Glasgow PrognosticScore as a Predictor of BevacizumabEfficacy in the First-line Treatment with Metastatic Colorectal Cancer.

abstract：:Background: To elucidate the expression of Aurora kinases (AURK) and the anticancer effects of pan-aurora kinase inhibitor Danusertib in hepatocarcinogenesis model in C56Bl6 mice. Methods: Thirty mice C56Bl6 were randomly divided into Group A or control, Group B animals who underwent experimental hepatocarcinogenesis ...

journal_title：Journal of Cancer

authors： Gavriilidis P,Poutahidis T,Giakoustidis A,Makedou K,Angelopoulou K,Hardas A,Andreani P,Zacharioudaki A,Saridis G,Gargavanis A,Louri E,Antoniadis N,Karampela E,Psychalakis N,Michalopoulos A,Papalois A,Iliadis S,Mudan S,

更新日期：2018-02-27 00:00:00

abstract：:Background and objective: Long-term aspirin use for the primary prevention of cancer remains controversial, and variations in the effect of aspirin use on cancer outcomes by aspirin dose, follow-up duration, or study population have never been systematically evaluated. The objective of this study was to evaluate the e...

journal_title：Journal of Cancer

authors： Wu Q,Yao X,Chen H,Liu Z,Li T,Fan X,Zhang G,Yu L,Chen M,Xu C,Zhang R,Chen B,Sui X,Leung EL

更新日期：2020-09-14 00:00:00

abstract：:Purpose: Systemic therapy has often been used for patients with advanced hepatocellular carcinoma (HCC). However, due to drug resistance, the use of cytotoxic chemotherapy in the treatment of patients with advanced HCC has typically demonstrated low response rates. Secretory clusterin (sCLU) is expressed in aggressive...

journal_title：Journal of Cancer

authors： Wang X,Zou F,Zhong J,Yue L,Wang F,Wei H,Yang G,Jin T,Dong X,Li J,Xiu P

更新日期：2018-04-06 00:00:00

abstract：BACKGROUND:Heterogeneity of surgical care exists among surgeons regarding the conduct of thyroidectomy and parathyroidectomy. AIM:To identify the current patterns of technical conduct of operation amongst surgeons performing thyroidectomy or parathyroidectomy. METHODS:A survey was designed and beta-tested on five sur...

journal_title：Journal of Cancer

authors： Henry L,Helou L,Solomon N,Chang A,Libutti S,Stojadinovic A

更新日期：2012-01-01 00:00:00

abstract：BACKGROUND:The 2010 guidelines by ASCO-CAP have mandated that breast cancer specimens with ≥1% positively staining cells by immunohistochemistry should be considered Estrogen Receptor (ER) positive. This has led to a subclass of low-ER positive (1-10%) breast cancers. We have examined the biology and clinical behavior ...

journal_title：Journal of Cancer

authors： Prabhu JS,Korlimarla A,Desai K,Alexander A,Raghavan R,Anupama C,Dendukuri N,Manjunath S,Correa M,Raman N,Kalamdani A,Prasad M,Gopinath KS,Srinath BS,Sridhar TS

更新日期：2014-01-23 00:00:00

abstract：:Objective: The purpose of this study was to evaluate the efficacy and feasibility of the R.E.N.A.L. Nephrometry Score to postoperatively predict high-grade clear-cell renal carcinoma (ccRCC). Methods: The study included 288 patients diagnosed with ccRCC who had complete CT/CTA data and R.E.N.A.L. Nephrometry Scores an...

journal_title：Journal of Cancer

authors： Chen SH,Wu YP,Li XD,Lin T,Guo QY,Chen YH,Huang JB,Wei Y,Xue XY,Zheng QS,Xu N

更新日期：2017-10-17 00:00:00

abstract：:Stromal fibroblasts are suggested to be a key determinant in the malignant progression of breast cancer. To find an in vitro culture model that best mimics the in vivo tumor microenvironment so we can study the effects of stromal fibroblasts on breast cancer progression, we evaluated several three-dimensional (3D) co-...

