Zhao Z,Huang L,Li L,Li J,Zeng Y,Wu J,Miao Y

更新日期：2018-02-28 00:00:00

abstract：:Esophageal cancer is an aggressive disease featured by early lymphatic and hematogenous dissemination, and is the sixth leading cause of cancer-related deaths worldwide. The proper formation of apicobasal polarity is essential for normal epithelium physiology and tissue homeostasis, while loss of polarity is a hallmar...

journal_title：Journal of Cancer

authors： Li XM,Wang H,Zhu LL,Zhao RZ,Ji HL

更新日期：2015-06-11 00:00:00

abstract：:Purpose: We examined the effect of GV1001 in castration castration-resistant prostate cancer (CRPC) cell growth and invasion and explored the potential molecular mechanisms of action. Materials and Methods: The in vitro anti-cancer effects of GV1001 in CRPC cells were examined using cell viability assay, TUNEL assay, ...

journal_title：Journal of Cancer

authors： Park YH,Jung AR,Kim GE,Kim MY,Sung JW,Shin D,Cho HJ,Ha US,Hong SH,Kim SW,Lee JY

更新日期：2019-10-17 00:00:00

abstract：:Breast cancer therapy has improved following the development of drugs with specific molecular targets, exemplified by inhibitors of human epidermal growth factor receptor-2 (HER2) or epidermal growth factor receptor (EGFR) such as trastuzumab and lapatinib. However, these drugs have little effect on brain metastasis d...

journal_title：Journal of Cancer

authors： Nakayama A,Takagi S,Yusa T,Yaguchi M,Hayashi A,Tamura T,Kawakita Y,Ishikawa T,Ohta Y

更新日期：2013-08-16 00:00:00

abstract：:MicroRNAs (miRNAs) have been recognized as key regulators of tumorigenesis and progression. Serum miR-302c-3p expression is prominently deregulated in HCV-related hepatocellular carcinoma (HCC). However, the expression of miR-302c-3p and its functional role in HBV-related HCC are rarely investigated. In this study, we...

journal_title：Journal of Cancer

authors： Yang L,Guo Y,Liu X,Wang T,Tong X,Lei K,Wang J,Huang D,Xu Q

更新日期：2018-06-23 00:00:00