Abstract：
:Objective: Multiple reports have described the proportion of T-regulatory cells (Tregs) in peripheral blood (PB) and tissues in patients with gynecological cancers (GCs) with controversial results. Thus, the aim of this study was to investigate the proportion of Tregs and its prognostic survival role in GCs patients. Methods: We performed a comprehensive search from database inception for all studies presenting changes of Tregs in GCs patients versus controls to evaluate the pooled standardized mean differences (SMD) with 95% confidence intervals (95% CI). And hazard ratios (HRs) with 95% CI were recorded if available to determine the prognostic significance of Tregs. Results: Totally, 22 studies were included. Compared with controls, GCs patients had a higher proportion of Tregs in PB (SMD = 2.32, 95% CI = 1.47 to 3.17, P = 0.000) as well as in tissues (SMD = 3.47, 95% CI = 0.77 to 6.18, P = 0.012). Furthermore, more significant elevated frequency of Tregs was observed in GCs patients with advanced stage than those in the early stage in both PB and tissues. However, no association was found between Tregs and survival of GCs patients with an HR of 1.34 (95% CI = 0.96 to 1.88, P = 0.09). Conclusions: Compared to controls, proportion of Tregs in PB and tissues was both higher among GCs patients, and it can be considered as a clinical biomarker for screening and prediction of clinical characteristics of GCs patients. But larger researches with rigorous design should be carried to explore the deep mechanisms of Tregs in GCs.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Hu J,Wu X,Huang P,Teng F,Wang Y,Xue Fdoi
10.7150/jca.42472subject
Has Abstractpub_date
2020-03-05 00:00:00pages
3340-3348issue
11issn
1837-9664pii
jcav11p3340journal_volume
11pub_type
杂志文章abstract：:Background: The effect of adjuvant chemotherapy on stage II colon cancer remains constantly controversial. Recently, however, several studies have reported the definite survival benefit of adjuvant chemotherapy (ACT) in T4 disease (stage IIB and IIC) among stage II colon cancer patients. The following study investigat...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.28917
更新日期：2019-01-29 00:00:00
abstract：:Despite advancement in the treatment of diffuse large B-cell lymphoma (DLBCL), many patients tend to relapse or become refractory after initial therapy. Therefore, it is essential to identify novel therapeutic targets and drugs, understand the molecular pathogenesis mechanism of DLBCL, and find ways to prevent and tre...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.48310
更新日期：2021-01-01 00:00:00
abstract：:Objective: The applicability of the linear quadratic (LQ) model to local control (LC) modeling after hypofractionated radiotherapy to treat lung cancer is highly debated. To date, the differences in predicted outcomes between the LQ model and other radiobiological models, which are characterized by additional dose mod...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.33001
更新日期：2019-08-08 00:00:00
abstract：:Objective: Chemotherapy is a major therapeutic method for bladder urothelial carcinoma (BUC), which can effectively improve the prognosis of BUC patients, but the chemoresistance often leads to chemotherapy failure. This study will research the regulatory roles and molecular mechanism of miR-101-3p in BUC chemoresista...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.33117
更新日期：2019-06-02 00:00:00
abstract：:Tyrosine phosphorylation is an important post-translation modification of proteins that is controlled by tyrosine kinases and phosphatases. Disruption of the balance between the activity of tyrosine kinases and phosphatases may result in diseases. Receptor type protein tyrosine phosphatase epsilon (PTPRE) is closely r...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.27633
更新日期：2019-01-01 00:00:00
abstract：:Objective: The purpose of this study was to evaluate the efficacy and feasibility of the R.E.N.A.L. Nephrometry Score to postoperatively predict high-grade clear-cell renal carcinoma (ccRCC). Methods: The study included 288 patients diagnosed with ccRCC who had complete CT/CTA data and R.E.N.A.L. Nephrometry Scores an...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.21189
更新日期：2017-10-17 00:00:00
abstract：:Purpose: We explored the influence of age on clinicopathologic features and survival of patients with M0 gastric cancer (GC). Methods: 16856 GC patients from Surveillance, Epidemiology and End Results (SEER) database and 1037 GC patients from Chinese multiple centers were enrolled in the U.S. and Chinese cohort, respe...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.22085
更新日期：2018-03-08 00:00:00