journal_title：Journal of Cancer

authors： Li L,Lu Y

更新日期：2011-01-01 00:00:00

abstract：UNLABELLED:The mechanism of progression from ductal carcinoma in situ (DCIS) to invasive ductal carcinoma (IDC) remains largely unknown. We compared gene expression in tumors with simultaneous DCIS and IDC to decipher how diverse proteins participate in the local invasive process.Twenty frozen tumor specimens with conc...

journal_title：Journal of Cancer

authors： Castellana B,Escuin D,Peiró G,Garcia-Valdecasas B,Vázquez T,Pons C,Pérez-Olabarria M,Barnadas A,Lerma E

更新日期：2012-01-01 00:00:00

abstract：:Cancer-associated fibroblasts (CAFs), which are an important component of the tumor microenvironment, have been identified in the blood circulation of patients with cancer metastasis, and metastatic cancer cells can recruit circulating CAFs. However, primary carcinoma sites usually regulate the behavior of metastatic ...

journal_title：Journal of Cancer

authors： Zhang YF,Zhou YZ,Zhang B,Huang SF,Li PP,He XM,Cao GD,Kang MX,Dong X,Wu YL

更新日期：2019-07-23 00:00:00

abstract：:As a crucial event involved in the metastasis and relapse of esophageal cancer, c-Met overexpression has been considered as one of the culprits responsible for the failure in patients who received radiochemotherapy. Since c-Met has been confirmed to be pivotal for cell survival, proliferation and migration, little is ...

journal_title：Journal of Cancer

authors： Chen GZ,Dai WS,Zhu HC,Song HM,Yang X,Wang YD,Min H,Lu Q,Liu S,Sun XC,Zeng XN

更新日期：2017-03-12 00:00:00

abstract：:Triple negative breast cancer (TNBC) is characterized by distinctive biological features that confer an aggressive clinical behavior. In TNBC patients, the absence of well-defined driver pathways such as hormonal receptor expression or hyperactivation of the human epidermal growth factor receptor 2 (HER2) significantl...

journal_title：Journal of Cancer

authors： Pizzuti L,Krasniqi E,Barchiesi G,Mazzotta M,Barba M,Amodio A,Massimiani G,Pelle F,Kayal R,Vizza E,Grassadonia A,Tomao S,Venuti A,Gamucci T,Marchetti P,Natoli C,Sanguineti G,Ciliberto G,Vici P

更新日期：2019-10-12 00:00:00

abstract：:Transforming growth factor β1 (TGF-β1) plays an important role in tumor initiation and development by inducing epithelial-mesenchymal Transition (EMT). Metastasis-Associated Lung Adenocarcinoma Transcript 1 (MALAT1) is a long noncoding RNA (lncRNA) that contributes to the invasion and metastasis of tumors, including e...

journal_title：Journal of Cancer

authors： Liu Q,Zheng S,Chen Y,Liu T,Han X,Zhang X,Shen T,Lu X

更新日期：2020-10-04 00:00:00

abstract：:Cancer cells express epithelial markers, and when progressing in malignancy they may express markers of the mesenchymal cell type. Therefore an epithelial-mesenchymal transition of the cancer cells is assumed. However the mesenchymal markers can equally well be interpreted as myeloid markers since they are common in b...

journal_title：Journal of Cancer

authors： Schramm HM

更新日期：2014-01-15 00:00:00

abstract：:Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase and works as an oncogene in various cancers. Recently, PTK6 has been used as a therapeutic target for breast cancer patients in a clinical study. However, the prognostic value of PTK6 in bladder cancer (BC) remains vague. Therefore, we retrieved 3 inde...

journal_title：Journal of Cancer

authors： Xu XL,Ye YL,Wu ZM,He QM,Tan L,Xiao KH,Wu RY,Yu Y,Mai J,Li ZL,Peng XD,Huang Y,Li X,Zhang HL,Zhu XF,Qin ZK

