Abstract:
:Osteosarcoma (OS) is the most common primary bone malignancy, predominately affecting children and adolescents. Due to the introduction of chemotherapy, the 5-year survival rate of OS patients has dramatically improved to 60-70%. Unfortunately, OS patients with recurrence or metastatic disease have less than a 20% chance of long-term survival, despite aggressive therapies. In this study, we aimed to identify gene expression patterns associated with metastasis and recurrence in order to identify potential biomarkers with prognostic power. We found that high expression of polyglutamine tract-binding protein 1 (PQBP1) and low expression of phosphoenolpyruvate carboxykinase 2 (PCK2) were related to a high probability of recurrence and metastasis in OS patients and also predicted shorter recurrence-free survival (RFS) and metastasis-free survival (MFS) after adjustment for other clinical variables. Prediction models based on the combination of PQBP1 and PCK2 expression had good and robust predictive power for recurrence and metastasis. A PQBP1 and PCK2-centered protein interaction network was built, and the hypothetical regulatory path between them was identified and termed the PQBP1-SF3A2-UBA52-PCK2 axis. Gene enrichment analysis indicated that aberrations of metabolism might play an important role in recurrence and metastasis in OS patients. Accordingly, PQBP1 and PCK2 are crucial for recurrence and metastasis in OS, and these findings provide a molecular basis for the exploitation of diagnostic and therapeutic strategies for overcoming recurrence and metastasis in OS.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Zhang Y,Zhao H,Xu W,Jiang D,Huang L,Li Ldoi
10.7150/jca.28480subject
Has Abstractpub_date
2019-05-12 00:00:00pages
2091-2101issue
9issn
1837-9664pii
jcav10p2091journal_volume
10pub_type
杂志文章abstract::Background: Colorectal cancer (CRC) remains to be one of the most common malignancies worldwide. Various studies have demonstrated that microRNAs (miRs) play a critical role in regulating cancer progression and sensitivity to chemoradiotherapy. miR-1 was found to be aberrantly expressed in CRC. However, it has not bee...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.44753
更新日期:2020-06-07 00:00:00
abstract::Objective: Multiple reports have described the proportion of T-regulatory cells (Tregs) in peripheral blood (PB) and tissues in patients with gynecological cancers (GCs) with controversial results. Thus, the aim of this study was to investigate the proportion of Tregs and its prognostic survival role in GCs patients. ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.42472
更新日期:2020-03-05 00:00:00
abstract::Background: Heavy metal pollution in farm soils is a grave concern in Taiwan. Previously, we found the incidence of oral cancer (OC) correlated positively with levels of nickel and arsenic in farm soils. Many OC patients have a second malignancy, among which esophageal cancer (EC) is the most common one in Taiwan. Obj...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.15441
更新日期:2016-08-06 00:00:00
abstract::Background: Esophageal squamous cell carcinoma (ESCC) has been having a high mortality rate in China. Most patients are diagnosed in advanced stages, leading to the poor prognosis and low 5-year survival rate. Detection of precancerous lesions or early cancers is the key to improving this situation. Although previous ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29979
更新日期:2019-06-02 00:00:00
abstract::Yes-associated protein (YAP) is a transcriptional coactivator that promotes cell proliferation, migration, and tissue homeostasis in colorectal cancer (CRC). Here, we established 5-Fu resistant CRC cell line (SW620R) and examined the role of YAP in chemotherapy resistance. We showed that YAP promoted cell proliferatio...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.44775
更新日期:2020-07-11 00:00:00
abstract::Background: Identification of new predictive markers in melanoma is of great clinical importance. This study was aimed to analyze association between selected common variants in the cancer susceptibility genes and melanoma progression at the time of diagnosis. Material and Method: The study included 243 consecutive pa...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26404
更新日期:2018-08-06 00:00:00
abstract::Chemotherapy resistance represents a major obstacle for the treatment of patients with breast cancer (BC) and greatly restricts the therapeutic effect of the first-line chemotherapeutic agent doxorubicin (DOX). The present study aimed to investigate the feasibility of the recombinant dual-target murine double minute 2...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.32765
更新日期:2020-01-01 00:00:00
