Abstract：
:Background: The effect of adjuvant chemotherapy on stage II colon cancer remains constantly controversial. Recently, however, several studies have reported the definite survival benefit of adjuvant chemotherapy (ACT) in T4 disease (stage IIB and IIC) among stage II colon cancer patients. The following study investigates the efficacy of ACT in patients with poorly differentiated stage IIA colon cancer. Methods: The first cohort of eligible patients (N=38384) diagnosed with stage IIA colon cancer was selected from the Surveillance, Epidemiology, and End Results database (SEER) between January 1, 2004, and December 31, 2010. Cox proportional hazards regression analyses and Kaplan-Meier curves were used to evaluate the survival benefit following ACT. Our findings were also evaluated in Fudan University Shanghai Cancer Center (FUSCC) cohort form FUSCC database. Results: In SEER cohort, poorly differentiated or undifferentiated tumor grade was associated with 21.5% increased cancer-specific mortality in patients who did not receive ACT (HR=1.215, 1.004-1.469, P=0.045, using poorly differentiated or undifferentiated ACT as a reference). In FUSCC cohort, poorly differentiated or undifferentiated tumor grade was also associated with increased DFS in patients who received ACT (HR = 0.160, 95% CI = 0.017-1.505, P=0.109, using poorly differentiated or undifferentiated, non-ACT as a reference). In addition, patients with poorly differentiated or undifferentiated tumor who did not receive ACT had a higher risk of distant metastasis and recurrence compared to patients who received ACT (log-rank P=0.027 and 0.119, respectively). Conclusion: ACT decreased the recurrence rate and distant metastasis rate thus improving prognosis for poorly differentiated or undifferentiated stage IIA colon cancer.
journal_name
J Cancerjournal_title
Journal of Cancerauthors
Liu Q,Luo D,An H,Zhang S,Cai S,Li Q,Li Xdoi
10.7150/jca.28917subject
Has Abstractpub_date
2019-01-29 00:00:00pages
1209-1215issue
5issn
1837-9664pii
jcav10p1209journal_volume
10pub_type
杂志文章abstract：PURPOSE:We conducted a meta-analysis to evaluate and compare the short- and long-term results of laparoscopic colorectal surgery (LCRS) and conventional open surgery (OCRS) for colorectal cancer (CRC). METHODS:We searched relevant papers published between January 1990 and May 2011. We analyzed the outcomes of each typ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.2.425
更新日期：2011-01-01 00:00:00
abstract：:Rac activation is precisely regulated temporally and spatially by intracellular signaling pathways in migrating cells to guarantee the formation of specific cell protrusions-lamellipodia at the leading edge. Integrins-mediated adhesions also control the signaling pathway for localized Rac activation in the cells, but ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.32853
更新日期：2020-01-01 00:00:00
abstract：:The alterations of MET have been detected in non-small-cell lung cancer (NSCLC). However, the prognostic impact of MET gene copy number gain (CNG) has not been consistent among studies. We performed this meta-analysis to evaluate the prognostic value of high MET CNG in patients with NSCLC. A systematic computerized se...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.24980
更新日期：2018-04-23 00:00:00
abstract：:Non-small-cell lung cancer (NSCLC) patients with epidermal growth factor receptor (EGFR) mutation inevitably have a relapse due to the occurrence of acquired resistance, resulting in treatment failure. However, little is known about the mechanisms of acquired resistance of NSCLC patients. Here, we elucidated the expre...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.35097
更新日期：2019-10-15 00:00:00
abstract：:Background: In the various cancer, mast cells (MCs) infiltration is correlated with a worse prognosis. There is an increasing evidence that MCs and their mediators are participated in remodeling of the tumor microenvironment and facilitate tumor growth, epithelial-to-mesenchymal transition (EMT) and metastasis. Method...
journal_title：Journal of Cancer
pub_type： 杂志文章,收录出版
doi：10.7150/jca.29953
更新日期：2019-06-09 00:00:00
abstract：:Neural invasion (NI) is one of the important routes for local spread of gastric cancer (GC) correlated with poor prognosis. However, the exact cellular characteristics and molecular mechanisms of NI in GC are still unclear. Netrin-1(NTN1) as an axon guidance molecule was firstly found during neural system development....