更新日期：2017-09-27 00:00:00

abstract：PURPOSE:Methotrexate, vinblastine, doxorubicin plus cisplatin (MVAC) and gemcitabine plus cisplatin (GC) are both effective first-line chemotherapy. We explore the responsive variables of MVAC and GC for patients with metastatic urothelial carcinoma of bladder (mUCB). MATERIALS AND METHODS:Patients who were initially ...

journal_title：Journal of Cancer

authors： Hsieh MC,Huang CH,Chiang PH,Chen YY,Tang Y,Su YL

更新日期：2016-06-27 00:00:00

abstract：:Hepatocellular carcinoma (HCC) cells exhibit multidrug resistance (MDR), but the underlying mechanisms remain unclear. Cancer cells that overexpress telomerase are resistant to chemotherapeutic drugs. This study aimed to determine the effects of mitochondrial translocation of telomerase on MDR in HCC cells. HepG2 cell...

journal_title：Journal of Cancer

authors： Yan J,Zhou Y,Chen D,Li L,Yang X,You Y,Ling X

更新日期：2015-01-05 00:00:00

abstract：:Objective: As a member of the N-myc downregulated gene family, N-Myc downstream-regulated gene 2 (NDRG2) contributes to tumorigenesis of various types of cancer. The expression status of NDRG2 in colorectal cancer (CRC) and its prognostic value remain to be elucidated. The goal of this study was to determine the expre...

journal_title：Journal of Cancer

authors： Chen W,Peng J,Ou Q,Wen Y,Jiang W,Deng Y,Zhao Y,Wan D,Pan Z,Fang Y

更新日期：2019-06-09 00:00:00

abstract：:Traditional chemotherapy and radiotherapy for cancer treatment face serious challenges such as drug resistance and toxic side effects. Complementary / Alternative medicine is increasingly being practiced worldwide due to its safety beneficial therapeutic effects. We hypothesized that a super combination (SC) of known ...

journal_title：Journal of Cancer

authors： Ouhtit A,Gaur RL,Abdraboh M,Ireland SK,Rao PN,Raj SG,Al-Riyami H,Shanmuganathan S,Gupta I,Murthy SN,Hollenbach A,Raj MH

更新日期：2013-11-14 00:00:00

abstract：OBJECTIVE:The expression of DACH1 was frequently lost in human breast cancer, which significantly correlated with poor prognosis. Herein, we aim to investigate its underlying mechanisms. METHODS:The expression of miR-217 was detected by Taqman PCR. The mRNA and protein level of DACH1 were investigated by real time PCR...

journal_title：Journal of Cancer

authors： Zhang Q,Yuan Y,Cui J,Xiao T,Jiang D

更新日期：2015-01-01 00:00:00

abstract：:Cisplatin chemoresistance is a clinical obstacle in the treatment of gastric cancer (GC). Enhanced DNA repair capacity may lead to cisplatin resistance. However, the detailed molecular mechanism of GC cisplatin resistance specifically involving nucleotide excision repair (NER) is not clear. However, the mechanism thro...

journal_title：Journal of Cancer

authors： Xie X,Huang N,Zhang Y,Wei X,Gao M,Li M,Ning J,Liu W,Zhao Q,Wang H,Gu K

更新日期：2019-01-29 00:00:00

abstract：:Lung cancer is the most common malignancy in China and is associated with a poor survival rate amongst Han Chinese. The high mortality is largely attributed to late-stage diagnosis, when treatment is largely ineffective. Identification of genetic variants could potentially assist with earlier diagnosis and thus more e...

journal_title：Journal of Cancer

authors： Hu W,Tang CH,Chen HT,Zhao J,Jin L,Kang L,Wu Y,Ying P,Wang CQ,Su CM

更新日期：2019-06-02 00:00:00

abstract：:Background: We performed a meta-analysis to evaluate the risk of immune-related colitis associated with PD1/PD-L1 inhibitors as compared to chemotherapy in solid tumor patients. Methods: Eligible studies were identified through a comprehensive search of multiple databases and included solid tumor patients in randomize...