abstract：: Purpose: Differentiated thyroid cancer (DTC) accounts for approximately 95% of thyroid carcinomas. In the metastatic RAI-refractory disease, chemotherapy has very limited efficacy and is associated with substantial toxicity. With increasing knowledge of the molecular patho...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.22318
更新日期：2018-01-01 00:00:00
abstract：:Colon cancer is one of the most common types of gastrointestinal cancers and the fourth cause of cancer death worldwide. To discover novel diagnostic biomarkers for colon cancer and investigate potential mechanisms of oncogenesis, quantitative proteomic approach using iTRAQ-tagging and 2D-LC-MS/MS was performed to cha...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.17192
更新日期：2017-02-11 00:00:00
abstract：:Purpose: Eukaryotic initiation factor 4A-3 (EIF4A3) is an RNA-binding protein (RBP) that is a core component of the exon junction complex (EJC). It has been identified as an important player in post-transcriptional regulation processes. Recently, investigations have focused on EIF4A3 dysfunction in carcinogenesis. The...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.27655
更新日期：2018-11-11 00:00:00
abstract：OBJECTIVE:With the survival rate of acute lymphoblastic leukemia (ALL) surpassing 90 percent within this decade, new research is emerging in the field of late effects. A review of the research investigating the relationship of treatment regimens for ALL to specific late effect deficits, underlying mechanisms, and possi...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.2.292
更新日期：2011-01-01 00:00:00
abstract：PURPOSE:To evaluate acute hypersensitivity reactions at the UCSD Moores Cancer Center in San Diego, compare our findings to those reported previously in the literature, and examine the effectiveness of the objective grading scale as represented by the Common Terminology Criteria for Adverse Events (CTCAE). PATIENTS AN...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.2.153
更新日期：2011-03-10 00:00:00
abstract：:Background: Hepatitis B virus infection had been identified its relationship with liver diseases, including liver tumors. We aimed to explore diagnostic and prognostic values between the Human Leukocyte Antigen (HLA) complex and hepatocellular carcinoma (HCC). Methods: We used the GSE14520 dataset to explore diagnosti...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.29655
更新日期：2019-08-28 00:00:00
abstract：:Ovarian cancer, cervical cancer and endometrial cancer are three relatively common malignant cancers of the female reproductive system. Despite improvements in female genital tract cancer detection and development of new therapeutic approaches, there are still poor prognoses and some do not respond to therapeutic patt...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.44727
更新日期：2020-10-21 00:00:00
abstract：:Background: Immunotherapy including immune checkpoint blockade, cancer vaccines, and adoptive cell therapy. However, no immune therapies support ovarian cancer. It is not clear whether the neutrophils, the component of the immune system derived from umbilical cord blood play a role in inhibiting the progression of ova...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.41035
更新日期：2020-05-18 00:00:00
abstract：:Objective: There are controversial indications for neoadjuvant chemotherapy (NAT) in the treatment of locally advanced gastric cancer (LAGC). Here, we aimed to identify indications for NAT based on pre-treatment clinicopathological and laboratory parameters. Methods: This study included a retrospective cohort of 1083 ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.46430
更新日期：2020-08-18 00:00:00
abstract：BACKGROUND:Mitochondria play crucial roles in cell signaling events, interorganellar communication, aging, cell proliferation and apoptosis, and mitochondrial impairment has been shown to accelerate or modulate cancer progression. Ubiquitous mitochondrial creatine kinase (uMtCK) is predominantly localized in the interm...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.13207
更新日期：2016-01-01 00:00:00
abstract：:Cancer is a genetic disease where genetic variations cause abnormally functioning genes that appear to alter expression. Proteins, the final products of gene expression, determine the phenotypes and biological processes. Therefore, detecting gene expression levels can be used for cancer diagnosis, prognosis, and treat...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.24744
更新日期：2018-06-05 00:00:00
abstract：:Distant metastasis is the primary cause of cancer-related death among patients with colorectal cancer (CRC), and the discovery of novel therapeutic targets by further exploring the molecular mechanisms of CRC metastasis is therefore urgently needed. We previously illustrated that CDC27 overexpression promoted prolifer...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.19381
