Latest Overview of the Cyclin-Dependent Kinases 4/6 Inhibitors in Breast Cancer: The Past, the Present and the Future.

abstract：:Objectives: For patients with multiple small-sized pulmonary cancers, a lobectomy can disrupt future therapeutic options for other lesions. It was recently reported that limited pulmonary resections were not inferior to lobectomy for the management of selected peripheral small-sized pulmonary adenocarcinomas. Patients...

journal_title：Journal of Cancer

authors： Nakagiri T,Nakayama T,Tokunaga T,Takenaka A,Kunoh H,Ishida H,Tomita Y,Nakatsuka SI,Nakamura H,Okami J,Higashiyama M

更新日期：2020-02-20 00:00:00

abstract：:Cisplatin-based chemotherapy is the foundation of treatment for major non-small cell lung cancer (NSCLC) patients. However, cisplatin resistance is still a challenging issue, and the molecular mechanisms underlying this resistance remain to be fully explored. CLEC4M, a Ca2+-dependent C-type lectin, has recently been f...

journal_title：Journal of Cancer

authors： Tan LM,Li X,Qiu CF,Zhu T,Hu CP,Yin JY,Zhang W,Zhou HH,Liu ZQ

更新日期：2019-10-19 00:00:00

abstract：:Ovarian cancer is a highly lethal malignancy in the female reproductive system. Platinum drugs, represented by cisplatin, are the first-line chemotherapeutic agents for treatment of various malignancies including ovarian cancer, but drug resistance leads to chemotherapy failure. MicroRNAs emerged as promising molecule...

journal_title：Journal of Cancer

authors： Xiang Y,Chen YJ,Yan YB,Liu Y,Qiu J,Tan RQ,Tian Q,Guan L,Niu SS,Xin HW

更新日期：2020-03-13 00:00:00

abstract：BACKGROUND:Mathematical models can be useful tools in exploring disease trends and health consequences of interventions in a population over time. Most cancers, in particular cervical cancer, have long incubation periods. The time from acquisition of HPV infection to development of invasive cancer can be up to two deca...

journal_title：Journal of Cancer

authors： Lee SL,Tameru AM

更新日期：2012-01-01 00:00:00

abstract：:Many preclinical and clinical studies are currently evaluating metformin in combination with classical therapeutic agents as anti-cancer therapy. In this study we used three distinct pancreatic cancer cell lines and evaluated cell death by trypan blue assay and Western Blots using antibodies directed against cleaved c...

journal_title：Journal of Cancer

authors： Zechner D,Albert AC,Bürtin F,Vollmar B

更新日期：2017-07-01 00:00:00

abstract：:Purpose: The objective of this study was to develop and validate a nomogram for predicting the cancer-specific survival (CSS) in patients with Wilms' tumor (WT). Methods: Patients with WT diagnosed between 2002 and 2015 in the Surveillance, Epidemiology, and End Results (SEER) database were divided randomly into train...

journal_title：Journal of Cancer

authors： Pan Z,You H,Bu Q,Feng X,Zhao F,Li Y,Lyu J

更新日期：2019-08-28 00:00:00

abstract：:Nasopharyngeal carcinoma (NPC), is one of the most common malignant tumor in southern China and southeast Asia. MYH10 is a coding gene of the NMMHC-IIB protein. Previous studies have shown that MYH10 expression was up-regulated in breast cancer, glioma and meningioma. Moreover, it was targeted by miR200 family. Howeve...

journal_title：Journal of Cancer

authors： Liu W,Cai T,Li L,Chen H,Chen R,Zhang M,Zhang W,Zhao L,Xiong H,Qin P,Gao X,Jiang Q

更新日期：2020-03-04 00:00:00

abstract：BACKGROUND:Age-adjusted evaluations have explored the possible utility of (HPV test results in women with LSIL Pap. We investigated HPV test results and histopathologic follow-up results of LSIL patients from China's largest CAP-certified laboratory. METHODS:Patients with LSIL between 2011 and 2015 from the Guangzhou ...