abstract::Background: Integrative oncology (IO) is a relatively new field that seeks to bring evidence-based, non-conventional approaches into conventional oncology care in a coordinated and safe manner. Though complementary and alternative medicine (CAM) are highly utilized by cancer patients, little is known about the charact...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.17506
更新日期:2017-02-10 00:00:00
abstract::GOAL: To investigate the HPV prevalence and characterize the expression of potential molecular surrogate markers of HPV infection in esophageal squamous cell carcinoma. MATERIALS AND METHODS: The prevalence of HPV in individuals with and without esophageal cancer (EC) was determined by using multiplex PCR; p16 and p53...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.17080
更新日期:2017-04-09 00:00:00
abstract::Junctional adhesion molecule B (JAM-B) is a multifunctional transmembrane protein that plays an important role in tumor progression. JAM-B is significantly upregulated in gastric cancer, melanoma cell metastasis and oral squamous cell carcinoma. JAM-2 may also function as a putative tumor suppressor in the progression...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.40953
更新日期:2020-03-05 00:00:00
abstract::Cancer-testis (CT) genes played important roles in the progression of malignant tumors and were recognized as promising therapeutic targets. However, the roles of genetic variants in CT genes in lung cancer susceptibility have not been well depicted. This study aimed to evaluate the associations between genetic varian...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.40002
更新日期:2020-02-03 00:00:00
abstract::Background: The Matrix metalloproteinase-14 (MMP-14) expression has been shown to be overexpressed in different cancers. However, there is no comprehensive quantitative evaluation of the MMP-14 prognostic value in digestive system carcinoma (DSC). The aim of this study is to explore the correlation between the MMP-14 ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.36469
更新日期:2020-01-01 00:00:00
abstract::Aims: To compare the long-term prognosis of younger and elderly patients with combined hepatocellular-cholangiocarcinoma (CHC) who underwent curative resection between 1993 and 2014 at our center. Methods: Two hundred and thirteen patients who underwent liver resection for CHC were enrolled in our study. The overall s...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.23921
更新日期:2018-02-28 00:00:00
abstract::Purpose: The aberrant of fibroblast growth factors and their receptors (FGF/FGFR) is an emerging target in the treatment of solid tumors. This study aimed to explore the landscape of FGF/FGFR alterations in a large cohort of cancer patients. Material and Methods: The formalin-fixed paraffin-embedded specimens of cance...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.49269
更新日期:2020-09-23 00:00:00
abstract::Background: Malnutrition and systemic inflammatory response are frequently associated with prognosis in patients with several types of cancer, including renal cell carcinoma (RCC). The study is aimed to investigate the ability of preoperative serum albumin to globulin ratio (AGR) to predict the long-term mortality of ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16525
更新日期:2017-01-15 00:00:00
abstract::Objectives: To investigate the role of inflammation-related factors, lymphocyte-to-monocyte ratio (LMR) alone and combined detection with cancer antigen 125 (CA125), in the prognostic assessment of ovarian cancer (OC). Methods: A retrospective clinicopathologic review was performed. The receiver-operating characterist...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.42477
更新日期:2020-03-04 00:00:00
abstract::Hepatocellular Carcinoma is a major healthcare problem, representing the third most common cause of cancer-related mortality worldwide. There are 130 million Hepatitis C virus infected patients worldwide who are at a high-risk for developing Hepatocellular Carcinoma. Due to the fact that reliable parameters and/or too...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.4280
更新日期:2012-01-01 00:00:00
abstract::Purpose: The objective of this study was to develop and validate a nomogram for predicting the cancer-specific survival (CSS) in patients with Wilms' tumor (WT). Methods: Patients with WT diagnosed between 2002 and 2015 in the Surveillance, Epidemiology, and End Results (SEER) database were divided randomly into train...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.32741
更新日期:2019-08-28 00:00:00
abstract::Background: We performed a meta-analysis to evaluate the risk of immune-related colitis associated with PD1/PD-L1 inhibitors as compared to chemotherapy in solid tumor patients. Methods: Eligible studies were identified through a comprehensive search of multiple databases and included solid tumor patients in randomize...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24200