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.30230
更新日期：2019-06-02 00:00:00
abstract：:Background: Epithelial-mesenchymal transition (EMT) plays an important role in the invasion and migration during cancer metastasis. Wnt3a is one of the ligands in canonical Wnt/β-catenin signaling pathway, which contributes to the carcinogenesis and progression of lung cancer cell lines. The aim of this study was to e...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.18560
更新日期：2017-08-02 00:00:00
abstract：:Background: To develop and validate a radiomic nomogram incorporating radiomic features with clinical variables for individual local recurrence risk assessment in nasopharyngeal carcinoma (NPC) patients before initial treatment. Methods: One hundred and forty patients were randomly divided into a training cohort (n = ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.33345
更新日期：2019-07-10 00:00:00
abstract：:Purpose: Several new treatment options for patients with metastatic castration resistant prostate cancer (mCRPC) have been approved within the last years - among them cabazitaxel (CAB), abiraterone acetate, enzalutamide, and radium-223. The aim of this study was to assess factors predictive for efficacy of CAB. Method...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.17644
更新日期：2017-02-11 00:00:00
abstract：:For many years, the medical treatment of breast cancer was reliant solely on cytotoxic chemotherapy. However, over the past twenty years, treatment has evolved to a more target-directed approach. We now employ tailored therapy based on the presence or absence of receptors for estrogen, progesterone, and human epiderma...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.4925
更新日期：2013-01-01 00:00:00
abstract：:Objective: Although previous studies suggest that previous pulmonary tuberculosis was associated with increased risk of lung cancer. It remains controversial whether pulmonary tuberculosis is a risk factor for lung cancer. Our study was aimed to examine the association between pulmonary tuberculosis and lung cancer ri...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.37022
更新日期：2020-01-20 00:00:00
abstract：:Purpose: The aberrant of fibroblast growth factors and their receptors (FGF/FGFR) is an emerging target in the treatment of solid tumors. This study aimed to explore the landscape of FGF/FGFR alterations in a large cohort of cancer patients. Material and Methods: The formalin-fixed paraffin-embedded specimens of cance...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.49269
更新日期：2020-09-23 00:00:00
abstract：:Purpose: Hypoxia-inducible factor-1alpha (HIF-1A) is a transcription factor that plays an "angiogenic switch" role especially under hypoxia microenvironment in solid tumor. However, the functions and clinical significance of HIF-1A in gallbladder cancer (GBC) are still controversial, and it has not been studied in nor...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.46749
更新日期：2021-01-01 00:00:00
abstract：:Background: To elucidate the expression of Aurora kinases (AURK) and the anticancer effects of pan-aurora kinase inhibitor Danusertib in hepatocarcinogenesis model in C56Bl6 mice. Methods: Thirty mice C56Bl6 were randomly divided into Group A or control, Group B animals who underwent experimental hepatocarcinogenesis ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.22329
更新日期：2018-02-27 00:00:00
abstract：:Hepatocellular carcinoma (HCC) is the sixth most common tumor worldwide. The relationship between the gene methylation accumulation and HCC has been widely studied. In our study, we used the Sequenom EpiTYPER assay to investigate the methylation levels of the RASA3 in 164 HCC samples and paired adjacent non-cancerous ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.24567
更新日期：2018-05-25 00:00:00
abstract：:Background: Early gastric carcinoma (EGC) with pure signet ring cell carcinoma (pSRCC) has been reported to have favourable prognosis and low risk of lymph node metastasis (LNM). However, risk factors of LNM and clinicopathological features for early gastric mixed signet ring cell carcinoma (mSRCC) remain poorly inves...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.29245
更新日期：2019-01-29 00:00:00
abstract：:Cancer is a leading cause of death throughout the world, and cancer therapy remains a big medical challenge in terms of both its therapeutic efficacy and safety. Therefore, to find out a safe anticancer drug has been long goal for oncologist and medical scientists. Among clinically used medicines with no or little tox...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.24488
更新日期：2018-04-06 00:00:00
abstract：:Background: Programmed death-ligand 1 (PD-L1) expression in non-small cell lung cancer (NSCLC) is considered as a predictive biomarker of anti-PD-1/PD-L1 cancer therapies. However, the correlation of PD-L1 expression status between the primary and paired metastatic NSCLC is still not clear. The current study aims to a...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.34793
