Centromere Protein N Participates in Cellular Proliferation of Human Oral Cancer by Cell-Cycle Enhancement.

abstract：:GOAL: To investigate the HPV prevalence and characterize the expression of potential molecular surrogate markers of HPV infection in esophageal squamous cell carcinoma. MATERIALS AND METHODS: The prevalence of HPV in individuals with and without esophageal cancer (EC) was determined by using multiplex PCR; p16 and p53...

journal_title：Journal of Cancer

authors： Pastrez PRA,Mariano VS,da Costa AM,Silva EM,Scapulatempo-Neto C,Guimarães DP,Fava G,Neto SAZ,Nunes EM,Sichero L,Villa LL,Syrjanen KJ,Longatto-Filho A

更新日期：2017-04-09 00:00:00

abstract：:Objective: There are controversial indications for neoadjuvant chemotherapy (NAT) in the treatment of locally advanced gastric cancer (LAGC). Here, we aimed to identify indications for NAT based on pre-treatment clinicopathological and laboratory parameters. Methods: This study included a retrospective cohort of 1083 ...

journal_title：Journal of Cancer

authors： Wang Y,Zhang J,Guo S,Meng XY,Zheng ZC,Zhao Y

更新日期：2020-08-18 00:00:00

abstract：OBJECTIVE:To elucidate the oncologic behavior of Micropapillary Urothelial Bladder Carcinoma (MPBC), a rare aggressive variant histology. METHODS:All MPBC patients in SEER 17 database were compared with those with traditional urothelial carcinoma (UC). Kaplan-Meier curves were used to determine OS and CSS. A Cox propo...

journal_title：Journal of Cancer

authors： Vourganti S,Harbin A,Singer EA,Shuch B,Metwalli AR,Agarwal PK

更新日期：2013-05-06 00:00:00

abstract：BACKGROUND:We conducted this pooled analysis to investigate the impact of RECIST 1.1 on the selection of target lesions and classification of tumor response, in comparison with RECIST 1.0. Methods : We searched MEDLINE and EMBASE for articles with terms of RECIST 1.0 or RECIST 1.1. We looked into all abstracts and virt...

journal_title：Journal of Cancer

authors： Kim JH,Min SJ,Jang HJ,Cho JW,Kim SH,Kim HS

更新日期：2015-02-25 00:00:00

abstract：:Background: Carbonic anhydrase 4 (CA4) maintains homeostasis of carbon dioxide and bicarbonate. It is suggested to be a potential prognostic biomarker, while the correlations between CA4 and different cancers are indistinct. Methods: Differential mRNA expression of CA4 among different cancers and corresponding normal ...

journal_title：Journal of Cancer

authors： Xu Y,Xu WH,Shi SN,Yang XL,Ren YR,Zhuang XY,Qu YY,Zhang HL,Zhang XF

更新日期：2020-08-25 00:00:00

abstract：:We hypothesised that the blood levels of immune cells would be related to the progression of colorectal cancer and regional lymph node metastasis. We investigated the association between the blood levels of immune cells and regional lymph node metastasis in colorectal cancer patients. Patients with American Joint Comm...

journal_title：Journal of Cancer

authors： Lee JY,Seo EH,Oh CS,Paik JH,Hwang DY,Lee SH,Kim SH

更新日期：2017-05-10 00:00:00

abstract：:Background: Radiotherapy is a primary treatment strategy for patients with unresectable hepatocellular carcinoma (HCC); however, the prognostic factors among HCC patients who have received radiotherapy but not undergone surgery have not been systematically studied. Thus, the prognostic factors were investigated in thi...

journal_title：Journal of Cancer

authors： Zhang L,Yan L,Niu H,Ma J,Yuan BY,Chen YH,Zhuang Y,Hu Y,Zeng ZC,Xiang ZL

更新日期：2019-07-25 00:00:00

abstract：:Dihydroorotate dehydrogenase (DHODH) is a rate-limiting enzyme in the de novo biosynthesis pathway of pyrimidines. Inhibition of this enzyme impedes cancer cell proliferation but the exact mechanisms of action of these inhibitors in cancer cells are poorly understood. In this study, we showed that cancer cells, namely...