journal_title：Journal of Cancer

authors： Zheng B,Yang H,Li Z,Wei G,You J,Liang X,Zhao C

更新日期：2017-07-23 00:00:00

abstract：:Studies have indicated the significance of tumor associated macrophages (TAMs) in breast cancer; however, inconsistent results still exist. We retrospectively reviewed the macrophage distribution in 1579 breast cancer specimens with anti-CD68 or anti-CD163 immunohistochemical staining, and further analyzed the overall...

journal_title：Journal of Cancer

authors： Ni C,Yang L,Xu Q,Yuan H,Wang W,Xia W,Gong D,Zhang W,Yu K

更新日期：2019-07-23 00:00:00

abstract：:Purpose Increasing evidences revealed that cancer cells with the characteristics of epithelial-mesenchymal transition (EMT) or cancer stem cells (CSC) have high ability of progression, invasion, metastasis and chemoresistance. TWIST1 and BMI1 are crucial transcription factors required for EMT and CSC. Both TWIST1 and ...

journal_title：Journal of Cancer

authors： Ren H,Du P,Ge Z,Jin Y,Ding D,Liu X,Zou Q

更新日期：2016-05-25 00:00:00

abstract：:Purpose: Eukaryotic initiation factor 4A-3 (EIF4A3) is an RNA-binding protein (RBP) that is a core component of the exon junction complex (EJC). It has been identified as an important player in post-transcriptional regulation processes. Recently, investigations have focused on EIF4A3 dysfunction in carcinogenesis. The...

journal_title：Journal of Cancer

authors： Lin Y,Zhang J,Cai J,Liang R,Chen G,Qin G,Han X,Yuan C,Liu Z,Li Y,Zou D,Mao Y

更新日期：2018-11-11 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the sixth most common tumor worldwide. The relationship between the gene methylation accumulation and HCC has been widely studied. In our study, we used the Sequenom EpiTYPER assay to investigate the methylation levels of the RASA3 in 164 HCC samples and paired adjacent non-cancerous ...

journal_title：Journal of Cancer

authors： Lin H,Fan X,He L,Zhou D

更新日期：2018-05-25 00:00:00

abstract：:Long non-coding RNAs (LncRNAs) have been reported to be involved in tumorigenesis and tumor progression. Single nucleotide polymorphisms (SNPs) in the lncRNAs also play a vital role in carcinogenesis. The aim of this study was to assess the relationships between the four selected tagSNPs (rs944289, rs3787016, rs145631...

journal_title：Journal of Cancer

authors： Xu T,Hu XX,Liu XX,Wang HJ,Lin K,Pan YQ,Sun HL,Peng HX,Chen XX,Wang SK,He BS

更新日期：2017-04-09 00:00:00

abstract：:Cancer is a leading cause of death throughout the world, and cancer therapy remains a big medical challenge in terms of both its therapeutic efficacy and safety. Therefore, to find out a safe anticancer drug has been long goal for oncologist and medical scientists. Among clinically used medicines with no or little tox...

journal_title：Journal of Cancer

authors： Lian X,Wang G,Zhou H,Zheng Z,Fu Y,Cai L

更新日期：2018-04-06 00:00:00

abstract：:Ovarian cancer, cervical cancer and endometrial cancer are three relatively common malignant cancers of the female reproductive system. Despite improvements in female genital tract cancer detection and development of new therapeutic approaches, there are still poor prognoses and some do not respond to therapeutic patt...

journal_title：Journal of Cancer

authors： Zhu DL,Tuo XM,Rong Y,Zhang K,Guo Y

更新日期：2020-10-21 00:00:00

abstract：:Dihydroorotate dehydrogenase (DHODH) is a rate-limiting enzyme in the de novo biosynthesis pathway of pyrimidines. Inhibition of this enzyme impedes cancer cell proliferation but the exact mechanisms of action of these inhibitors in cancer cells are poorly understood. In this study, we showed that cancer cells, namely...

