Survival benefit of adjuvant chemotherapy for patients with poorly differentiated stage IIA colon cancer.


:Background: The effect of adjuvant chemotherapy on stage II colon cancer remains constantly controversial. Recently, however, several studies have reported the definite survival benefit of adjuvant chemotherapy (ACT) in T4 disease (stage IIB and IIC) among stage II colon cancer patients. The following study investigates the efficacy of ACT in patients with poorly differentiated stage IIA colon cancer. Methods: The first cohort of eligible patients (N=38384) diagnosed with stage IIA colon cancer was selected from the Surveillance, Epidemiology, and End Results database (SEER) between January 1, 2004, and December 31, 2010. Cox proportional hazards regression analyses and Kaplan-Meier curves were used to evaluate the survival benefit following ACT. Our findings were also evaluated in Fudan University Shanghai Cancer Center (FUSCC) cohort form FUSCC database. Results: In SEER cohort, poorly differentiated or undifferentiated tumor grade was associated with 21.5% increased cancer-specific mortality in patients who did not receive ACT (HR=1.215, 1.004-1.469, P=0.045, using poorly differentiated or undifferentiated ACT as a reference). In FUSCC cohort, poorly differentiated or undifferentiated tumor grade was also associated with increased DFS in patients who received ACT (HR = 0.160, 95% CI = 0.017-1.505, P=0.109, using poorly differentiated or undifferentiated, non-ACT as a reference). In addition, patients with poorly differentiated or undifferentiated tumor who did not receive ACT had a higher risk of distant metastasis and recurrence compared to patients who received ACT (log-rank P=0.027 and 0.119, respectively). Conclusion: ACT decreased the recurrence rate and distant metastasis rate thus improving prognosis for poorly differentiated or undifferentiated stage IIA colon cancer.


J Cancer


Journal of Cancer


Liu Q,Luo D,An H,Zhang S,Cai S,Li Q,Li X




Has Abstract


2019-01-29 00:00:00












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    abstract::Background: Heavy metal pollution in farm soils is a grave concern in Taiwan. Previously, we found the incidence of oral cancer (OC) correlated positively with levels of nickel and arsenic in farm soils. Many OC patients have a second malignancy, among which esophageal cancer (EC) is the most common one in Taiwan. Obj...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Lee CP,Lee YH,Lian IB,Su CC

    更新日期:2016-08-06 00:00:00

  • Medullary Thyroid Cancer: It is a pain in the neck?

    abstract:BACKGROUND:Medullary thyroid cancer (MTC) commonly presents with lymph node (LN) metastases, and has a worse prognosis than papillary thyroid cancer (PTC). Tumor size and LN involvement have been shown to affect stage of disease; however, to our knowledge, ours is the first study that attempts to correlate anterior nec...

    journal_title:Journal of Cancer

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    authors: Guerrero MA,Lindsay S,Suh I,Vriens MR,Khanafshar E,Shen WT,Gosnell J,Kebebew E,Duh QY,Clark OH

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  • A meta-analysis of the short- and long-term results of randomized controlled trials that compared laparoscopy-assisted and open colectomy for colon cancer.

    abstract:PURPOSE:We conducted a meta-analysis to evaluate and compare the short- and long-term results of laparoscopy-assisted colectomy (LAC) and open colectomy (OC) for colon cancer. METHODS:We searched MEDLINE, EMBASE, Science Citation Index, and Cochrane Controlled Trial Register for relevant papers published between Janua...

    journal_title:Journal of Cancer

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    authors: Ohtani H,Tamamori Y,Arimoto Y,Nishiguchi Y,Maeda K,Hirakawa K

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  • Transcriptional cofactor Mask2 is required for YAP-induced cell growth and migration in bladder cancer cell.

    abstract::The highly conserved Hippo signaling pathway is an important pathway involved in tumorigenesis and development. In previous studies, YAP, the transcription coactivator of Hippo pathway, is found to be highly expressed in many clinical bladder cancer samples. To investigate the function of YAP and its cofactor Mask2 in...

    journal_title:Journal of Cancer

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    authors: Dong L,Lin F,Wu W,Huang W,Cai Z

    更新日期:2016-10-23 00:00:00

  • Optimizing a 3D Culture System to Study the Interaction between Epithelial Breast Cancer and Its Surrounding Fibroblasts.

    abstract::Stromal fibroblasts are suggested to be a key determinant in the malignant progression of breast cancer. To find an in vitro culture model that best mimics the in vivo tumor microenvironment so we can study the effects of stromal fibroblasts on breast cancer progression, we evaluated several three-dimensional (3D) co-...

    journal_title:Journal of Cancer

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    authors: Li L,Lu Y

    更新日期:2011-01-01 00:00:00

  • PD-1 and PD-L1 Expression Predicts Radiosensitivity and Clinical Outcomes in Head and Neck Cancer and is Associated with HPV Infection.