更新日期：2017-08-21 00:00:00
abstract：:Purpose: We retrospectively collected consecutive survival data of lung adenosquamous cell carcinoma (ASC) patients with brain metastasis (BM) in our institute and discussed the factors related to prognosis of these patients. Patients and Methods: A total of 42 patients diagnosed as lung ASC with BM between July 1, 20...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.27441
更新日期：2018-09-08 00:00:00
abstract：:RBP7 is a member of the cellular retinol-binding protein (CRBP) family and previous data suggested a link between CRBPs and the malignant transformation of colon cancer cells. Here, we investigated the potential of RBP7 as a predictive biomarker for patients with colon cancer and determined its functional relevance fo...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.35180
更新日期：2019-08-27 00:00:00
abstract：:Glioblastoma (GBM) is a common malignant brain tumor of the central nervous system with a poor prognosis. In order to identify the prognostic signatures of GBM, we screened differentially expressed genes (DEGs) that were based on a single-cell RNA sequencing (scRNA-seq) dataset. These genes characteristically represen...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.44034
更新日期：2020-04-06 00:00:00
abstract：:Background: Anti-EGFR therapies have been recommended for advanced colorectal cancer (CRC) with wild-type RAS and PIK3CA mutation. However, PIK3CA mutations are a poor prognostic marker and a negative predictor of response to anti-EGFR therapies in RAS wild-type CRC. Therefore, new and advanced treatment strategies ar...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.19458
更新日期：2017-08-22 00:00:00
abstract：:Galectins are the member of soluble proteins that bind with β-galactoside containing glycans. These proteins have been considered to be associated in various important events such as different types of cancers. It has been found that galectins could contribute to neoplastic transformation or regulate cell growth, cell...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.23628
更新日期：2018-11-25 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is the sixth most common tumor worldwide. The relationship between the gene methylation accumulation and HCC has been widely studied. In our study, we used the Sequenom EpiTYPER assay to investigate the methylation levels of the RASA3 in 164 HCC samples and paired adjacent non-cancerous ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.24567
更新日期：2018-05-25 00:00:00
abstract：:Background: Esophageal squamous cell carcinoma (ESCC) has been having a high mortality rate in China. Most patients are diagnosed in advanced stages, leading to the poor prognosis and low 5-year survival rate. Detection of precancerous lesions or early cancers is the key to improving this situation. Although previous ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.29979
更新日期：2019-06-02 00:00:00
abstract：:Background: To identify associated risk factors and develop a predictive nomogram for the early death of metastatic gastric cancer patients. Methods: A total of 4575 patients in the SEER cohort and 220 patients in the Chinese cohort diagnosed with metastatic gastric cancer in our Cancer Center were obtained. Univariat...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.46563
更新日期：2020-07-14 00:00:00
abstract：:Background: The incidence and mortality rate of gastric cancer has markedly declined over the past few decades, due to the progress and advances in the development of diagnostic and treatment regimens. However, there is still a large portion of patients who are first diagnosed during the advanced stage of gastric canc...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.31303
更新日期：2019-10-06 00:00:00
abstract：:Background: The study of CTLA-4 inhibitors has been one of the hot spots in the field of tumor immunotherapy. As the most immunogenic subtype of breast cancer, Triple negative breast cancer (TNBC) has a great potential in the treatment strategy. The aim of this study was to explore the relevant genes and pathways of C...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.46301
更新日期：2020-09-09 00:00:00
abstract：:Objective: Liposarcoma is a mesenchymal malignant tumor characterized by adipocyte differentiation which is divided into four subtypes with different prognosis. Accurate histopathological diagnosis is essential for precise treatment. Perilipins, including PLIN1, PLIN2, PLIN3, PLIN4, PLIN5, is a family of lipid droplet...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.41736
更新日期：2020-04-07 00:00:00