journal_title：Journal of Cancer

authors： Dorasamy MS,Choudhary B,Nellore K,Subramanya H,Wong PF

更新日期：2017-09-05 00:00:00

abstract：:Background: Given recent results indicating that diminished LKB1 expression in laryngeal cancer correlates with shorter survival. We aim to perform an analysis estimate the role of decreased liver kinase B1(LKB1) and in the prognostication of human laryngeal squamous cell carcinoma (LSCC). Methods: We conducted a retr...

journal_title：Journal of Cancer

authors： He SS,Chen Y,Wang HZ,Shen XM,Sun P,Dong J,Liao XB,Guo GF,Chen JG,Xia LP,Hu PL,Qiu HJ,Liu SS,Zhou YX,Wang W,Hu WH,Cai XY

更新日期：2017-09-30 00:00:00

abstract：:We use pulmonary interventional procedures for the diagnosis of pulmonary diseases either for benign or malignant lesions. Flexible bronchoscopy with or without radial endobronchial ultrasound, convex-probe endobronchial ultrasound and electromagnetic navigation are procedures performed in centers with experience in d...

journal_title：Journal of Cancer

authors： Hohenforst-Schmidt W,Zarogoulidis P,Huang H,Man YG,Laskou S,Koulouris C,Giannakidis D,Mantalobas S,Florou MC,Amaniti A,Steinheimer M,Sinha A,Freitag L,Turner JF,Browning R,Vogl T,Roman A,Benhassen N,Kesisoglou I,Sap

更新日期：2018-02-12 00:00:00

abstract：:MicroRNAs (miRNAs) have been extensively studied over the decades and have been proposed as potential molecular targets for cancer treatment. Studies have shown that miR-378 participates in numerous biological processes in various cancers; whereas miR-1827 has only been reported in pediatric glioma. The mechanism of h...

journal_title：Journal of Cancer

authors： Ho CS,Noor SM,Nagoor NH

更新日期：2018-01-01 00:00:00

abstract：:Background: The Matrix metalloproteinase-14 (MMP-14) expression has been shown to be overexpressed in different cancers. However, there is no comprehensive quantitative evaluation of the MMP-14 prognostic value in digestive system carcinoma (DSC). The aim of this study is to explore the correlation between the MMP-14 ...

journal_title：Journal of Cancer

authors： Duan F,Peng Z,Yin J,Yang Z,Shang J

更新日期：2020-01-01 00:00:00

abstract：:Aim: Skin cutaneous melanoma (SKCM) is one of the most life-threatening malignancies damaging human health. APOBEC3G (A3G) has been found in several cancers; however, the role of A3G in SKCM is rarely studied. This study aimed to investigate the expression of A3G in tumor tissue and its prognostic value in SKCM patien...

journal_title：Journal of Cancer

authors： Han W,Xu J,Shen GL

更新日期：2020-07-06 00:00:00

abstract：:Our previous study has demonstrated that cytochalasin H (CyH) isolated from mangrove-derived endophytic fungus induces apoptosis and inhibits migration in A549 non-small cell lung cancer (NSCLC) cells. In this study, we further explored the effect of CyH on angiogenesis in NSCLC cells and the underlying molecular mech...

journal_title：Journal of Cancer

authors： Ma Y,Xiu Z,Zhou Z,Huang B,Liu J,Wu X,Li S,Tang X

更新日期：2019-05-12 00:00:00

abstract：BACKGROUND:The 2010 guidelines by ASCO-CAP have mandated that breast cancer specimens with ≥1% positively staining cells by immunohistochemistry should be considered Estrogen Receptor (ER) positive. This has led to a subclass of low-ER positive (1-10%) breast cancers. We have examined the biology and clinical behavior ...