journal_title：Journal of Cancer

authors： Dorasamy MS,Choudhary B,Nellore K,Subramanya H,Wong PF

更新日期：2017-09-05 00:00:00

abstract：:Increasing studies indicate that long noncoding RNA (lncRNA) plays a critical role in aerobic glycolysis of various tumors. However, the contribution of lncRNA in gastric cancer (GC) cell glycolysis is still poorly understood. The objective of this research was to investigate the functional role and mechanism of lncRN...

journal_title：Journal of Cancer

authors： Qian C,Xu Z,Chen L,Wang Y,Yao J

更新日期：2020-08-27 00:00:00

abstract：:Butyrate, a product of dietary fiber and a histone deacetylase inhibitor, induces apoptosis of colorectal cancer cells; this effect of butyrate is in part mediated by its ability to hyperactivate Wnt signaling, and may in part explain the preventive action of dietary fiber against colorectal cancer. However, the mecha...

journal_title：Journal of Cancer

authors： Bordonaro M

更新日期：2020-01-01 00:00:00

abstract：:Background: Immune cells recognize tumor antigens presented on major histocompatibility complex class I (MHC-I) molecule. Increase of MHC-I molecular expression makes tumor cells more susceptible to lysis by immune cells. Methods: Tumor lysate vaccine was prepared to damage glioma cells including cell lines and primar...

journal_title：Journal of Cancer

authors： Sun T,Li Y,Yang W,Wu H,Li X,Huang Y,Zhou Y,Du Z

更新日期：2019-09-07 00:00:00

abstract：OBJECTIVES:To study whether radical nephrectomy (RN) with lymph node dissection (LND) can benefit pT3 renal cell carcinoma (RCC) patients versus no LND under the 2018 American Joint Committee on Cancer TNM classification system. Subjects/Patients and Methods: We performed a retrospective cohort study of clinicopatholog...

journal_title：Journal of Cancer

authors： Li P,Peng C,Gu L,Xie Y,Nie W,Zhang Y,Xuan Y,Shen D,Du S,Tang L,Yao Y,Fan Y,Ma X,Zhang X

更新日期：2019-05-26 00:00:00

abstract：:Various factors modulate the risk of hepatoblastoma. In this study, we aimed to investigate whether single nucleotide polymorphisms (SNPs) in the YTHDF1 gene could predispose to hepatoblastoma. We used TaqMan assay to genotype two YTHDF1 SNPs (rs6011668 C>T and rs6090311 A>G) in a Chinese population composed of 313 su...

journal_title：Journal of Cancer

authors： Luo Z,Li G,Wang M,Zhu J,Yang Z,Li Y,Zhang J,Xin Y,Li S,Li L,Zhuo Z,He J

更新日期：2020-06-28 00:00:00

abstract：:Lung cancer is a major cause of death worldwide, with lung adenocarcinoma being the most frequently diagnosed subtype in Japan. Finding the target of an anticancer drug can improve lung adenocarcinoma treatments. Polo-like kinase 1 (PLK1) is an essential mitotic kinase in mitotic progression, and PLK1 inhibition induc...

journal_title：Journal of Cancer

authors： Sekimoto N,Suzuki Y,Sugano S

更新日期：2017-11-06 00:00:00

abstract：:Levels of plasma cell-free DNA (cfDNA) of a large series of children with classical Hodgkin lymphoma (cHL) were evaluated and analyzed at diagnosis and during chemotherapy treatment in relation with clinical characteristics. CfDNA levels in cHL patients were significantly higher compared with controls (p=0.002). CfDNA...

journal_title：Journal of Cancer

authors： Primerano S,Burnelli R,Carraro E,Pillon M,Elia C,Farruggia P,Sala A,Vinti L,Buffardi S,Basso G,Mascarin M,Mussolin L