更新日期：2020-01-01 00:00:00
abstract：:Ever since its discovery (1924) the Warburg effect (aerobic glycolysis) remains an unresolved puzzle: why the aggressive cancer cells "prefer" to use the energetically highly inefficient method of burning the glucose at the cellular level? While in the course of the last 90 years several hypotheses have been suggested...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.14274
更新日期：2016-04-26 00:00:00
abstract：:Objectives: Lung cancer in young adults is a distinct disease with particular socioeconomic implications. This study aimed to clarify the clinicopathological characteristics, best interventions, and outcomes of this distinctive entity. Methods: A retrospective review of patients with lung cancer was performed in our i...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.27490
更新日期：2019-06-09 00:00:00
abstract：:Transarterial chemoembolization (TACE) has been considered the standard treatment for intermediate-stage hepatocellular carcinoma according to BCLC algorithm. However, it has been unclear about the TACE-related predictive bio-markers and underlying molecular mechanisms. This investigation revealed that HCCs with highe...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.35631
更新日期：2020-01-01 00:00:00
abstract：:Objectives: We aimed to investigate the interaction between fasting blood glucose and tumor embolus, and the potential mediation effect of fasting blood glucose on tumor embolus in predicting gastrointestinal tract cancer-specific mortality risk postoperatively. Methods and Results: 4330 patients were consecutively re...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.34843
更新日期：2020-01-01 00:00:00
abstract：:Several studies have reported the association between MAPK signaling pathway gene polymorphisms and papillary thyroid carcinoma (PTC). KRAS gene, an oncogene from the mammalian RAS gene family plays an important role in the MAPK pathway. This study aimed to identify the potential association of KRAS gene polymorphisms...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.16507
更新日期：2016-12-09 00:00:00
abstract：:The INT0116 trial was a milestone study and laid the foundation for the adjuvant radiotherapy (RT) associated to concurrent chemotherapy (CT) for the treatment of gastric cancer (GC) after gastrectomy. However, it is still controversial whether adding RT to CT could further benefit D2-dissected GC patients. The ARTIST...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.27335
更新日期：2019-01-01 00:00:00
abstract：:Red blood cell distribution width (RDW) has been recently demonstrated to be a predictor of inflammation. High pretreatment RDW level is associated with poor survival outcomes in various malignancies, although the results are controversial. We aimed to investigate the prognostic role of RDW. A systematic literature se...
journal_title：Journal of Cancer
pub_type： 杂志文章,评审
doi：10.7150/jca.31598
更新日期：2019-07-10 00:00:00
abstract：:Background: Malignant biliary and/or pancreatic obstruction has often encountered in the advanced stages of periampullary and cholangicarcinomas. HabibTM Radiofrequency (RF) ablation has been successfully used in the management of various cancers of liver and pancreas. Percutaneous HPB probe (EMcision Ltd, London, UK)...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.23280
更新日期：2018-01-05 00:00:00
abstract：:Melanoma is the most aggressive and treatment-resistant form of skin cancer. Curcumol is a Chinese medicinal herb traditionally used as a cancer remedy. However, the molecular mechanisms underlying the anticancer activity of curcumol in melanoma remains largely unknown. In the present study, we observed that Curcumol ...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.38624
更新日期：2020-01-14 00:00:00
abstract：:Many preclinical and clinical studies are currently evaluating metformin in combination with classical therapeutic agents as anti-cancer therapy. In this study we used three distinct pancreatic cancer cell lines and evaluated cell death by trypan blue assay and Western Blots using antibodies directed against cleaved c...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.17972
更新日期：2017-07-01 00:00:00
abstract：:Background: Heavy metal pollution in farm soils is a grave concern in Taiwan. Previously, we found the incidence of oral cancer (OC) correlated positively with levels of nickel and arsenic in farm soils. Many OC patients have a second malignancy, among which esophageal cancer (EC) is the most common one in Taiwan. Obj...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.15441
更新日期：2016-08-06 00:00:00
abstract：:Long non-coding RNAs (lncRNAs) have been considered as biomarkers for the carcinogenesis and development of various cancers. However, the prognostic significance of lncRNAs in renal cell carcinoma (RCC) remains unclear. This study aimed to determine the predictive ability of lncRNAs in clear cell RCC (ccRCC). Among th...
journal_title：Journal of Cancer
pub_type： 杂志文章
doi：10.7150/jca.40421
更新日期：2020-04-27 00:00:00
