Abstract:
:Background: Uterine cervical cancer (UCC) is a common malignant tumor in women. We conducted this work to provide a though description on the patterns of distant metastases and to investigate the relevant factors for prognosis of UCC patients based on a large population. Patients and methods: UCC patients with FIGO stage IVB, being the study group, were identified from the Surveillance, Epidemiology, and End Result (SEER) database from 2010 to 2016. UCC patients with same inclusion criteria, being validation group, were identified from Tianjin First Central Hospital from 2004 to 2017. Patterns of distant metastases were described according to the number of metastatic sites. Survival of different patterns were calculated and prognostic factors were investigated by Cox hazard regression analysis. Results: Distant metastases were recorded in 1448 UCC patients among whom 295 patients (30.8%) developed metastases in two or more organs. Compared with the median OS of 8 (95%CI, 7.07-8.93) months in the patients with the single site, worse survival of 5 (95%CI, 4.29-5.71) months was noticed in the patients with multiple metastases. Age ≥ 65 years, black race, higher grade, higher T stage and more metastatic sites were proved to be the prognostic factors for all the patients in the advanced stage and the results were partly validated in the validation cohort. Moreover, black race and higher T-stage for the patients with the single metastatic sites and age ≥ 65, uninsured status, surgical treatment and metastatic pattern for the patients with two metastatic sites were prognostic factors. No independent factor was found in patients with three or more metastases. Conclusion: Around 70% of the patients suffered one site distant metastasis in UCC patients with IVB stage while 30% with multiple metastases and a significantly reduced survival. Different survivals and prognostic factors were noticed for different patterns of distant metastases.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Zhang Y,Guo Y,Zhou X,Wang X,Wang Xdoi
10.7150/jca.37390subject
Has Abstractpub_date
2020-01-14 00:00:00pages
1532-1541issue
6issn
1837-9664pii
jcav11p1532journal_volume
11pub_type
杂志文章abstract::Esophageal cancer is an aggressive disease featured by early lymphatic and hematogenous dissemination, and is the sixth leading cause of cancer-related deaths worldwide. The proper formation of apicobasal polarity is essential for normal epithelium physiology and tissue homeostasis, while loss of polarity is a hallmar...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
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journal_title:Journal of Cancer
pub_type: 杂志文章,评审
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更新日期:2018-04-06 00:00:00
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journal_title:Journal of Cancer
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abstract::Glioblastoma multiforme (GBM) is commonly known as the most aggressive primary CNS tumor in adults. The mean survival of it is 14 to 15 months, following the standard therapy from surgery, chemotherapy, to radiotherapy. Efforts in recent decades have brought many novel therapies to light, however, with limitations. In...
journal_title:Journal of Cancer
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doi:10.7150/jca.2.329
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journal_title:Journal of Cancer
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更新日期:2019-01-01 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.7668
更新日期:2014-01-23 00:00:00
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pub_type: 杂志文章,评审
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更新日期:2019-07-10 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.11189
更新日期:2015-03-18 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.33720
更新日期:2020-01-13 00:00:00
abstract::The use of polyADPribose polymerase inhibitors in cancer treatment provides a unique opportunity to target DNA repair processes in cancer cells while leaving normal tissue intact. The PARP-1 enzyme repairs DNA single strand breaks (SSB). Therefore PARP-1 inhibition in BRCA1 negative cancers results in the formation of...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.21338
更新日期:2017-10-23 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.19611
更新日期:2017-07-20 00:00:00
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pub_type: 杂志文章
doi:10.7150/jca.2.458
更新日期:2011-01-01 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.27490
更新日期:2019-06-09 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
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更新日期:2019-07-05 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章,评审
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更新日期:2019-06-09 00:00:00
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journal_title:Journal of Cancer
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pub_type: 杂志文章
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更新日期:2020-04-06 00:00:00
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更新日期:2020-02-19 00:00:00
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journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.33237
更新日期:2019-06-09 00:00:00
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journal_title:Journal of Cancer
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更新日期:2020-09-17 00:00:00
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更新日期:2019-08-28 00:00:00