    abstract::Objectives: PD-1 and PD-L1 overexpression in malignant tumors in response to radiotherapy is correlated with a poor prognosis. Human papilloma virus (HPV) infection impacts intrinsic radiosensitivity of head and neck cancers (HNCs). Herein, this study aims to determine PD-1/PD-L1 expression differences in tumors with ...

    journal_title:Journal of Cancer

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    authors: Lyu X,Zhang M,Li G,Jiang Y,Qiao Q

    更新日期:2019-01-29 00:00:00

  • Daily Pomegranate Intake Has No Impact on PSA Levels in Patients with Advanced Prostate Cancer - Results of a Phase IIb Randomized Controlled Trial.

    abstract::Pomegranate has been shown to prolong PSA doubling time in early prostate cancer, but no data from a placebo controlled trial has been published yet. The objective of this study was to prospectively evaluate the impact of pomegranate juice in patients with prostate cancer. We conducted a phase IIb, double blinded, ran...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Stenner-Liewen F,Liewen H,Cathomas R,Renner C,Petrausch U,Sulser T,Spanaus K,Seifert HH,Strebel RT,Knuth A,Samaras P,Müntener M

    更新日期:2013-08-29 00:00:00

  • Cyclin-Dependent Kinase Inhibitor 3 Promoted Cell Proliferation by Driving Cell Cycle from G1 to S Phase in Esophageal Squamous Cell Carcinoma.

    abstract::Background and aims. Cyclin-dependent kinase inhibitor 3 (CDKN3) has been found playing a varying role in carcinogenesis, but its biological function in esophageal squamous cell carcinoma (ESCC) is unclear. The aim of this study was to demonstrate the role of CDKN3 in ESCC. Materials and Methods: Real-time PCR and Wes...

    journal_title:Journal of Cancer

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    authors: Liu J,Min L,Zhu S,Guo Q,Li H,Zhang Z,Zhao Y,Xu C,Zhang S

    更新日期:2019-04-21 00:00:00

  • Should EMT of Cancer Cells Be Understood as Epithelial-Myeloid Transition?

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    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审


    authors: Schramm HM

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  • Predictors that Influence Election of Contralateral Prophylactic Mastectomy among Women with Ductal Carcinoma in Situ who are BRCA-Negative.

    abstract::The authors retrospectively examined the contralateral prophylactic mastectomy (CPM) rate among 100 women with ductal carcinoma in situ who are BRCA negative. Of 100 women with ductal carcinoma in situ, 31 elected contralateral prophylactic mastectomy (CPM). Factors associated with increased likelihood of undergoing c...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Elsayegh N,Profato J,Barrera AM,Lin H,Kuerer HM,Ardic C,Litton JK,Tripathy D,Arun BK

    更新日期:2015-05-23 00:00:00

  • Efficacy of the Additional Neoadjuvant Chemotherapy to Concurrent Chemoradiotherapy for Patients with Locoregionally Advanced Nasopharyngeal Carcinoma: a Bayesian Network Meta-analysis of Randomized Controlled Trials.

    abstract:BACKGROUND:Due to the lack of studies, it remains unclear whether the additional neoadjuvant chemotherapy (NACT) to concurrent chemoradiotherapy (CCRT) is superior to CCRT alone for locoregionally advanced nasopharyngeal carcinoma (NPC). The main objective of this Bayesian network meta-analysis was to determine the eff...

    journal_title:Journal of Cancer

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    authors: Chen YP,Guo R,Liu N,Liu X,Mao YP,Tang LL,Zhou GQ,Lin AH,Sun Y,Ma J

    更新日期:2015-07-17 00:00:00

  • Weaknesses and Pitfalls of Using Mice and Rats in Cancer Chemoprevention Studies.

    abstract::Many studies, using different chemical agents, have shown excellent cancer prevention efficacy in mice and rats. However, equivalent tests of cancer prevention in humans require decades of intake of the agents while the rodents' short lifespans cannot give us information of the long-term safety. Therefore, animals wit...

    journal_title:Journal of Cancer

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    authors: Ma Y,Jia Y,Chen L,Ezeogu L,Yu B,Xu N,Liao DJ

    更新日期:2015-09-01 00:00:00

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    abstract::Cullin family proteins function as scaffolds to form numerous E3 ubiquitin ligases with RING proteins, adaptor proteins and substrate recognition receptors. These E3 ligases further recognize numerous substrates to participate in a variety of cellular processes, such as DNA damage and repair, cell death and cell cycle...

    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审


    authors: Chen Z,Sui J,Zhang F,Zhang C

    更新日期:2015-01-16 00:00:00

  • Novel biomarkers and prediction model for the pathological complete response to neoadjuvant treatment of triple-negative breast cancer.

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    journal_title:Journal of Cancer

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    authors: Han Y,Wang J,Xu B

    更新日期:2021-01-01 00:00:00

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    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Chen XZ,Song XH,Chen XL,Li CC,Mo XM,Hu JK

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    authors: Li YC,Cheng AJ,Lee LY,Huang YC,Chang JT

    更新日期:2019-07-08 00:00:00

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    journal_title:Journal of Cancer

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    authors: Zhang YF,Zhou YZ,Zhang B,Huang SF,Li PP,He XM,Cao GD,Kang MX,Dong X,Wu YL

    更新日期:2019-07-23 00:00:00

  • Ki67 Proliferation Index as a Histopathological Predictive and Prognostic Parameter of Oral Mucosal Melanoma in Patients without Distant Metastases.