journal_title：Journal of Cancer

authors： Su Q,Zhang X,Shen X,Hou Y,Sun Z,Gao ZH

更新日期：2018-04-12 00:00:00

abstract：:Background: Lung carcinoma is the leading cause of malignant tumor related mortality in China in recent decades, and the development of new and effective therapies for patients with advanced lung carcinoma is needed. We recently found that fluorofenidone (FD), a newly developed pyridine compound, reduced the activatio...

journal_title：Journal of Cancer

authors： Deng ZH,Meng J,Tang J,Hu GY,Tao LJ

更新日期：2017-07-04 00:00:00

abstract：:Breast cancer therapy has improved following the development of drugs with specific molecular targets, exemplified by inhibitors of human epidermal growth factor receptor-2 (HER2) or epidermal growth factor receptor (EGFR) such as trastuzumab and lapatinib. However, these drugs have little effect on brain metastasis d...

journal_title：Journal of Cancer

authors： Nakayama A,Takagi S,Yusa T,Yaguchi M,Hayashi A,Tamura T,Kawakita Y,Ishikawa T,Ohta Y

更新日期：2013-08-16 00:00:00

abstract：BACKGROUND:We conducted this pooled analysis to investigate the impact of RECIST 1.1 on the selection of target lesions and classification of tumor response, in comparison with RECIST 1.0. Methods : We searched MEDLINE and EMBASE for articles with terms of RECIST 1.0 or RECIST 1.1. We looked into all abstracts and virt...

journal_title：Journal of Cancer

authors： Kim JH,Min SJ,Jang HJ,Cho JW,Kim SH,Kim HS

更新日期：2015-02-25 00:00:00

abstract：:Studies have indicated the significance of tumor associated macrophages (TAMs) in breast cancer; however, inconsistent results still exist. We retrospectively reviewed the macrophage distribution in 1579 breast cancer specimens with anti-CD68 or anti-CD163 immunohistochemical staining, and further analyzed the overall...

journal_title：Journal of Cancer

authors： Ni C,Yang L,Xu Q,Yuan H,Wang W,Xia W,Gong D,Zhang W,Yu K

更新日期：2019-07-23 00:00:00

abstract：:Objective: Emerging evidence suggests that calreticulin (CALR) has great impacts on the tumor formation and progression of various cancers, but the role of CALR remains controversial. We investigated the expression and clinical significance of CALR in nasopharyngeal carcinoma (NPC). Methods: Immunohistochemistry was u...

journal_title：Journal of Cancer

authors： Han Y,Liao Q,Wang H,Rao S,Yi P,Tang L,Tian Y,Oyang L,Wang H,Shi Y,Zhou Y

更新日期：2019-08-29 00:00:00

abstract：:Objective: To develop and validate a prediction model for the pathological complete response (pCR) to neoadjuvant chemotherapy (NCT) of triple-negative breast cancer (TNBC). Methods: We systematically searched Gene Expression Omnibus, ArrayExpress, and PubMed for the gene expression profiles of operable TNBC accessibl...

journal_title：Journal of Cancer

authors： Han Y,Wang J,Xu B

更新日期：2021-01-01 00:00:00

abstract：:Endocrine resistance in hormone receptor positive breast cancer patients urges us to develop novel approaches such as inhibitors of the cyclin-dependent kinases (CDK) 4/6 to reverse its resistance. Nowadays, three selective CDK4/6 inhibitors (Palbociclib, Ribociclib and Abemaciclib) are approved by Federal Drug Admini...

journal_title：Journal of Cancer

authors： Chen X,Xu D,Li X,Zhang J,Xu W,Hou J,Zhang W,Tang J

更新日期：2019-10-21 00:00:00

abstract：:Introduction: Preoperative risk stratification is crucial for clinical treatment of endometrial cancer (EC). This study aimed to establish a model based on magnetic resonance imaging (MRI) and clinical factors for risk classification of EC. Materials and Methods: A total of 102 patients with pathologically proven Stag...

journal_title：Journal of Cancer

authors： Chen J,Gu H,Fan W,Wang Y,Chen S,Chen X,Wang Z

更新日期：2021-01-01 00:00:00