更新日期：2016-01-12 00:00:00

abstract：:Thyroid transcription factor-1 (TTF-1) is overexpressed in up to 95% of primary lung adenocarcinoma while negative for almost all squamous cell carcinomas. TTF-1 expression has been investigated as a prognostic factor in non-small-cell lung cancer (NSCLC) with conflicting results. We conducted this meta-analysis to ga...

journal_title：Journal of Cancer

authors： Kim JH,Kim HS,Kim BJ,Han B,Choi DR,Kwon JH

更新日期：2018-10-20 00:00:00

abstract：:Endometrium is the mucosal lining of the uterus which expressed a cyclic process of proliferation, secretion and scaling under the control of hormones secreted by the ovary, and it also plays an indispensable role in the embryo implantation, the constitution of fetal-maternal interface, and the maintaining of pregnanc...

journal_title：Journal of Cancer

authors： Yang S,Wang H,Li D,Li M

更新日期：2019-06-09 00:00:00

abstract：:Objective: This study aimed to evaluate the efficacy and safety of doxorubicin-loaded drug-eluting beads transarterial chemoembolization (DEB-TACE) with CalliSpheres microspheres (CSM) in treating unresectable intrahepatic cholangiocarcinoma (ICC). Methods: 88 unresectable ICC patients who received DEB-TACE treatment ...

journal_title：Journal of Cancer

authors： Zhou TY,Zhou GH,Zhang YL,Nie CH,Zhu TY,Wang HL,Chen SQ,Wang BQ,Yu ZN,Wu LM,Zheng SS,Sun JH

更新日期：2020-05-18 00:00:00

abstract：:The 21-gene recurrence score (RS) is increasingly being used for patients with early stage, hormone receptor-positive, Her-2-negative breast cancer. However, these results are largely from populations with infiltrating ductal carcinoma (IDC). The clinical value of RS testing in mucinous carcinoma has not been well inv...

journal_title：Journal of Cancer

authors： Wang W,Chen X,Lin L,Fei X,Garfield DH,Hong J,Gao W,Zhu S,Wu J,Huang O,He J,Li Y,Zhu L,Chen W,Shen K

更新日期：2018-08-06 00:00:00

abstract：:Several studies have reported the association between MAPK signaling pathway gene polymorphisms and papillary thyroid carcinoma (PTC). KRAS gene, an oncogene from the mammalian RAS gene family plays an important role in the MAPK pathway. This study aimed to identify the potential association of KRAS gene polymorphisms...

journal_title：Journal of Cancer

authors： Ning L,Rao W,Yu Y,Liu X,Pan Y,Ma Y,Liu R,Zhang S,Sun H,Yu Q

更新日期：2016-12-09 00:00:00

abstract：:Objectives: LncRNA associated with microvascular invasion in hepatocellular carcinoma (lncRNA MVIH) is a newly discovered long non-coding RNA that aberrantly up-regulates and holds prognostic value in various tumors. The aim of the review and meta-analysis is to assess its prognostic potential and functions in maligna...

journal_title：Journal of Cancer

authors： Zhang Y,Lin S,Yang X,Zhang X

更新日期：2019-02-26 00:00:00

abstract：:Background: We performed a meta-analysis to evaluate the risk of immune-related colitis associated with PD1/PD-L1 inhibitors as compared to chemotherapy in solid tumor patients. Methods: Eligible studies were identified through a comprehensive search of multiple databases and included solid tumor patients in randomize...

journal_title：Journal of Cancer

authors： Su Q,Zhang X,Shen X,Hou Y,Sun Z,Gao ZH

更新日期：2018-04-12 00:00:00

abstract：:Background and aim: Understanding the molecular biological mechanisms underlying laryngeal squamous cell carcinoma (LSCC) invasion and metastasis is crucial for diagnosis, treatment, and prognosis. We aimed to examine the expression of the tumor suppressor microRNA-204-5p (miR-204-5p) and its target gene, forkhead box...