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    authors: Ma X,Wu Y,Zhang T,Song H,Jv H,Guo W,Ren G

    更新日期:2017-10-17 00:00:00

  • Significant prognostic impact of chemoradiotherapy-induced hemoglobin decrease on treatment outcomes of nasopharyngeal carcinoma.

    abstract:PURPOSE:To investigate prognostic impact of chemoradiotherapy-induced hemoglobin (Hb) decrease on treatment outcomes of endemic nasopharyngeal carcinoma (NPC). MATERIALS AND METHODS:Eight hundred and fifteen non-metastatic NPC, receiving neoadjuvant chemotherapy followed by radiotherapy (NACT+RT group) or concomitant ...

    journal_title:Journal of Cancer

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    authors: Liang XX,Li Q,Su Z,Lan XW,Ouyang PY,Mao YP,Shi DB,Deng WG,Cheng ZB,Wang SY,Xie FY

    更新日期:2015-04-02 00:00:00

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    abstract::Background: Malignant biliary and/or pancreatic obstruction has often encountered in the advanced stages of periampullary and cholangicarcinomas. HabibTM Radiofrequency (RF) ablation has been successfully used in the management of various cancers of liver and pancreas. Percutaneous HPB probe (EMcision Ltd, London, UK)...

    journal_title:Journal of Cancer

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    authors: Mizandari M,Kumar J,Pai M,Chikovani T,Azrumelashvili T,Reccia I,Habib N

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  • The Kinetic Changes of Systemic Inflammatory Factors during Bevacizumab Treatment and Its Prognostic Role in Advanced Non-small Cell Lung Cancer Patients.

    abstract::Background: Bevacizumab combined with chemotherapy is still one of the standard options for treatment of advanced non-small cell lung cancer (NSCLC) patients without driver mutations. Serum inflammatory factors, representing the systemic immune status, are shown to have complicated relationships with tumor angiogenesi...

    journal_title:Journal of Cancer

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    authors: Li B,Wang S,Li C,Guo M,Xu Y,Sun X,Yu J,Wang L

    更新日期:2019-08-28 00:00:00

  • Stromal mesenchymal stem cells facilitate pancreatic cancer progression by regulating specific secretory molecules through mutual cellular interaction.

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    journal_title:Journal of Cancer

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    authors: Saito K,Sakaguchi M,Maruyama S,Iioka H,Putranto EW,Sumardika IW,Tomonobu N,Kawasaki T,Homma K,Kondo E

    更新日期:2018-07-30 00:00:00

  • Prognostic value of MET copy number gain in non-small-cell lung cancer: an updated meta-analysis.

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    journal_title:Journal of Cancer

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    authors: Kim JH,Kim HS,Kim BJ

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  • Prognostic Impact of TTF-1 Expression in Non-Squamous Non-Small-Cell Lung Cancer: A Meta-Analysis.

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    journal_title:Journal of Cancer

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    authors: Kim JH,Kim HS,Kim BJ,Han B,Choi DR,Kwon JH

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    abstract::Hepatocellular carcinoma (HCC) cells exhibit multidrug resistance (MDR), but the underlying mechanisms remain unclear. Cancer cells that overexpress telomerase are resistant to chemotherapeutic drugs. This study aimed to determine the effects of mitochondrial translocation of telomerase on MDR in HCC cells. HepG2 cell...

    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Yan J,Zhou Y,Chen D,Li L,Yang X,You Y,Ling X

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  • Tyrosine Kinase Inhibitors for the Elderly.

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    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审


    authors: Hohenforst-Schmidt W,Zarogoulidis P,Steinheimer M,Benhassen N,Tsiouda T,Baka S,Yarmus L,Stratakos G,Organtzis J,Pataka A,Tsakiridis K,Karapantzos I,Karapantzou C,Darwiche K,Zissimopoulos A,Pitsiou G,Zarogoulidis K,Man Y

    更新日期:2016-03-21 00:00:00

  • Identification of CTLA-4 associated with tumor microenvironment and competing interactions in triple negative breast cancer by co-expression network analysis.

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    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Peng Z,Su P,Yang Y,Yao X,Zhang Y,Jin F,Yang B

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    journal_title:Journal of Cancer

    pub_type: 杂志文章,评审


    authors: Ren H,Du P,Ge Z,Jin Y,Ding D,Liu X,Zou Q

    更新日期:2016-05-25 00:00:00

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    journal_title:Journal of Cancer

    pub_type: 杂志文章


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    journal_title:Journal of Cancer

    pub_type: 杂志文章


    authors: Lee SL,Tameru AM

    更新日期:2012-01-01 00:00:00