更新日期:2018-04-12 00:00:00
abstract::Thyroid transcription factor-1 (TTF-1) is overexpressed in up to 95% of primary lung adenocarcinoma while negative for almost all squamous cell carcinomas. TTF-1 expression has been investigated as a prognostic factor in non-small-cell lung cancer (NSCLC) with conflicting results. We conducted this meta-analysis to ga...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.26830
更新日期:2018-10-20 00:00:00
abstract::Objective: Emerging evidence suggests that calreticulin (CALR) has great impacts on the tumor formation and progression of various cancers, but the role of CALR remains controversial. We investigated the expression and clinical significance of CALR in nasopharyngeal carcinoma (NPC). Methods: Immunohistochemistry was u...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.35362
更新日期:2019-08-29 00:00:00
abstract::Background: Inflammation might play an important role in promoting cancer growth partly by affecting tumor angiogenesis. We explored the role of Glasgow prognostic score (GPS) in metastatic colorectal cancer patients receiving first-linebevacizumab. Methods: All consecutive metastatic colorectal cancer patients treate...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.31182
更新日期:2019-11-15 00:00:00
abstract::Background and Aim: Glioblastoma multiforme (GBM) is a highly aggressive brain malignancy that lacks reliable treatments. Resveratrol possesses anti-cancer effects, but its activity against glioblastoma cells is variable for unknown reasons. One mechanism through which anti-cancer drugs exert their effects is oxidativ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.45489
更新日期:2021-01-01 00:00:00
abstract::Nasopharyngeal carcinoma (NPC), is one of the most common malignant tumor in southern China and southeast Asia. MYH10 is a coding gene of the NMMHC-IIB protein. Previous studies have shown that MYH10 expression was up-regulated in breast cancer, glioma and meningioma. Moreover, it was targeted by miR200 family. Howeve...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.40438
更新日期:2020-03-04 00:00:00
abstract::The 21-gene recurrence score (RS) is increasingly being used for patients with early stage, hormone receptor-positive, Her-2-negative breast cancer. However, these results are largely from populations with infiltrating ductal carcinoma (IDC). The clinical value of RS testing in mucinous carcinoma has not been well inv...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.27291
更新日期:2018-08-06 00:00:00
abstract::Studies have indicated the significance of tumor associated macrophages (TAMs) in breast cancer; however, inconsistent results still exist. We retrospectively reviewed the macrophage distribution in 1579 breast cancer specimens with anti-CD68 or anti-CD163 immunohistochemical staining, and further analyzed the overall...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.33914
更新日期:2019-07-23 00:00:00
abstract::Colorectal cancer is a commonly diagnosed malignancy and also the major cause of death worldwide. Chemotherapy is the primary therapy for advanced colorectal cancer. Although oxaliplatin has potential effect in colorectal cancer therapy, the molecular mechanisms involved in its cytotoxic effects are not well elucidate...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24474
更新日期:2018-05-22 00:00:00
abstract::Purpose: This study aimed to comprehensively investigate the differential expression and prognostic indicators of the tripartite motif-containing (TRIM) gene family in non-small cell lung cancer (NSCLC). Methods: The Cancer Genome Atlas (TCGA) Research Network and three datasets from Gene Expression Omnibus (GEO) data...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.27856
更新日期:2019-01-29 00:00:00
abstract::Background: Regulatory T cells (Tregs) and plasmacytoid dendritic cells (pDCs) are the main immunosuppressive cells in tumor microenvironment of gastric cancer (GC). In this prospective study, the association of prognosis with Tregs subsets and pDCs were further analyzed. Methods: pDCs, Tregs population and its expres...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.34826
更新日期:2019-10-22 00:00:00
abstract::Mechanistic target of rapamycin (mTOR) plays a critical role in the development of oral squamous cell carcinoma (OSCC), but the underlying mechanisms remain poorly understood. Here we have demonstrated that the expression of osteopontin (OPN) was dramatically up-regulated in OSCC tissues and cell lines. Moreover, redu...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18031
更新日期:2017-05-12 00:00:00