journal_title：Journal of Cancer

authors： Gao W,Wu Y,He X,Zhang C,Zhu M,Chen B,Liu Q,Qu X,Li W,Wen S,Wang B

更新日期：2017-07-21 00:00:00

abstract：:Background: Radiotherapy is a standard treatment for a significant fraction of cancer patients. Nonetheless, to this day radiation resistance is a key impediment in gastric cancer (GC) treatment. Moreover, GC is characterized by its substantial neo-angiogenesis, driven by high levels of vascular endothelial growth fac...

journal_title：Journal of Cancer

authors： Li G,Lin H,Tian R,Zhao P,Huang Y,Pang X,Zhao L,Cao B

更新日期：2018-10-18 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the sixth most common cancer, and the third most common cause of cancer related death worldwide. The multi-kinase inhibitor Sorafenib represents the only systemic treatment option until today, and results from clinical trials with allosteric mTOR inhibitors were sobering. Since the PI...

journal_title：Journal of Cancer

authors： Ewald F,Nörz D,Grottke A,Bach J,Herzberger C,Hofmann BT,Nashan B,Jücker M

更新日期：2015-09-16 00:00:00

abstract：:Purpose: Diffuse large B cell lymphoma (DLBCL) is one of the most common B cell lymphomas, which displays heterogeneous pathologies. Programmed cell death 1/ programmed cell death ligand 1 (PD-1/PD-L1) plays an essential role in immunosuppression in multiple malignancies. Signal transducer and activator of transcripti...

journal_title：Journal of Cancer

authors： Fei Y,Yu J,Li Y,Li L,Zhou S,Zhang T,Li L,Qiu L,Meng B,Pan Y,Ren X,Qian Z,Wang X,Zhang H

更新日期：2020-10-17 00:00:00

abstract：:Aims: We previously demonstrated that a loss of lean body mass loss at one month after gastrectomy was an independent risk factor for the continuation of adjuvant chemotherapy with S-1. However, it is unclear whether or not lean body mass loss after gastrectomy leads to a poor survival through poor compliance to adjuv...

journal_title：Journal of Cancer

authors： Aoyama T,Yoshikawa T,Maezawa Y,Kano K,Numata M,Hara K,Komori K,Yamada T,Hayashi T,Sato T,Tamagawa H,Yukawa N,Rino Y,Masuda M,Ogata T,Cho H,Oshima T

更新日期：2019-05-28 00:00:00

abstract：:Lung cancer is the deadliest cancer in the world. Angiogenesis plays a crucial role of the incidence, progression, and metastasis in lung cancer. Angiogenesis inhibitors are used to treat non-small cell lung cancer (NSCLC) patients, and the molecular biomarkers are also being assessed to predict treatment response/the...

journal_title：Journal of Cancer

authors： Guo S,Martin MG,Tian C,Cui J,Wang L,Wu S,Gu W

更新日期：2018-03-22 00:00:00

abstract：:Background: Pancreatic ductal adenocarcinoma (PDAC) is one of the most aggressive human malignancies. The metabolomic approaches are developed to discover the novel biomarkers of PDAC. Methods: 550 preoperative, postoperative PDAC and normal controls (NCs) serums were employed to characterize metabolic alterations in ...

journal_title：Journal of Cancer

authors： Zhang X,Shi X,Lu X,Li Y,Zhan C,Akhtar ML,Yang L,Bai Y,Zhao J,Wang Y,Yao Y,Li Y,Nie H

更新日期：2020-05-19 00:00:00

abstract：:Studies have indicated the significance of tumor associated macrophages (TAMs) in breast cancer; however, inconsistent results still exist. We retrospectively reviewed the macrophage distribution in 1579 breast cancer specimens with anti-CD68 or anti-CD163 immunohistochemical staining, and further analyzed the overall...

journal_title：Journal of Cancer

authors： Ni C,Yang L,Xu Q,Yuan H,Wang W,Xia W,Gong D,Zhang W,Yu K

更新日期：2019-07-23 00:00:00