journal_title：Journal of Cancer

authors： Prabhu JS,Korlimarla A,Desai K,Alexander A,Raghavan R,Anupama C,Dendukuri N,Manjunath S,Correa M,Raman N,Kalamdani A,Prasad M,Gopinath KS,Srinath BS,Sridhar TS

更新日期：2014-01-23 00:00:00

abstract：:RBP7 is a member of the cellular retinol-binding protein (CRBP) family and previous data suggested a link between CRBPs and the malignant transformation of colon cancer cells. Here, we investigated the potential of RBP7 as a predictive biomarker for patients with colon cancer and determined its functional relevance fo...

journal_title：Journal of Cancer

authors： Elmasry M,Brandl L,Engel J,Jung A,Kirchner T,Horst D

更新日期：2019-08-27 00:00:00

abstract：:Cancer-testis (CT) genes played important roles in the progression of malignant tumors and were recognized as promising therapeutic targets. However, the roles of genetic variants in CT genes in lung cancer susceptibility have not been well depicted. This study aimed to evaluate the associations between genetic varian...

journal_title：Journal of Cancer

authors： Li Z,Tang J,Wen W,Wu W,Wang J,Xu J,Yu Y,He Z,Pan X,Wei H,Zhu Y,Hu S,Cao J,Shen H,Que J,Wang W,Zhu Q,Chen L

更新日期：2020-02-03 00:00:00

abstract：:Objective: Increasing evidence suggested that dysregulated small nucleolar RNAs (snoRNAs) were involved in tumor development. The roles of snoRNA 71A (SNORA71A) in the progression of non-small cell lung cancer (NSCLC) remained unclear. Methods: Dataset GSE19188 from Gene Expression Omnibus (GEO) database was downloade...

journal_title：Journal of Cancer

authors： Tang G,Zeng Z,Sun W,Li S,You C,Tang F,Peng S,Ma S,Luo Y,Xu J,Tian X,Zhang N,Gong Y,Xie C

更新日期：2019-05-21 00:00:00

abstract：:The capture of peritoneal metastatic cancer stem cell of human gastric cancer (pMCSC-hGC) is important to further understand the mechanism of peritoneal metastasis in gastric cancer patients. Previously, cancer stem cells (CSCs) of gastric and rectal cancers were captured and identified. However, the bottleneck of cap...

journal_title：Journal of Cancer

authors： Chen XZ,Song XH,Chen XL,Li CC,Mo XM,Hu JK

更新日期：2017-09-16 00:00:00

abstract：:Background: The use of PCI in early operable patients with small cell lung cancer (SCLC) is still controversial. Therefore, we conducted a systematic review with meta-analysis to investigate the effects of PCI in resected SCLC patients. Methods: Relevant studies were identified from PubMed and EMBASE databases, the po...

journal_title：Journal of Cancer

authors： Yang Y,Zhang D,Zhou X,Bao W,Ji Y,Sheng L,Cheng L,Chen Y,Du X,Qiu G

更新日期：2018-01-01 00:00:00

abstract：:Objectives: LncRNA associated with microvascular invasion in hepatocellular carcinoma (lncRNA MVIH) is a newly discovered long non-coding RNA that aberrantly up-regulates and holds prognostic value in various tumors. The aim of the review and meta-analysis is to assess its prognostic potential and functions in maligna...

journal_title：Journal of Cancer

authors： Zhang Y,Lin S,Yang X,Zhang X

更新日期：2019-02-26 00:00:00

abstract：BACKGROUND:Neoadjuvant chemotherapy with concurrent docetaxel, doxorubicin and cyclophosphamide is commonly used for patients with locally advanced breast cancer. Epirubicin is another anthracycline used in breast cancer but the concurrent use of epirubicin and taxane is not well-established. We conducted a single inst...

journal_title：Journal of Cancer

authors： Yao X,Hosenpud J,Chitambar CR,Charlson J,Cheng YC

更新日期：2012-01-01 00:00:00