Abstract:
:Colon cancer is one of the most common types of gastrointestinal cancers and the fourth cause of cancer death worldwide. To discover novel diagnostic biomarkers for colon cancer and investigate potential mechanisms of oncogenesis, quantitative proteomic approach using iTRAQ-tagging and 2D-LC-MS/MS was performed to characterize proteins alterations in colon cancer and non-neoplastic colonic mucosa (NNCM) using laser capture microdissection-harvested from the two types of tissues, respectively. As a result, 188 DEPs were identified, and the differential expression of two DEPs (DCN and HSPD1) was further verified by Western blotting and immunohistochemistry. KEGG pathway analysis disclosed that the DEPs were related to signaling pathways associated with cancer; furthermore, DCN and HSPD1 are in the relative central hub position among protein-protein interaction subnetwork of the DEPs. The results not only shed light on the mechanism by the DEPs contributed to colonic carcinogenesis, but also showed that DCN and HSPD1 are novel potential biomarkers for the diagnosis of colon cancer.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Li G,Li M,Liang X,Xiao Z,Zhang P,Shao M,Peng F,Chen Y,Li Y,Chen Zdoi
10.7150/jca.17192subject
Has Abstractpub_date
2017-02-11 00:00:00pages
479-489issue
3issn
1837-9664pii
jcav08p0479journal_volume
8pub_type
杂志文章abstract::Long non-coding RNAs (lncRNAs) have been considered as biomarkers for the carcinogenesis and development of various cancers. However, the prognostic significance of lncRNAs in renal cell carcinoma (RCC) remains unclear. This study aimed to determine the predictive ability of lncRNAs in clear cell RCC (ccRCC). Among th...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.40421
更新日期:2020-04-27 00:00:00
abstract::Stromal fibroblasts are suggested to be a key determinant in the malignant progression of breast cancer. To find an in vitro culture model that best mimics the in vivo tumor microenvironment so we can study the effects of stromal fibroblasts on breast cancer progression, we evaluated several three-dimensional (3D) co-...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.458
更新日期:2011-01-01 00:00:00
abstract:PURPOSE:Chemotherapy regimens containing anthracyclines and taxanes represent the landmark of neoadjuvant systemic therapy of breast cancer. In advanced breast cancer patients liposomal anthracyclines (LA) have shown similar efficacy and less cardiac toxicity when compared to conventional anthracyclines. We performed t...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.9132
更新日期:2014-04-25 00:00:00
abstract::Background: Surgery for pancreatic cancer with liver metastases (PCL) is not recommended in the international guidelines, and investigation of its clinical significance in patients with PCL is very limited. This study explored whether surgery, especially synchronous resection of the primary tumor and liver metastases ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.51218
更新日期:2021-01-01 00:00:00
abstract::Dysbindin has been reported to be correlated with several malignancies. However, the clinical significance and biological role of dysbindin in epithelial ovarian cancer remains largely unknown. Here we demonstrated that the mRNA and protein levels of dysbindin were significantly upregulated in EOC tissues compared wit...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.39269
更新日期:2020-02-21 00:00:00
abstract::Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human malignancies. The metabolomic approaches are developed to discover the novel biomarkers of PDAC. Methods: 550 preoperative, postoperative PDAC and normal controls (NCs) serums were employed to characterize metabolic alterations in ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.41250
更新日期:2020-05-19 00:00:00
abstract::Objectives: To investigate the role of inflammation-related factors, lymphocyte-to-monocyte ratio (LMR) alone and combined detection with cancer antigen 125 (CA125), in the prognostic assessment of ovarian cancer (OC). Methods: A retrospective clinicopathologic review was performed. The receiver-operating characterist...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.42477
更新日期:2020-03-04 00:00:00
abstract::Protein tyrosine kinase 6 (PTK6) is a non-receptor tyrosine kinase and works as an oncogene in various cancers. Recently, PTK6 has been used as a therapeutic target for breast cancer patients in a clinical study. However, the prognostic value of PTK6 in bladder cancer (BC) remains vague. Therefore, we retrieved 3 inde...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.21318
更新日期:2017-09-27 00:00:00
abstract::Despite advancement in the treatment of diffuse large B-cell lymphoma (DLBCL), many patients tend to relapse or become refractory after initial therapy. Therefore, it is essential to identify novel therapeutic targets and drugs, understand the molecular pathogenesis mechanism of DLBCL, and find ways to prevent and tre...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.48310
更新日期:2021-01-01 00:00:00
abstract::Background: To elucidate the expression of Aurora kinases (AURK) and the anticancer effects of pan-aurora kinase inhibitor Danusertib in hepatocarcinogenesis model in C56Bl6 mice. Methods: Thirty mice C56Bl6 were randomly divided into Group A or control, Group B animals who underwent experimental hepatocarcinogenesis ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.22329
更新日期:2018-02-27 00:00:00
abstract::Purpose: We retrospectively collected consecutive survival data of lung adenosquamous cell carcinoma (ASC) patients with brain metastasis (BM) in our institute and discussed the factors related to prognosis of these patients. Patients and Methods: A total of 42 patients diagnosed as lung ASC with BM between July 1, 20...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.27441
更新日期:2018-09-08 00:00:00
abstract::Background: Malnutrition and systemic inflammatory response are frequently associated with prognosis in patients with several types of cancer, including renal cell carcinoma (RCC). The study is aimed to investigate the ability of preoperative serum albumin to globulin ratio (AGR) to predict the long-term mortality of ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16525
更新日期:2017-01-15 00:00:00
abstract::Liquid biopsy is becoming a promising method for non-invasive cancer detection. In several proof-of-concept studies, long non-coding RNAs (lncRNAs) were found to be potential biomarkers for bladder cancer detection. The objective of this study was to discover a panel of cell-free, urinary lncRNAs as liquid biopsy biom...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.37006
更新日期:2020-01-01 00:00:00
abstract::The incidence of colorectal cancer (CRC) ranks third among all cancers in China and improvements in screening for CRC have an important impact on prevention and control of the disease. Paraoxonase 1 (PON1) is a calcium ion-dependent hydrolase that is widely distributed in tissue. Its diagnostic value in colorectal can...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.45204
更新日期:2020-09-17 00:00:00
abstract::Background: To support cancer therapy, development of low cost library preparation techniques for targeted next generation sequencing (NGS) is needed. In this study we designed and tested a PCR-based library preparation panel with limited target area for sequencing the top 12 somatic mutation hot spots in colorectal c...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.16037
更新日期:2017-01-12 00:00:00
abstract::Pancreatic ductal adenocarcinoma (PDAC) is currently one of the most intractable malignancies with a typical scirrhous pattern in histology. Due to its abundant tumor stroma and scant vascularization, chemotherapeutic agents are considered inefficiently permeable to cancer nests, making it highly difficult to cure the...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24415
更新日期:2018-07-30 00:00:00
abstract::Background: Integrative oncology (IO) is a relatively new field that seeks to bring evidence-based, non-conventional approaches into conventional oncology care in a coordinated and safe manner. Though complementary and alternative medicine (CAM) are highly utilized by cancer patients, little is known about the charact...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.17506
更新日期:2017-02-10 00:00:00
abstract:BACKGROUND:MicroRNA (miRNA) have been shown to regulate gene expression in many cancers. MiR-182 has recently been found to be prognostic for patients treated with radical prostatectomy for prostate cancer. We sought to assess miR-182 as a prognostic marker and understand its role in prostate cancer progression and met...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.13176
更新日期:2015-10-25 00:00:00
abstract::Objectives: To investigate the effect of the concurrent use of trastuzumab and anthracycline-based neoadjuvant chemotherapy (NAC) for HER2-positive breast cancer in terms of pCR and cardiotoxicity. Methods: We systematically searched Pubmed, Embase, Cochrane and SinoMed databases from inception until 1 July 2017 for r...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24701
更新日期:2018-08-06 00:00:00
abstract::Background: Programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer (NSCLC) is considered as a predictive biomarker of anti-PD-1/PD-L1 cancer therapies. However, the correlation of PD-L1 expression status between the primary and paired metastatic NSCLC is still not clear. The current study aims to a...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.34793
更新日期:2020-01-01 00:00:00
abstract::Objective: The purpose of this study was to evaluate the efficacy and feasibility of the R.E.N.A.L. Nephrometry Score to postoperatively predict high-grade clear-cell renal carcinoma (ccRCC). Methods: The study included 288 patients diagnosed with ccRCC who had complete CT/CTA data and R.E.N.A.L. Nephrometry Scores an...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.21189
更新日期:2017-10-17 00:00:00
abstract::Colorectal cancer is a commonly diagnosed malignancy and also the major cause of death worldwide. Chemotherapy is the primary therapy for advanced colorectal cancer. Although oxaliplatin has potential effect in colorectal cancer therapy, the molecular mechanisms involved in its cytotoxic effects are not well elucidate...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.24474
更新日期:2018-05-22 00:00:00
abstract::Non epithelial ovarian tumors represent a small group of rare gynecological cancers but they have a high incidence in young childbearing women. The recent years fertility preservation surgeries have become a common practice in specific ovarian malignancies when the patients wish to maintain their fertility. Specific t...
journal_title:Journal of Cancer
pub_type: 杂志文章,评审
doi:10.7150/jca.26674
更新日期:2018-11-24 00:00:00
abstract::Purpose: Extremity soft tissue leiomyosarcoma (LMS) with metastasis is a rare disease with a poor prognosis. The purpose of our study was to define clinical features of extremity soft tissue LMS with metastasis as well as to identify multivariable predictors of survival. Methods: During 1973-2015, 239 patients with me...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.29874
更新日期:2019-05-21 00:00:00
abstract::Rac activation is precisely regulated temporally and spatially by intracellular signaling pathways in migrating cells to guarantee the formation of specific cell protrusions-lamellipodia at the leading edge. Integrins-mediated adhesions also control the signaling pathway for localized Rac activation in the cells, but ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.32853
更新日期:2020-01-01 00:00:00
abstract::Purpose Neuroblastoma is an embryonic solid tumor derived from the progenitors of the sympathetic nervous system. More than half of the patients developed metastatic disease at the time of initial diagnosis and had poor outcome with current therapeutic approaches. In recent years, some obligate and facultative anaerob...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.18776
更新日期:2017-06-03 00:00:00
abstract::Introduction: Preoperative risk stratification is crucial for clinical treatment of endometrial cancer (EC). This study aimed to establish a model based on magnetic resonance imaging (MRI) and clinical factors for risk classification of EC. Materials and Methods: A total of 102 patients with pathologically proven Stag...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.50872
更新日期:2021-01-01 00:00:00
abstract::Purpose: We examined the effect of GV1001 in castration castration-resistant prostate cancer (CRPC) cell growth and invasion and explored the potential molecular mechanisms of action. Materials and Methods: The in vitro anti-cancer effects of GV1001 in CRPC cells were examined using cell viability assay, TUNEL assay, ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.34859
更新日期:2019-10-17 00:00:00
abstract::Background: The genetic heterogeneity between primary and metastatic lesions has rarely studied. Purpose: This study aims to compare the mutation profiling of key cancer-related genes in primary lung cancers and their matched lymph nodes (LN) metastasis. Methods: The gene mutation profiling of both primary cancers and...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.28266
更新日期:2019-03-03 00:00:00
abstract::Our results show that using an EBV-LCL feeder cell line, large numbers of pure populations of highly activated NK cells can be expanded ex vivo under GMP conditions. With the exception of thyroiditis and constitutional symptoms related to IL-2 therapy, infusions of up to 1 x 10(8) cells/kg of ex vivo expanded NK have ...
journal_title:Journal of Cancer
pub_type: 杂志文章
doi:10.7150/jca.2.383
更新日期:2011-01-01 00:00:00